Effects of digoxin on cardiac iron content in rat model of Iron overload

ARYA Atherosclerosis

Volumn 12, Issue 4, 2016, Pages 180-184

  Nasri, Hamid Reza ^a   Shahouzehi, Beydolah ^b   Masoumi Ardakani, Yaser ^c   Iranpour, Maryam ^a  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cardiac iron content; Digoxin; Iron dextran complex; Iron overload

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM CHANNEL; DIGOXIN; FERRIC FERROCYANIDE; IRON; IRON DEXTRAN; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART FAILURE; HEMOCHROMATOSIS; IRON OVERLOAD; IRON TRANSPORT; MALE; NONHUMAN; RAT; SCORING SYSTEM; SODIUM CELL LEVEL; THALASSEMIA;

EID: 85008213247     PISSN: 17353955     EISSN: 22516638     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Andrews NC. Disorders of iron metabolism. N Engl J Med 1999; 341(26): 1986-95.
2. Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell 2004; 117(3): 285-97.
3. Templeton DM, Liu Y. Genetic regulation of cell function in response to iron overload or chelation. Biochim Biophys Acta 2003; 1619(2): 113-24.
4. Oudit G, Moe G. Iron-overload Cardiomyopathy Associated with Iron-overload Conditions: Incidence, Pathophysiology, and Treatment [Online]. [cited 2007]; Available from: URL: http://www.cardiologyrounds.ca/crus/cardeng0407.pdf
5. Kremastinos DT, Farmakis D, Aessopos A, Hahalis G, Hamodraka E, Tsiapras D, et al. Betathalassemia cardiomyopathy: history, present considerations, and future perspectives. Circ Heart Fail 2010; 3(3): 451-8.
6. Zurlo MG, De Stefano P, Borgna-Pignatti C, Di Palma A, Piga A, Melevendi C, et al. Survival and causes of death in thalassaemia major. Lancet 1989; 2(8653): 27-30.
7. Xu KY, Zhu W, Chen L, DeFilippi C, Zhang J, Xiao RP. Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPasemediated Ca2+ influx in cardiomyocytes. Biochem Biophys Res Commun 2011; 406(2): 200-3.
8. Smith TW. Digitalis. Mechanisms of action and clinical use. N Engl J Med 1988; 318(6): 358-65.
9. Oudit GY, Trivieri MG, Khaper N, Liu PP, Backx PH. Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy. J Mol Med (Berl) 2006; 84(5): 349-64.
10. Tsushima RG, Wickenden AD, Bouchard RA, Oudit GY, Liu PP, Backx PH. Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload. Circ Res 1999; 84(11): 1302-9.
11. Atar D, Backx PH, Appel MM, Gao WD, Marban E. Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels. J Biol Chem 1995; 270(6): 2473-7.
12. Winegar BD, Kelly R, Lansman JB. Block of current through single calcium channels by Fe, Co, and Ni. Location of the transition metal binding site in the pore. J Gen Physiol 1991; 97(2): 351-67.
13. Koren G, MacLeod SM. Postmortem redistribution of digoxin in rats. J Forensic Sci 1985; 30(1): 92-6.
14. Ibrahim NG, Hoffstein ST, Freedman ML. Induction of liver cell haem oxygenase in ironoverloaded rats. Biochem J 1979; 180(2): 257-63.
15. Whittaker P, Hines FA, Robl MG, Dunkel VC. Histopathological evaluation of liver, pancreas, spleen, and heart from iron-overloaded Sprague-Dawley rats. Toxicol Pathol 1996; 24(5): 558-63.
16. Vassort G, Talavera K, Alvarez JL. Role of T-type Ca2+ channels in the heart. Cell Calcium 2006; 40(2): 205-20.
17. Kumfu S, Chattipakorn S, Srichairatanakool S, Settakorn J, Fucharoen S, Chattipakorn N. T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice. Eur J Haematol 2011; 86(2): 156-66.
18. Oudit GY, Sun H, Trivieri MG, Koch SE, Dawood F, Ackerley C, et al. L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat Med 2003; 9(9): 1187-94.