SiO2@antisense molecules covered by nepetalactone, extracted from Nepeta gloeocephala, inhibits ILK phosphorylation and downstream PKB/AKT signaling in HeLa cells

Cancer Gene Therapy

Volumn 24, Issue 1, 2017, Pages 28-32

  Dehghany Ashkezary, M ^a   Aboee Mehrizi, F ^b   Moradi, P ^a  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

4AALPHA,7ALPHA,7AALPHA NEPETALACTONE; 4AALPHA,7BETA,7AALPHA NEPETALACTONE; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; BETA PINENE; CAMPHOR; CARYOPHYLLENE; CARYOPHYLLENE OXIDE; CINEOLE; ESSENTIAL OIL; HERBACEOUS AGENT; INTEGRIN LINKED KINASE; LACTONE DERIVATIVE; LINALOOL; MYRTENAL; NEPETALACTONE; NOPINONE; PARA CYMENE; PINENE; PINOCARVEOL; PINOCARVONE; PROTEIN KINASE B; SABINENE; SERINE; SILICON DIOXIDE; SPATHULENOL; TERPINEN 4 OL; TERPINEOL; THREONINE; UNCLASSIFIED DRUG; CYCLOPENTANE DERIVATIVE; INTEGRIN-LINKED KINASE; PLANT EXTRACT; PROTEIN SERINE THREONINE KINASE; PYRONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTISENSE THERAPY; APOPTOSIS; ARTICLE; CANCER GENE THERAPY; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; ETHNOPHARMACOLOGY; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION PROFILING; HELA CELL LINE; HUMAN; HUMAN CELL; HYDRODISTILLATION; INTRACELLULAR SIGNALING; MASS SPECTROMETRY; MTT ASSAY; NEPETA; NEPETA GLOEOCEPHALA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUNEL ASSAY; WESTERN BLOTTING; CELL CYCLE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL CYCLE; CELL SURVIVAL; CYCLOPENTANES; HELA CELLS; HUMANS; NEPETA; PHOSPHORYLATION; PLANT EXTRACTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRONES; SIGNAL TRANSDUCTION; SILICON DIOXIDE;

EID: 85006312585     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2016.75     Document Type: Article

References (20)

1. Kordali S, Tazegul A, Cakir A. Phytotoxic effects of Nepeta meyeri Benth. extracts and essential oil on seed germinations and seedling growths of four weed species. Rec Nat Prod 2015; 9: 404-418.
2. Moustafa AE-RA, El-Azeem HA, Omran MA, Nasr SA, Nabi IMA, Teleb ZA. Biochemical effect of Nepeta septemcrenata growing in South Sinai, Egypt. Am J Ethnomed 2015; 2: 157-168.
3. Satish S. Studies on therapeutic potential of essential oils of Nepeta cataria in treatment of Alzheimer's disease. Asian J Biomed Pharm Sci 2013; 3: 42-45.
4. Mancini E, De Martino L, Malova H, De Feo V. Chemical composition and biological activities of the essential oil from Calamintha nepeta plants from the wild in southern Italy. Nat Prod Commun 2013; 8: 139-142.
5. Shakeri A, Khakdan F, Soheili V, Sahebkar A, Rassam G, Asili J. Chemical composition, antibacterial activity, and cytotoxicity of essential oil from Nepeta ucrainica L. spp. kopetdaghensis. Indus Crops Prod 2014; 58: 315-321.
6. Pandey AK, Mohan M, Singh P, Tripathi NN. Chemical composition, antioxidant and antimicrobial activities of the essential oil of Nepeta hindostana (Roth) Haines from India. Rec Nat Prod 2015; 9: 224-233.
7. Meier R, Frech MAM, Hemmings BA. The protein kinase B family-structure. Interact Protein Domains 2013; 102: 161-169.
8. Xue G, Hemmings BA. PKB/Akt-dependent regulation of cell motility. J Natl Cancer Inst 2013; 1: 648-652.
9. Hemmings BA, Restuccia DF. PI3K-PKB/AKT pathway. Cold Spring Harbor Perspect Biol 2012; 4: A011189-A011195.
10. Aloqail M, Al-Sheddi E, Siddiqui M, Musarrat J, Al-Khedhairy A, Farshori N. Anticancer activity of sub-fractions of chloroform extracts of Nepeta deflersianaon on human breast and lung cancer cells: An in vitro cytotoxicity assessment. Planta Med 2014; 80: 28-36.
11. Pacifico S, Galasso S, Piccolella S, Kretschmer N, Pan S-P, Marciano S et al. Seasonal variation in phenolic composition and antioxidant and anti-inflammatory activities of Calamintha nepeta (L.) Savi. Food Res Int 2015; 69: 121-132.
12. Moustafa AE-RA, El-Azeem HA, Omran MA, Nasr SA, Nabi IMA, Teleb ZA. Two flavonoid compounds isolated from Nepeta septemcrenata growing in South Sinai, Egypt. Am J Ethnomed 2015; 2: 143-156.
13. Jebali A, Hajjar FHE, Hekmatimoghaddam S, Kazemi B, Jesus M, Rashidi M. Triangular gold nanoparticles conjugated with peptide ligands: A new class of inhibitor for Candida albicans secreted aspartyl proteinase. Biochem Pharmacol 2014; 90: 349-355.
14. Pourdanesh F, Jebali A, Hekmatimoghaddam S, Allaveisie A. In vitro and in vivo evaluation of a new nanocomposite, containing high density polyethylene, tricalcium phosphate, hydroxyapatite, and magnesium oxide nanoparticles. Mater Sci Eng C 2014; 40: 382-388.
15. Jebali A, Hekmatimoghaddam S, Kazemi B. The cytotoxicity of silver nanoparticles coated with different free fatty acids on the Balb/c macrophages: An in vitro study. Drug Chem Toxicol 2014; 37: 433-439.
16. Jebali A, Anvari-Tafti MH. Hybridization of different antisense oligonucleotides on the surface of gold nanoparticles to silence zinc metalloproteinase gene after uptake by Leishmania major. Colloids Surf B 2015; 129: 107-113.
17. Sato SB, Park J, Kawamoto J, Sato S, Kurihara T. Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453. Biochim Biophys Acta 2013; 1831: 306-313.
18. Porta C, Paglino C, Mosca A. Targeting PI3K/Akt/mTOR signaling in cancer. Front Oncol 2014; 2: 47-54.
19. Hoshyar R, Mostafavinia SE, Zarban A, Hassanpour M, Partovfari M, Taheri A et al. Correlation of anticancer effects of 12 Iranian herbs on human breast adenocarcinoma cells with antioxidant properties. Free Radic Antioxid 2015; 5: 65-73.
20. Kahkeshani N, Razzaghirad Y, Ostad SN, Hadjiakhoondi A, Shams Ardekani MR, Hajimehdipoor H et al. Cytotoxic, acetylcholinesterase inhibitor and antioxidant activity of Nepeta menthoides Boiss & Buhse essential oil. J Essent Oil Bear Pl 2014; 17: 544-552.