Defining the binding region in factor H to develop a therapeutic factor H-Fc fusion protein against non-typeable Haemophilus influenzae

Frontiers in Cellular and Infection Microbiology

Volumn 6, Issue APR, 2016, Pages

  Wong, Sandy M ^a   Shaughnessy, Jutamas ^b   Ram, Sanjay ^b   Akerley, Brian J ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Complement; Factor H; Lung infection; Non typeable Haemophilus influenzae; Outer membrane protein; P5

Indexed keywords

COMPLEMENT FACTOR H; FC FUSION PROTEIN; FC FUSION PROTEIN 18; FC FUSION PROTEIN 20; FC FUSION PROTEIN 6; FC FUSION PROTEIN 7; HYBRID PROTEIN; OUTER MEMBRANE PROTEIN; UNCLASSIFIED DRUG; COMPLEMENT FACTOR H, HUMAN; IMMUNOGLOBULIN FC FRAGMENT;

ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BLOOD ANALYSIS; COLONY FORMATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENETIC ANALYSIS; HAEMOPHILUS INFLUENZAE; HEMOLYSIS; HUMAN; LUNG INFECTION; MOUSE; MUTATION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SERUM BACTERICIDAL ANTIBODY ASSAY; SURVIVAL; ANIMAL; BINDING SITE; C57BL MOUSE; FEMALE; GENETICS; HAEMOPHILUS INFECTIONS; IMMUNOLOGY; LUNG; MICROBIOLOGY; PATHOLOGY;

ANIMALS; BINDING SITES; COMPLEMENT FACTOR H; FEMALE; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; LUNG; MICE; MICE, INBRED C57BL; RECOMBINANT FUSION PROTEINS;

EID: 85006191483     PISSN: None     EISSN: 22352988     Source Type: Journal    
DOI: 10.3389/fcimb.2016.00040     Document Type: Article

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