Modelling effects of sotalol on action potential morphology using a novel markov model of the HERG channel

IFMBE Proceedings

Volumn 16, Issue 1, 2007, Pages 50-53

  Brennan, Thomas P ^a   Fink, M ^a   Rodriguez, B ^a   Tarassenko, L T ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Computer simulation; HERG; Markov model; Sotalol

Indexed keywords

COMPUTER SIMULATION; ELECTRIC RECTIFIERS; ELECTROPHYSIOLOGY; MAMMALS; MORPHOLOGY;

ACTION POTENTIAL DURATIONS; HERG; HUMAN EMBRYONIC KIDNEYS; HUMAN ETHER-A-GO-GO RELATED GENE (HERG); INTRACELLULAR CAVITIES; MARKOV MODEL; SOTALOL; TRANSMURAL DISPERSION OF REPOLARIZATION;

MARKOV PROCESSES;

EID: 85007072138     PISSN: 16800737     EISSN: 14339277     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-540-73044-6_14     Document Type: Conference Paper

References (18)

1. Zhang L et al. (2000), ‘Spectrum of ST-T-Wave Patterns and Repolarization Parameters in Congenital Long-QT Syndrome: ECG Findings Identify Genotypes’, Circulation 102(23), 2849-2855.
2. Curran ME et al. (1995), ‘A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.’, Cell 80(5), 795-803.
3. Kiehn J, Lacerda AE, Wible B & Brown AM (1996), ‘Molecular physiology and pharmacology of HERG. Singlechannel currents and block by dofetilide’, Circulation 94(10), 2572-2579.
4. Colquhoun D & Hawkes AG (1981), ‘On the stochastic properties of single ion channels’, Proc R Soc Lond B Biol Sci 211(1183), 205-235.
5. Horn R & Lange K (1983), ‘Estimating kinetic constants from single channel data.’, Biophys. J. 43(2), 207-223.
6. Destexhe A, Mainen ZF & Sejnowski TJ (1994), ‘Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism’, Journal of Computational Neuroscience V1(3), 195-230.
7. Clancy CE & Rudy Y (2001), ‘Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death.’, Cardiovasc Res 50(2), 301-313.
8. Oehmen CS, Giles WR & Demir SS (2002), ‘Mathematical model of the rapidly activating delayed rectifier potassium current I(Kr) in rabbit sinoatrial node.’, J Cardiovasc Electrophysiol 13(11), 1131-1140.
9. Weerapura M et al. (2000), ‘State-dependent barium block of wild-type and inactivation-deficient HERG channels in Xenopus oocytes.’, J Physiol 526, 265-278.
10. Lu Y et al. (2001), ‘Effects of premature stimulation on HERG K(+) channels.’, J Physiol 537(Pt 3), 843-851.
11. Mazhari R et al. (2001), ‘Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis.’, Circ Res 89(1), 33-38.
12. + current to repolarization of the human ventricular action potential’, Prog Biophys Mol Biol [In press].
13. Sanguinetti MC & Tristani-Firouzi M (2006), ‘hERG potassium channels and cardiac arrhythmia’, Nature 440, 463-469.
14. Mitcheson JS, Chen J & Sanguinetti MC (2000), ‘Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate’, J Gen Physiol 115(3), 229-240.
15. +]Dofetilide binding: biological models that manifest solely the high or the low affinity binding site’ J Moll Cell Cardiol 28, 1085-1096.
16. GE, Kirsch et al. (2004), ‘Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern’, J Pharm Tox Meth 50, 93-101.
17. ten Tusscher KHW et al. (2004), ‘A model for human ventricular tissue’, Am J Physiol Heart Circ Physiol 286, H1573-H1589.
18. Gima K & Rudy Y (2002), ‘Ionic current basis of electrocardiographic waveforms: a model study’, Circ Res 90, 889-896.