Different diabetogenic response to moderate doses of streptozotocin in pregnant rats, and its long-term consequences in the offspring

Experimental Diabesity Research

Volumn 4, Issue 2, 2003, Pages 107-118

  López Soldado, Iliana ^a   Herrera, Emilio ^a  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

Macrosomia; Pregnancy; Rat; Streptozotocin diabetes

Indexed keywords

GLUCOSE; INSULIN; STREPTOZOCIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY FAT; BODY WEIGHT; CONGENITAL MALFORMATION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FETUS RISK; FETUS WEIGHT; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; LONG TERM EXPOSURE; MACROSOMIA; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROGENY; RAT; REGULATORY MECHANISM; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0041326298     PISSN: 15438600     EISSN: None     Source Type: Journal    
DOI: 10.1155/EDR.2003.107     Document Type: Article

References (51)

1. Martin, F. I., Heath, P., and Mountain, K. R. (1987) Pregnancy in women with diabetes mellitus. Fifteen years' experience. 1970-1985. Med. J. Aust., 146, 187-190.
2. Fuhrmann, K., Reiher, H., Semmier, K., Fischer, F., Fischer, M., and Glockner, E. (1983) Prevention of congenital malformations in infants of insulin-dependent diabetic mothers. Diabetes Care, 6, 219-223.
3. Cowett, R. M., and Shwartz, R. (1982) The infant of the diabetic mother. Pediatr. Clin. North Am., 29, 1213-1231.
4. Small, M., Cameron, A., Lunan, C. B., and MacCuish, A. C. (1987) Macrosomia in pregnancy complicated by insulin-dependent diabetes mellitus. Diabetes Care, 10, 594-599.
5. Pettitt, D. J., Aleck, K. A., Baird, H. R., Carraher, M. J., Bennett, P. H., and Knowler, W. C. (1988) Congenital susceptibility to NID-DM. Role of intrauterine environment. Diabetes, 37, 622-628.
6. Martin, A. O., Simpson, J. L., Ober, C., and Freinkel, N. (1985) Frequency of diabetes mellitus in mothers of probands with gestational diabetes: Possible maternal influence on the predisposition to gestational diabetes. Am. J. Obstet. Gynecol., 151, 471-475.
7. Pettitt, D. J., Nelson, R. G., Saad, M. F., Bennett, P. H., and Knowler, W. C. (1993) Diabetes and obesity in the offspring of Pima Indian women with diabetes during pregnancy. Diabetes Care, 16, 310-314.
8. Pettitt, D. J., Baird, H. R., Aleck, K. H., Bennett, P. H., and Knowler, W. C. (1983) Excessive obesity in offspring of Pima Indian women with diabetes during pregnancy. N. Engl. J. Med., 308, 242-245.
9. Vohr, B. B., Lipsitt, L. P., and Oh, W. (1980) Somatic growth of children of diabetic mothers and reference to birth size. J. Pediatr., 97, 196-199.
10. Buchanan, T. A., Denno, K. M., Sipos, G. F., and Sadler, T. W. (1994) Diabetic teratogenesis: In vitro evidence for a multifactorial etiology with little contribution from glucose per se. Diabetes, 43, 656-660.
11. Ktorza, A., Nurjhan, N., Girard, J. R., and Picon, L. (1983) Hiperglycaemia induced by glucose infusion in the unrestrained pregnant rat: Effect on body weight and lipid synthesis in postmature fetuses. Diabetologia, 24, 128-130.
12. Gauguier, D., Bihoreau, M. T., Ktorza, A., Berthault, M. F., and Picon, L. (1990) Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in rats. Diabetes, 39, 734-739.
13. Ward, D. T., Yau, S. K., Mee, A. P., Mawer, E. B., Miller, C. A., Garland, H. O., and Riccardi, D. (2001) Functional, molecular, and biochemical characterization of streptozotocin-induced diabetes. J. Am. Soc. Nephrol., 12, 779-790.
