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Volumn 59, Issue 24, 2016, Pages 10859-10864

No Denying It: Medicinal Chemistry Training Is in Big Trouble

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DESIGN; DRUG INDUSTRY; EXPERIENTIAL LEARNING; HUMAN; MEDICAL EDUCATION; MEDICAL RESEARCH; MEDICINAL CHEMISTRY; ORGANIZATION; REVIEW; SOLUTION AND SOLUBILITY; DRUG DEVELOPMENT; MOLECULAR LIBRARY;

EID: 85007228226     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00741     Document Type: Review
Times cited : (27)

References (33)
  • 1
    • 0029799015 scopus 로고    scopus 로고
    • Vocational training for medicinal chemists: Views from industry
    • Busse, W. D.; Ganellin, C. R.; Mitscher, L. A. Vocational training for medicinal chemists: views from industry Eur. J. Med. Chem. 1996, 31, 747-760 10.1016/0223-5234(96)83968-7
    • (1996) Eur. J. Med. Chem. , vol.31 , pp. 747-760
    • Busse, W.D.1    Ganellin, C.R.2    Mitscher, L.A.3
  • 3
    • 84984933106 scopus 로고    scopus 로고
    • Training academic chemists for industry
    • Frantz, S. Training academic chemists for industry Nat. Rev. Drug Discovery 2004, 3, 719 10.1038/nrd1483
    • (2004) Nat. Rev. Drug Discovery , vol.3 , pp. 719
    • Frantz, S.1
  • 4
    • 67749116407 scopus 로고    scopus 로고
    • Medicinal chemistry teaching and training: A continuous adaptation
    • Timmerman, H.; de Souza, N. J. Medicinal chemistry teaching and training: a continuous adaptation ChemMedChem 2009, 4, 1055-1058 10.1002/cmdc.200900128
    • (2009) ChemMedChem , vol.4 , pp. 1055-1058
    • Timmerman, H.1    De Souza, N.J.2
  • 5
    • 0003095407 scopus 로고    scopus 로고
    • Challenges for medicinal chemistry
    • Wess, G. Challenges for medicinal chemistry Drug Discovery Today 1996, 1, 529-532 10.1016/S1359-6446(96)10047-7
    • (1996) Drug Discovery Today , vol.1 , pp. 529-532
    • Wess, G.1
  • 7
    • 85071797297 scopus 로고    scopus 로고
    • Experiential Learning Theory: Previous Research and New Directions
    • Sternberg, R. J. Zhang, L. F. Lawrence Erlbaum and Associates: Mahwah, NJ
    • Kolb, D. A.; Boyatzis, R. E.; Mainemelis, C. Experiential Learning Theory: Previous Research and New Directions. In Perspectives on Thinking, Learning, and Cognitive Styles; Sternberg, R. J.; Zhang, L. F., Eds.; Lawrence Erlbaum and Associates: Mahwah, NJ, 2000; pp 227-248.
    • (2000) Perspectives on Thinking, Learning and Cognitive Styles , pp. 227-248
    • Kolb, D.A.1    Boyatzis, R.E.2    Mainemelis, C.3
  • 8
    • 0000423219 scopus 로고
    • Expert judgment: Some necessary conditions and an example
    • Einhorn, H. J. Expert judgment: some necessary conditions and an example J. Appl. Psychol. 1974, 59, 562-571 10.1037/h0037164
    • (1974) J. Appl. Psychol. , vol.59 , pp. 562-571
    • Einhorn, H.J.1
  • 9
    • 33745809902 scopus 로고    scopus 로고
    • Hit discovery and hit-to-lead approaches
    • Keseru, G. M.; Makara, G. M. Hit discovery and hit-to-lead approaches Drug Discovery Today 2006, 11, 741-748 10.1016/j.drudis.2006.06.016
    • (2006) Drug Discovery Today , vol.11 , pp. 741-748
    • Keseru, G.M.1    Makara, G.M.2
  • 10
    • 4544338170 scopus 로고    scopus 로고
    • Assessment of the consistency of medicinal chemists in reviewing sets of compounds
    • Lajiness, M. S.; Maggiora, G. M.; Shanmugasundaram, V. Assessment of the consistency of medicinal chemists in reviewing sets of compounds J. Med. Chem. 2004, 47, 4891-4896 10.1021/jm049740z
    • (2004) J. Med. Chem. , vol.47 , pp. 4891-4896
    • Lajiness, M.S.1    Maggiora, G.M.2    Shanmugasundaram, V.3
  • 11
    • 61649109015 scopus 로고    scopus 로고
    • The influence of lead discovery strategies on the properties of drug candidates
    • Keseru, G. M.; Makara, G. M. The influence of lead discovery strategies on the properties of drug candidates Nat. Rev. Drug Discovery 2009, 8, 203-212 10.1038/nrd2796
    • (2009) Nat. Rev. Drug Discovery , vol.8 , pp. 203-212
    • Keseru, G.M.1    Makara, G.M.2
  • 12
    • 0141726877 scopus 로고    scopus 로고
    • A rule of Three for fragment-based lead discovery?
