Physical Exercise for Late-Life Depression: Customizing an Intervention for Primary Care

Journal of the American Geriatrics Society

Volumn 65, Issue 2, 2017, Pages 348-355

  Zanetidou, Stamatula ^a   Belvederi Murri, Martino ^b,c   Menchetti, Marco ^d   Toni, Giulio ^e   Asioli, Fabrizio ^f   Bagnoli, Luigi ^f   Zocchi, Donato ^f   Siena, Matteo ^f   Assirelli, Barbara ^f   Luciano, Claudia ^d   Masotti, Mattia ^b   Spezia, Carlo ^f   Magagnoli, Monica ^f   Neri, Mirco ^g   Amore, Mario ^b   Bertakis, Klea D ^h  

^a Consultation Liaison Psychiatry Service ^*  (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e S Sebastiano Hospital   (Italy)

^f Primary Care Physicians in Private Practice   (Italy)

^g UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antidepressant; depression; elderly; physical exercise; primary care; randomized controlled trial

Indexed keywords

SERTRALINE; ANTIDEPRESSANT AGENT;

AEROBIC CAPACITY; AGED; ANXIETY; ARTICLE; CLINICAL PRACTICE; CONSULTATION; CONTROLLED STUDY; DSM-IV; EFFECT SIZE; EXERCISE; FEMALE; GENERAL PRACTITIONER; HEALTH CARE SYSTEM; HUMAN; LATE LIFE DEPRESSION; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL DISEASE; MULTICENTER STUDY; POLYPHARMACY; PRIMARY MEDICAL CARE; PSYCHOMOTOR RETARDATION; RANDOMIZED CONTROLLED TRIAL; REMISSION; SECONDARY ANALYSIS; SINGLE BLIND PROCEDURE; TREATMENT OUTCOME; AGE; CLINICAL TRIAL; DEPRESSIVE DISORDER, MAJOR; HEALTH PERSONNEL ATTITUDE; MULTIMODALITY CANCER THERAPY; OXYGEN CONSUMPTION; PRIMARY HEALTH CARE; PSYCHOMOTOR PERFORMANCE; SEVERITY OF ILLNESS INDEX;

AGE FACTORS; AGED; ANTIDEPRESSIVE AGENTS; ANXIETY; ATTITUDE OF HEALTH PERSONNEL; COMBINED MODALITY THERAPY; DEPRESSIVE DISORDER, MAJOR; EXERCISE; FEMALE; HUMANS; MALE; OXYGEN CONSUMPTION; PHYSICIANS, PRIMARY CARE; POLYPHARMACY; PRIMARY HEALTH CARE; PSYCHOMOTOR PERFORMANCE; REMISSION INDUCTION; SERTRALINE; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD;

EID: 85006152862     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.14525     Document Type: Article

References (50)

