The iron status at birth of neonates with risk factors for developing iron deficiency: A pilot study

Journal of Perinatology

Volumn 37, Issue 4, 2017, Pages 436-440

  Macqueen, B C ^a   Christensen, R D ^a,b   Ward, D M ^a   Bennett, S T ^c   O'brien, E A ^a,b   Sheffield, M J ^b   Baer, V L ^b   Snow, G L ^d   Weaver Lewis, K A ^b   Fleming, R E ^e   Kaplan, J ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b INTERMOUNTAIN HEALTHCARE   (United States)

^c Intermountain Medical Center   (United States)

^d LDS HOSPITAL   (United States)

^e SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEME; HEMOGLOBIN; IRON; PROTOPORPHYRIN ZINC; TRANSFERRIN RECEPTOR;

ARTICLE; BIOCHEMICAL ANALYSIS; BIOCHEMICAL IRON DEFICIENCY; BLOOD CELL COUNT; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; ERYTHROPOIESIS; FERRITIN BLOOD LEVEL; GESTATIONAL AGE; HEMATOCRIT; HIGH RISK INFANT; HUMAN; IRON BALANCE; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON SATURATION; MATERNAL DIABETES MELLITUS; MEAN CORPUSCULAR VOLUME; NEWBORN; NEWBORN ASSESSMENT; NEWBORN SCREENING; PILOT STUDY; PROSPECTIVE STUDY; RETICULOCYTE HEMOGLOBIN CONTENT; RISK FACTOR; SMALL FOR DATE INFANT; UMBILICAL CORD BLOOD; VERY LOW BIRTH WEIGHT; BLOOD; CASE CONTROL STUDY; CHEMISTRY; CLINICAL TRIAL; FEMALE; FETUS BLOOD; MALE; MULTICENTER STUDY; PREGNANCY; PREGNANCY DIABETES MELLITUS; STATISTICAL MODEL; UTAH;

ANEMIA, IRON-DEFICIENCY; CASE-CONTROL STUDIES; DIABETES, GESTATIONAL; FEMALE; FERRITINS; FETAL BLOOD; HUMANS; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; INFANT, VERY LOW BIRTH WEIGHT; IRON; LINEAR MODELS; MALE; PILOT PROJECTS; PREGNANCY; PREGNANCY IN DIABETICS; PROSPECTIVE STUDIES; RISK FACTORS; UTAH;

EID: 85006320118     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/jp.2016.234     Document Type: Article

References (37)

