In the defence against hyperglycamiea: An avian strategy

World's Poultry Science Journal

Volumn 55, Issue 3, 1999, Pages 251-268

  Klandorf, H ^a   Probert, I L ^a   Iqbal, M ^b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b UNIVERSITY OF ARKANSAS   (United States)

Author keywords

AGEs; Birds; free radicals; hyperglycamiea; longevity; oxidative stress; pentosidine; utric acid

Indexed keywords

EID: 85008581311     PISSN: 00439339     EISSN: 17434777     Source Type: Journal    
DOI: 10.1079/WPS19990019     Document Type: Article

References (109)

1. AMES, B.N., CATHCART, R., SCHWIERS, E. and HOCHSTEIN, P. (1981) Uric acid provides an antioxidant defence in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proceedings of the National Academy of Sciences, USA 78 : 6858–6862
2. AMES, B.N., SHIGENAGA, M.K. and HAGEN, T.M. (1993) Oxidants, antioxidants, and the degenerative diseases of ageing. Proceedings of the National Academy of Sciences, USA 90: 7915
3. ANDREASSEN, T.T. and OXLUND, H. (1987) Changes in collagen and elastin of rat aorta induced by experimental diabetes and food restriction. Acta Endocrinology 98 : 432–436
4. ANDREASSEN, T.T., SEYER-HANSEN, K. and OXLUND, H. (1981) Biomechanical changes in connective tissues induced by experimental diabetes. Acta Endocrinologia 98 : 432–436
5. AOKI, Y., YANAGISAWA, Y., YAZAKI, K., OGUCHI, H., KIYOSAWA, K. and FURUTA, S. (1992) Protective effect of vitamin E supplementation on increased thermal stability of collagen in diabetic rats. Diabetologia 35: 913–916
6. AUSTAD, S. and FISCHER, K. (1991) Mammalian aging, metabolism, and ecology: evidence from bats and marsupials. Journal of Gerontology: Biological Science 46: B47-B53
7. BANDY, B. and DAVISON, A. (1990) Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radical Biology and Medicine 8:523
8. BARJA DE QUIROGA, G., LOPEZ-TORRES, M. and PEREZ-CAMPO, R. (1992) Relationship between antioxidants, lipid peroxidation and aging. In: Free Radicals and Aging (Emerit, I. and Chance, B., Eds), Birkauser Verlag, Basel, pp. 109–123
9. BAYNES, J.W. (1991) Role of oxidative stress on development to complications in diabetes. Diabetes 40: 405–412
10. BECKER, F.B. (1993) Towards the physiological function of uric acid. Free Radical Biology and Medicine 14 : 615–631
11. BERG, T.J., DAHL-JORGENSEN, K., TORJESEN, P.A. and HUNNSEN, K.F. (1997) Increased serum levels of advanced glycosylation end products (AGEs) in children and adolescents with IDDM. Diabetes Care 20: 1006–1008
12. BEUCHAT, C.A. and CHONG, C.R. (1997) Hyperglycemia in hummingbirds: implications for hummingbird ecology and human health. Federation of American Societies for Experimental Biology Journal 11: A91
13. BILOUS, R.W., MAUER, S.M., SUTHERLAND, E.R. and STEFFES, M.W. (1989) Mean glomerular volume and rate of development of diabetic nephropathy. Diabetes 38: 1142–1147
14. BISHOP, M.L., DUBEN-ENGELKINK, J.L. and FODY, E.P. (1992) Clinical Chemistry, Principles, Procedures, Correlations. 2nd Edition, Lippincott, Philadelphia
15. BOTTJE, W.G. and WIDEMAN, R.F. (1995) Potential role of free radicals in the pathogenesis of pulmonary hypertension syndrome. Poultry and Avian Biology 6 : 211–231
16. BOTTJE, W. G., WANG, S., BEERS, K.W. and CAWTHON, D. (1998) Lung lining fluid antioxidants in male broilers: age-related changes under thermoneutral and cold temperature conditions. Poultry Science 77: 1905–1912
