-
3
-
-
84886894440
-
Novel generation of agents with proven clinical activity in multiple myeloma
-
Mateos MV, Ocio EM, San Miguel JF. Novel generation of agents with proven clinical activity in multiple myeloma. Semin Oncol. 2013;40(5): 618–633.
-
(2013)
Semin Oncol
, vol.40
, Issue.5
, pp. 618-633
-
-
Mateos, M.V.1
Ocio, E.M.2
San Miguel, J.F.3
-
4
-
-
41949114641
-
Recent major improvement in long-term survival in younger patients with multiple myeloma
-
Brenner H, Gondos A, Pulte D. Recent major improvement in long-term survival in younger patients with multiple myeloma. Blood. 2008;111: 2521–2526.
-
(2008)
Blood
, vol.111
, pp. 2521-2526
-
-
Brenner, H.1
Gondos, A.2
Pulte, D.3
-
5
-
-
84886935750
-
Novel agents for multiple myeloma to overcome resistance in Phase III clinical trials
-
Orlowski RZ. Novel agents for multiple myeloma to overcome resistance in Phase III clinical trials. Semin Oncol. 2013;40(5):634–651.
-
(2013)
Semin Oncol
, vol.40
, Issue.5
, pp. 634-651
-
-
Orlowski, R.Z.1
-
6
-
-
3042775299
-
Clinical course of patients with relapsed multiple myeloma
-
Kumar SK, Therneau TM, Gertz MA, et al. Clinical course of patients with relapsed multiple myeloma. Mayo Clin Proc. 2004;79:867–874.
-
(2004)
Mayo Clin Proc
, vol.79
, pp. 867-874
-
-
Kumar, S.K.1
Therneau, T.M.2
Gertz, M.A.3
-
7
-
-
0036884062
-
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
-
Hideshima T, Anderson KC. Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer. 2002; 2(12):927–937.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.12
, pp. 927-937
-
-
Hideshima, T.1
Erson, K.C.2
-
8
-
-
84855471990
-
HDAC inhibitors in cancer biology: Emerging mechanisms and clinical applications
-
Khan O, La Thangue NB. HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. Immunol Cell Biol. 2012;90(1): 85–94.
-
(2012)
Immunol Cell Biol
, vol.90
, Issue.1
, pp. 85-94
-
-
Khan, O.1
La Thangue, N.B.2
-
9
-
-
84876441234
-
Epigenetic modulating agents as a new therapeutic approach in multiple myeloma
-
Maes K, Menu E, Van Valckenborgh E, Van Riet I, Vanderkerken K, De Bruyne E. Epigenetic modulating agents as a new therapeutic approach in multiple myeloma. Cancers. 2013;5(2):430–461.
-
(2013)
Cancers
, vol.5
, Issue.2
, pp. 430-461
-
-
Maes, K.1
Menu, E.2
Van Valckenborgh, E.3
Van Riet, I.4
Vanderkerken, K.5
De Bruyne, E.6
-
10
-
-
34248631385
-
The role of histone deacetylases (HDACs) in human cancer
-
Ropero S, Esteller M. The role of histone deacetylases (HDACs) in human cancer. Mol Oncol. 2007;1(1):19–25.
-
(2007)
Mol Oncol
, vol.1
, Issue.1
, pp. 19-25
-
-
Ropero, S.1
Esteller, M.2
-
11
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
Fraga MF, Ballestar E, Villar-Garea A, et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet. 2005;37:391–400.
-
(2005)
Nat Genet
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
-
12
-
-
84864773480
-
Danger: Protein overload. Targeting protein degradation to treat myeloma
-
Aronson LI, Davies FE. Danger: protein overload. Targeting protein degradation to treat myeloma. Haematologica. 2012;97(8):1119–1130.
-
(2012)
Haematologica
, vol.97
, Issue.8
, pp. 1119-1130
-
-
Aronson, L.I.1
Davies, F.E.2
-
13
-
-
84871020567
-
Molecular mechanisms of acquired proteasome inhibitor resistance
-
Kale AJ, Moore BS. Molecular mechanisms of acquired proteasome inhibitor resistance. J Med Chem. 2012;55(23):10317–10327.
-
(2012)
J Med Chem
, vol.55
, Issue.23
, pp. 10317-10327
-
-
Kale, A.J.1
Moore, B.S.2
-
14
-
-
84908133844
-
Interplay between HDAC6 and its interacting partners: Essential roles in the aggresome-autophagy pathway and neurodegenerative diseases
-
Yan J. Interplay between HDAC6 and its interacting partners: essential roles in the aggresome-autophagy pathway and neurodegenerative diseases. DNA Cell Biol. 2014;33(9):567–580.
