On the Nature of Physiologically-Based Pharmacokinetic Models –A Priori or A Posteriori? Mechanistic or Empirical?

Pharmaceutical Research

Volumn 34, Issue 3, 2017, Pages 529-534

  Korzekwa, Ken ^a   Nagar, Swati ^a  

^a TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

Author keywords

clearance; PBPK; tissue partitioning

Indexed keywords

OCTANOL; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID; PLASMA PROTEIN; DRUG;

ARTICLE; BIOLOGICAL MODEL; BLOOD FLOW; CELL PH; COMPARTMENT MODEL; DRUG CLEARANCE; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; LIPID BILAYER; PARTITION COEFFICIENT; PHARMACOKINETICS; PHYSIOLOGICAL PROCESS; PHYSIOLOGICALLY BASED PHARMACOKINETICS; PRIORITY JOURNAL; UNBOUND FRACTION; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; MEDICINAL CHEMISTRY; METABOLISM; TISSUE DISTRIBUTION;

CHEMISTRY, PHARMACEUTICAL; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PHOSPHOLIPIDS; TISSUE DISTRIBUTION;

EID: 85007495762     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-016-2089-8     Document Type: Article

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