Curcumin treatment recovery the decrease of protein phosphatase 2A subunit B induced by focal cerebral ischemia in Sprague-Dawley rats

Laboratory Animal Research

Volumn 31, Issue 3, 2015, Pages 134-138

  Shah, Fawad Ali ^a   Park, Dong Ju ^a   Gim, Sang Ah ^a   Koh, Phil Ok ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

Curcumin; neuroprotection; protein phosphatase 2A subunit B

Indexed keywords

EID: 85006324523     PISSN: 17386055     EISSN: 22337660     Source Type: Journal    
DOI: 10.5625/lar.2015.31.3.134     Document Type: Letter

References (30)

1. Olmez I, Ozyurt H. Reactive oxygen species and ischemic cerebrovascular disease. Neurochem Int 2012; 60(3): 208–212. DOI: 10.1016/j.neuint.2011.11.009
2. Kawabori M, Yenari MA. Inflammatory responses in brain ischemia. Curr Med Chem 2015; 22(10): 1258–1277. DOI: 10.2174/0929867322666150209154036
3. Dutta S, Padhye S, Priyadarsini KI, Newton C. Antioxidant and antiproliferative activity of curcumin semicarbazone. Bioorg Med Chem Lett 2005; 15(11): 2738–2744. DOI: 10.1016/j.bmcl.2005.04.001
4. Suryanarayana P, Satyanarayana A, Balakrishna N, Kumar PU, Reddy GB. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med Sci Monit 2007; 13(12): 286–292.
5. Antonio AM, Druse MJ. Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons. Brain Res 2008; 1204: 16–23. DOI: 10.1016/j.brainres.2008.02.018
6. Lim CS, Jin DQ, Mok H, Oh SJ, Lee JU, Hwang JK, Ha I, Han JS. Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. J Neurosci Res 2005; 82(3): 831–838. DOI: 10.1002/jnr.20692
7. Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. Curcumin induces glutathione biosynthesis and inhibits NFkappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid Redox Signal 2005; 7(1-2): 32–41. DOI: 10.1089/ars.2005.7.32
8. Singh S, Khar A. Biological effects of curcumin and its role in cancer chemoprevention and therapy. Anticancer Agents Med Chem 2006; 6(2): 259–270. DOI: 10.2174/187152006776930918
9. Chen A, Xu J, Johnson AC. Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. Oncogene 2006; 25(3): 278–287. DOI: 10.1038/sj.onc.1209019
10. Ghoneim AI, Abdel-Naim AB, Khalifa AE, El-Denshary ES. Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Pharmacol Res 2002; 46(3): 273–279. DOI: 10.1016/S1043-6618(02)00123-8
11. Thiyagarajan M, Sharma SS. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci 2004; 74(3): 969–985. DOI: 10.1016/j.lfs.2003.06.042
12. Wang Q, Sun AY, Simonyi A, Jensen MD, Shelat PB, Rottinghaus GE, MacDonald RS, Miller DK, Lubahn DE, Weisman GA, Sun GY. Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. J Neurosci Res 2005; 82(3): 138–148. DOI: 10.1002/jnr.20610
13. Zhao J, Zhao Y, Zheng W, Lu Y, Feng G, Yu S. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res 2008; 1229: 224–232. DOI: 10.1016/j.brainres.2008.06.117
14. Zhao J, Yu S, Zheng W, Feng G, Luo G, Wang L, Zhao Y. Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Neurochem Res 2010; 35(3): 374–379. DOI: 10.1007/s11064-009-0065-y
15. Janssens V, Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 2001; 353(4): 417–439. DOI: 10.1042/bj3530417
16. Sontag E. Protein phosphatase 2A: the Trojan Horse of cellular signaling. Cell Signal 2001; 13(3): 7–16. DOI: 10.1016/S0898-6568(00)00123-6
17. Zolnierowicz S. Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. Biochem Pharmacol 2000; 60(3): 1225–1235. DOI: 10.1016/S0006-2952(00)00424-X
18. Stone SR, Hofsteenge J, Hemmings BA. Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A. Biochemistry 1987; 26(23): 7215–7220. DOI: 10.1021/bi00397a003
19. Millward TA, Zolnierowicz S, Hemmings BA. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 1999; 24(3): 186–191. DOI: 10.1016/S0968-0004(99)01375-4
20. Sim AT. The regulation and function of protein phosphatases in the brain. Mol Neurobiol 1991; 5(2-4): 229–246. DOI: 10.1007/BF02935548
21. Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE. Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. J Comp Neurol 1998; 392(4): 515–527. DOI: 10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3
22. Koh PO. Focal Cerebral Ischemia Reduces Protein Phosphatase 2A Subunit B Expression in Brain Tissue and HT22 Cells. Lab Anim Res 2011; 27(3): 73–76. DOI: 10.5625/lar.2011.27.1.73
23. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989; 20(3): 84–91. DOI: 10.1161/01.STR.20.1.84
24. Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer’s disease. J Biol Chem 2000; 275(4): 5535–5544. DOI: 10.1074/jbc.275.8.5535
25. Liu R, Wang JZ. Protein phosphatase 2A in Alzheimer’s disease. Pathophysiology 2009; 16(3): 273–277. DOI: 10.1016/j.pathophys.2009.02.008
26. Sontag E, Nunbhakdi-Craig V, Lee G, Bloom GS, Mumby MC. Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A. Neuron 1996; 17(3): 1201–1207. DOI: 10.1016/S0896-6273(00)80250-0
27. Sontag E, Hladik C, Montgomery L, Luangpirom A, Mudrak I, Ogris E, White CL 3rd. Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 2004; 63(10): 1080–1091. DOI: 10.1093/jnen/63.10.1080
28. Cancino GI, Toledo EM, Leal NR, Hernandez DE, Yévenes LF, Inestrosa NC, Alvarez AR. STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer’s beta-amyloid deposits. Brain 2008; 131:2425–2442. DOI: 10.1093/brain/awn125
29. Kanemaru K. [Immunotherapy targeting misfolded proteins in neurodegenerative disease]. Brain Nerve 2013; 65(3): 469–474.
30. Zhu LQ, Wang SH, Liu D, Yin YY, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ. Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J Neurosci 2007; 27(45): 12211–12220. DOI: 10.1523/JNEUROSCI.3321-07.2007