1. Alexopoulos GS. Depression in the elderly. Lancet 2005;365:1961–1970.
2. Belvederi Murri M, Pariante C, Mondelli V et al. HPA axis and aging in depression: Systematic review and meta-analysis. Psychoneuroendocrinology 2014;41:46–62.
3. Alexopoulos GS, Morimoto SS. The inflammation hypothesis in geriatric depression. Int J Geriatr Psychiatry 2011;26:1109–1118.
4. Gleason OC, Pierce AM, Walker AE et al. The two-way relationship between medical illness and late-life depression. Psychiatr Clin North Am 2013;36:533–544.
5. Hall CA, Reynolds-Iii CF. Late-life depression in the primary care setting: Challenges, collaborative care, and prevention. Maturitas 2014;79:147–152.
6. Alexopoulos GS, Bruce ML. A model for intervention research in late-life depression. Int J Geriatr Psychiatry 2009;24:1325–1334.
7. Kiosses DN, Leon AC, Arean PA. Psychosocial interventions for late-life major depression: Evidence-based treatments, predictors of treatment outcomes, and moderators of treatment effects. Psychiatr Clin North Am 2011;34:377–401, viii.
8. Avari JN, Alexopoulos GS. Models of care for late-life depression of the medically ill: Examples from chronic obstructive pulmonary disease and stroke. Am J Geriatr Psychiatry 2015;23:477–487.
9. Chmelo EA, Crotts CI, Newman JC et al. Heterogeneity of physical function responses to exercise training in older adults. J Am Geriatr Soc 2015;63:462–469.
10. Sighinolfi C, Norcini PA, Casini F et al. Adaptation and psychometric evaluation of the Italian version of the depression attitude questionnaire (DAQ). Epidemiol Psychiatr Sci 2013;22:93–100.
11. Martin-Agueda B, Lopez-Munoz F, Rubio G et al. Management of depression in primary care: A survey of general practitioners in Spain. Gen Hosp Psychiatry 2005;27:305–312.
12. Nutting PA, Gallagher K, Riley K et al. Care management for depression in primary care practice: Findings from the RESPECT-Depression trial. Ann Fam Med 2008;6:30–37.
13. Belvederi Murri M, Amore M, Menchetti M et al. Physical exercise for late-life major depression. Br J Psychiatry 2015;207:235–242.
14. Rucci P, Piazza A, Menchetti M et al. Integration between primary care and mental health services in Italy: Determinants of referral and stepped care. Int J Family Med 2012;2012:507464.
15. Berardi D, Ferrannini L, Menchetti M et al. Primary care psychiatry in Italy. J Nerv Ment Dis 2014;202:460–463.
16. Miller MD, Paradis CF, Houck PR et al. Rating chronic medical illness burden in geropsychiatric practice and research: Application of the Cumulative Illness Rating Scale. Psychiatry Res 1992;41:237–248.
17. Nasreddine ZS, Phillips NA, Bedirian V et al. The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005;53:695–699.
18. Calati R, Salvina SM, Balestri M et al. Antidepressants in elderly: Metaregression of doubleblind, randomized clinical trials. J Affect Disord 2013;147:1–8.
19. Manning KJ, Alexopoulos GS, Banerjee S et al. Executive functioning complaints and escitalopram treatment response in late-life depression. Am J Geriatr Psychiatry 2015;23:440–445.
20. Bridle C, Spanjers K, Patel S et al. Effect of exercise on depression severity in older people: Systematic review and meta-analysis of randomised controlled trials. Br J Psychiatry 2012;201:180–185.
21. Tedeschini E, Levkovitz Y, Iovieno N et al. Efficacy of antidepressants for late-life depression: A meta-analysis and meta-regression of placebo-controlled randomized trials. J Clin Psychiatry 2011;72:1660–1668.
22. Morimoto SS, Alexopoulos GS. Cognitive deficits in geriatric depression: Clinical correlates and implications for current and future treatment. Psychiatr Clin North Am 2013;36:517–531.
23. Fleg JL, Morrell CH, Bos AG et al. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation 2005;112:674–682.
24. Bokhof B, Junius-Walker U. Reducing polypharmacy from the perspectives of general practitioners and older patients: A synthesis of qualitative studies. Drugs Aging 2016;33:249–266.
25. Kraemer HC, Wilson GT, Fairburn CG et al. Mediators and moderators of treatment effects in randomized clinical trials. Arch Gen Psychiatry 2002;59:877–883.
26. Menchetti M, Rucci P, Bortolotti B et al. Moderators of remission with interpersonal counselling or drug treatment in primary care patients with depression: Randomised controlled trial. Br J Psychiatry 2014;204:144–150.
