Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins

International Journal of Epidemiology

Volumn 43, Issue 6, 2014, Pages 1799-1805

  Benetos, Athanase ^a,b,c   Dalgård, Christine ^d   Labat, Carlos ^b,c   Kark, Jeremy D ^e   Verhulst, Simon ^f   Christensen, Kaare ^d,g   Kimura, Masayuki ^h   Horvath, Kent ^h   Kyvik, Kirsten Ohm ^d   Aviv, Abraham ^h  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE LORRAINE   (France)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^e HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^f UNIVERSITY OF GRONINGEN   (Netherlands)

^g ODENSE UNIVERSITY HOSPITAL   (Denmark)

^h University of Medicine and Dentistry of New Jersey Medical School   (United States)

Author keywords

Men; Sex; Telomeres; Twins; Women

Indexed keywords

HERITABILITY; HORMONE; HUMAN GEOGRAPHY; NUCLEIC ACID; SEX-RELATED DIFFERENCE;

ARTICLE; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIZYGOTIC TWINS; FEMALE; FOLLOW UP; GENDER IDENTITY; HUMAN; LEUKOCYTE; LEUKOCYTE TELOMERE LENGTH; MALE; MONOZYGOTIC TWINS; PRIORITY JOURNAL; RESTRICTION FRAGMENT; SEX DIFFERENCE; TELOMERE; ZYGOSITY; ADULT; AGING; GENETICS; METABOLISM; MIDDLE AGED; SOUTHERN BLOTTING; TWINS;

EUTHERIA;

ADULT; AGING; BLOTTING, SOUTHERN; FEMALE; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; SEX FACTORS; TELOMERE; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 84920571553     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyu146     Document Type: Article

References (32)

1. Andrew T, Aviv A, Falchi M et al. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Gene. 2006;78:480-86.
2. Broer L, Codd V, Nyholt DR et al. Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet 2013;21:1163-68.
3. Slagboom PE, Droog S, Boomsma DI et al. Genetic determination of telomere size in humans: A twin study of three age groups. Am J Hum Genet 1994;55:876-82.
4. Aviv A, Susser E. Leukocyte telomere length and the father's age enigma: implications for population health and for life course. Int J Epidemiol 2013;42:457-62.
5. Aviv A. Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res 2012;730:68-74.
6. Nawrot TS, Staessen JA, Gardner JP et al. Telomere length and possible link to X chromosome. Lancet 2004;363:507-10.
7. Hunt SC, Chen W, Gardner JP et al. Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell 2008;7:451-58.
8. Elbers CC, Garcia ME, Kimura M et al. Comparison between Southern blots and qPCR analysis of leukocyte telomere length in the Health ABC Study. J Gerontol A Biol Sci Med Sci 2014;69:527-31.
9. Lummaa V, Pettay JE, Russell AF. Male twins reduce fitness of female co-twins in humans. Proc Natl Acad Sci U S A 2007;104:10915-20.
10. Vuoksimaa E, Eriksson CJ, Pulkkinen L et al. Decreased prevalence of left-handedness among females with male co-twins: evidence suggesting prenatal testosterone transfer in humans? Psychoneuroendocrinology 2010;35:1462-72.
11. Ribeiro DC, Brook AH, Hughes TE et al. Intrauterine hormone effects on tooth dimensions. J Dent Res 2013;92:425-31.
12. Benyamin B, Sørensen TI, Schousboe K et al. Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? Diabetologia 2007;50:1880-88.
13. Schousboe K, Visscher PM, Henriksen JE, Hopper JL, Sorensen TI, Kyvik KO. Twin study of genetic and environmental influences on glucose tolerance and indices of insulin sensitivity and secretion. Diabetologia 2003;46:1276-83.
14. Kimura M, Stone R, Hunt S et al. Measurement of telomere length by the Southern blot analysis of the terminal restriction fragment lengths. Nat Protoc 2010;5:1596-607.
15. Van de Pol M, Wright J. A simple method for distinguishing within-versus between-subject effects using mixed models. Anim Behav 2009;77:753-58.
16. Benetos A, Kark JD, Susser E et al. Tracking and fixed ranking of leukocyte telomere length across the adult life course. Aging Cell 2013;12:615-21.
17. Daniali L, Benetos A, Susser E et al. Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun 2013;4:1597.
18. Akkad A, Hastings R, Konje JC et al. Telomere length in smallfor-gestational-age babies. BJOG. 2006;113:318-23.
19. Okuda K, Bardeguez A, Gardner JP et al. Telomere length in the newborn. Pediatr Res 2002;52:377-81.
20. Tapp AL, Maybery MT, Whitehouse AJ. Evaluating the twin testosterone transfer hypothesis: a review of the empirical evidence. Horm Behav 2011;60:713-22.
21. Ryan BC, Vandenbergh JG. Intrauterine position effects. Neurosci Biobehav Rev 2002;26:665-78.
22. Gaist D, Bathum L, Skytthe A et al. Strength and anthropometric measures in identical and fraternal twins: no evidence of masculinization of females with male co-twins. Epidemiology 2000;11:340-43.
23. Christensen KI, Basso O, Kyvik KO et al. Fecundability of female twins. Epidemiology 1998;9:189-92.
24. Korsten P, Clutton-Brock T, Pilkington JG, Pemberton JM, Kruuk LE. Sexual conflict in twins: male co-twins reduce fitness of female Soay sheep. Biol Lett 2009;5:663-66.
25. Gray KE, Schiff MA, Fitzpatrick AL, Kimura M, Aviv A, Starr JR. Leukocyte telomere length and age at menopause. Epidemiology 2014;25:139-46.
26. Wright WE, Piatyszek MA, Rainey WE et al. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet 1996;18:173-79.
27. Ulaner GA, Giudice LC. Developmental regulation of telomerase activity in human fetal tissues during gestation. Mol Hum Reprod 1997;3:769-73.
28. Li H, Simpson ER, Liu JP et al. Oestrogen, telomerase, ovarian ageing and cancer. Clin Exp Pharmacol Physiol 2010;37:78-82.
29. Vasan RS, Demissie S, Kimura M et al. Association of leukocyte telomere length with circulating biomarkers of the reninangiotensin-aldosterone system: the Framingham Heart Study. Circulation 2008;117:1138-44.
30. Valdes AM, Andrew T, Gardner JP et al. Obesity, cigarette smoking, and telomere length in women. Lancet 2005;366:662-64.
31. Silventoinen K, Bartels M, Posthuma D et al. Genetic regulation of growth in height and weight from 3 to 12 years of age: A longitudinal study of Dutch twin children. Twin Res Hum Genet 2007;10:354-63.
32. Dubois L, Kyvik KO, GirardMet al. Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: An International study of over 12,000 twin pairs. PLoS One 2012;7:e30153.