Hippocampal neurochemical markers in bipolar disorder patients following the first-manic episode: A prospective 12-month proton magnetic resonance spectroscopy study

Australian and New Zealand Journal of Psychiatry

Volumn 51, Issue 1, 2017, Pages 65-74

  Silveira, Leonardo E ^a,b,c   Bond, David J ^a,d   MacMillan, Erin Leigh ^a   Kozicky, Jan Marie ^a   Muralidharan, Kesavan ^a,e   Bücker, Joana ^a,b   Rosa, Adriane Ribeiro ^b,c   Kapczinski, Flavio ^b   Yatham, Lakshmi N ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d UNIVERSITY OF MINNESOTA   (United States)

^e NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Bipolar disorder; first mania; hippocampus; metabolites; spectroscopy

Indexed keywords

ANTIDEPRESSANT AGENT; GLUTAMIC ACID; GLUTAMINE; LITHIUM; MOOD STABILIZER; N ACETYLASPARTIC ACID; NEUROLEPTIC AGENT; VALPROIC ACID; ASPARTIC ACID; N-ACETYLASPARTATE;

ADULT; ARTICLE; BIPOLAR DISORDER; BIPOLAR MANIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLOBAL ASSESSMENT OF FUNCTIONING; HIPPOCAMPUS; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE SCANNER; PROSPECTIVE STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; RECURRENT DISEASE; ANALOGS AND DERIVATIVES; METABOLISM; PROCEDURES; YOUNG ADULT;

ADULT; ASPARTIC ACID; BIPOLAR DISORDER; FEMALE; GLUTAMIC ACID; GLUTAMINE; HIPPOCAMPUS; HUMANS; MALE; PROSPECTIVE STUDIES; PROTON MAGNETIC RESONANCE SPECTROSCOPY; YOUNG ADULT;

EID: 85008612492     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1177/0004867415623859     Document Type: Article

References (50)

