Malnutrition and Risk of Structural Brain Changes Seen on Magnetic Resonance Imaging in Older Adults

Journal of the American Geriatrics Society

Volumn 64, Issue 12, 2016, Pages 2457-2463

  de van der Schueren, Marian A E ^a,b   Lonterman Monasch, Sabine ^c   van der Flier, Wiesje M ^d   Kramer, Mark H ^a   Maier, Andrea B ^a   Muller, Majon ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b HAN UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

^c HAGA HOSPITAL   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

brain atrophy; malnutrition; Mini Nutritional Assessment; nutritional status; older adults; white matter hyperintensities

Indexed keywords

ALCOHOL; CYANOCOBALAMIN; FOLIC ACID; PYRIDOXINE; THIAMINE; VITAMIN D; TRACE ELEMENT;

AGED; ALCOHOL CONSUMPTION; ARTICLE; BRAIN ATROPHY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; COGNITION; CROSS-SECTIONAL STUDY; DAILY LIFE ACTIVITY; DEPRESSION; DIABETES MELLITUS; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MEDIAL TEMPORAL LOBE; MINI MENTAL STATE EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; NUTRITIONAL STATUS; PROTEIN CALORIE MALNUTRITION; SMOKING; VITAMIN BLOOD LEVEL; ATROPHY; BLOOD; BRAIN; GERIATRIC ASSESSMENT; NUTRITIONAL ASSESSMENT; PATHOLOGY; PROCEDURES; RISK FACTOR; VERY ELDERLY;

AGED, 80 AND OVER; ATROPHY; BRAIN; CROSS-SECTIONAL STUDIES; FEMALE; GERIATRIC ASSESSMENT; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MALNUTRITION; MICRONUTRIENTS; NUTRITION ASSESSMENT; NUTRITIONAL STATUS; RISK FACTORS;

EID: 85006051807     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.14385     Document Type: Article

References (33)

1. Kaiser MJ, Bauer JM, Ramsch C et al. Frequency of malnutrition in older adults: A multinational perspective using the Mini Nutritional Assessment. J Am Geriatr Soc 2010;58:1734–1738.
2. Meijers JMM, Schols JMGA, van Bokhorst-de van der Schueren M et al. Malnutrition prevalence in the Netherlands: Results of the annual Dutch national prevalence measurement of care problems. Br J Nutr 2009;101:417–423.
3. Schilp J, Kruizenga HM, Wijnhoven HAH et al. High prevalence of undernutrition in Dutch community-dwelling older individuals. Nutrition 2012;28:1151–1156.
4. Odlund Olin A, Koochek A, Ljungqvist O et al. Nutritional status, well-being and functional ability in frail elderly service flat residents. Eur J Clin Nutr 2005;59:263–270.
5. Stuck AE, Walthert JM, Nikolaus T et al. Risk factors for functional status decline in community-living elderly people: A systematic literature review. Soc Sci Med 1999;48:445–469.
6. Gauthier S, Gelinas I, Gauthier L. Functional disability in Alzheimer's disease. Int Psychogeriatr 1997;9(Suppl 1):163–165.
7. Fleta Zaragozano J, Jimenez Vidal A, Velilla Picazo M et al. [Anorexia nervosa and cerebral atrophy in adolescents]. Med Clin 2005;124:571–572.
8. Mukai M, Mukai K, Ichikawa M et al. Malnutrition and cerebral white matter lesions in dialysis patients. Nippon Toseki Igakkai Zasshi 2008;41:421–428.
9. Kamphuis PJGH, Scheltens P. Can nutrients prevent or delay onset of Alzheimer's disease? J Alzheimers Dis 2010;20:765–775.
10. van Overbeek EC, Staals J, van Oostenbrugge RJ. Vitamin B12 and progression of white matter lesions. A 2-year follow-up study in first-ever lacunar stroke patients. PLoS ONE 2013;8:e78100.
11. Annweiler C, Annweiler T, Montero-Odasso M et al. Vitamin D and brain volumetric changes: Systematic review and meta-analysis. Maturitas 2014;78:30–39.
12. Douaud G, Refsum H, de Jager CA et al. Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci U S A 2013;110:9523–9528.
13. Mulder C, van der Flier WM, Veerhuis R et al. Association between vitamin B6 and white matter hyperintensities in patients with Alzheimer's disease not mediated by homocysteine metabolism. J Am Geriatr Soc 2007;55:956–958.
14. Gillette-Guyonnet S, Secher M, Vellas B. Nutrition and neurodegeneration: Epidemiological evidence and challenges for future research. Br J Clin Pharmacol 2013;75:738–755.
15. Guigoz Y. The Mini Nutritional Assessment (MNA) review of the literature—what does it tell us? J Nutr Health Aging 2006;10:466–485.
16. Scheltens P, Pasquier F, Weerts JG et al. Qualitative assessment of cerebral atrophy on MRI: Inter- and intra-observer reproducibility in dementia and normal aging. Eur Neurol 1997;37:95–99.
17. Scheltens P, Leys D, Barkhof F et al. Atrophy of medial temporal lobes on MRI in “probable” Alzheimer's disease and normal ageing: Diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry 1992;55:967–972.
18. Fazekas F, Chawluk JB, Alavi A et al. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987;149:351–356.
19. Lyness JM, Noel TK, Cox C et al. Screening for depression in elderly primary care patients. A comparison of the Center for Epidemiologic Studies-Depression Scale and the Geriatric Depression Scale. Arch Intern Med 1997;157:449–454.
20. Fountoulakis KN, Tsolaki M, Chantzi H et al. Mini Mental State Examination (MMSE): A validation study in Greece. Am J Alzheimers Dis Other Demen 2000;15:342–345.
21. De Martinis M, Franceschi C, Monti D et al. Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol 2006;80:219–227.
22. Franceschi C, Bonafe M, Valensin S et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908:244–254.
23. van Bokhorst-de van der Schueren M, Lonterman-Monasch S, de Vries OJ et al. Prevalence and determinants for malnutrition in geriatric outpatients. Clin Nutr 2013;32:1007–1011.
24. Handler P, Bernheim F. Influence of dietary factors on hypertension induced by choline deficiency. Am J Physiol 1950;162:189–192.
25. Smith AD. The worldwide challenge of the dementias: A role for B vitamins and homocysteine? Food Nutr Bull 2008;29(2 Suppl):S143–S172.
26. McGarel C, Pentieva K, Strain JJ et al. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proc Nutr Soc 2015;74:46–55.
27. Gallucci M, Zanardo A, Bendini M et al. Serum folate, homocysteine, brain atrophy, and auto-CM system: The Treviso Dementia (TREDEM) study. J Alzheimers Dis 2014;38:581–587.
28. Bottiglieri T. Homocysteine and folate metabolism in depression. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:1103–1112.
29. Peng HY, Man CF, Xu J et al. Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: A meta-analysis of prospective studies. J Zhejiang Univ Sci B 2015;16:78–86.
30. Hoque MM, Rahman MZ, Rahman MR. Role of homocysteine in cerebrovascular disease. Mymensingh Med J 2008;17(2 Suppl):S39–S42.
31. Wright CB, Paik MC, Brown TR et al. Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan Study. Stroke 2005;36:1207–1211.
32. Vermeer SE, van Dijk EJ, Koudstaal PJ et al. Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study. Ann Neurol 2002;51:285–289.
33. van Asselt DZB, van Bokhorst-de van der Schueren M, van der CammenTJM et al. Assessment and treatment of malnutrition in Dutch geriatric practice: Consensus through a modified Delphi study. Age Ageing 2012;41:399–404.