Clinical Features and Outcome of Ebola Virus Disease in Pediatric Patients: A Retrospective Case Series

Journal of Pediatrics

Volumn 182, Issue , 2017, Pages 378-381.e1

  Damkjær, Mads ^a,b,c,d   Rudolf, Frauke ^a,b,e   Mishra, Sharmistha ^f   Young, Alyssa ^a   Storgaard, Merete ^a,b,g  

^a GOAL Global   (Sierra Leone)

^b Danish Armed Forces Health Services   (Denmark)

^c Hans Christian Andersen Children's Hospital   (Denmark)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^e Mental Health Services CPH   (Denmark)

^f ST MICHAEL'S HOSPITAL   (Canada)

^g AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

case fatality rate; Ebola virus disease; hemorrhagic symptoms; pediatric; Sierra Leone

Indexed keywords

ADULT; ARTICLE; CASE FATALITY RATE; CHILD DEATH; CLINICAL ARTICLE; CLINICAL FEATURE; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; FEMALE; HOSPITAL ADMISSION; HUMAN; MALE; NONHUMAN; PRIORITY JOURNAL; RETROSPECTIVE STUDY; CHILD; COHORT ANALYSIS; CRITICAL ILLNESS; DEVELOPING COUNTRY; EPIDEMIC; FLUID THERAPY; HEMORRHAGIC FEVER, EBOLA; HOSPITAL MORTALITY; HOSPITALIZATION; INFANT; INTENSIVE CARE; KAPLAN MEIER METHOD; MULTIMODALITY CANCER THERAPY; NONPARAMETRIC TEST; PRESCHOOL CHILD; PROCEDURES; PROGNOSIS; RISK ASSESSMENT; SIERRA LEONE; STATISTICS AND NUMERICAL DATA; SURVIVAL RATE; TREATMENT OUTCOME; TRENDS;

ANTIINFECTIVE AGENT; ANTIVIRUS AGENT;

ANTI-BACTERIAL AGENTS; ANTIVIRAL AGENTS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COMBINED MODALITY THERAPY; CRITICAL CARE; CRITICAL ILLNESS; DEVELOPING COUNTRIES; DISEASE OUTBREAKS; FEMALE; FLUID THERAPY; HEMORRHAGIC FEVER, EBOLA; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; INFANT; KAPLAN-MEIER ESTIMATE; MALE; PROGNOSIS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SIERRA LEONE; STATISTICS, NONPARAMETRIC; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 85008210935     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2016.11.034     Document Type: Article

References (27)