1. Adler CM, DelBello MP, Weber WA, et al. (2013) Neurochemical effects of quetiapine in patients with bipolar mania. Journal of Clinical Psychopharmacology 33: 528-532. Available at: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00004714-201308000-00013 (. accessed 23 November 2014).
2. Atmaca M, Yildirim H, Ozdemir H, et al. (2006) Hippocampal 1H MRS in first-episode bipolar I patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry 30: 1235-1239. Available at: www.ncbi.nlm.nih.gov/pubmed/16725248 (. accessed 23 November 2014).
3. Atmaca M, Yildirim H, (2012) Altered neurochemical ingredient of hippocampus in patients with bipolar depression. Depression Research and Treatment 2012: 485249. Available at: www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3303615&tool=pmcentrez&rendertype=abstract (. accessed 23 November 2014).
4. Berk M, Brnabic A, Dodd S, et al. (2011a) Does stage of illness impact treatment response in bipolar disorder? Empirical treatment data and their implication for the staging model and early intervention. Bipolar Disorders 13: 87-98. Available at: www.ncbi.nlm.nih.gov/pubmed/21320256 (. accessed 25 November 2014).
5. Berk M, Kapczinski F, Andreazza AC, et al. (2011b) Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors. Neuroscience and Biobehavioral Reviews 35: 804-817. Available at: http://dx.doi.org/10.1016/j.neubiorev.2010.10.001 (. accessed 25 November 2014).
6. Bertolino A, Frye M, Callicott JH, et al. (2003) Neuronal pathology in the hippocampal area of patients with bipolar disorder: A study with proton magnetic resonance spectroscopic imaging. Biological Psychiatry 53: 906-913. Available at: http://linkinghub.elsevier.com/retrieve/pii/S000632230201911X (. accessed 23 November 2014).
7. Blasi G, Bertolino A, Brudaglio F, et al. (2004) Hippocampal neurochemical pathology in patients at first episode of affective psychosis: A proton magnetic resonance spectroscopic imaging study. Psychiatry Research 131: 95-105. Available at: www.ncbi.nlm.nih.gov/pubmed/15313516 (. accessed 23 November 2014).
8. Brietzke E, Stertz L, Fernandes BS, et al. (2009) Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder. Journal of Affective Disorders 116: 214-217. Available at: www.ncbi.nlm.nih.gov/pubmed/19251324 (. accessed 16 January 2015).
9. Brietzke E, Kapczinski F, (2008) TNF-alpha as a molecular target in bipolar disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry 32: 1355-1361. Available at: www.ncbi.nlm.nih.gov/pubmed/18316149 (. accessed 16 January 2015).
10. Brown NC, Andreazza AC, Young LT, (2014) An updated meta-analysis of oxidative stress markers in bipolar disorder. Psychiatry Research 218: 61-68. Available at: www.ncbi.nlm.nih.gov/pubmed/24794031 (. accessed 16 January 2015).
11. Catalá-López F, Gènova-Maleras R, Vieta E, et al. (2013) The increasing burden of mental and neurological disorders. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology 23: 1337-1339. Available at: www.ncbi.nlm.nih.gov/pubmed/23643344 (. accessed 23 November 2014).
12. Chitty KM, Lagopoulos J, Lee RSC, et al. (2013) A systematic review and meta-analysis of proton magnetic resonance spectroscopy and mismatch negativity in bipolar disorder. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology 23: 1348-1363. Available at: www.ncbi.nlm.nih.gov/pubmed/23968965 (. accessed 23 November 2014).
13. Colla M, Schubert F, Bubner M, et al. (2009) Glutamate as a spectroscopic marker of hippocampal structural plasticity is elevated in long-term euthymic bipolar patients on chronic lithium therapy and correlates inversely with diurnal cortisol. Molecular Psychiatry 14: 696-704, 647. Available at: www.ncbi.nlm.nih.gov/pubmed/18347601 (. accessed 23 November 2014).
14. Crump C, Sundquist K, Winkleby MA, et al. (2013) Comorbidities and mortality in bipolar disorder: A Swedish national cohort study. JAMA Psychiatry 70: 931-939. Available at: www.ncbi.nlm.nih.gov/pubmed/23863861 (. accessed 25 November 2014).
15. Cunha ABM, Frey BN, Andreazza AC, et al. (2006) Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neuroscience Letters 398: 215-219. Available at: www.ncbi.nlm.nih.gov/pubmed/16480819 (. accessed 29 December 2014).
16. Dager SR, Friedman SD, Parow A, et al. (2004) Brain metabolic alterations in medication-free patients with bipolar disorder. Archives of General Psychiatry 61: 450-458. Available at: www.ncbi.nlm.nih.gov/pubmed/15123489 (. accessed 25 November 2014).
