Molecular mechanisms of pruritus

Current Research in Translational Medicine

Volumn 64, Issue 4, 2016, Pages 203-206

  Meng, J ^a   Steinhoff, M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Endothelin 1; Itch; Neuropeptide receptor; Protease activated receptor; Pruritogens; Sensory nerves; Signal transduction; Translational medicine

Indexed keywords

CATHEPSIN; CHEMOKINE; CYTOKINE; GASTRIN RELEASING PEPTIDE; GASTRIN RELEASING PEPTIDE RECEPTOR; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; KALLIKREIN; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 2; SEROTONIN; TRYPSIN; TRYPTASE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

CYTOLOGY; HUMAN; MOLECULAR MECHANICS; NERVE CELL NETWORK; NERVE CONDUCTION; NEUROBIOLOGY; NEUROPHYSIOLOGY; NOCICEPTION; PAIN INTENSITY; PROTEIN EXPRESSION; PRURITUS; RECEPTOR UPREGULATION; REVIEW; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; UNPLEASANT SENSATION; ANIMAL; BIOLOGICAL MODEL; DERMATITIS; HISTAMINE RELEASE; INTERNEURON; MOUSE; PAIN; PATHOPHYSIOLOGY; PERCEPTION; PHYSIOLOGY; POSTERIOR HORN CELL; SENSORY NERVE; SPINOTHALAMIC TRACT;

AFFERENT PATHWAYS; ANIMALS; CYTOKINES; DERMATITIS; HISTAMINE RELEASE; HUMANS; INTERNEURONS; MICE; MODELS, BIOLOGICAL; NEUROTRANSMITTER AGENTS; PAIN; PERCEPTION; POSTERIOR HORN CELLS; PRURITUS; SENSORY RECEPTOR CELLS; SPINOTHALAMIC TRACTS;

EID: 85006176705     PISSN: None     EISSN: 24523186     Source Type: Journal    
DOI: 10.1016/j.retram.2016.08.006     Document Type: Review

References (38)