14. Martin, M. E., Garcia, A. M., Blanco, L., Herrera, E., and Salinas, M. (1995) Effect of streptozotocin diabetes on polysomal aggregation and protein synthesis rate in the liver of pregnant rats and their offspring. Biosci. Rep., 15, 15-20.
15. Martín, A., and Herrera, E. (1991) Different responses to maternal diabetes during the first and second half of gestation in the streptozotocin-treated rat. Isr. J. Med. Sci., 27, 442-448.
16. Viana, M., Aruoma, O. I., Herrera, E., and Bonet, B. (2000) Oxidative damage in pregnant diabetic rats and their embryos. Free Radic. Biol. Med., 29, 1115-1121.
17. Viana, M., Herrera, E., and Bonet, B. (1996) Teratogenic effects of diabetes mellitus in the rat. Prevention by vitamin E. Diabetologia, 39, 1041-1046.
18. Cederberg, J., Simán, C. M., and Eriksson, U. J. (2001) Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy. Pediatr. Res., 49, 755-762.
19. Cederberg, J., and Eriksson, U. J. (2001) Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy. Diabetologia, 44, 766-774.
20. Simán, C. M., and Eriksson, U. J. (1997) Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats. Diabetes, 46, 1054-1061.
21. Aerts, L., Holemans, K., and Van Assche, A. (1990) Maternal diabetes during pregnancy: Consequences for the offspring. Diabet. Metab. Rev., 6, 147-167.
22. Aerts, L., and Van Assche, A. (1977) Rat fetal endocrine pancreas in experimental diabetes. J. Endocrinol., 73, 339-346.
23. Aerts, L., and Van Assche, F. A. (1998) Ultrastructural evaluation of β-cell recruitment in virgin and pregnant offspring of diabetic mothers. Diabetes Res. Clin. Pract., 41, 9-14.
24. Holemans, K., Aerts, L., and Van Assche, F. A. (1991) Evidence for an insulin resistance in the adult offspring of pregnant streptozotocin-diabetic rats. Diabetologia, 34, 81-85.
25. Holemans, K., Van Bree, R., Verhaeghe, J., Aerts, L., and Van Assche, F. A. (1993) In vivo glucose utilization by individual tissues in virgin and pregnant offspring of severely diabetic rats. Diabetes, 42, 530-536.
26. Merzouk, H., Madani, S., Sari, D. C., Prost, J., Bouchenak, M., and Belleville, J. (2000) Time course of changes in serum glucose, insulin, lipids and tissue lipase activities in macrosomic offspring of rats with streptozotocin-induced diabetes. Clin. Sci., 98, 21-30.
27. Reynolds, W. A., Chez, R. A., Bhuyan, B. K., and Neil, G. L. (1974) Placental transfer of streptozotocin in the rhesus monkey. Diabetes, 23, 777-782.
28. Schein, P. S., and Loftus, S. (1968) Streptozotocin: Depression of mouse liver pyridine nucleotides. Cancer Res., 28, 1501-1506.
29. Holemans, K., Van Bree, R., Verhaeghe, J., Meurrens, K., and Van Assche, F. A. (1997) Maternal semistarvation and streptozotocin-diabetes in rats have different effects on the in vivo glucose uptake by peripheral tissues in their female adult offspring. J. Nutr., 127, 1371-1376.
30. Aerts, L., Holemans, K., and Van Assche, A. (1990) Impaired insulin response and action in offspring of severely diabetic rats. In: Frontiers in Diabetes Research. Lessons from Animal Diabetes III, edited by Shafrir, E., pp. 561-566. London, Smith-Gordon.
31. Ishihara, G., Hiramatsu, Y., Masuyama, H., and Kudo, T. (2000) Streptozotocin-induced diabetic pregnant rats exhibit signs and symptoms mimicking preeclampsia. Metabolism, 49, 853-857.
32. 2α in maternal and fetal blood of rats with streptozotocin-induced diabetes: Evidence of lipid peroxidation. Am. J. Obstet. Gynecol., 183, 1035-1040.