17. BRAUN, E.J. and DANTZLER, W.H. (1997) Vertebrate renal system. In: Handbook of Physiology: Comparative Physiology (Dantzler, W.H., Ed.), Volume 1, Oxford University Press, New York, pp. 481–576
18. BROWNLEE, M., VLASSARA, H. and CERAMI, A. (1984) Nonenzymatic glycosylation and the pathogenesis of diabetic complication. Annals of Internal Medicine 101 : 527–537
19. BROWNLEE, M., VLASSARA, H., KOONEY, A., ULRICH, P. and CERAMI, A. (1986) Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science 232: 1629–1632
20. BROWNLEE, M., CERAMI, A. and VLASSARA, H. (1988a) Advanced products of nonenzymatic glycosylation and the pathogenesis of diabetic vascular disease. Diabetes Metabolism Reviews. 4 : 437–451
21. BROWNLEE, M., CERAMI, A. and VLASSARA, H. (1988b) Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. Science 318: 1315–1321
22. BUCALA, R. and CERAMI, A. (1992) Advanced glycosylation: chemistry, biology, and implications for diabetes and aging. Advances in Pharmacology 23 : 1–33
23. CEFALU, W.T., BELL-FARROW, A.D., WANG, Z.Q., SONNTAG, W.E., FU, M., BAYNES, J.W. and THORPE, S.R. (1995) Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N-(carboxymethyl)lysine and pentosidine, in rat skin collagen. Journal of Gerontology: Biological Science. 50A: B337-B341
24. CERIELLO, A., GUIGLIANO, D., QUATARO, A., DONZELLA, C., DIPALO, G. and LEFEBVRE, P.J. (1991) Vitamin E reduction of protein glycosylation in diabetes. Diabetes Care 14: 68–72
25. CHANDLER, M.I., SHANNON, W.A. and DESANTIS, L. (1984) Prevention of capillary basement membrane thickening in diabetic rats by aldose reductase inhibitors. Investigative Ophthalmology and Visual Science 25 (Supplement): 159
26. CONLON, P., SMITH, D. and GOWLETT, T. (1991) Oxygen radical production by avian leukocytes. Canadian Journal of Veterinary Research 55 : 193–195
27. CUTLER, R.G. (1984a) Antioxidants, aging, and longevity. In: Free Radicals in Biology (Pryor, W.A., Ed.), Volume VI, Academic Press, Orlando, pp. 371–428
28. CUTLER, R.G. (1984b) Urate and ascorbate: their possible roles as antioxidants in determining longevity of mammalian species. Archives of Gerontology and Geriatrics 3 : 321–348
29. DANBY, R., BLUFF, L., DEHENY, T.P. and GIBSON, W.R. (1981) Effects of alloxan and streptozotocin at high doses on blood glucose levels, glucose tolerance, and responsiveness to sulphonylureas in chickens. General Comparative Endocrinology 47 : 159–169
30. DAVIE, S.J., GOULD, B.J. and YADKIN, J.S. (1992) Effect of vitamin C on glycosylation of protein. Diabetes 41: 167–173
31. DUNN, J.S., PATRICK, J.S., THORPE, S.R. and BAYENS, J.W. (1989) Oxidation of glycated protein: age dependent accumulation of N-(carboxymethyl)lysine in lens proteins. Biochemistry 28: 9464–9468
32. DUNN, F.A., McCANCE, D.R., THORPE, S.R., LYONS, T.J. and BAYNES, J.W. (1991) Age-dependent accumulation of N-(carboxymethyl)lysine and N-(carboxymethyl)hydroxylysine in human skin collagen. Biochemistry 30: 1205–1210
33. DYER, D.G., BLACKLEDGE, J.A., THORPE, S.R. and BAYNES, J.W. (1991a) Formation of pentosidine during nonenzymatic browning of proteins by glucose. Journal of Biological Chemistry 266: 11554–11560
34. DYER, D.G., BLACKLEDGE, J.A., THORPE, S.R. and BAYNES, J.W. (1991b) Formation of pentosidine during nonenzymatic browning of proteins by glucose: identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo. Journal of Biological Chemistry 266: 11654–11660
