Regulation of the expression of LXR in rat hypothalamic and hippocampal explants

Neuroscience Letters

Volumn 639, Issue , 2017, Pages 53-58

  Kruse, María Sol ^a   Suarez, Lucas Gabriel ^a   Coirini, Héctor ^a,b  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

ABCA1; Cholesterol; Cholic acid; Glucose; GLUT2; Insulin

Indexed keywords

ABC TRANSPORTER A1; CHOLESTEROL; CHOLIC ACID; F ACTIN; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; LIVER X RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXPLANT; HIPPOCAMPUS; HYPOTHALAMUS; INSULIN TREATMENT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; WESTERN BLOTTING; ANIMAL; GENE EXPRESSION REGULATION; HOMEOSTASIS; LIPID METABOLISM; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CHOLESTEROL; GENE EXPRESSION REGULATION; GLUCOSE; HIPPOCAMPUS; HOMEOSTASIS; HYPOTHALAMUS; LIPID METABOLISM; LIVER X RECEPTORS; MALE; RATS, SPRAGUE-DAWLEY;

EID: 85007482736     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2016.12.065     Document Type: Article

References (36)

1. [1] Whitney, K.D., Watson, M.A., Collins, J.L., Benson, W.G., Stone, T.M., Numerick, M.J., Tippin, T.K., Wilson, J.G., Winegar, D.A., Kliewer, S.A., Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol. Endocrinol. 16 (2002), 1378–1385.
2. [2] Fitz, N.F., Cronican, A., Pham, T., Fogg, A., Fauq, A.H., Chapman, R., Lefterov, I., Koldamova, R., Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice. J. Neurosci. 30 (2010), 6862–6872.
3. [3] Gabbi, C., Kong, X., Suzuki, H., Kim, H.J., Gao, M., Jia, X., Ohnishi, H., Ueta, Y., Warner, M., Guan, Y., Gustafsson, J.A., Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor beta. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 3030–3034.
4. [4] Ghaddab-Zroud, R., Seugnet, I., Steffensen, K.R., Demeneix, B.A., Clerget-Froidevaux, M.S., Liver X receptor regulation of thyrotropin-releasing hormone transcription in mouse hypothalamus is dependent on thyroid status. PLoS One, 9, 2014, e106983.
5. [5] Kruse, M.S., Rey, M., Vega, M.C., Coirini, H., Alterations of LXRalpha and LXRbeta expression in the hypothalamus of glucose-intolerant rats. J. Endocrinol. 215 (2012), 51–58.
6. [6] Kruse, M.S., Vega, M.C., Rey, M., Coirini, H., Sex differences in LXR expression in normal offspring and in rats born to diabetic dams. J. Endocrinol. 222 (2014), 53–60.
7. [7] Theofilopoulos, S., Wang, Y., Kitambi, S.S., Sacchetti, P., Sousa, K.M., Bodin, K., Kirk, J., Salto, C., Gustafsson, M., Toledo, E.M., Karu, K., Gustafsson, J.A., Steffensen, K.R., Ernfors, P., Sjovall, J., Griffiths, W.J., Arenas, E., Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat. Chem. Biol. 9 (2013), 126–133.
8. [8] Lee, K., Li, B., Xi, X., Suh, Y., Martin, R.J., Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. Endocrinology 146 (2005), 3–10.
9. [9] Relling, A.E., Lee, K., Loerch, S.C., Reynolds, C.K., Effects of glucose, propionate and splanchnic hormones on neuropeptide mRNA concentrations in the ovine hypothalamus. J. Anim. Physiol. Anim. Nutr. (Berl.) 96 (2012), 648–654.
10. [10] Tringali, G., Greco, M.C., Lisi, L., Pozzoli, G., Navarra, P., Cortistatin modulates the expression and release of corticotrophin releasing hormone in rat brain. Comparison with somatostatin and octreotide. Peptides 34 (2012), 353–359.
11. [11] Kruse, M.S., Rey, M., Barutta, J., Coirini, H., Allopregnanolone effects on astrogliosis induced by hypoxia in organotypic cultures of striatum, hippocampus, and neocortex. Brain Res. 1303 (2009), 1–7.
12. [12] Kruse, M.S., Premont, J., Krebs, M.O., Jay, T.M., Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex. Eur. Neuropsychopharmacol. 19 (2009), 296–304.
13. [13] Hami, J., Sadr-Nabavi, A., Sankian, M., Balali-Mood, M., Haghir, H., The effects of maternal diabetes on expression of insulin-like growth factor-1 and insulin receptors in male developing rat hippocampus. Brain Struct. Funct. 218 (2013), 73–84.
14. [14] Jurcovicova, J., Glucose transport in brain – effect of inflammation. Endocr. Regul. 48 (2014), 35–48.
15. [15] Mitro, N., Mak, P.A., Vargas, L., Godio, C., Hampton, E., Molteni, V., Kreusch, A., Saez, E., The nuclear receptor LXR is a glucose sensor. Nature 445 (2007), 219–223.