    • Congreve, M.; Carr, R.; Murray, C.; Jhoti, H. A Rule of Three for fragment-based lead discovery? Drug Discovery Today 2003, 8, 876-877 10.1016/S1359-6446(03)02831-9
    • (2003) Drug Discovery Today , vol.8 , pp. 876-877
    • Congreve, M.1    Carr, R.2    Murray, C.3    Jhoti, H.4
  • 13
    • 84869744217 scopus 로고    scopus 로고
    • Inside the mind of a medicinal chemist: The role of human bias in compound prioritization during drug discovery
    • Kutchukian, P. S.; Vasilyeva, N. Y.; Xu, J.; Lindvall, M. K.; Dillon, M. P.; Glick, M.; Coley, J. D.; Brooijmans, N. Inside the mind of a medicinal chemist: the role of human bias in compound prioritization during drug discovery PLoS One 2012, 7, e48476 10.1371/journal.pone.0048476
    • (2012) PLoS One , vol.7 , pp. e48476
    • Kutchukian, P.S.1    Vasilyeva, N.Y.2    Xu, J.3    Lindvall, M.K.4    Dillon, M.P.5    Glick, M.6    Coley, J.D.7    Brooijmans, N.8
  • 14
    • 84938495908 scopus 로고    scopus 로고
    • Molecular property design: Does everyone get it?
    • Leeson, P. D.; Young, R. J. Molecular property design: does everyone get it? ACS Med. Chem. Lett. 2015, 6, 722-725 10.1021/acsmedchemlett.5b00157
    • (2015) ACS Med. Chem. Lett. , vol.6 , pp. 722-725
    • Leeson, P.D.1    Young, R.J.2
  • 15
    • 1942453243 scopus 로고    scopus 로고
    • Ligand efficiency: A useful metric for lead selection
    • Hopkins, A. L.; Groom, C. R.; Alex, A. Ligand efficiency: a useful metric for lead selection Drug Discovery Today 2004, 9, 430-431 10.1016/S1359-6446(04)03069-7
    • (2004) Drug Discovery Today , vol.9 , pp. 430-431
    • Hopkins, A.L.1    Groom, C.R.2    Alex, A.3
  • 16
    • 35748934487 scopus 로고    scopus 로고
    • The influence of drug-like concepts on decision-making in medicinal chemistry
    • Leeson, P. D.; Springthorpe, B. The influence of drug-like concepts on decision-making in medicinal chemistry Nat. Rev. Drug Discovery 2007, 6, 881-890 10.1038/nrd2445
    • (2007) Nat. Rev. Drug Discovery , vol.6 , pp. 881-890
    • Leeson, P.D.1    Springthorpe, B.2
  • 17
    • 61649109015 scopus 로고    scopus 로고
    • The influence of lead discovery strategies on the properties of drug candidates
    • Keseru, G. M.; Makara, G. M. The influence of lead discovery strategies on the properties of drug candidates Nat. Rev. Drug Discovery 2009, 8, 203-212 10.1038/nrd2796
    • (2009) Nat. Rev. Drug Discovery , vol.8 , pp. 203-212
    • Keseru, G.M.1    Makara, G.M.2
  • 18
    • 0347419177 scopus 로고    scopus 로고
    • Prediction of aqueous solubility of organic compounds by topological descriptors
    • Yan, A.; Gasteiger, J. Prediction of aqueous solubility of organic compounds by topological descriptors QSAR Comb. Sci. 2003, 22, 821-829 10.1002/qsar.200330822
    • (2003) QSAR Comb. Sci. , vol.22 , pp. 821-829
    • Yan, A.1    Gasteiger, J.2
  • 19
    • 77953675980 scopus 로고    scopus 로고
    • Moving beyond rules: Development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties
    • Wager, T. T.; Hou, X.; Verhoest, P. R.; Villalobos, A. Moving beyond rules: development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties ACS Chem. Neurosci. 2010, 1, 435-449 10.1021/cn100008c
    • (2010) ACS Chem. Neurosci. , vol.1 , pp. 435-449
    • Wager, T.T.1    Hou, X.2    Verhoest, P.R.3    Villalobos, A.4
  • 21
    • 80052830823 scopus 로고    scopus 로고
    • How well do medicinal chemists learn from experience?
