Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells

Arthritis Research and Therapy

Volumn 6, Issue 2, 2004, Pages

  Schramm, Christoph ^a   Kriegsmann, Jörg ^b   Protschka, Martina ^a   Huber, Samuel ^a   Hansen, Torsten ^a   Schmitt, Edgar ^c   Galle, Peter Robert ^a   Blessing, Manfred ^b,d  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b Gemeinschaftspraxis fur Pathologie   (Germany)

^c Institut f?r Immunologie   (Germany)

^d Institut für Bioanalytische Chemie   (Germany)

Author keywords

dominant negative TGF type II receptor; IFN ; transgenic mice

Indexed keywords

COLLAGEN TYPE 2; CYTOKINE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTHRITIS; ARTICLE; BIOSYNTHESIS; CATTLE; CELL CULTURE; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; CROSS BREEDING; DBA MOUSE; DISEASE PREDISPOSITION; HOSPITALIZATION; IMMUNOLOGY; LYMPH NODE; METABOLISM; MOUSE; MOUSE STRAIN; PATHOLOGY; PHYSIOLOGY; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; TH1 CELL; TRANSGENIC MOUSE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE II; CROSSES, GENETIC; CYTOKINES; DISEASE SUSCEPTIBILITY; LYMPH NODES; MICE; MICE, INBRED DBA; MICE, INBRED STRAINS; MICE, TRANSGENIC; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES; TH1 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 5644230401     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar1039     Document Type: Article

References (16)

1. Anthony DD, Haqqi TM: Collagen-induced arthritis in mice: an animal model to study the pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol. 1999, 17: 240-244.
2. Taneja V, Taneja N, Paisansinsup T, Behrens M, Griffiths M, Luthra H, David CS: CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis. J Immunol. 2002, 168: 5867-5875. DOI: 10.4049/jimmunol.168.11.5867
3. Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol. 1996, 14: 397-440. 10.1146/annurev.immunol.14.1.397. DOI: 10.1146/annurev.immunol.14.1.397
4. Letterio JJ, Roberts AB: Regulation of immune responses by TGF-beta. Annu Rev Immunol. 1998, 16: 137-161. 10.1146/annurev.immunol.16.1.137. DOI: 10.1146/annurev.immunol.16.1.137
5. Lotz M, Kekow J, Carson DA: Transforming growth factor-beta and cellular immune responses in synovial fluids. J Immunol. 1990, 144: 4189-4194.
6. Thorbecke GJ, Shah R, Leu CH, Kuruvilla AP, Hardison AM, Palladino MA: Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice. Proc Natl Acad Sci USA. 1992, 89: 7375-7379. DOI: 10.1073/pnas.89.16.7375
7. Allen JB, Manthey CL, Hand AR, Ohura K, Ellingsworth L, Wahl SM: Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta. J Exp Med. 1990, 171: 231-247. 10.1084/jem.171.1.231. DOI: 10.1084/jem.171.1.231
8. Wahl SM, Allen JB, Costa GL, Wong HL, Dasch JR: Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta. J Exp Med. 1993, 177: 225-230. 10.1084/jem.177.1.225. DOI: 10.1084/jem.177.1.225
9. Serra R, Johnson M, Filvaroff EH, LaBorde J, Sheehan DM, Derynck R, Moses HL: Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol. 1997, 139: 541-552. 10.1083/jcb.139.2.541. DOI: 10.1083/jcb.139.2.541
10. Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, Roberts AB, Sporn MB, Ward JM, Karlsson S: Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA. 1993, 90: 770-774. DOI: 10.1073/pnas.90.2.770
11. Schramm C, Protschka M, Köhler H, Podlech J, Reddehase MJ, Schirmacher P, Galle PR, Lohse AW, Blessing M: Impairment of TGF-beta signaling in T-cells increases susceptibility to experimental autoimmune hepatitis in mice. Am J Physiol. 2003, 284: G525-G535.
12. Brand T, MacLellan WR, Schneider MD: A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain. J Biol Chem. 1993, 268: 11500-11503.
13. Gorelik L, Flavell RA: Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity. 2000, 12: 171-181. 10.1016/S1074-7613(00)80170-3. DOI: 10.1016/S1074-7613(00)80170-3
14. Lucas PJ, Kim SJ, Melby SJ, Gress RE: Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J Exp Med. 2000, 191: 1187-1196. 10.1084/jem.191.7.1187. DOI: 10.1084/jem.191.7.1187
15. Osman GE, Hannibal MC, Anderson JP, Lasky SR, Ladiges WC, Hood L: FVB/N (H2(q)) mouse is resistant to arthritis induction and exhibits a genomic deletion of T-cell receptor V beta gene segments. Immunogenetics. 1999, 49: 851-859. 10.1007/s002510050564. DOI: 10.1007/s002510050564
16. Nakao A, Miike S, Hatano M, Okumura K, Tokuhisa T, Ra C, Iwamoto I: Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity. J Exp Med. 2000, 192: 151-158. 10.1084/jem.192.2.151. DOI: 10.1084/jem.192.2.151