1. 1 Pattyn, S., van der Groen, G., Jacob, W., Piot, P., Courteille, G., Isolation of Marburg-like virus from a case of haemorrhagic fever in Zaire. Lancet 1 (1977), 573–574.
2. 2 Centers for Disease Control, 2014 Ebola Outbreak in West Africa - Case Counts. 2016.
3. 3 Mupere, E., Kaducu, O.F., Yoti, Z., Ebola haemorrhagic fever among hospitalised children and adolescents in northern Uganda: epidemiologic and clinical observations. Afr Health Sci 1 (2001), 60–65.
4. 4 McElroy, A.K., Erickson, B.R., Flietstra, T.D., Rollin, P.E., Nichol, S.T., Towner, J.S., et al. Biomarker correlates of survival in pediatric patients with Ebola virus disease. Emerg Infect Dis 20 (2014), 1683–1690.
5. 5 Beeching, N.J., Fenech, M., Houlihan, C.F., Ebola virus disease. BMJ, 349, 2014, g7348.
6. 6 WHO, Clinical management of patients with viral haemorrhagic fever. A pocket guide for the front-line health worker. 2014, World Health Organization (WHO), Geneva, Switzerland, 103.
7. 7 Lado, M., Walker, N.F., Baker, P., Haroon, S., Brown, C.S., Youkee, D., et al. Clinical features of patients isolated for suspected Ebola virus disease at Connaught Hospital, Freetown, Sierra Leone: a retrospective cohort study. Lancet Infect Dis 15 (2015), 1024–1033.
8. 8 Hunt, L., Gupta-Wright, A., Simms, V., Tamba, F., Knott, V., Tamba, K., et al. Clinical presentation, biochemical, and haematological parameters and their association with outcome in patients with Ebola virus disease: an observational cohort study. Lancet Infect Dis 15 (2015), 1292–1299.
9. 9 Fitzpatrick, G., Vogt, F., Moi Gbabai, O.B., Decroo, T., Keane, M., De Clerck, H., et al. The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Medecins Sans Frontieres Ebola Case Management Centre, Kailahun, Sierra Leone, June-October 2014. J Infect Dis 212 (2015), 1752–1758.
10. 10 Bah, E.I., Lamah, M.C., Fletcher, T., Jacob, S.T., Brett-Major, D.M., Sall, A.A., et al. Clinical presentation of patients with Ebola virus disease in Conakry, Guinea. N Engl J Med 372 (2015), 40–47.
11. 11 Dye, C., Team WHOER. Ebola virus disease in West Africa–the first 9 months. N Engl J Med, 372, 2015, 189.
12. 12 Team, W.H.O.E.R., Agua-Agum, J., Ariyarajah, A., Blake, I.M., Cori, A., Donnelly, C.A., et al. Ebola virus disease among children in West Africa. N Engl J Med 372 (2015), 1274–1277.
13. 13 Glynn, J.R., Age-specific incidence of Ebola virus disease. Lancet, 386, 2015, 432.
14. 14 Bower, H., Johnson, S., Bangura, M.S., Kamara, A.J., Kamara, O., Mansaray, S.H., et al. Effects of mother's illness and breastfeeding on risk of Ebola virus disease in a cohort of very young children. PLoS Negl Trop Dis, 10, 2016 e0004622.
15. 15 WHO, Clinical management of patients in the Ebola Treatment Centres and other care centres in Sierra Leone: Interim emergency guidelines;. 2014.
16. 16 Jassal, S., Basic, S., Symptom control in paediatric palliative care. 9th ed, 2013, The Rainbows Children's Hospice Guidelines, Bristol, UK.
17. 17 Spengler, J.R., McElroy, A.K., Harmon, J.R., Stroher, U., Nichol, S.T., Spiropoulou, C.F., Relationship between Ebola virus real-time quantitative polymerase chain reaction-based threshold cycle value and virus isolation from human plasma. J Infect Dis, 212(Suppl 2), 2015 S346-9.
18. 18 Fortuna, E.L., Carney, M.M., Macy, M., Stanley, R.M., Younger, J.G., Bradin, S.A., Accuracy of non-contact infrared thermometry versus rectal thermometry in young children evaluated in the emergency department for fever. J Emerg Nurs 36 (2010), 101–104.
19. 19 Schieffelin, J.S., Shaffer, J.G., Goba, A., Gbakie, M., Gire, S.K., Colubri, A., et al. Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med 371 (2014), 2092–2100.
20. 20 Yan, T., Mu, J., Qin, E., Wang, Y., Liu, L., Wu, D., et al. Clinical characteristics of 154 patients suspected of having Ebola virus disease in the Ebola holding center of Jui Government Hospital in Sierra Leone during the 2014 Ebola outbreak. Eur J Clin Microbiol Infect Dis 34 (2015), 2089–2095.
21. 21 Olitsky, S.E., Hug, D., Plummer, L.S., Stahl, E.D., Ariss, M.M., Lindquist, T.P., Disorders of the conjunctiva. Nelson textbook of pediatrics, 2-volume set, 20th ed, 2016, Elsevier, Philadelphia (PA) 19103-2899.
22. 22 Falasca, L., Agrati, C., Petrosillo, N., Di Caro, A., Capobianchi, M.R., Ippolito, G., et al. Molecular mechanisms of Ebola virus pathogenesis: focus on cell death. Cell Death Differ 22 (2015), 1250–1259.
23. 23 Trehan, I., Kelly, T., Marsh, R.H., George, P.M., Callahan, C.W., Moving towards a more aggressive and comprehensive model of care for children with Ebola. J Pediatr 170 (2016), 28–33.
24. 24 Li, S.T., Grossman, D.C., Cummings, P., Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis. PLoS Med, 4, 2007, e98.
25. 25 Dunning, J., Sahr, F., Rojek, A., Gannon, F., Carson, G., Idriss, B., et al. Experimental treatment of ebola virus disease with TKM-130803: a single-arm phase 2 clinical trial. PLoS Med, 13, 2016 e1001997.
26. 26 van Griensven, J., Edwards, T., de Lamballerie, X., Semple, M.G., Gallian, P., Baize, S., et al. Evaluation of convalescent plasma for Ebola virus disease in Guinea. N Engl J Med 374 (2016), 33–42.
27. 27 World Health Organization, Questions and answers – Ebola ça suffit! - Phase III Vaccine Trial in Guinea;. 2015.