메뉴 건너뛰기




Volumn 3, Issue 12, 2015, Pages

Hypoxia reduces placental mTOR activation in a hypoxia-induced model of intrauterine growth restriction (IUGR)

Author keywords

Hypoxia; IUGR; MTOR; Placenta; Trophoblast

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN P70;

EID: 85006036890     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12651     Document Type: Article
Times cited : (25)

References (43)
  • 1
    • 18844362084 scopus 로고    scopus 로고
    • Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway
    • Ain, R., L. N. Canham, and M. J. Soares. 2005. Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway. J. Endocrinol. 185:253–263.
    • (2005) J. Endocrinol , vol.185 , pp. 253-263
    • Ain, R.1    Canham, L.N.2    Soares, M.J.3
  • 2
    • 45649083688 scopus 로고    scopus 로고
    • Decreased placental X-linked inhibitor of apoptosis protein in an ovine model of intrauterine growth restriction
    • Arroyo, J. A., R. V. Anthony, and H. L. Galan. 2008. Decreased placental X-linked inhibitor of apoptosis protein in an ovine model of intrauterine growth restriction. Am. J. Obstet. Gynecol. 199:80–88.
    • (2008) Am. J. Obstet. Gynecol , vol.199 , pp. 80-88
    • Arroyo, J.A.1    Anthony, R.V.2    Galan, H.L.3
  • 3
    • 70749147279 scopus 로고    scopus 로고
    • Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction
    • Arroyo, J. A., L. D. Brown, and H. L. Galan. 2009. Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction. Am. J. Obstet. Gynecol. 201:616 e611–616 e617.
    • (2009) Am. J. Obstet. Gynecol , vol.201
    • Arroyo, J.A.1    Brown, L.D.2    Galan, H.L.3
  • 4
    • 84907979146 scopus 로고    scopus 로고
    • Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies
    • Bahr, B. L., M. D. Price, D. Merrill, C. Mejia, L. Call, D. Bearss, et al. 2014. Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies. Placenta 35:883–890.
    • (2014) Placenta , vol.35 , pp. 883-890
    • Bahr, B.L.1    Price, M.D.2    Merrill, D.3    Mejia, C.4    Call, L.5    Bearss, D.6
  • 5
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen, P., and T. Hunter. 2001. Oncogenic kinase signalling. Nature 411:355–365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 6
    • 84859157597 scopus 로고    scopus 로고
    • Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia
    • Bourque, S. L., V. W. Dolinsky, J. R. Dyck, and S. T. Davidge. 2012. Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia. Placenta 33:449–452.
    • (2012) Placenta , vol.33 , pp. 449-452
    • Bourque, S.L.1    Dolinsky, V.W.2    Dyck, J.R.3    Davidge, S.T.4
  • 7
    • 0023679409 scopus 로고
    • Classification of intrauterine growth retardation
    • Brar, H. S., and S. E. Rutherford. 1988. Classification of intrauterine growth retardation. Semin. Perinatol. 12:2–10.
    • (1988) Semin. Perinatol , vol.12 , pp. 2-10
    • Brar, H.S.1    Rutherford, S.E.2
  • 8
    • 10644283807 scopus 로고    scopus 로고
    • Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: Oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies–a review
    • Caniggia, I., and J. L. Winter. 2002. Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies–a review. Placenta 23(Suppl. A):S47–S57.
    • (2002) Placenta , vol.23 , pp. S47-S57
    • Caniggia, I.1    Winter, J.L.2
  • 9
    • 84866122780 scopus 로고    scopus 로고
    • Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
    • Copps, K. D., and M. F. White. 2012. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 55:2565–2582.
    • (2012) Diabetologia , vol.55 , pp. 2565-2582
    • Copps, K.D.1    White, M.F.2
  • 10
    • 17044441694 scopus 로고    scopus 로고
    • Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers
    • Eriksson, A., R. Cao, R. Pawliuk, S. M. Berg, M. Tsang, D. Zhou, et al. 2002. Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers. Cancer Cell 1:99–108.
    • (2002) Cancer Cell , vol.1 , pp. 99-108