33. Plagemann, A., Harder, T., Rake, A., Melchior, K., Rittel, F., Rohde, W., and Dörner, G. (1998) Hypothalamic insulin and neuropeptide Y in the offspring of gestational diabetic mother rats. Neuroreport, 9, 4069-4073.
34. Oh, W., Gelardi, N. L., and Cha, C. M. (1991) The cross-generation effect of neonatal macrosomia in rat pups of streptozotocin induced diabetes. Pediatr. Res., 29, 606-610.
35. Gelardi, N. L., Cha, C. M., and Oh, W. (1990) Glucose metabolism in adipocytes of obese offspring of mild hyperglycemic rats. Pediatr. Res., 28, 641-645.
36. Mulay, S., Philip, A., and Solomon, S. (1983) Influence of maternal diabetes on fetal rat development: Alteration of insulin receptors in fetal liver and lung. J. Endocrinol., 98, 401-410.
37. Ryan, E. A., Tobin, B. W., Tang, J., and Finegood, D. T. (1993) A new model for the study of mild diabetes during pregnancy: Syngeneic islet-transplanted STZ-induced diabetic rats. Diabetes, 42, 316-323.
38. Ryan, E. A., Liu, D. T., Bell, R. C., Finegood, D. T., and Crawford, J. (1995) Long term consequences in offspring of diabetes in pregnancy: Studies with syngeneic islet-transplanted streptozotocin-diabetic rats. Endocrinology, 136, 5587-5592.
39. Eriksson, U., Dahlstrom, E., Larsson, K. S., and Hellerstrom, C. (1982) Increased incidence of congenital malformations in the offspring of diabetic rats and their prevention by maternal insulin. Diabetes, 31, 1-6.
40. Boloker, J., Gertz, S. J., and Simmons, R. A. (2002) Gestational diabetes leads to the development of diabetes in adulthood in the rat. Diabetes, 51, 1499-1506.
41. Munilla, M. A., and Herrera, E. (1997) A cholesterol-rich diet causes a greater hypercholesterolemic response in pregnant than in nonpregnant rats and does not modify fetal lipoprotein profile. J. Nutr., 127, 2239-2245.
42. Folch, J., Lees, M., and Sloane Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 22, 24-36.
43. Ruiz, J. I., and Ochoa, B. (1997) Quantification in the subnanomolar range of phospholipids and neutral lipids by monodimension thin-layer chromatography and image analysis. J. Lipid Res., 38, 1482-1489.
44. Aerts, L., and Van Assche, A. (1981) Endocrine pancreas in the offspring of rats with experimentally induced diabetes. J. Endocrinol., 88, 81-88.
45. Herrera, E., and Amusquivar, E. (2000) Lipid metabolism in the fetus and the newborn. Diabetes Metab. Res. Rev., 16, 202-210.
46. Gelardi, N. L., Cha, C. M., and Oh, W. (1991) Evaluation of insulin sensitivity in obese offspring of diabetic rats by hyperinsulinemic-euglycemic clamp technique. Pediatr. Res., 30, 40-44.
47. Plagemann, A., Harder, T., Melchior, K., Rake, A., Rohde, W., and Dörner, G. (1999) Elevation of hypothalamic neuropeptide Y-neurons in adult offspring of diabetic mother rats. Neuroreport, 10, 3211-3216.
48. Herrera, E., Bonet, B., and Lasunción, M. A. (1998) Maternal-fetal transfer of lipid metabolites. In: Fetal and Neonatal Physiology, edited by Polin, R. A., and Fox, W. W., pp. 447-458. Philadelphia, W. B. Saunders.
49. Herrera, E. (2002) Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development - A review. Placenta, 23, S9-S19.
50. Casson, I. F., Clarke, C. A., Howard, C. V., McKendrick, O., Pennycook, S., Pharoah, P. O. D., Platt, A J., Stanisstreet, M., Van Velszen, D., and Walkinshaw, S. (1997) Outcomes of pregnancy in insulin dependent diabetic women: Results of a five year population cohort study. BMJ, 315, 275-278.
51. Ekbom, P., Damm, P., Feldt-Rasmussen, B., Feldt-Rasmussen, U., Molvig, J., and Mathiesen, E. R. (2001) Pregnancy outcome in type 1 diabetic women with microalbuminuria. Diabetes Care, 24, 1739-1744.