Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 51, 2016, Pages 14781-14786

  Sagan, Sharon A ^a,b   Winger, Ryan C ^a,b   Cruz Herranz, Andrés ^a   Nelson, Patricia A ^a,b   Hagberg, Sarah ^a,b   Miller, Corey N ^b   Spencer, Collin M ^a,b   Ho, Peggy P ^c   Bennett, Jeffrey L ^d,e   Levy, Michael ^f   Levin, Marc H ^a   Verkman, Alan S ^a,b   Steinman, Lawrence ^c   Green, Ari J ^a   Anderson, Mark S ^b   Sobel, Raymond A ^g   Zamvil, Scott S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aquaporin 4; ENMO; Neuromyelitis optica; T cell receptor; Tolerance

Indexed keywords

AQUAPORIN 4; AQP4 PROTEIN, MOUSE; AUTOANTIBODY; AUTOANTIGEN; EPITOPE; IMMUNOGLOBULIN G;

ADOPTIVE TRANSFER; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL POLARITY; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; IMMUNOLOGICAL TOLERANCE; MOUSE; MYELOOPTIC NEUROPATHY; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH17 CELL; ANIMAL; AUTOIMMUNE DISEASE; C57BL MOUSE; CENTRAL NERVOUS SYSTEM; CHEMISTRY; CYTOLOGY; EPITOPE MAPPING; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE; METABOLISM; SPLEEN; TRANSGENIC MOUSE;

ANIMALS; AQUAPORIN 4; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; INFLAMMATION; LEUKOCYTES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROMYELITIS OPTICA; SPLEEN; T-LYMPHOCYTES; TH17 CELLS;

EID: 85006445890     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1617859114     Document Type: Article

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