Bone Morphogenetic Protein 2 and Transforming Growth Factor β1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts

American Journal of Pathology

Volumn 187, Issue 1, 2017, Pages 156-162

  Chemel, Marguerite ^a,b,c   Brion, Regis ^a,b   Segaliny, Aude Isabelle ^a,b   Lamora, Audrey ^a,b   Charrier, Celine ^a,b   Brulin, Benedicte ^a,b   Maugars, Yves ^c   Le Goff, Benoit ^a,b,c   Heymann, Dominique ^a,b,c,d   Verrecchia, Franck ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c NANTES UNIVERSITY HOSPITAL   (France)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ACTIVIN RECEPTOR LIKE KINASE 1; ADALIMUMAB; BONE MORPHOGENETIC PROTEIN 2; COLONY STIMULATING FACTOR 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INFLIXIMAB; INTERLEUKIN 34; LEFLUNOMIDE; MESSENGER RNA; METHOTREXATE; RITUXIMAB; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; TOCILIZUMAB; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; ACTIVIN RECEPTOR 2; ACVRL1 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; INTERLEUKIN-34, HUMAN; INTERLEUKIN-34, MOUSE; PROTEIN SERINE THREONINE KINASE; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ADULT; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE EROSION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DOSE RESPONSE; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE COUNT; MALE; MESENCHYMAL STEM CELL; MIDDLE AGED; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; STEADY STATE; SYNOVIAL FLUID LEVEL; SYNOVIOCYTE; VERY ELDERLY; ANIMAL; BIOLOGICAL MODEL; INFLAMMATION; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; SYNOVIUM;

ACTIVIN RECEPTORS, TYPE II; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ARTHRITIS, RHEUMATOID; BONE MORPHOGENETIC PROTEIN 2; FEMALE; FIBROBLASTS; HUMANS; INFLAMMATION; INTERLEUKINS; MALE; MESENCHYMAL STROMAL CELLS; MICE; MIDDLE AGED; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SYNOVIAL MEMBRANE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85006380409     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2016.09.015     Document Type: Article

References (16)

1. 1 Klareskog, L., Catrina, A.I., Paget, S., Rheumatoid arthritis. Lancet 373 (2009), 659–672.
2. 2 Bartok, B., Firestein, G.S., Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 233 (2010), 233–255.
3. 3 Lin, H., Lee, E., Hestir, K., Leo, C., Huang, M., Bosch, E., Halenbeck, R., Wu, G., Zhou, A., Behrens, D., Hollenbaugh, D., Linnemann, T., Qin, M., Wong, J., Chu, K., Doberstein, S.K., Williams, L.T., Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 320 (2008), 807–811.
4. 4 Baud'huin, M., Renault, R., Charrier, C., Riet, A., Moreau, A., Brion, R., Gouin, F., Duplomb, L., Heymann, D., Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis. J Pathol 221 (2010), 77–86.
5. 5 Chemel, M., Le Goff, B., Brion, R., Cozic, C., Berreur, M., Amiaud, J., Bougras, G., Touchais, S., Blanchard, F., Heymann, M.F., Berthelot, J.M., Verrecchia, F., Heymann, D., Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients. Ann Rheum Dis 71 (2012), 150–154.
6. 6 Pohlers, D., Brenmoehl, J., Löffler, I., Müller, C.K., Leipner, C., Schultze-Mosgau, S., Stallmach, A., Kinne, R.W., Wolf, G., TGF-[beta] and fibrosis in different organs - molecular pathway imprints. Biochim Biophys Acta 1792 (2009), 746–756.
7. 7 Pohlers, D., Beyer, A., Koczan, D., Wilhelm, T., Thiesen, H.J., Kinne, R.W., Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther, 9, 2007, R59.
8. 8 Cho, M.L., Min, S.Y., Chang, S.H., Transforming growth factor beta1 (TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. Immunol Lett 105 (2006), 159–166.
9. 9 Müssener, A., Funa, K., Kleinau, S., Klareskog, L., Dynamic expression of transforming growth factor-betas (TGF-beta) and their type I and type II receptors in the synovial tissue of arthritic rats. Clin Exp Immunol 107 (1997), 112–119.
10. 10 Schramm, C., Kriegsmann, J., Protschka, M., Huber, S., Hansen, T., Schmitt, E., Galle, P.R., Blessing, M., Susceptibility to collagen-induced arthritis is modulated by TGFbeta responsiveness of T cells. Arthritis Res Ther 6 (2004), R114–R119.
11. 11 Lories, R.J., Luyten, F.P., Bone morphogenetic protein signaling in joint homeostasis and disease. Cytokine Growth Factor Rev 16 (2005), 287–298.
12. 12 Segaliny, A.I., Mohamadi, A., Dizier, B., Lokajczyk, A., Brion, R., Lanel, R., Amiaud, J., Charrier, C., Boisson-Vidal, C., Heymann, D., Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment. Int J Cancer 137 (2005), 73–85.
13. 13 Venkatesha, S.H., Dudics, S., Acharya, B., Moudgil, K.D., Cytokine-modulating strategies and newer cytokine targets for arthritis therapy. Int J Mol Sci 16 (2014), 887–906.
14. 14 Verrecchia, F., Mauviel, A., Farge, D., Transforming growth factor-beta signaling through the Smad proteins: role in systemic sclerosis. Autoimmun Rev 5 (2006), 563–569.
15. 15 Brandes, M.E., Allen, J.B., Ogawa, Y., Wahl, S.M., Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals. J Clin Invest 87 (1991), 1108–1113.
16. 16 Omata, Y., Nakamura, S., Koyama, T., Yasui, T., Hirose, J., Izawa, N., Matsumoto, T., Imai, Y., Seo, S., Kurokawa, M., Tsutsumi, S., Kadono, Y., Morimoto, C., Aburatani, H., Miyamoto, T., Tanaka, S., Identification of Nedd9 as a TGF-[beta]-Smad2/3 target gene involved in RANKL-induced osteoclastogenesis by comprehensive analysis. PLoS One, 11, 2016, e0157992.