Effect of ulinastatin on the permeability of the blood-brain barrier on rats with global cerebral ischemia/reperfusion injury as assessed by MRI

Biomedicine and Pharmacotherapy

Volumn 85, Issue , 2017, Pages 412-417

  Liu, Ming ^a,b   Shen, Jie ^b   Zou, Fan ^c   Zhao, Yunfeng ^a   Li, Bing ^b   Fan, Mingxia ^d  

^a SHANGHAI PUNAN HOSPITAL   (China)

^b JINSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^c Pudong Gongli Hospital   (China)

^d EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

Global cerebral ischemia reperfusion injury; MRI; Ulinastatin

Indexed keywords

EVANS BLUE; GADOLINIUM PENTETATE; ULINASTATIN; GLYCOPROTEIN; TRYPSIN INHIBITOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; DRUG PENETRATION; MALE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; RAT; RAT MODEL; REPERFUSION INJURY; STAINING; ANIMAL; DIAGNOSTIC IMAGING; DRUG EFFECTS; PATHOLOGY;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; GLYCOPROTEINS; MAGNETIC RESONANCE IMAGING; RATS; REPERFUSION INJURY; TRYPSIN INHIBITORS;

EID: 85007417098     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.11.044     Document Type: Article

References (28)

1. [1] Murray, V., Norrving, B., Sandercock, P.A.G., Terént, A., Waldlaw, J.M., Wester, P., The molecular basis of thrombolysis and its clinical application in stroke. Intern. Med. 267 (2010), 191–208.
2. [2] Sun, Kai, Fan, Jingyu, Han, Jingyan, Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusioninduced cerebral microcirculatory disturbances and neuron damage. Acta Pharm. Sin. B 5:1 (2015), 8–24.
3. [3] Laver, S., Farrow, C., Turner, D., et al. Mode of death after admission to an intensive care unit following cardiac arrest. Intensive Care Med. 30:11 (2004), 2126–2128.
4. [5] Koga, Y., Fujita, M., Tsurta, R., et al. Urinary trypsin inhibitior suppress excessive superoxide anion radical generation in blood,oxidative stress,early inflammation,and endothelial injury in forebrain ischemia/reperfusion rats. Neurol. Res., 32, 2010, 925.
5. [6] Jönsson-Berling, B.M., Ohlsson, K., Rosengren, M., Radio-immunological quantitation of the urinary trypsin inhibitor in normal blood and urine. Biol. Chem. Hoppe-Seyler 370 (1989), 1157–1161.
6. [7] Ramos, A.B., Vasconcelos-Dos-Santos, A., Lopes de Souza, S.A., et al. Bone-marrow mononuclear cells reduce neurodegeneration in hippocampal CA1 layer after transient global ischemia in rats. Brain Res. 1522 (2013), 1–11.
7. [8] Willard, W., Dynamin-related protein 1 as a therapeutic target in cardiac arrest. J Mol Med (Berl) 93:March (3) (2015), 243–252.
8. [9] Moretti, R., Pansiot, J., Bettati, D., et al. Blood-brain barrier dysfunction in disorders of the developing brain. Front. Neurosci., 10, 2015, 3389.
9. [10] Gerriets, T., Walberer, M., Ritschel, N., et al. Edema formation in the hyperacute phase of ischemic stroke. Neurosurgery 5 (2009), 1036–1042.
10. [11] Cucullo, L., Mc Allister, M.S., Kight, K., et al. A new dynamicin vitro mode l for the multidimensional study of astrocyte-endothelial cell interaction sat the blood-brain barrier. Brain Res. 951:2 (2002), 244–254.
11. [12] Marchi, N., Fazio, V., Cucullo, L., et al. Serum transthyretin monomer as a possible marker of blood-to-CSF barrier disruption. Neuroscience 23:5 (2003), 1949–1955.
12. [13] Zheng, Z., Yenari, M.A., Post-ischemic inflammation: molecular mechanisms and therapeutic implications. Neurol. Res. 26 (2004), 884–892.
13. [14] Ikede, Y., Wang, M., Nakazawa, S., Simple quantitative evaluation of blood brain barrier disruption in vasogenic brain edema. Acta Neurochir. 60 (1994), 119–120.
14. [15] Saunders, N.R., Dziegielewska, K.M., Møllgård, K., Habgood, M.D., Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?. Front. Neurosci., 9, 2015, 385.
15. [16] Piao, M.S., Lee, J.K., Park, C.S., Early activation of matrix metalloProteinase-9 is associated with blood-brain barrier disruption after photothrombotic cerebral ischemia in rats. Acta Neurochir. (Wien) 151:12 (2009), 1649–1653.
16. [17] Neumann-Haefelin, T., Kastrup, A., et al. Serial MRI after transient focal cerebral ischemia in rats:dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke, 31(8), 2000, 1965.
17. [18] Stoll, G., Kleinschnitz, C., Meuth, S.G., et al. Transient widespread blood-brain barrier alterations after cerebral photothrombosis as revealed by gadofluorine M-enhanced magnetic resonance imaging. Cereb. Blood Flow Metab. 29 (2009), 33–41.
18. [19] DR, Pillai, MS, Dittmar, D, Baldaranov, et al. Cerebral ischemia–reperfusion injury in rats—a 3T MRI study on biphasic blood–brain barrier opening and the dynamics of edema formation. J. Cereb. Blood Flow Metab. 11 (2009), 1846–1855.
19. [20] Quarantelli, M., MRI/MRS in neuroinflammation: methodology and applications. Clin. Transl. Imaging 3 (2015), 475–489.
20. [21] Chen, C.C., Wang, S.S., Lee, F.Y., Action of antiproteases on the inflammatory response in acute pancreatitis. Pancreas 8 (2007), 488–494.
21. [22] Luo, H.M., Hu, S., Zhou, G.Y., et al. The effects of ulinastatin on systemic inflammation, visceral vasopermeability and tissue water content in rats with scald injury. Burns 39 (2013), 916–922 (2012.11.004).
22. [23] Park, J.H., Kwak, S.H., Jeong, C.W., et al. Effect of ulinastatin on cytokine reaction during gastrectomy. Korean J. Anesthesiol. 58 (2010), 334–337.
23. [24] Chen, C.C., Liu, Z.M., Wang, H.H., et al. Effects of ulinastatin on renal ischemia-reperfusion injury in rats. Acta Pharmacol. Sin. 25 (2004), 1334–1340.
24. [25] Yano, T., Anraku, S., Nakayama, R., Ushijima, K., Neuroprotective effect of urinary trypsin inhibitor against focal cerebral ischemia-reperfusion injury in rats. Anesthesiology 98 (2003), 465–473.
25. [27] Yano, T., Anraku, S., Nakayama, R., Ushijima, K., Neuroprotective effect of urinary trypsin inhibitor against focal cerebral ischemia-reperfusion injury in rats. Anesthesiology 98 (2003), 465–473.
26. [28] Koga, Y., Fujita, M., Tsuruta, R., et al. Urinary trypsin inhibi¬tor suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats. Neurol. Res. 32 (2010), 925–932.
27. [29] Chen, H.M., Huang, H.S., Ruan, L., et al. Ulinastatin attenuates cerebral ischemia-reperfusion injury in rats. Int. J. Clin. Exp. Med. 7 (2014), 1483–1489.
28. [30] YS, Cho, MS, Shin, IG, Ko, et al. Ulinastatin inhibits cerebral ischemia-induced apoptosis in the hippocampus of gerbils. Mol. Med. Rep. 12 (2015), 1796–1802.