35. DYER, D.G., DUNN, J.A., THORPE, S.R. and LYONS, T.J. (1992) Accumulation of Maillard reaction products in skin collagen in diabetes and aging. Annals of the New York Academy of Science 663 : 421–422
36. EDELSTEIN, D. and BROWNLEE, M. (1992a) Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine. Diabetes 41: 26–29
37. EDELSTEIN, D. and BROWNLEE, M. (1992b) Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats. Diabetologia 35: 96–97
38. FRAGA., C.G., SHIGENAGA, M.K., PARK, J.W., DEAGAN, P. and AMES, B.N. (1990) Oxidative damage to DNA during aging; 8-hydroxyguanosine in rat organ DNA and urine. Proceedings of the National Academy of Sciences, USA 87 : 55–63
39. FREI, B. (1994) Reactive oxygen species and antioxidant vitamins: mechanisms of action, American Journal of Medicine 97:5
40. GALESKI, A., KASTELIC, J., BAER, E. and KOHN, R.R. (1977) Mechanical and structural changes in rat tail tendon induced by alloxan diabetes and aging. Journal of Biomechanics 10: 775–782
41. GRANDHEE, S.K. and MONNIER, V.M. (1991) Mechanisms of formation of the Maillard protein cross-link pentosidine: ribose, glucose, fructose and ascorbate as pentosidine precursors. Journal of Biological Chemistry 266: 11649–53
42. GRGIC, A., ROSENBLOOM, A.L., WEBER, F.T. and GIORDANO, B. (1975) Joint contract in childhood diabetes. New England Journal of Medicine 292 : 372–379
43. GUARNIERI, C., MUSCARI, C. and CALDARERA, C.M. (1993) Mitochondrial production of oxygen free radicals in the heart muscle during the life-span of the rat: peak at middle age. Experientia Supplementia 62: 47
44. HADLEY, E.C. (1993) Morbid consequences of aging processes: methodologie issues. In: Musculoskeletal Soft-Tissue Aging: Impact on Mobility (Buckwalter, J.A., Goldberg, B.M. and Woo S.L., Eds), American Academy of Orthopedic Surgeons, Rosemont, IL, pp. 35–47
45. HALLIWELL, B. and GUTTERIDGE, J.M.C. (1989) Free Radicals in Biology and Medicine, 2nd edition, Clarendon Press, Oxford
46. HAYASE, F., KIM, Y.H. and KATO, H. (1991) Inhibition of the protein crosslinking in a Maillard reaction by aminoguanidine and semicarbazide. Agricultural Biological Chemistry 55 : 1435–1436
47. HAZELWOOD, R.L. (1986) Carbohydrate metabolism. In: Avian Physiology (Sturkie, P.D., Ed.), 4th Edition, Springer-Verlag, New York, pp. 303–325
48. HAZELWOOD, R.L. and LORENZ, F. (1959) Effects of fasting and insulin on carbohydrate metabolism of the domestic fowl. American Journal of Physiology 197 : 47–51
49. HELLERSTORM, C., ANDERSSON, A., SANDLER, S. and SWENNE, I. (1986) Mechanisms of destruction and repair of the pancreatic β-cell. Transplant Proceedings 18 : 1509–1512
50. HELLSTEN, Y., TULLSON, P.C., RICHTER, E.A. and BANGSBO, J. (1997) Oxidation of urate in human skeletal muscle during exercise. Free Radical Biology and Medicine 22 : 169–174
51. HERRERO, A. and BARJA, G. (1998) H202 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice: sites of free radical generation and mechanisms involved. Mechanism of Aging and Development 103 : 133–146
52. HOLMES, D. and AUSTAD, S. (1995) Birds as animal models for the comparative biology of aging: a prospectus. Journal of Gerontology: Biological Science 50A: B59-B66
53. IKEBE, S., TANAKA, M., OHNO, K., SATO, W., HATTORI, K., KONDO, T., MIZUNO, Y. and OZAWA, T. (1990) Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence. Biochemistry Biophysics Research Communications 170 : 1044–1048