27. Pincus T, Miles C, Froud R et al. Methodological criteria for the assessment of moderators in systematic reviews of randomised controlled trials: A consensus study. BMC Med Res Methodol 2011;11:14.
28. Kraemer HC, Kupfer DJ. Size of treatment effects and their importance to clinical research and practice. Biol Psychiatry 2006;59:990–996.
29. Bennabi D, Vandel P, Papaxanthis C et al. Psychomotor retardation in depression: A systematic review of diagnostic, pathophysiologic, and therapeutic implications. Biomed Res Int 2013;2013:158746.
30. Seidler RD, Bernard JA, Burutolu TB et al. Motor control and aging: Links to age-related brain structural, functional, and biochemical effects. Neurosci Biobehav Rev 2010;34:721–733.
31. Kalayam B, Alexopoulos GS. Prefrontal dysfunction and treatment response in geriatric depression. Arch Gen Psychiatry 1999;56:713–718.
32. Buyukdura JS, McClintock SM, Croarkin PE. Psychomotor retardation in depression: Biological underpinnings, measurement, and treatment. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:395–409.
33. Bruder GE, Alvarenga JE, Alschuler D et al. Neurocognitive predictors of antidepressant clinical response. J Affect Disord 2014;166:108–114.
34. Yuen GS, Bhutani S, Lucas BJ et al. Apathy in late-life depression: Common, persistent, and disabling. Am J Geriatr Psychiatry 2015;23:488–494.
35. Scherder E, Scherder R, Verburgh L et al. Executive functions of sedentary elderly may benefit from walking: A systematic review and meta-analysis. Am J Geriatr Psychiatry 2014;22:782–791.
36. Rizvi SJ, Grima E, Tan M et al. Treatment-resistant depression in primary care across Canada. Can J Psychiatry 2014;59:349–357.
37. Zivin K, Kales HC. Adherence to depression treatment in older adults: A narrative review. Drugs Aging 2008;25:559–571.
38. Sanada K, Kuchiki T, Miyachi M et al. Effects of age on ventilatory threshold and peak oxygen uptake normalised for regional skeletal muscle mass in Japanese men and women aged 20-80 years. Eur J Appl Physiol 2007;99:475–483.
39. Ekkekakis P, Parfitt G, Petruzzello SJ. The pleasure and displeasure people feel when they exercise at different intensities: Decennial update and progress towards a tripartite rationale for exercise intensity prescription. Sports Med 2011;41:641–671.
40. Rebar AL, Stanton R, Geard D et al. A meta-meta-analysis of the effect of physical activity on depression and anxiety in non-clinical adult populations. Health Psychol Rev 2015;9:366–378.
41. Forlani M, Morri M, Belvederi MM et al. Anxiety symptoms in 74+ community-dwelling elderly: Associations with physical morbidity, depression and alcohol consumption. PLoS ONE 2014;9:e89859.
42. Lord SR, Murray SM, Chapman K et al. Sit-to-stand performance depends on sensation, speed, balance, and psychological status in addition to strength in older people. J Gerontol A Biol Sci Med Sci 2002;57:M539–M543.
43. Neuman A, Gunnbjornsdottir M, Tunsater A et al. Dyspnea in relation to symptoms of anxiety and depression: A prospective population study. Respir Med 2006;100:1843–1849.
44. Ekkekakis P, Cook DB. Routledge Handbook of Physical Activity and Mental Health. Routledge, New York, 2013.
45. Stanton R, Happell BM. An exercise prescription primer for people with depression. Issues Ment Health Nurs 2013;34:626–630.
46. Harvey JA, Chastin SF, Skelton DA. Prevalence of sedentary behavior in older adults: A systematic review. Int J Environ Res Public Health 2013;10:6645–6661.
47. Orrow G, Kinmonth AL, Sanderson S et al. Effectiveness of physical activity promotion based in primary care: Systematic review and meta-analysis of randomised controlled trials. BMJ 2012;344:e1389.
48. Luppa M, Heinrich S, Matschinger H et al. Direct costs associated with depression in old age in Germany. J Affect Disord 2008;105:195–204.
49. Stanton R, Franck C, Reaburn P et al. A pilot study of the views of general practitioners regarding exercise for the treatment of depression. Perspect Psychiatr Care 2015;51:253–259.
50. Vigorito C, Giallauria F. Effects of exercise on cardiovascular performance in the elderly. Front Physiol 2014;5:51.