1. Ikoma, A., Steinhoff, M., Stander, S., Yosipovitch, G., Schmelz, M., The neurobiology of itch. Nat Rev Neurosci 7 (2006), 535–547, 10.1038/nrn1950.
2. Jutel, M., Akdis, M., Akdis, C.A., Histamine, histamine receptors and their role in immune pathology. Clin Exp Allergy 39 (2009), 1786–1800, 10.1111/j.1365-2222.2009.03374.x.
3. Steinhoff, M., Neisius, U., Ikoma, A., Fartasch, M., Heyer, G., Skov, P.S., et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 23 (2003), 6176–6180.
4. Rosenthal, S.R., Histamine as the chemical mediator for cutaneous pain. J Invest Dermatol 69 (1977), 98–105.
5. Tillu, D.V., et al. Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state. Pain 156 (2015), 859–867, 10.1097/j.pain.0000000000000125.
6. Kido-Nakahara, M., et al. Necrolytic migratory erythema associated with alteration from predominantly gastrin-secreting to predominantly glucagon-secreting pancreatic neuroendocrine tumor. Eur J Dermatol 24 (2014), 702–703, 10.1684/ejd.2014.2443.
7. Han, L., et al. A subpopulation of nociceptors specifically linked to itch. Nat Neurosci 16 (2013), 174–182, 10.1038/nn.3289.
8. Cavanaugh, D.J., et al. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A 106 (2009), 9075–9080, 10.1073/pnas.0901507106.
9. Liu, Q., et al. Mechanisms of itch evoked by beta-alanine. J Neurosci 32 (2012), 14532–14537, 10.1523/JNEUROSCI. 3509-12(2012).
10. Tuckett, R.P., Itch evoked by electrical stimulation of the skin. J Invest Dermatol 79 (1982), 368–373.
11. Liu, Y., et al. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron 68 (2010), 543–556, 10.1016/j.neuron.2010.09.008.
12. Silberstein, S.D., Neurotoxins in the neurobiology of pain. Headache 43:Suppl 1 (2003), S2–S8.
13. Wilson, S.R., et al. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat Neurosci 14 (2011), 595–602, 10.1038/nn.2789.
14. McCoy, E.S., et al. Peptidergic CGRPalpha primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold. Neuron 78 (2013), 138–151, 10.1016/j.neuron.2013.01.030.
15. Andoh, T., Nagasawa, T., Satoh, M., Kuraishi, Y., Substance, P., induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J Pharmacol Exp Ther 286 (1998), 1140–1145.
16. Weidner, C., et al. Acute effects of substance P and calcitonin gene-related peptide in human skin—a microdialysis study. J Invest Dermatol 115 (2000), 1015–1020, 10.1046/j.1523-1747.2000.00142.x.
17. Feld, M., et al. The pruritus- and T2-associated cytokine IL-31 promotes growth of sensory nerves. J Allergy Clin Immunol, 2016, 10.1016/j.jaci.2016.02.020.
18. Meng, J., Wang, J., Steinhoff, M., Dolly, J.O., TNFalpha induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion. Sci Rep, 6, 2016, 21226, 10.1038/srep21226.
19. Nojima, H., Carstens, M.I., Carstens, E., c-fos expression in superficial dorsal horn of cervical spinal cord associated with spontaneous scratching in rats with dry skin. Neurosci Lett 347 (2003), 62–64.
20. Nakano, T., Andoh, T., Lee, J.B., Kuraishi, Y., Different dorsal horn neurons responding to histamine and allergic itch stimuli. Neuroreport 19 (2008), 723–726, 10.1097/WNR.0b013e3282fdf6c5.
21. Akiyama, T., Merrill, A.W., Carstens, M.I., Carstens, E., Activation of superficial dorsal horn neurons in the mouse by a PAR-2 agonist and 5-HT: potential role in itch. J Neurosci 29 (2009), 6691–6699, 10.1523/JNEUROSCI.6103-08.2009.
22. Akiyama, T., Carstens, M.I., Carstens, E., Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch. J Neurophysiol 102 (2009), 2176–2183, 10.1152/jn.00463.2009.
23. Cevikbas, F., Steinhoff, M., Ikoma, A., Role of spinal neurotransmitter receptors in itch: new insights into therapies and drug development. CNS Neurosci Ther 17 (2011), 742–749, 10.1111/j.1755-5949.2010.00201.x.
24. Bautista, D.M., Wilson, S.R., Hoon, M.A., Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci 17 (2014), 175–182, 10.1038/nn.3619.
25. Sun, Y.G., et al. Cellular basis of itch sensation. Science 325 (2009), 1531–1534, 10.1126/science.1174868.
26. Solorzano, C., et al. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J Neurosci 35 (2015), 648–657, 10.1523/JNEUROSCI.2955-14.2015.
27. Kardon, A.P., et al. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron 82 (2014), 573–586, 10.1016/j.neuron.2014.02.046.
28. Pereira, P.J., et al. GRPR/PI3Kgamma: partners in central transmission of itch. J Neurosci 35 (2015), 16272–16281, 10.1523/JNEUROSCI. 2310-15.2015.
29. Green, D., Dong, X., The cell biology of acute itch. J Cell Biol 213 (2016), 155–161, 10.1083/jcb.201603042.
30. Ikoma, A., Cevikbas, F., Kempkes, C., Steinhoff, M., Anatomy and neurophysiology of pruritus. Semin Cutan Med Surg 30 (2011), 64–70, 10.1016/j.sder.2011.04.001.
31. Darsow, U., et al. Processing of histamine-induced itch in the human cerebral cortex: a correlation analysis with dermal reactions. J Invest Dermatol 115 (2000), 1029–1033, 10.1046/j.1523-1747.2000.00193.x.
32. 2O positron emission tomography studies. Pain 92 (2001), 295–305.
33. Hsieh, J.C., et al. Urge to scratch represented in the human cerebral cortex during itch. J Neurophysiol 72 (1994), 3004–3008.
34. Mochizuki, H., et al. Imaging of central itch modulation in the human brain using positron emission tomography. Pain 105 (2003), 339–346.
35. Vierow, V., et al. Cerebral representation of the relief of itch by scratching. J Neurophysiol 102 (2009), 3216–3224, 10.1152/jn.00207. 2009.
36. Yosipovitch, G., Tang, M.B., Practical management of psoriasis in the elderly: epidemiology, clinical aspects, quality of life, patient education and treatment options. Drugs Aging 19 (2002), 847–863.
37. Desbordes, G., et al. Evoked itch perception is associated with changes in functional brain connectivity. Neuroimage Clin 7 (2015), 213–221, 10.1016/j.nicl.2014.12.002.
38. Napadow, V., Harris, R.E., What has functional connectivity and chemical neuroimaging in fibromyalgia taught us about the mechanisms and management of ‘centralized’ pain?. Arthritis Res Ther, 16, 2014, 425.