The Contribution of Ebola Viral Load at Admission and Other Patient Characteristics to Mortality in a Médecins Sans Frontières Ebola Case Management Centre, Kailahun, Sierra Leone, June-October 2014

Journal of Infectious Diseases

Volumn 212, Issue 10, 2015, Pages 1752-1758

  Fitzpatrick, Gabriel ^a   Vogt, Florian ^b   Gbabai, Osman B Moi ^c   Decroo, Tom ^a   Keane, Marian ^d   De Clerck, Hilde ^b   Grolla, Allen ^e   Brechard, Raphael ^b   Stinson, Kathryn ^b   Van Herp, Michel ^b  

^a MÉDECINS SANS FRONTIÈRES   (Switzerland)

^b MÉDECINS SANS FRONTIÈRES   (Belgium)

^c Ministry of Health and Sanitation   (United States)

^d DUBLIN CITY UNIVERSITY   (Ireland)

^e PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

Ebola virus; Mortality; Outbreak; Sierra Leone; Viral load

Indexed keywords

ADULT; AGE; ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE DURATION; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; FEMALE; HEALTH CARE PERSONNEL; HOSPITAL ADMISSION; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SIERRA LEONE; SURVIVAL RATE; VIRUS LOAD; ADOLESCENT; EPIDEMIC; GENETICS; HEMORRHAGIC FEVER, EBOLA; HOSPITALIZATION; STATISTICS AND NUMERICAL DATA; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; DISEASE OUTBREAKS; EBOLAVIRUS; FEMALE; HEMORRHAGIC FEVER, EBOLA; HOSPITALIZATION; HUMANS; MALE; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; SIERRA LEONE; VIRAL LOAD; YOUNG ADULT;

EID: 84943631429     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv304     Document Type: Article

References (22)

1. Baize S, Pannetier D, Oestereich L, et al. Emergence of Zaire Ebola virus disease in guinea-preliminary report. N Engl J Med 2014; 371: 1418-25.
2. WHO. Situation report, Ebola response roadmap. Geneva, Switzerland: World Health Organisation, 2014. http://www.who.int/csr/disease/ebola/situation-reports/en/. Accessed 28 December 2014.
3. WHO. Ebola response roadmap. Geneva, Switzerland: World Health Organisation, 2014. http://www.who.int/csr/resources/publications/ebola/response-roadmap/en/. Accessed 28 December 2014.
4. Ftika L, Maltezou HC. Viral haemorrhagic fevers in healthcare settings. J Hosp Infect 2013; 83:185-92.
5. Feldmann H, Geisbert TW. Ebola haemorrhagic fever. Lancet 2011; 377:849-62.
6. MacNeil A, Rollin PE. Ebola and Marburg hemorrhagic fevers: neglected tropical diseases? PLOS Negl Trop Dis 2012; 6:e1546.
7. Dowell SF, Mukunu R, Ksiazek TG, Khan AS, Rollin PE, Peters CJ. Transmission of Ebola hemorrhagic fever: A study of risk factors in family members, Kikwit, Democratic Republic of the Congo, 1995. Commission de Lutte contre les Epidémies à Kikwit. J Infect Dis 1999; 179(suppl 1):S87-91.
8. WHO. Sierra Leone country profile. Geneva, Switzerland:World Health Organization, 2014. http://www.who.int/countries/sle/en/. Accessed 28 December 2014.
9. Kerstiëns B, Matthys F. Interventions to control virus transmission during an outbreak of Ebola hemorrhagic fever: experience from Kikwit, Democratic Republic of the Congo, 1995. J Infect Dis 1999; 179(suppl 1): S263-7.
10. Sterk E. Medecins Sans Frontieres Filovirus haemorrhagic fever guidelines. 2008. www.medbox.org/ebola-guidelines/filovirus-haemorrhagicfever-guideline/preview. Accessed 28 December 2014.
11. Wolz A. Face to face with Ebola-an emergency care center in Sierra Leone. N Engl J Med 2014; 371:1081-3.
12. WHO. Case definition recommendations for Ebola or Marburg virus diseases. Geneva, Switzerland: World Health Organisation, 2014. www.who.int/csr/resources/publications/ebola/ebola-case-definitioncontact-en.pdf?ua=1. Accessed 28 December 2014.
13. Fitzpatrick G, Vogt F, Moi Gbabai O, et al. Describing readmissions to an Ebola case management centre (CMC), Sierra Leone, 2014. Euro Surveill 2014; 19:pii:20924.
14. Grolla A, Mehedi M, Lindsay R, Bosio C, Duse A, Feldmann H. Enhanced detection of Rift Valley fever virus using molecular assays on whole blood samples. J Clin Virol 2012; 54:313-7.
15. Demby AH, Chamberlain J, Brown DW, Clegg CS. Early diagnosis of Lassa fever by reverse transcription-PCR. J Clin Microbiol 1994; 32:2898-903.
16. Lee MA, Tan CH, Aw LT, et al. Real-time fluorescence-based PCR for detection of malaria parasites. J Clin Microbiol 2002; 40:4343-5.
17. Dreier J, Störmer M, Kleesiek K. Use of bacteriophage MS2 as an internal control in viral reverse transcription-PCR assays. J Clin Microbiol 2005; 43:4551-7.
18. Bah EI, Lamah MC, Fletcher T, et al. Clinical presentation of patients with Ebola virus disease in Conakry, Guinea. N Engl J Med 2014; 372: 40-7.
19. Schieffelin JS, Shaffer JG, Goba A, et al. Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med 2014; 371: 2092-100.
20. Team WER. Ebola virus disease in West Africa-The first 9 months of the epidemic and forward projections. N Engl J Med 2014; 371: 1481-95.
21. Towner JS, Rollin PE, Bausch DG, et al. Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome. J Virol 2004; 78:4330-41.
22. Sanchez A, Lukwiya M, Bausch D, et al. Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels. J Virol 2004; 78:10370-7.