54. IQBAL, M., PROBERT, L.L. and KLANDORF, H. (1997) Effect of dietary aminoguanidine on tissue pentosidine and reproductive performance in broiler breeder hens. Poultry Science 76: 1574–1579
55. IQBAL, M., PROBERT, L.L., AL-HUMADI, N.H. and KLANDORF, H. (1999a) Protein glycosylation and advanced glycosylation end products (AGEs): an avian solution. Journal of Gerontology: Biological Science 54A: B171-B176
56. IQBAL, M., KENN EY, P. B. AL-HUMA DI N.H., and KLANDORF, H. (1999b) Relationship between mechanical properties and pentosidine in tendon: effect of age, diet restriction and aminoguanidine in broiler breeder hens. Journal of Gerontology: Biological Science (submitted for publication)
57. JAMES, V.J., DELBRIDGE, L., McLENNAN, S.V. and YUE, D.K. (1991) Use of X-ray diffraction in study of human diabetic and aging collagen. Diabetes 40: 391–394
58. JUNAD, A., LAMBERT, A., STAUFFACHER, W. and RENOLD, A. (1969) Diabetogenic action of streptozotocin: relationship of dose to metabolic response. Journal of Clinical Investigation 48:2129
59. KAWADA, J., TOIDE, J., NISHIDA, M., YOSHIMURA, Y. and TSUJIHARA, K. (1986) New diabetogenic streptozotocin analogue, 3–0-methyl-2([(methylnitrosoamino)carbonyl]amino]-D-glucopyranose: evidence for a glucose recognition site on pancreatic β-cells. Diabetes 35:74
60. KILO, C. VOLGER N., and WILLIAMSON, J.R. (1972) Muscle capillary basement membrane charges related to aging and to diabetes mellitus. Diabetes 2: 881–905
61. KLANDORF, H., HOLT, S., McGOWAN, J., PINCHASOV, Y., DEYETTE, D. and PETERSON, R. (1995) Hyperglycemia and non-enzymatic glycation of serum and tissue proteins in chickens. Comparative Biochemistry and Physiology 110C: 215–220
62. KLANDORF, H., ZHOU, Q. and SAMS, A. R. (1996) Inhibition by aminoguanidine of glucose-derived collagen cross-linking in skeletal muscle of broiler breeder hens. Poultry Science 75: 432–437
63. KOHN, R.R. and SCHNIDER, S.L. (1982) Glycosylation of human collagen. Diabetes 31: 47–51
64. KRISTAL, B. and YU, B. (1992) An emerging hypothesis: synergistic induction of aging by free radicals and Maillard reactions. Journal of Gerontology: Biological Science 47: B107-B114
65. KU, H. and SOHAL, R.S. (1993) Comparison of mitochondrial prooxidant generation and antioxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential. Mechanism of Aging Development 72 : 67–76
66. LINDSTEDT, S. L. and CALDE, W. A. (1976) Body size and longevity in birds. Condor 78 : 91–94
67. MASORO, E., KATZ, M. and McMAHAN, C. (1989) Evidence for the glycation hypothesis of aging from the food-restricted rodent model. Journal of Gerontology: Biological Science 44: B20–B22
68. MEADOWS, J., SMITH, R.C. and REEVES, J. (1986) Uric acid protects membranes and linolenic acid from ozone-induced oxidation. Biochemistry Biophysics Research Communications 137 : 536–541
69. MERRIWETHER, A.A., CLARK, A.G., BALLINGER, S.W., SCHYRR, T.G., SOODYALL, H., JENDKINS, T., SHENY, T.T. and WALLACE, D.C. (1991) The structure of human mitochondrial DNA variation. Journal of Molecular Evolution 33 : 543–555
70. MINAKER, K.L. (1987) Aging and diabetes mellitus are risk factors for vascular disease. American Journal of Medicine 82 (Supplement 1B): 47–53
71. MONNIER, V., GLOMB, M., ELGAWISH, A. and SELL, D. (1996) The mechanism of collagen crosslinking in diabetes: a puzzle nearing resolution. Diabetes 45 : S67–S72