-
(2014)
DNA Cell Biol
, vol.33
, Issue.9
, pp. 567-580
-
-
Yan, J.1
-
15
-
-
0034770423
-
Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression
-
Lavelle D, Chen YH, Hankewych M, DeSimone J. Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression. Am J Hematol. 2001;68(3):170–178.
-
(2001)
Am J Hematol
, vol.68
, Issue.3
, pp. 170-178
-
-
Lavelle, D.1
Chen, Y.H.2
Hankewych, M.3
Desimone, J.4
-
16
-
-
0141593496
-
NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
-
Catley L, Weisberg E, Tai YT, et al. NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003;102(7):2615–2622.
-
(2003)
Blood
, vol.102
, Issue.7
, pp. 2615-2622
-
-
Catley, L.1
Weisberg, E.2
Tai, Y.T.3
-
17
-
-
0037589018
-
Molecular sequelae of histone deacetylase inhibition in human malignant B cells
-
Mitsiades N, Mitsiades CS, Richardson PG, et al. Molecular sequelae of histone deacetylase inhibition in human malignant B cells. Blood. 2003;101(10):4055–4062.
-
(2003)
Blood
, vol.101
, Issue.10
, pp. 4055-4062
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Richardson, P.G.3
-
18
-
-
9144220841
-
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications
-
Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications. Proc Natl Acad Sci U S A. 2004;101(2): 540–545.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.2
, pp. 540-545
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
-
19
-
-
84937764448
-
Panobinostat: First global approval
-
Garnock-Jones KP. Panobinostat: first global approval. Drugs. 2015;75: 695–704.
-
(2015)
Drugs
, vol.75
, pp. 695-704
-
-
Garnock-Jones, K.P.1
-
20
-
-
67349228774
-
Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges
-
Atadja P. Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges. Cancer Lett. 2009;280(2): 233–241.
-
(2009)
Cancer Lett
, vol.280
, Issue.2
, pp. 233-241
-
-
Atadja, P.1
-
21
-
-
84993729247
-
The potential of panobinostat as a treatment option in patients with relapsed and refractory multiple myeloma
-
Andreu-Vieyra CV, Berenson JR. The potential of panobinostat as a treatment option in patients with relapsed and refractory multiple myeloma. Ther Adv Hematol. 2014;5(6):197–210.
-
(2014)
Ther Adv Hematol
, vol.5
, Issue.6
, pp. 197-210
-
-
Andreu-Vieyra, C.V.1
Berenson, J.R.2
-
22
-
-
81055149914
-
Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma
-
Hideshima T, Richardson PG, Anderson KC. Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma. Mol Cancer Ther. 2011;10(11): 2034–2042.
-
(2011)
Mol Cancer Ther
, vol.10
, Issue.11
, pp. 2034-2042
-
-
Hideshima, T.1
Richardson, P.G.2
Erson, K.C.3
-
23
-
-
77952306482
-
In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma
-
Ocio EM, Vilanova D, Atadja P, et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica. 2010;95(5):794–803.
-
(2010)
Haematologica
, vol.95
, Issue.5
, pp. 794-803
-
-
Ocio, E.M.1
Vilanova, D.2
Atadja, P.3
-
24
-
-
84881478015
-
Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies
-
DeAngelo DJ, Spencer A, Bhalla KN, et al. Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies. Leukemia. 2013;27(8):1628–1636.
-
(2013)
Leukemia
, vol.27
, Issue.8
, pp. 1628-1636
-
-
Deangelo, D.J.1
Spencer, A.2
Bhalla, K.N.3
-
25
-
-
84862878624
-
Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma
-
Wolf JL, Siegel D, Goldschmidt H, et al. Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma. Leuk Lymphoma. 2012;53(9): 1820–1823.
-
(2012)
Leuk Lymphoma
, vol.53
, Issue.9
, pp. 1820-1823
-
-
Wolf, J.L.1
Siegel, D.2
Goldschmidt, H.3
-
26
-
-
84891597843
-
Phase Ib study of panobinostat and bortezomib in relapsed or relapsed and refractory multiple myeloma
-
San-Miguel JF, Richardson PG, Gunther A, et al. Phase Ib study of panobinostat and bortezomib in relapsed or relapsed and refractory multiple myeloma. J Clin Oncol. 2013;31(29):3696–3703.
-
(2013)
J Clin Oncol
, vol.31
, Issue.29
, pp. 3696-3703
-
-
San-Miguel, J.F.1
Richardson, P.G.2
Gunther, A.3
-
27
-
-
84884699420
-
PANORAMA 2: Panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma
-
Richardson PG, Schlossman RL, Alsina M, et al. PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma. Blood. 2013;122(14):2331–2337.