17. Deicken RF, Pegues MP, Anzalone S, et al. (2003) Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder. The American Journal of Psychiatry 160: 873-882. Available at: www.ncbi.nlm.nih.gov/pubmed/12727690 (. accessed 25 November 2014).
18. DelBello MP, Cecil KM, Adler CM, et al. (2006) Neurochemical effects of olanzapine in first-hospitalization manic adolescents: A proton magnetic resonance spectroscopy study. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 31: 1264-1273. Available at: www.ncbi.nlm.nih.gov/pubmed/16292323 (. accessed 23 November 2014).
19. Ekman CJ, Lind J, Rydén E, et al. (2010) Manic episodes are associated with grey matter volume reduction-A voxel-based morphometry brain analysis. Acta Psychiatrica Scandinavica 122: 507-515. Available at: www.ncbi.nlm.nih.gov/pubmed/20712826 (. accessed 25 November 2014).
20. Frey BN, Andreazza AC, Nery FG, et al. (2007) The role of hippocampus in the pathophysiology of bipolar disorder. Behavioural Pharmacology 18: 419-430. Available at: www.ncbi.nlm.nih.gov/pubmed/17762510 (. accessed 25 November 2014).
21. Fries GR, Vasconcelos-Moreno MP, Gubert C, et al. (2014) Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder. Journal of Affective Disorders 152-154: 474-477. Available at: http://dx.doi.org/10.1016/j.jad.2013.07.027 (. accessed 23 November 2014).
22. Gigante AD, Bond DJ, Lafer B, et al. (2012) Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: A meta-analysis. Bipolar Disorders 14: 478-487. Available at: www.ncbi.nlm.nih.gov/pubmed/22834460 (. accessed 14 November 2014).
23. Gigante AD, Lafer B, Yatham LN, (2014) (1)H-MRS of hippocampus in patients after first manic episode. The World Journal of Biological Psychiatry: The Official Journal of the World Federation of Societies of Biological Psychiatry 15: 145-154. Available at: www.ncbi.nlm.nih.gov/pubmed/23984710 (. accessed 23 November 2014).
24. Hallahan B, Newell J, Soares JC, et al. (2011) Structural magnetic resonance imaging in bipolar disorder: An international collaborative mega-analysis of individual adult patient data. Biological Psychiatry 69: 326-335. Available at: www.ncbi.nlm.nih.gov/pubmed/21030008 (. accessed 25 November 2014).
25. Kapczinski F, Vieta E, Cristina A, et al. (2008) Allostatic load in bipolar disorder: Implications for pathophysiology and treatment. Neuroscience and Biobehavioral Reviews 32: 675-692.
26. Kapczinski F, Dias VV, Kauer-Sant'Anna M, et al. (2009) The potential use of biomarkers as an adjunctive tool for staging bipolar disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry 33: 1366-1371. Available at: http://dx.doi.org/10.1016/j.pnpbp.2009.07.027 (. accessed 24 November 2014).
27. Kauer-Sant'Anna M, Kapczinski F, Andreazza AC, et al. (2009) Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder. The International Journal of Neuropsychopharmacology: Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 12: 447-458. Available at: www.ncbi.nlm.nih.gov/pubmed/18771602 (. accessed 25 November 2014).
28. Kessing LV, Andersen PK, Mortensen PB, (2004) The predictive effect of episodes on the risk of recurrence in depressive and bipolar disorders-A life-long perspective. Acta Psychiatrica Scandinavica 109: 339-344. Available at: www.ncbi.nlm.nih.gov/pubmed/15049770 (. accessed 25 November 2014).
29. Kessing LV, Andersen PK, Mortensen PB, (1998) Predictors of recurrence in affective disorder: A case register study. Journal of Affective Disorders 49: 101-108. Available at: www.ncbi.nlm.nih.gov/pubmed/9609673 (. accessed 10 November 2014).
30. López-Jaramillo C, Lopera-Vásquez J, Gallo A, et al. (2010) Effects of recurrence on the cognitive performance of patients with bipolar I disorder: Implications for relapse prevention and treatment adherence. Bipolar Disorders 12: 557-567. Available at: www.ncbi.nlm.nih.gov/pubmed/20712758 (. accessed 25 November 2014).
31. Magalhães PV, Kapczinski F, Nierenberg AA, et al. (2012) Illness burden and medical comorbidity in the Systematic Treatment Enhancement Program for Bipolar Disorder. Acta Psychiatrica Scandinavica 125: 303-308. Available at: www.ncbi.nlm.nih.gov/pubmed/22098628
32. Martinez-Aran A, Vieta E, Torrent C, et al. (2007) Functional outcome in bipolar disorder: The role of clinical and cognitive factors. Bipolar Disorders 9: 103-113. Available at: www.ncbi.nlm.nih.gov/pubmed/17391354 (. accessed 26 November 2014).
33. Nordengen K, Heuser C, Rinholm JE, et al. (2013) Localisation of N-acetylaspartate in oligodendrocytes/myelin. Brain Structure and Function. Available at: www.ncbi.nlm.nih.gov/pubmed/24379086 (. accessed 17 December 2014).
