Adults with philadelphia chromosome–like acute lymphoblastic leukemia frequently have igh-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis

Haematologica

Volumn 102, Issue 1, 2017, Pages 130-138

  Herold, Tobias ^a,b   Schneider, Stephanie ^a   Metzeler, Klaus H ^a,b   Neumann, Martin ^b,c   Hartmann, Luise ^a,b   Roberts, Kathryn G ^d   Konstandin, Nikola P ^a   Greif, Philipp A ^a,b   Bräundl, Kathrin ^a,b   Ksienzyk, Bianka ^a   Huk, Natalia ^a   Schneider, Irene ^a   Zellmeier, Evelyn ^a   Jurinovic, Vindi ^e   Mansmann, Ulrich ^e   Hiddemann, Wolfgang ^a,b   Mullighan, Charles G ^d   Bohlander, Stefan K ^f   Spiekermann, Karsten ^a,b   Hoelzer, Dieter ^g   Brüggemann, Monika ^h   Baldus, Claudia D ^b,c   Dreyling, Mar Tin ^a   Gökbuget, Nicola ^g   more..

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e UNIVERSITY OF MUNICH   (Germany)

^f UNIVERSITY OF AUCKLAND   (New Zealand)

^g UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^h UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; CRLF2 PROTEIN, HUMAN; CYTOKINE RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; JAK2 PROTEIN, HUMAN; ONCOPROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CANCER PROGNOSIS; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DISEASE FREE SURVIVAL; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; HUMAN; IGH CRLF2 GENE; JAK2 GENE; LEUKEMIA REMISSION; MAJOR CLINICAL STUDY; MALE; MINIMAL RESIDUAL DISEASE; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; OVERALL SURVIVAL; PHILADELPHIA 1 CHROMOSOME; POLYMERASE CHAIN REACTION; PRE B LYMPHOCYTE; TREATMENT OUTCOME; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETICS; MIDDLE AGED; MORTALITY; MUTATION; PATHOLOGY; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; SURVIVAL ANALYSIS; YOUNG ADULT;

ADOLESCENT; ADULT; CLUSTER ANALYSIS; DNA COPY NUMBER VARIATIONS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; JANUS KINASE 2; MALE; MIDDLE AGED; MUTATION; NEOPLASM, RESIDUAL; ONCOGENE PROTEINS, FUSION; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; RECEPTORS, CYTOKINE; SURVIVAL ANALYSIS; TRANSLOCATION, GENETIC; YOUNG ADULT;

EID: 85008323482     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2015.136366     Document Type: Article

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