-
(2013)
Blood
, vol.122
, Issue.14
, pp. 2331-2337
-
-
Richardson, P.G.1
Schlossman, R.L.2
Alsina, M.3
-
28
-
-
84912523531
-
Time to event analyses in PANORAMA 2: A phase 2 study of panobinostat, bortezomib, and dexamethasone in patients with relapsed and bortezomib-refractory multiple myeloma
-
Richardson PG, Schlossman RL, Alsina M, et al. Time to event analyses in PANORAMA 2: a phase 2 study of panobinostat, bortezomib, and dexamethasone in patients with relapsed and bortezomib-refractory multiple myeloma. Blood. 2013;122(21):1970.
-
(2013)
Blood
, vol.122
, Issue.21
, pp. 1970
-
-
Richardson, P.G.1
Schlossman, R.L.2
Alsina, M.3
-
29
-
-
84908133944
-
Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: A multicentre, randomised, double-blind phase 3 trial
-
San-Miguel JF, Hungria VT, Yoon S, et al. Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. Lancet Oncol. 2014;15(11):1195–1206.
-
(2014)
Lancet Oncol
, vol.15
, Issue.11
, pp. 1195-1206
-
-
San-Miguel, J.F.1
Hungria, V.T.2
Yoon, S.3
-
30
-
-
79955498420
-
Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: A link to clinical adverse events
-
Arastu-Kapur S, Anderl JL, Kraus M, et al. Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res. 2011;17(9):2734–2743.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.9
, pp. 2734-2743
-
-
Arastu-Kapur, S.1
Erl, J.L.2
Kraus, M.3
-
31
-
-
84929152720
-
Phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma
-
Berdeja JG, Hart LL, Mace JR, et al. Phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma. Haematologica. 2015;100(5):670–676.
-
(2015)
Haematologica
, vol.100
, Issue.5
, pp. 670-676
-
-
Berdeja, J.G.1
Hart, L.L.2
Mace, J.R.3
-
32
-
-
84891891143
-
A phase 1/2 study of oral panobinostat combined with melphalan for patients with relapsed or refractory multiple myeloma
-
Berenson JR, Hilger JD, Yellin O, et al. A phase 1/2 study of oral panobinostat combined with melphalan for patients with relapsed or refractory multiple myeloma. Ann Hematol. 2014;93(1):89–98.
-
(2014)
Ann Hematol
, vol.93
, Issue.1
, pp. 89-98
-
-
Berenson, J.R.1
Hilger, J.D.2
Yellin, O.3
-
33
-
-
84862895569
-
Phase II study of melphalan, thalidomide and prednisone combined with oral panobinostat in patients with relapsed/refractory multiple myeloma
-
Offidani M, Polloni C, Cavallo F, et al. Phase II study of melphalan, thalidomide and prednisone combined with oral panobinostat in patients with relapsed/refractory multiple myeloma. Leuk Lymphoma. 2012; 53(9):1722–1727.
-
(2012)
Leuk Lymphoma
, vol.53
, Issue.9
, pp. 1722-1727
-
-
Offidani, M.1
Polloni, C.2
Cavallo, F.3
-
34
-
-
84927691932
-
Ricolinostat (ACY-1215) induced inhibition of aggresome formation accelerates carfilzomib-induced multiple myeloma cell death
-
Mishima Y, Santo L, Eda H, et al. Ricolinostat (ACY-1215) induced inhibition of aggresome formation accelerates carfilzomib-induced multiple myeloma cell death. Br J Haematol. 2015;169(3):423–434.
-
(2015)
Br J Haematol
, vol.169
, Issue.3
, pp. 423-434
-
-
Mishima, Y.1
Santo, L.2
Eda, H.3
-
35
-
-
84938842856
-
-
NJ: Novartis Pharmaceuticals Corporation, Accessed April 15, 2015
-
Farydak® (panobinostat capsules) [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2015. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205353s000lbl.pdf. Accessed April 15, 2015.
-
(2015)
East Hanover
-
-
-
36
-
-
84880918648
-
A phase I dose-escalation study of intravenous panobinostat in patients with lymphoma and solid tumors
-
Sharma S, Beck J, Mita M, et al. A phase I dose-escalation study of intravenous panobinostat in patients with lymphoma and solid tumors. Invest New Drugs. 2013;31(4):974–985.
-
(2013)
Invest New Drugs
, vol.31
, Issue.4
, pp. 974-985
-
-
Sharma, S.1
Beck, J.2
Mita, M.3
-
37
-
-
84922004566
-
A phase I, open-label, multicenter study to evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and various degrees of hepatic function
-
Slingerland M, Hess D, Clive S, et al. A phase I, open-label, multicenter study to evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and various degrees of hepatic function. Cancer Chemother Pharmacol. 2014;74(5):1089–1098.
-
(2014)
Cancer Chemother Pharmacol
, vol.74
, Issue.5
, pp. 1089-1098
-
-
Slingerland, M.1
Hess, D.2
Clive, S.3
|