Occult H. pylori infection partially explains ‘false-positive’ results of 13C-urea breath test

United European Gastroenterology Journal

Volumn 3, Issue 5, 2015, Pages 437-442

  Ramírez Lázaro, María J ^a,b,c   Lario, Sergio ^a,b,c   Calvet, Xavier ^a,b,c   Sánchez Delgado, Jordi ^a,b,c   Montserrat, Antònia ^a,b,c   Quílez, Elisa M ^a,b   Casalots, Alex ^d   Suarez, David ^e   Campo, Rafel ^a,b,c   Brullet, Enric ^a,b,c   Junquera, Félix ^a,b,c   Sanfeliu, Isabel ^d,f   Segura, Ferran ^a,b,f  

^a Centre de Salut Mental   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d UDIAT CD   (Spain)

^e Unit of Clinical Trials   (Spain)

^f Spanish Network for the Research in Infectious Diseases ^*  (Spain)

Author keywords

Bacterial infection; diagnostic tests; false positive results; Helicobacter pylori; sensitivity; specificity; urea breath tests

Indexed keywords

CATALASE; CITRIC ACID; RNA 16S; UREA C 13; UREASE;

ADULT; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DYSPEPSIA; FEMALE; HELICOBACTER INFECTION; HISTOLOGY; HUMAN; HUMAN TISSUE; INTESTINE METAPLASIA; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAPID UREASE TEST; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS; STOMACH ATROPHY; STOMACH BIOPSY;

EID: 85006200480     PISSN: 20506406     EISSN: 20506414     Source Type: Journal    
DOI: 10.1177/2050640615572723     Document Type: Article

References (20)

1. X.CalvetJ.Sanchez-DelgadoA.Montserrat. Accuracy of diagnostic tests for Helicobacter pylori: A reappraisal. Clin Infect Dis2009; 48: 1385–1391.
2. J.E.Dominguez-MunozA.LeodolterT.Sauerbruch. A citric acid solution is an optimal test drink in the 13C-urea breath test for the diagnosis of Helicobacter pylori infection. Gut1997; 40: 459–462.
3. A.LeodolterJ.E.Dominguez-MunozU.Von Arnim. Citric acid or orange juice for the 13C-urea breath test: The impact of pH and gastric emptying. Aliment Pharmacol Ther1999; 13: 1057–1062.
4. E.LahnerM.MilioneG.Delle Fave. H. pylori negative MALT lymphoma patients successfully treated with antibiotics: Doubts about their. H pylori negativity. Gut2006; 55: 1669–1669.
5. M.RadererB.StreubelS.Wohrer. Successful antibiotic treatment of Helicobacter pylori-negative gastric mucosa associated lymphoid tissue lymphomas. Gut2006; 55: 616–618.
6. M.GuellE.ArtigauV.Esteve. Usefulness of a delayed test for the diagnosis of Helicobacter pylori infection in bleeding peptic ulcer. Aliment Pharmacol Ther2006; 23: 53–59.
7. E.M.BikP.B.EckburgS.R.Gill. Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci USA2006; 103: 732–737.
8. M.J.Ramirez-LazaroS.LarioA.Casalots. Real-time PCR improves Helicobacter pylori detection in patients with peptic ulcer bleeding. PLoS One2011; 6: e20009–e20009.
9. J.WeissT.K.TsangX.Meng. Detection of Helicobacter pylori gastritis by PCR. Correlation with inflammation scores and immunohistochemical and CLOtest findings. Am J Clinical Pathol2008; 129: 89–96.
10. T.ChenX.MengH.Zhang. Comparing multiplex PCR and Rapid Urease Test in the detection of H. pylori in patients on proton pump inhibitors. Gastroenterol Res Pract2012; 2012: 898276–898276.
11. M.BarenysA.AbadJ.M.Pons. Scoring system has better discriminative value than Helicobacter pylori testing in patients with dyspepsia, in a setting with high prevalence of infection. Eur J Gastroenterol Hepatol2000; 12: 1275–1282.
12. P.M.BossuytJ.B.ReitsmaD.E.Bruns. Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative. Ann Intern Med2003; 138: 40–44.
13. P.M.BossuytJ.B.ReitsmaD.E.Bruns. The STARD statement for reporting studies of diagnostic accuracy: Explanation and elaboration. Ann Intern Med2003; 138: W1–W12.
14. BreathTek, http://www.breathtek.com/pages/default.aspx. (accessed December 2012)
15. L.LaineR.EstradaM.Trujillo. Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori. Ann Intern Med1998; 129: 547–550.
16. P.MalfertheinerF.MegraudC.A.O'Morain. Management of Helicobacter pylori infection: The Maastricht IV/ Florence Consensus Report. Gut2012; 61: 646–664.
17. J.P.GisbertX.Calvet. Review article: Helicobacter pylori-negative duodenal ulcer disease. Aliment Pharmacol Ther2009; 30: 791–815.
18. J.Sanchez-DelgadoE.GeneD.Suarez. Has H. pylori prevalence in bleeding peptic ulcer been underestimated? A meta-regression. Am J Gastroenterol2011; 106: 398–405.
19. D.KobayashiY.EishiT.Ohkusa. Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of Urea Breath Test and histological grading. J Med Microbiol2002; 51: 305–311.
20. C.Schabereiter-GurtnerA.M.HirschlB.Dragosics. Novel real-time PCR assay for detection of Helicobacter pylori infection and simultaneous clarithromycin susceptibility testing of stool and biopsy specimens. J Clin Microbiol2004; 42: 4512–4518.