34. Pfaffenseller B, Wollenhaupt-aguiar B, Fries GR, et al. (2014) Impaired endoplasmic reticulum stress response in bipolar disorder: Cellular evidence of illness progression. The International Journal of Neuropsychopharmacology: Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 17: 1453-1463. Available at: www.ncbi.nlm.nih.gov/pubmed/24800824 (. accessed 23 November 2014).
35. Provencher SW, (1993) Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine 30: 672-679. Available at: www.ncbi.nlm.nih.gov/pubmed/8139448 (. accessed 23 November 2014).
36. Rosa AR, Reinares M, Franco C, et al. (2009) Clinical predictors of functional outcome of bipolar patients in remission. Bipolar Disorders 11: 401-409. Available at: www.ncbi.nlm.nih.gov/pubmed/19500093 (. accessed 4 January 2015).
37. Rosa AR, González-Ortega I, González-Pinto A, et al. (2012) One-year psychosocial functioning in patients in the early vs. late stage of bipolar disorder. Acta Psychiatrica Scandinavica 125: 335-341. Available at: www.ncbi.nlm.nih.gov/pubmed/22283440 (. accessed 25 November 2014).
38. Rosa AR, Magalhães PVS, Czepielewski L, et al. (2014) Clinical staging in bipolar disorder: Focus on cognition and functioning. The Journal of Clinical Psychiatry 75: e450-e456. Available at: www.ncbi.nlm.nih.gov/pubmed/24922497 (. accessed 8 November 2014).
39. Scherk H, Backens M, Schneider-Axmann T, et al. (2008) Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder. Acta Psychiatrica Scandinavica 117: 283-288. Available at: http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0447.2007.01142.x/full (. accessed 24 November 2014).
40. Scott J, Paykel E, Morriss R, et al. (2006) Cognitive-behavioural therapy for severe and recurrent bipolar disorders: Randomised controlled trial. The British Journal of Psychiatry: The Journal of Mental Science 188: 313-320. Available at: www.ncbi.nlm.nih.gov/pubmed/16582056 (. accessed 25 November 2014).
41. Smith SM, Jenkinson M, Woolrich MW, (2004) Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23: S208-S219. Available at: www.ncbi.nlm.nih.gov/pubmed/15501092 (. accessed 17 July 2014).
42. Stender M, Bryant-Comstock L, Phillips S, (2002) Medical resource use among patients treated for bipolar disorder: A retrospective, cross-sectional, descriptive analysis. Clinical Therapeutics 24: 1668-1676. Available at: www.ncbi.nlm.nih.gov/pubmed/12462295 (. accessed 25 November 2014).
43. Strakowski SM, DelBello MP, Zimmerman ME, et al. (2002) Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder. The American Journal of Psychiatry 159: 1841-1847. Available at: www.ncbi.nlm.nih.gov/pubmed/12411217 (. accessed 25 November 2014).
44. Swann AC, Bowden CL, Calabrese JR, et al. (1999) Differential effect of number of previous episodes of affective disorder on response to lithium or divalproex in acute mania. The American Journal of Psychiatry 156: 1264-1266. Available at: www.ncbi.nlm.nih.gov/pubmed/10450271 (. accessed 25 November 2014).
45. Tohen M, Zarate CA, Hennen J, et al. (2003) The McLean-Harvard First-Episode Mania Study: Prediction of recovery and first recurrence. The American Journal of Psychiatry 160: 2099-2107. Available at: www.ncbi.nlm.nih.gov/pubmed/14638578 (. accessed 25 November 2014).
46. Torres IJ, DeFreitas VG, DeFreitas CM, et al. (2010) Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode. The Journal of Clinical Psychiatry 71: 1234-1242. Available at: www.ncbi.nlm.nih.gov/pubmed/20361907 (. accessed 14 March 2013).
47. Vianna-Sulzbach M, Goi PD, Rosa AR, et al. (2013) Association of obesity with reduced hippocampal volume in bipolar disorder-Poster Session II. Bipolar Disorders 15: 140. Available at: http://doi.wiley.com/10.1111/bdi.12084 (. accessed 21 January 2015).
48. Xu J, Dydak U, Harezlak J, et al. (2013) Neurochemical abnormalities in unmedicated bipolar depression and mania: A 2D 1H MRS investigation. Psychiatry Research 213: 235-241. Available at: www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3729606&tool=pmcentrez&rendertype=abstract (. accessed 23 November 2014).
49. Yatham LN, Kennedy SH, Parikh SV, et al. (2013) Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: Update 2013. Bipolar Disorders 15: 1-44. Available at: www.ncbi.nlm.nih.gov/pubmed/23237061 (. accessed 30 May 2013).
50. Zhong S, Wang Y, Zhao G, et al. (2014) Similarities of biochemical abnormalities between major depressive disorder and bipolar depression: A proton magnetic resonance spectroscopy study. Journal of Affective Disorders 168: 380-386. Available at: www.ncbi.nlm.nih.gov/pubmed/25106035 (. accessed 23 November 2014).