72. MUNSCHER, C., RIEGER, T., MULLER-HOCKER, J. and KADENBACH, B. (1993) The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. Federation of Experimental Biology Societies Lucent 317 : 27–30
73. NAGARAJ, R.H., TIMOTHY, T.S., SELL, D.R., FORGARTY, J., ENGERMAN, R.L. and MONNIER, V.M. (1996) Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen. Diabetes 45: 587–594
74. NOHAL, H. and HEGNER, D. (1990) Do mitochondria produce oxygen radicals in vivo? European Journal of Biochemistry 82:563
75. ODETTI, P.R., BORGOFLIO, A.A., PASCALE, D., POLANDI, R. and ADEZATI, L. (1990) Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin. Diabetes 39: 796–801
76. OXULAND, H. and ANDREASSEN, T. (1992) Aminoguanidine treatment reduces increase in collagen stability of rats with experimental diabetes mellitus. Diabetologia 35a: 19–25
77. PARMLEY, L., MUFTI, A.G. and DOWNEY, J.M. (1992) Allopurinol therapy of ischemic heart disease with infarct extension. Canadian Journal of Cardiology 8 : 280–286
78. PIERREFICHE, G. and LABORIT, H. (1995) Oxygen free radicals, melatonin, and aging. Experimental Gerontology 30 : 213–227
79. PILLSBURY, H.C., HUNG, W., KYLE, M.C. and FREIS, E.D. (1974) Arterial pulse wave velocity and systolic time intervals in diabetic children. American Heart Journal 87 : 783–790
80. RAMMAMURTHY, N.S., ZEBROWSKI, E.J. and GOLUB, L.M. (1972) The effects of alloxan diabetes on gingival collagen metabolism in rats. Archive of Oral Biology 17 : 1551–1560
81. REAGAN, T.J., LYONS, M.M., AHMED, S.S., LEVINSON, G.E., OLDEWURTEL, H.A., AHMED, M.R. and HAIDER, B. (1977) Evidence for cardiomyopathy in familial diabetes mellitus. Journal of Clinical Investigation 60: 885–899
82. REISER, K. M. (1991) Nonenzymatic glycation of collagen in aging and diabetes. Proceedings of the Society of Experimental Biology and Medicine 196 : 17–29
83. REISER, K. M. (1994) Influence of age and long-term dietary restriction on enzymatically mediated crosslinks and nonenzymatic glycation of collagen in mice. Journal of Gerontology: Biological Science 49: B71–B79
84. RENDELL, M., STEPHEN, P.M., PAULSEN, R., VALENTINE, J.L., RASBOLD, K., HESTORFF, T., EASTBERG, S. and SHINT, D. (1985) An interspecies comparison of normal levels of glycosylated hemoglobin and glycosylated albumin. Comparative Biochemistry and Physiology 81B: 819–822
85. ROBINSON, W.G., KADOR, P.F. and KINOSHITA, J.H. (1983) Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor. Science 221: 1177–1179
86. ROSENTHAL, M. and OLENICK, L.J. (1988) Evaluation of a single color reading method for determining fructosamine. Clinical Chemistry 34 : 360–363
87. ROSSINI, A.A. and DUBIN, W.E. (1976) Studies of streptozotocin anomers on pancreatic beta cell toxicity. Diabetes 35:384
88. SCHEYNIUS, A. and TALJEDAL, I.B. (1971) On the mechanism of glucose protection against alloxan toxicity. Diabetologia 7: 252–255
89. SCHNIDER, S.L. and KOHN, R.R. (1982) Effects of age and diabetes mellitus on the solubility of collagen from human skin, tracheal cartilage and dura mater. Experimental Gerontology 17 : 185–194
90. SCHUYLER, M.R., NIEWOHNER, D., INKLEY, S.R. and KOHN, R.R. (1976) Abnormal lung elasticity in juvenile diabetes mellitus. American Review of Respiratory Diseases 13 : 37–41
91. SCHWEIGER, F.E., UEHLEIN-HARRELL, S., VON HEGEL G., and WIESNER, H. (1991) Vitamin A (retinol and retinyl esters), α-tocopherol and lipid levels in plasma of captive wild mammals and birds. Xentralblatt fur Veterinarmedizin-Reihe A38: 35–42
