1,25-DihydroxyVitamin D3 and type 2 diabetes: Ca2+-dependent molecular mechanisms and the role of Vitamin D status

Hormone Molecular Biology and Clinical Investigation

Volumn 26, Issue 1, 2016, Pages 61-65

  Sergeev, Igor N ^a  

^a SOUTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

1,25 dihydroxyvitamin D3; insulin secretion; intracellular Ca2+; type 2 diabetes; Vitamin D status

Indexed keywords

25 HYDROXYVITAMIN D; ADIPONECTIN; CALCITRIOL; CALCIUM ION; GLUCOSE; INSULIN; VITAMIN D; VITAMIN D RECEPTOR;

CALCIUM SIGNALING; DIET INDUCED OBESITY; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIPID DIET; MOLECULAR MECHANICS; NON INSULIN DEPENDENT DIABETES MELLITUS; OSCILLATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW; RISK FACTOR; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; ANIMAL; METABOLISM;

ANIMALS; CALCITRIOL; CALCIUM SIGNALING; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; INSULIN-SECRETING CELLS;

EID: 85006201138     PISSN: 18681883     EISSN: 18681891     Source Type: Journal    
DOI: 10.1515/hmbci-2015-0069     Document Type: Review

References (45)

1. Sergeev IN, Rhoten WB, Spirichev VB. Vitamin D and intracellular calcium. Subcell Biochem 1998;30:271-97.
2. Norman AW, Nemere I, Zhou J, Bishop JE, Lowe KE, Maiyar AC, Collins ED, Taoka T, Sergeev I, Farach-Carson MC. 1,25(OH)2-Vitamin D3, a steroid hormone that produces biological effects via genomic and nongenomic pathways. J Steroid Biochem Mol Biol 1992;41:231-40.
3. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bilke DD. Vitamin D: beyond bone. Ann NY Acad Sci 2013;1287:45-58.
4. Sergeev IN. Regulation of apoptosis in adipocytes and breast cancer cells by 1,25(OH)2-vitamin D3: a link between metabolic disorders and breast cancer. Horm Mol Biol Clin Invest 2013; 14:99-106.
5. Sergeev IN. Vitamin D-mediated apoptosis in cancer and obesity. Horm Mol Biol Clin Invest 2014;20:43-9.
6. Norman AW, Bouillon R. Vitamin D nutritional policy needs a vision for the future. Exp Biol Med 2010;235:1034-45.
7. Sergeev IN. Vitamin D and cellular Ca2+ signaling in breast cancer. Anticancer Res 2012;32:299-302.
8. Sergeev IN. Calcium signaling in cancer and vitamin D. J Steroid Biochem Mol Biol 2005;97:145-51.
9. Sergeev IN. Calcium as a mediator of 1,25-dihydroxyvitamin D3-induced apoptosis. J Steroid Biochem Mol Biol 2004; 89-90:419-25.
10. Berridge MJ, Bootman MD, Lipp P. Calcium: a life and death signal. Nature 1988;395:645-8.
11. Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 2003;4:552-65.
12. Sergeev IN, Rhoten WB. 1,25-Dihydroxyvitamin D3 evokes oscillations of intracellular calcium in a pancreatic â-cell line. Endocrinology 1995;136:2852-61.
13. Song Q, Sergeev IN. Calcium and vitamin D in obesity. Nutr Res Rev 2012;25:130-41.
14. Seida JC, Mitri J, Colmers IN, Majumdar SR, Davidson MB, Edwards AL, Hanley DA, Pittas AG, Tjosvold L, Johnson JA. Clinical review: effect of vitamin D3 supplementation on improving glucose homeostasis and preventing diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab 2014;99:3551-60.
15. Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr 2011;65:1005-15.
16. Tabesh M, Azadbakht L, Faghihimani E, Tabesh M, Esmaillzadeh A. Effects of calcium-vitamin D co-supplementation on metabolic profiles in vitamin D insufficient people with type 2 diabetes: a randomised controlled clinical trial. Diabetologia 2014;57:2038-47.
17. Oosterwerff MM, Eekhoff EM, Van Schoor NM, Boeke AJ, Nanayakkara P, Meijnen R, Knol DL, Kramer MH, Lips P. Effect of moderate-dose vitamin D supplementation on insulin sensitivity in vitamin D-deficient non-western immigrants in the Netherlands: a randomized placebo-controlled trial. Am J Clin Nutr 2014;100:152-60.
18. Krul-Poel YH, Westra S, ten Boekel E, ter Wee MM, van Schoor NM, van Wijland H, Stam F, Lips PT, Simsek S. Effect of Vitamin D supplementation on glycemic control in patients with type 2 diabetes (SUNNY Trial): a randomized placebocontrolled trial. Diabetes Care 2015;38:1420-6.