1. Callahan LS, Thibert KA, Wobken JD, Georgieff MK. Early-life iron deficiency anemia alters the development and long-Term expression of parvalbumin and perineuronal nets in the rat hippocampus. Dev Neurosci 2013; 35: 427-436.
2. Tran PV, Dakoji S, Reise KH, Storey KK, Georgieff MK. Fetal iron deficiency alters the proteome of adult rat hippocampal synaptosomes. Am J Physiol Regul Integr Comp Physiol 2013; 305: R1297-R1306.
3. Fretham SJ, Carlson ES, Georgieff MK. The role of iron in learning and memory. Adv Nutr 2011; 2: 112-121.
4. Radlowski EC, Johnson RW. Perinatal iron deficiency and neurocognitive development. Front Hum Neurosci 2013; 7: 1-10.
5. Zamora TG, Guiang SF 3rd, Widness JA, Georgieff MK. Iron is prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs. Pediatr Res 2016; 79: 922-928.
6. Mukhopadhyay K, Yadav RK, Kishore SS, Garewal G, Jain V, Narang A. Iron status at birth and at 4 weeks in term small-for-gestation infants in comparison with appropriate-for-gestation infants. J Matern Fetal Neonatal Med 2011; 7: 886-890.
7. Rao R, Georgieff MK. Iron therapy for preterm infants. Clin Perinatol 2009; 36: 27-42.
8. Hokama T, Takenaka S, Hirayama K, Yara A, Yoshida K, Itokazu K, et al. Iron status of newborns born to iron deficient anaemic mothers. J Trop Pediatr 1996; 42: 75-77.
9. Emamghorashi F, Heidari T. Iron status of babies born to iron-deficient anaemic mothers in an Iranian hospital. East Mediterr Health J 2004; 10: 808-814.
10. Gambling L, Lang C, McArdle HJ. Fetal regulation of iron transport during pregnancy. Am J Clin Nutr 2011; 94: 1903 S-1907 S.
11. McArdle HJ, Lang C, Hayes H, Gambling L. Role of the placenta in regulation of fetal iron status. Nutr Rev 2011; 69: S17-S22.
12. Balesaria S, Hanif R, Salama MF, Raja K, Bayele HK, McArdle H, et al. Fetal iron levels are regulated by maternal and fetal Hfe genotype and dietary iron. Haematologica 2012; 97: 661-669.
13. Cao C, Fleming MD. The placenta: the forgotten essential organ of iron transport. Nutr Rev 2016; 74: 421-431.
14. Goodnough LT, Nemeth E. Clinical features of iron deficiency. In: Greer JP, Arber DA, Glader B, List AF, Means Jr. RT, Paraskevas F, et al. (eds). Wintrobe?s Clinical Hematology. 13th edn. Lippincott/Williams & Wilkins: Philadelphia, PA, USA. 2014. pp 626-627.
15. Christensen RD, Henry E, Bennett ST, Yaish HM. Reference intervals for reticulocyte parameters of infants during their first 90 days after birth. J Perinatol 2016; 36: 61-66.
16. Lorenz L, Arand J, Büchner K, Wacker-Gussmann A, Peter A, Poets CF, et al. Reticulocyte haemoglobin content as a marker of iron deficiency. Arch Dis Child Fetal Neonatal Ed 2015; 100: F198-F202.
17. Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. Lancet 2016; 387: 907-916.
18. Baer VL, Lambert DK, Carroll PD, Gerday E, Christensen RD. Using umbilical cord blood for the initial blood tests of VLBW neonates results in higher hemoglobin and fewer RBC transfusions. J Perinatol 2013; 33: 363-365.
19. Jopling J, Henry E, Wiedmeier SE, Christensen RD. Reference ranges for hematocrit and blood hemoglobin concentration during the neonatal period: data from a multihospital health care system. Pediatrics 2009; 123: e333-e337.
20. Christensen RD, Jopling J, Henry E, Wiedmeier SE. The erythrocyte indices of neonates, defined using data from over 12, 000 patients in a multihospital health care system. J Perinatol 2008; 28: 24-28.
21. McArdle HJ, Gambling L, Kennedy C. Iron deficiency during pregnancy: the consequences for placental function and fetal outcome. Proc Nutr Soc 2014; 73: 9-15.
22. O'Brien KO, Zavaleta N, Abrams SA, Caulfield LE. Maternal iron status influences iron transfer to the fetus during the third trimester of pregnancy. Am J Clin Nutr 2003; 77: 924-930.
23. Sweet DG, Savage GA, Tubman R, Lappin TR, Halliday HL. Cord blood transferrin receptors to assess fetal iron status. Arch Dis Child Fetal Neonatal Ed 2001; 85: F46-F68.
24. Lozoff B, Beard J, Connor J, Felt B, Georgieff M, Schallert T. Lost-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 2006; 64: S34-S91.
25. Cheng CF, Zerzan JC, Johnson DB, Juul SE. Zinc protoporphyrin-To-heme ratios in high-risk and preterm infants. J Pediatr 2012; 161: 81-87.
26. Lott DG, Zimmerman M, Labbe RF, Kling PJ, Widness JA. Erythrocyte zinc protoporphyrin is elevated with prematurity and fetal hypoxemia. Pediatrics 2005; 116: 414-422.
27. Ward DM, Kaplan J. Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta 2012; 1823: 1426-1433.
28. Kroot JJ, Tjalsma H, Fleming RE, Swinkels DW. Hepcidin in human iron disorders: diagnostic implications. Clin Chem 2011; 57: 1650-1669.
29. Lorenz L, Peter A, Poets CF, Franz AR. A review of cord blood concentrations of iron status parameters to define reference ranges for preterm infants. Neonatology 2013; 104: 194-202.
30. Rehu M, Punnonon K, Ostland V, Heinonen S, Westerman M, Pulkki K, et al. Maternal serum hepcidin is low at term and independent of cord blood iron status. Eur J Haematol 2010; 85: 345-352.
31. McCarthy PJ, Zundel HR, Johnson KR, Blohowiak SE, Kling PJ. Impact of growth restriction and other prenatal risk factors on cord blood iron status in prematurity. J Pediatr Hematol Oncol 2016; 38: 210-215.
32. Akkermans MD, Uijterschout L, Abbink M, Vos P, Rovekamp-Abels L, Boersma B et al. Predictive factors of iron depletion in late preterm infants at the postnatal age of 6 weeks. Eur J Clin Nutr 2016; 70: 941-946.
33. Siddappa AM, Rao R, Long JD, Widness JA, Georgieff MK. The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations. Neonatology 2007; 92: 73-82.
34. Lorenz L, Herbst J, Engel C, Peter A, Abele H, Poets CF, et al. Gestational age-specific reference ranges of hepcidin in cord blood. Neonatology 2014; 106: 133-139.
35. Miller SM, McPherson RJ, Juul SE. Iron sulfate supplementation decreases zinc protoporphyrin to heme ratio in premature infants. J Pediatr 2006; 148: 44-48.
36. Sweet DG, Savage G, Tubman TR, Lappin TR, Halliday HL. Study of maternal influences on fetal iron status at term using cord blood transferrin receptors. Arch Dis Child Fetal Neonatal Ed 2001; 84: F40-F43.
37. American Academy of Pediatrics, Committee on Nutrition. Nutritional needs of the preterm infant. In: Kleinman RD (ed). Pediatric Nutrition Handbook. vol. 5. American Academy of Pediatrics: Chapel Hill, NC, USA, 2004, pp 23-54.