16. [16] Otero-Rodino, C., Libran-Perez, M., Velasco, C., Lopez-Patino, M.A., Miguez, J.M., Soengas, J.L., Evidence for the presence of glucosensor mechanisms not dependent on glucokinase in hypothalamus and hindbrain of rainbow trout (Oncorhynchus mykiss). PLoS One, 10, 2015, e0128603.
17. [17] Otero-Rodino, C., Velasco, C., Alvarez-Otero, R., Lopez-Patino, M.A., Miguez, J.M., Soengas, J.L., In vitro evidence supports the presence of glucokinase-independent glucosensing mechanisms in hypothalamus and hindbrain of rainbow trout. J. Exp. Biol. 219 (2016), 1750–1759.
18. [18] Livingstone, C., Lyall, H., Gould, G.W., Hypothalamic GLUT 4 expression: a glucose- and insulin-sensing mechanism?. Mol. Cell. Endocrinol. 107 (1995), 67–70.
19. [19] Tobin, K.A., Ulven, S.M., Schuster, G.U., Steineger, H.H., Andresen, S.M., Gustafsson, J.A., Nebb, H.I., Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J. Biol. Chem. 277 (2002), 10691–10697.
20. [20] Folli, F., Ghidella, S., Bonfanti, L., Kahn, C.R., Merighi, A., The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system. Mol. Neurobiol. 13 (1996), 155–183.
21. [21] Hill, J.M., Lesniak, M.A., Pert, C.B., Roth, J., Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas. Neuroscience 17 (1986), 1127–1138.
22. [22] Unger, J.W., Livingston, J.N., Moss, A.M., Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Prog. Neurobiol. 36 (1991), 343–362.
23. [23] Schulingkamp, R.J., Pagano, T.C., Hung, D., Raffa, R.B., Insulin receptors and insulin action in the brain: review and clinical implications. Neurosci. Biobehav. Rev. 24 (2000), 855–872.
24. [24] Lopez-Soldado, I., Herrera, E., Different diabetogenic response to moderate doses of streptozotocin in pregnant rats, and its long-term consequences in the offspring. Exp. Diabesity Res. 4 (2003), 107–118.
25. [25] Yan, J., Li, X., Su, R., Zhang, K., Yang, H., Long-term effects of maternal diabetes on blood pressure and renal function in rat male offspring. PLoS One, 9, 2014, e88269.
26. [26] Zavaroni, I., Sander, S., Scott, S., Reaven, G.M., Effect of fructose feeding on insulin secretion and insulin action in the rat. Metabolism 29 (1980), 970–973.
27. [27] Zitzer, H., Wente, W., Brenner, M.B., Sewing, S., Buschard, K., Gromada, J., Efanov, A.M., Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels. Endocrinology 147 (2006), 3898–3905.
28. [28] Laffitte, B.A., Joseph, S.B., Walczak, R., Pei, L., Wilpitz, D.C., Collins, J.L., Tontonoz, P., Autoregulation of the human liver X receptor alpha promoter. Mol. Cell. Biol. 21 (2001), 7558–7568.
29. [29] Cozzone, D., Debard, C., Dif, N., Ricard, N., Disse, E., Vouillarmet, J., Rabasa-Lhoret, R., Laville, M., Pruneau, D., Rieusset, J., Lefai, E., Vidal, H., Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells. Diabetologia 49 (2006), 990–999.
30. [30] Ulven, S.M., Dalen, K.T., Gustafsson, J.A., Nebb, H.I., Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue. J. Lipid Res. 45 (2004), 2052–2062.
31. [31] Russell, D.W., Halford, R.W., Ramirez, D.M., Shah, R., Kotti, T., Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu. Rev. Biochem. 78 (2009), 1017–1040.
32. [32] Hulce, J.J., Cognetta, A.B., Niphakis, M.J., Tully, S.E., Cravatt, B.F., Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells. Nat. Methods 10 (2013), 259–264.
33. [33] Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J.M., Hammer, R.E., Mangelsdorf, D.J., Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93 (1998), 693–704.
34. [34] Gerin, I., Dolinsky, V.W., Shackman, J.G., Kennedy, R.T., Chiang, S.H., Burant, C.F., Steffensen, K.R., Gustafsson, J.A., MacDougald, O.A., LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J. Biol. Chem. 280 (2005), 23024–23031.
35. [35] Perez-Tilve, D., Hofmann, S.M., Basford, J., Nogueiras, R., Pfluger, P.T., Patterson, J.T., Grant, E., Wilson-Perez, H.E., Granholm, N.A., Arnold, M., Trevaskis, J.L., Butler, A.A., Davidson, W.S., Woods, S.C., Benoit, S.C., Sleeman, M.W., DiMarchi, R.D., Hui, D.Y., Tschop, M.H., Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat. Neurosci. 13 (2010), 877–882.
36. [36] Baranowski, M., Biological role of liver X receptors. J. Physiol. Pharmacol. 59:Suppl. 7 (2008), 31–55.