The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Weng, Qiao ^a,b   Du, Jiangbo ^a   Yu, Fei ^a   Huang, Tongtong ^a   Chen, Mengxi ^a   Lv, Hong ^a   Ma, Hongxia ^a   Hu, Zhibin ^a   Jin, Guangfu ^a   Hu, Yali ^a,b   Shen, Hongbing ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; ALLELE; BLOOD; CHINA; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMAN; NEWBORN; PREGNANCY; TELOMERE; YOUNG ADULT;

ADULT; ALLELES; CHINA; DNA; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INFANT, NEWBORN; PREGNANCY; TELOMERE; YOUNG ADULT;

EID: 85006078239     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep38729     Document Type: Article

References (42)

1. Blackburn, E. H. Telomeres and telomerase: the means to the end (Nobel lecture). Angew Chem Int Ed Engl 49, 7405-7421, doi: 10.1002/anie.201002387 (2010).
2. Olovnikov, A. M. Principle of marginotomy in template synthesis of polynucleotides. Doklady Akademii nauk SSSR 201, 1496-1499 (1971).
3. Frenck, R. W. Jr., Blackburn, E. H. and Shannon, K. M. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci USA 95, 5607-5610 (1998).
4. Blackburn, E. H., Greider, C. W. and Szostak, J. W. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nature medicine 12, 1133-1138, doi: 10.1038/nm1006-1133 (2006).
5. Cesare, A. J. and Reddel, R. R. Alternative lengthening of telomeres: models, mechanisms and implications. Nature reviews. Genetics 11, 319-330, doi: 10.1038/nrg2763 (2010).
6. Serrano, A. L. and Andres, V. Telomeres and cardiovascular disease: does size matter? Circ Res 94, 575-584 (2004).
7. Valdes, A. M. et al. Obesity, cigarette smoking, and telomere length in women. Lancet 366, 662-664, doi: 10.1016/S0140- 6736(05)66630-5 (2005).
8. Shapiro, S. D. Merging personalized medicine and biology of aging in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 184, 864-866, doi: 10.1164/rccm.201108-1486ED (2011).
9. Lee, J. et al. The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD). PLoS One 7, e35567 (2012).
10. Wentzensen, I. M., Mirabello, L., Pfeiffer, R. M. and Savage, S. A. The association of telomere length and cancer: a meta-analysis. Cancer epidemiology, biomarkers and prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20, 1238-1250, doi: 10.1158/1055-9965.EPI-11-0005 (2011).
11. Bestilny, L. J., Gill, M. J., Mody, C. H. and Riabowol, K. T. Accelerated replicative senescence of the peripheral immune system induced by HIV infection. AIDS 14, 771-780 (2000).
12. Bojesen, S. E. Telomeres and human health. Journal of internal medicine 274, 399-413, doi: 10.1111/joim.12083 (2013).
13. Benetos, A. et al. Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins. Int J Epidemiol 43, 1799-1805 (2014).
14. Slagboom, P. E., Droog, S. and Boomsma, D. I. Genetic determination of telomere size in humans: a twin study of three age groups. American journal of human genetics 55, 876-882 (1994).
15. Graakjaer, J. et al. The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life. Aging cell 3, 97-102, doi: 10.1111/j.1474-9728.2004.00093.x (2004).
16. Vasa-Nicotera, M. et al. Mapping of a major locus that determines telomere length in humans. Am J Hum Genet 76, 147-151 (2005).
17. Andrew, T. et al. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet 78, 480-486 (2006).
18. Mangino, M. et al. A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans. Hum Mol Genet 17, 2518-2523 (2008).
19. Codd, V. et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 45, 422-427, 427e421-422 (2013).
20. Codd, V. et al. Common variants near TERC are associated with mean telomere length. Nat Genet 42, 197-199 (2010).
21. Levy, D. et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci USA 107, 9293-9298 (2010).
22. Bojesen, S. E. et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet 45, 371-384, 384e371-372 (2013).
23. Du, J. et al. Telomere length, genetic variants and gastric cancer risk in a Chinese population. Carcinogenesis 36, 963-970, doi: 10.1093/carcin/bgv075 (2015).
24. Liu, Y. et al. A genome-wide association study identifies a locus on TERT for mean telomere length in Han Chinese. PLoS One 9, e85043 (2014).
25. Nawrot, T. S., Staessen, J. A., Gardner, J. P. and Aviv, A. Telomere length and possible link to X chromosome. Lancet 363, 507-510 (2004).
26. Unryn, B. M., Cook, L. S. and Riabowol, K. T. Paternal age is positively linked to telomere length of children. Aging Cell 4, 97-101 (2005).
27. Nordfjall, K., Larefalk, A., Lindgren, P., Holmberg, D. and Roos, G. Telomere length and heredity: Indications of paternal inheritance. Proc Natl Acad Sci USA 102, 16374-16378 (2005).
28. Njajou, O. T. et al. Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci USA 104, 12135-12139 (2007).
29. Brummendorf, T. H. et al. Telomere length dynamics in normal individuals and in patients with hematopoietic stem cell-associated disorders. Ann N Y Acad Sci 938, 293-303; discussion 303-294 (2001).
30. Yamaguchi, H. et al. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 352, 1413-1424 (2005).
31. Fitzpatrick, A. L. et al. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. American journal of epidemiology 165, 14-21 (2007).
32. Brouilette, S., Singh, R. K., Thompson, J. R., Goodall, A. H. and Samani, N. J. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol 23, 842-846 (2003).
33. Brouilette, S. W. et al. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet 369, 107-114 (2007).
34. De Meyer, T. et al. Paternal age at birth is an important determinant of offspring telomere length. Human molecular genetics 16, 3097-3102, doi: 10.1093/hmg/ddm271 (2007).
35. Friedrich, U., Schwab, M., Griese, E. U., Fritz, P. and Klotz, U. Telomeres in neonates: new insights in fetal hematopoiesis. Pediatric research 49, 252-256, doi: 10.1203/00006450-200102000-00020 (2001).
36. Wojcicki, J. M. et al. Cord blood telomere length in Latino infants: relation with maternal education and infant sex. Journal of perinatology: official journal of the California Perinatal Association 36, 235-241, doi: 10.1038/jp.2015.178 (2016).
37. Strohmaier, J. et al. Low Birth Weight in MZ Twins Discordant for Birth Weight is Associated with Shorter Telomere Length and lower IQ, but not Anxiety/Depression in Later Life. Twin research and human genetics: the official journal of the International Society for Twin Studies 18, 198-209, doi: 10.1017/thg.2015.3 (2015).
38. Marchetto, N. M. et al. Prenatal stress and newborn telomere length. American journal of obstetrics and gynecology 215, 94 e91-98, doi: 10.1016/j.ajog.2016.01.177 (2016).
39. Entringer, S. et al. Maternal estriol concentrations in early gestation predict infant telomere length. The Journal of clinical endocrinology and metabolism 100, 267-273, doi: 10.1210/jc.2014-2744 (2015).
40. Entringer, S. et al. Maternal Folate Concentration in Early Pregnancy and Newborn Telomere Length. Annals of nutrition and metabolism 66, 202-208, doi: 10.1159/000381925 (2015).
41. Cawthon, R. M. Telomere measurement by quantitative PCR. Nucleic Acids Res 30, e47 (2002).
42. Talmud, P. J. et al. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ 340, b4838, doi: 10.1136/bmj.b4838 (2010).