19. Chandler PD, Wang L, Zhang X, Sesso HD, Moorthy MV, Obi O, Lewis J, Prince RL, Danik JS, Manson JE, LeBoff MS, Song Y. Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev 2015;73:577-93.
20. Ceglia L, Nelson J, Ware J, Alysandratos KD, Bray GA, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B, Pittas AG. Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program. Eur J Nutr 2015. in press (DOI:10.1007/s00394-015-1066-z).
21. Rhoten WB, Sergeev IN. Calbindin-D28k appears to buffer intracellular Ca2+ in butyrate-treated rat insulinoma cells. Endocrine 1994;2:989-95.
22. Sergeev IN, Rhoten WB, Carney MD. Calbindins decreased after space flight. Endocrine 1996;5:335-40, Cover illustration.
23. Sergeev IN, Norman AW. 1,25-Dihydroxyvitamin D3 and calcium signaling. In: Norman AW, Bouillon R and Thomasset M, editors. Vitamin D endocrine system: structural, biological, genetic and clinical aspects. Riverside: University of California, 2000:715-8.
24. Bergsten P. Slow and fast oscillations of cytoplasmic Ca2+ in pancreatic islets correspond to pulsatile insulin release. Am J Physiol 1995;268(2 Pt 1):E282-7.
25. Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 2000;49:1751-60.
26. Nemere I, Hintze K. Novel hormone "receptors". J Cell Biochem 2008;103:401-7.
27. Farach-Carson MC, Sergeev IN, Norman AW. Nongenomic actions of 1,25-dihydroxyvitamin D3 in rat osteosarcoma cells: structure-function studies using ligand analogs. Endocrinology 1991;129:1876-84.
28. Norman AW, Sergeev IN, Bishop JE, Okamura WH. Selective biological response by target organs (intestine, kidney and bone) to 1,25-dihydroxyvitamin D3 and two analogs. Cancer Res 1993;53:3935-42.
29. Mathiasen IS, Sergeev IN, Bastholm L, Elling F, Norman AW, Jaattela M. Calcium and calpain as key mediators of apoptosislike death induced by vitamin D compounds in breast cancer cells. J Biol Chem 2002;277:30738-45.
30. Sergeev IN, Rhoten WB. Regulation of intracellular calcium in breast cancer cells. Endocrine 1998;9:321-7.
31. Sergeev IN. 1,25-Dihydroxyvitamin D3 induces Ca2+-mediated apoptosis in adipocytes via activation of calpain and caspase-12. Biochem Biophys Res Commun 2009;384:18-21.
32. Satin LS, Butler PC, Ha J, Sherman AS. Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med 2015;42:61-77.
33. Spirichev VB, Sergeev IN. Vitamin D: experimental research and its practical application. World Rev Nutr Diet 1988;56:173-216.
34. Sergeev IN, Norman AW. Calcium as a mediator of apoptosis in bovine oocytes and preimplantation embryos. Endocrine 2003;22:169-75.
35. Sergeev IN, Li S, Ho C-T, Rawson NE, Dushenkov S. Polymethoxyflavones activate Ca2+-dependent apoptotic targets in adipocytes. J Agric Food Chem 2009;57:5771-6.
36. Sergeev IN, Song, Q. High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. Mol Nutr Food Res 2014;58:1342-8.
37. Song Q, Sergeev IN. High vitamin D and calcium intakes increase bone mineral (Ca and P) content in high-fat dietinduced obese mice. Nutr Res 2015;35:146-54.
38. Bouillon R, Lieben L, Mathieu C, Verstuyf A, Carmeliet G. Vitamin D action: lessons from VDR and Cyp27b1 null mice. Pediatr Endocrinol Rev 2013;10(Suppl 2):354-66.
39. Demay, MB. Physiological insights from the vitamin D receptor knockout mouse. Calcif Tissue Int 2013;92:99-105.
40. Kato S, Takeyama K, Kitanaka S, Murayama A, Sekine K, Yoshizawa T. In vivo function of VDR in gene expression-VDR knock-out mice. J Steroid Biochem Mol Biol 1999;69:247-51.
41. Narvaez CJ, Matthews D, Broun E, Chan M, Welsh JE. Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology 2009;150:651-61.
42. Ogunkolade BW, Boucher BJ, Prahl JM, Bustin SA, Burrin JM, Noonan K, North BV, Mannan N, McDermott MF, DeLuca HF, Hitman GA. Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes 2002;51:2294-2300.
43. Bikle DD, Oda Y, Tu CL, Jiang Y. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol 2015;148:47-51.
44. Mitri J, Pittas AG. Vitamin D and diabetes. Endocrinol Metab Clin North Am 2014; 43:205-32.
45. Sergeev IN. Vitamin D-cellular Ca2+ link to obesity and diabetes. J. Steroid Biochem Mol Biol 2015;in press (DOI: 10.1016/j.jsbmb.2015.11.008).