    • Cheshire, D. R. How well do medicinal chemists learn from experience? Drug Discovery Today 2011, 16, 817-821 10.1016/j.drudis.2011.06.005
    • (2011) Drug Discovery Today , vol.16 , pp. 817-821
    • Cheshire, D.R.1
  • 22
    • 84933523521 scopus 로고    scopus 로고
    • Medicinal chemists of the 21st century-who are we and where to go?
    • Nussbaumer, P. Medicinal chemists of the 21st century-who are we and where to go? ChemMedChem 2015, 10, 1133-1139 10.1002/cmdc.201500133
    • (2015) ChemMedChem , vol.10 , pp. 1133-1139
    • Nussbaumer, P.1
  • 24
    • 79955613841 scopus 로고    scopus 로고
    • Molecular obesity, potency and other addictions in drug discovery
    • Hann, M. M. Molecular obesity, potency and other addictions in drug discovery MedChemComm 2011, 2, 349-355 10.1039/c1md00017a
    • (2011) MedChemComm , vol.2 , pp. 349-355
    • Hann, M.M.1
  • 25
    • 84860359784 scopus 로고    scopus 로고
    • Finding the sweet spot: The role of nature and nurture in medicinal chemistry
    • Hann, M. M.; Keseru, G. M. Finding the sweet spot: the role of nature and nurture in medicinal chemistry Nat. Rev. Drug Discovery 2012, 11, 355-365 10.1038/nrd3701
    • (2012) Nat. Rev. Drug Discovery , vol.11 , pp. 355-365
    • Hann, M.M.1    Keseru, G.M.2
  • 26
    • 80052974259 scopus 로고    scopus 로고
    • Improving drug candidates by design: A focus on physicochemical properties as a means of improving compound disposition and safety
    • Meanwell, N. Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety Chem. Res. Toxicol. 2011, 24, 1420-1456 10.1021/tx200211v
    • (2011) Chem. Res. Toxicol. , vol.24 , pp. 1420-1456
    • Meanwell, N.1
  • 27
    • 0037468884 scopus 로고    scopus 로고
    • A Comparison of physiochemical property profiles of development and marketed oral drugs
    • Wenlock, M. C.; Austin, R. P.; Barton, P.; Davis, A. M.; Leeson, P. D. A Comparison of physiochemical property profiles of development and marketed oral drugs J. Med. Chem. 2003, 46, 1250-1256 10.1021/jm021053p
    • (2003) J. Med. Chem. , vol.46 , pp. 1250-1256
    • Wenlock, M.C.1    Austin, R.P.2    Barton, P.3    Davis, A.M.4    Leeson, P.D.5
  • 29
    • 84974832037 scopus 로고    scopus 로고
    • Central nervous system multiparameter optimization desirability: Application in drug discovery
    • Wager, T. T.; Hou, X.; Verhoest, P. R.; Villalobos, A. Central nervous system multiparameter optimization desirability: application in drug discovery ACS Chem. Neurosci. 2016, 7, 767-775 10.1021/acschemneuro.6b00029
    • (2016) ACS Chem. Neurosci. , vol.7 , pp. 767-775
    • Wager, T.T.1    Hou, X.2    Verhoest, P.R.3    Villalobos, A.4
  • 30
    • 85007185382 scopus 로고    scopus 로고
    • About IFD. (accessed August 1)
    • About IFD. http://innovationsfonden.dk/en/about-ifd (accessed August 1, 2016).
    • (2016)
  • 31
    • 85007239925 scopus 로고    scopus 로고
    • Research & Innovation. Marie Sklodowska-Curie Actions. (accessed August 1)
    • Research & Innovation. Marie Sklodowska-Curie Actions. http://ec.europa.eu/research/mariecurieactions/ (accessed August 1, 2016).
    • (2016)
  • 32
    • 85007239928 scopus 로고    scopus 로고
    • Innovative Medicines Initiative. (accessed August 1)
    • Innovative Medicines Initiative. https://www.imi.europa.eu (accessed August 1, 2016).
    • (2016)
  • 33
    • 85007239471 scopus 로고    scopus 로고
    • Grant Opportunities for Academic Liaison with Industry (GOALI). (accessed August 1)
    • Grant Opportunities for Academic Liaison with Industry (GOALI). https://www.nsf.gov/funding/pgm-summ.jsp?pims-id=504699 (accessed August 1, 2016).
    • (2016)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.