92. SELL, D.R. and MONNIER, V.M. (1989) Structure elucidation of a senescence cross-link from human extracellular matrix: Implication of pentoses in the aging process. Journal of Biological Chemistry 264: 21597–21602
93. SELL, D.R., LAPOLLA, A., ODETTI, P., FORGARTY, J. and MONNIER, V.M. (1992) Pentosidine formation in skin correlates with severity of complications in individuals with long-standing IDDM. Diabetes 41: 1286–1291
94. SEVANIAN, A., DAVIES, K.J.A. and HOCHSTEIN, P. (1991) Serum urate as an antioxidant for ascorbic acid. American Journal of Clinical Nutrition 54: 1129S-1143S
95. SHAPIRO, F., MAHAGNA, M. and NIR, I. (1997) Stunting syndrome in broilers: effect of glucose or maltose supplementation on digestive organs, intestinal disaccharidases, and some blood metabolites. Poultry Science 76: 369–380
96. SHORT, R., WILLIAMS, D.D. and BOWDEN, D.M. (1997) Circulating antioxidants as determinants of the rate of biological aging in pigtailed macaques (Macaca nemestrina). Journal of Gerontology: Biological Science 52A: B26-B30
97. SIMON, H. and DUBOIS, M.P. (1980) Failure of a sublethal streptozotocin dose to induce diabetes in the chicken. Hormone Metabolism Research 12 : 631–632
98. SOUZA, A.V.G., PETRETSKI, J.H., DEMASI, M., BECHARA, E.J.H. and OLIVEIRA, P.L. (1996) Urate protects a blood-sucking insect against hemin-induced oxidative stress. Free Radical Biology and Medicine 22 : 209–214
99. STELLENWERF, W.A. and HAZELWOOD, R.L. (1979) Peripheral utilization of a glucose load after alloxan and streptozotocin in the rat and chicken: a comparison. General Comparative Endocrinology 39 : 131–140
100. VELASQUEZ, M.T., KIMMEL, P.L. and MICHAELIS, O.E. (1990) Animal models of spontaneously diabetic kidney disease. Federation of American Societies for Experimental Biology Journal 4 : 2850–2859
101. WEI, Y.H. (1992) Mitochondrial DNA alterations as ageing-associated molecular events. Mutation Research 275 : 145–155
102. WEI, Y.H. (1998) Oxidative stress and mitochondrial DNA mutations in human aging. Experimental Biology and Medicine 127 : 53–63
103. WU, J. (1993) Advanced glycosylation end products: a new disease marker for diabetes and aging. Journal of Clinical Laboratory Animals 7 : 252–255
104. WU, J. (1995) Nitric oxide synthesis and effect of aminoguanidine and N-monomethyl-L-arginine on the onset of diabetes in spontaneously diabetic BB rats. Diabetes 44: 364–365
105. YAGIHASHI, S., KAMIGO, M., BABAL, M., YAHISHI, N. and NAGAI, N. (1992) Effect of aminoguanidine on functional and structural abnormalities in peripheral nerve of STZ-induced diabetic rats. Diabetes 41: 47–52
106. YEN, T.C., SU, H., KING, K.L. and WEI, Y.G. (1991) Ageing-associated 5-kb deletion in human liver mitochondrial DNA. Biochemistry Biophysics Research Communications 178 : 124–131
107. YOSLA, S.F., ELDEN, F.R., RABIONOVEITCH, A., MINTZ, D.H. and BOUECKM, J. (1983) Experimental diabetes mellitus and age-stimulated changes in intact rat dermal collagen. Diabetes 32: 739–742
108. YU, B.P. (1993) Oxidative damage by free radicals and lipid peroxidation in aging. In: Free Radicals in Aging (Yu, B.P., Ed.), CRC Press, Boca Raton, FL, pp. 57–88
109. YUE, D.K., McLENNAN, S., DELBRIDGE, L., HANDLESMAN, D.J., REEVE, T. and TURTLE, J.R. (1983) The thermal stability of collagen in diabetic rats: correlation with severity of diabetes and nonenzymatic glycosylation. Diabetologia 24: 282–285