Clinical outcome of critically ill patients with thrombocytopenia and hypophosphatemia in the early stage of sepsis

Anaesthesiology Intensive Therapy

Volumn 48, Issue 5, 2016, Pages 294-299

  Brotfain, Evgeni ^a   Schwartz, Andrei ^a   Boniel, Avi ^a   Koyfman, Leonid ^a   Boyko, Matthew ^a   Kutz, Ruslan ^a   Klein, Moti ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Outcome; hypophosphatemia; Sepsis; Septic shock; sepsis; Severe sepsis; Thrombocytopenia

Indexed keywords

HYPERTENSIVE AGENT; INOTROPIC AGENT;

ADULT; AGED; ARTICLE; CLINICAL OUTCOME; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DATA COLLECTION METHOD; DISEASE SEVERITY; ELECTRONIC MEDICAL RECORD; FEMALE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMAN; HYPOPHOSPHATEMIA; INTENSIVE CARE UNIT; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY RATE; PROGNOSIS; RETROSPECTIVE STUDY; SEPSIS; SEPTIC SHOCK; THROMBOCYTOPENIA; TOTAL PARENTERAL NUTRITION; AGE; APACHE; CRITICAL ILLNESS; INTENSIVE CARE; KAPLAN MEIER METHOD; LENGTH OF STAY; MORTALITY; SEX DIFFERENCE; TREATMENT OUTCOME;

ADULT; AGE FACTORS; AGED; APACHE; CRITICAL CARE; CRITICAL ILLNESS; FEMALE; HOSPITAL MORTALITY; HUMANS; HYPOPHOSPHATEMIA; KAPLAN-MEIER ESTIMATE; LENGTH OF STAY; MALE; MIDDLE AGED; PARENTERAL NUTRITION, TOTAL; PROGNOSIS; RETROSPECTIVE STUDIES; SEPSIS; SEX FACTORS; THROMBOCYTOPENIA; TREATMENT OUTCOME;

EID: 85006901815     PISSN: 16425758     EISSN: 17312531     Source Type: Journal    
DOI: 10.5603/AIT.a2016.0053     Document Type: Article

References (20)

1. Dellinger RP, Levy HM, Carlet JM, Bion J et al.: Surviving sepsis Campaign: International guidelines for management of severe sepsis and septic shock. Crit Care Med 2008; 36: 1394-1396.
2. Shor R, Halabe A, Rishver S et al.: Severe hypophosphatemia in sepsis as a mortality predictor. Ann Clin Lab Sci 2006; 36: 67-72.
3. Nguyen TC, Carcillo JA: Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure-a newly appreciated syndrome in the critically ill. Crit Care 2006; 10: 235-247.
4. Bugg NC, Jones JA: Hypophosphatemia. Anesthesia 1998; 53: 895-902.
5. Riedler GF, Scheitlin WA: Hypophosphataemia in septicaemia: higher incidence in gram-negative than in gram-positive infections. Br Med J 1969; 1:753-756.
6. Schwartz A, Gurman GM,Cohen G et al.: Association betweenhypophosphatemia and cardiac arrhythmias in the early stages of sepsis. Eur J Inter Med 2002; 13: 434-438.
7. Suzuki S, Egi M, Schneider AG, Bellomo R, Hart GK, Hegarty C: Hypophosphatemia in critically ill patients. J Crit Care 2013; 28: 536-543. doi: 10.1016/j.jcrc.2012.10.011.
8. Von Landenerg P, Shoenfeld Y: New approaches in the diagnosis of sepsis. Isr Med Assoc J 2001; 3: 439-442.
9. Venkata C, Kashyap R, Farmer JC, Afessa B: Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. J Intensive Care 2013; 1: 9-14. doi: 10.1186/2052-0492-1-9.
10. Vanderschueren S, De Weerdt A, Malbrain M et al.: Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000; 28, 6: 1871-1876.
11. Saglikes Y, Massry SG, Iseki K, Brautbar N, Brandt R, Brunton LL: Effect of phosphate depletion on blood pressure and vascular reactivity to norepinephrine and angiotensin II in the rat. Am J Phisiol 1985; 248: 93-99.
12. Brautbar N, Leubovici H, Massry SG: On the mechanism of hypophosphatemia during acute hyperventilation: evidence for an increased muscle glycolysis. Mineral Electrolyte Metab 1983; 9: 45-50.
13. O'Connor LR, Wheeler WS, Bethune JE: Effect of hypophosphatemia on myocardial performance in man. N Engl J Med 1977; 297: 183-187.
14. Geerse DA, Bindels AJ, Kuiper MA, Roos AN, Spronk PE, Schultz MJ. Treatment of hypophosphatemia in the intensive care unit: a review. Crit Care 2010; 147: 1-8. doi: 10.1186/cc9215.
15. Cohen J, Kogan A, Sahar G, Lev S, Vidne B, Singer P: Hypophosphatemia following open heart surgery: incidence and consequences. Eur J Cardiothorac Surg 2004; 26: 306-310.
16. Bogdonoff DL, Williams ME, Stone DJ: Thrombocytopenia in the critically ill patient. J Crit Care 1990; 5: 186-205.
17. Lee KH, Hui KP, Tan WC: Thrombocytopenia in sepsis: A predictor of mortality in the intensive care unit. Singapore Med J 1993; 34: 245-246.
18. Akca S, Haji-Michael P, de MendoncaA, Suter P, Levi M, Vincent JL: Time course of platelet counts in critically ill patients. Crit Care Med 2002; 30:753-756.
19. Zazzo JF, Troche G, Ruel P et al.: High incidence of hypophosphatemia in surgical intensive care patients: efficacy of phosphorus therapy on myocardial function. Intensive Care Med 1995; 21: 826-831.
20. Farrokhi F, Chandra P, Smiley D et al.: Glucose variability is an independent predictor of mortality in hospitalized patients treated with total parenteral nutrition. Endocr Pract 2014; 20: 41-45. doi: 10.4158/EP13131.O.R.