    • Eriksson, A.1    Cao, R.2    Pawliuk, R.3    Berg, S.M.4    Tsang, M.5    Zhou, D.6
  • 11
    • 0030879909 scopus 로고    scopus 로고
    • Regulation of human placental development by oxygen tension
    • Genbacev, O., Y. Zhou, J. W. Ludlow, and S. J. Fisher. 1997. Regulation of human placental development by oxygen tension. Science 277:1669–1672.
    • (1997) Science , vol.277 , pp. 1669-1672
    • Genbacev, O.1    Zhou, Y.2    Ludlow, J.W.3    Fisher, S.J.4
  • 12
    • 84883404342 scopus 로고    scopus 로고
    • Developmental programming of cardiovascular disease by prenatal hypoxia
    • Giussani, D. A., and S. T. Davidge. 2013. Developmental programming of cardiovascular disease by prenatal hypoxia. J. Dev. Orig. Health Dis. 4:328–337.
    • (2013) J. Dev. Orig. Health Dis , vol.4 , pp. 328-337
    • Giussani, D.A.1    Davidge, S.T.2
  • 13
    • 0032934094 scopus 로고    scopus 로고
    • Placental pathology and neurodevelopment of the infant with intrauterine growth restriction
    • Gray, P. H., M. J. O’Callaghan, J. M. Harvey, C. J. Burke, and D. J. Payton. 1999. Placental pathology and neurodevelopment of the infant with intrauterine growth restriction. Dev. Med. Child Neurol. 41:16–20.
    • (1999) Dev. Med. Child Neurol , vol.41 , pp. 16-20
    • Gray, P.H.1    O’Callaghan, M.J.2    Harvey, J.M.3    Burke, C.J.4    Payton, D.J.5
  • 14
    • 84888638963 scopus 로고    scopus 로고
    • Effect of maternal chronic intermittent hypoxia during gestation on offspring growth in the rat
    • Iqbal, W., and J. Ciriello. 2013. Effect of maternal chronic intermittent hypoxia during gestation on offspring growth in the rat. Am. J. Obstet. Gynecol. 209:564 e561–564 e569.
    • (2013) Am. J. Obstet. Gynecol , vol.209
    • Iqbal, W.1    Ciriello, J.2
  • 15
    • 0036153117 scopus 로고    scopus 로고
    • Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation
    • Ishihara, N., H. Matsuo, H. Murakoshi, J. B. Laoag-Fernandez, T. Samoto, and T. Maruo. 2002. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am. J. Obstet. Gynecol. 186:158–166.
    • (2002) Am. J. Obstet. Gynecol , vol.186 , pp. 158-166
    • Ishihara, N.1    Matsuo, H.2    Murakoshi, H.3    Laoag-Fernandez, J.B.4    Samoto, T.5    Maruo, T.6
  • 16
    • 84930615356 scopus 로고    scopus 로고
    • Antenatal maternal hypoxia: Criterion for fetal growth restriction in rodents
    • Jang, E. A., L. D. Longo, and R. Goyal. 2015. Antenatal maternal hypoxia: criterion for fetal growth restriction in rodents. Front. Physiol. 6:176.
    • (2015) Front. Physiol , vol.6 , pp. 176
    • Jang, E.A.1    Longo, L.D.2    Goyal, R.3
  • 17
    • 33750426477 scopus 로고    scopus 로고
    • Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet
    • Jansson, N., J. Pettersson, A. Haafiz, A. Ericsson, I. Palmberg, M. Tranberg, et al. 2006. Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. J. Physiol. 576:935–946.
    • (2006) J. Physiol , vol.576 , pp. 935-946
    • Jansson, N.1    Pettersson, J.2    Haafiz, A.3    Ericsson, A.4    Palmberg, I.5    Tranberg, M.6
  • 18
    • 0033777446 scopus 로고    scopus 로고
    • Hypoxia prevents induction of aromatase expression in human trophoblast cells in culture: Potential inhibitory role of the hypoxia-inducible transcription factor Mash-2 (mammalian achaete-scute homologous protein-2)
    • Jiang, B., A. Kamat, and C. R. Mendelson. 2000. Hypoxia prevents induction of aromatase expression in human trophoblast cells in culture: potential inhibitory role of the hypoxia-inducible transcription factor Mash-2 (mammalian achaete-scute homologous protein-2). Mol. Endocrinol. 14:1661–1673.
    • (2000) Mol. Endocrinol , vol.14 , pp. 1661-1673
    • Jiang, B.1    Kamat, A.2    Mendelson, C.R.3
  • 19
    • 84924368654 scopus 로고    scopus 로고
    • Placenta growth factor induces invasion and activates p70 during rapamycin treatment in trophoblast cells
    • Knuth, A., L. Liu, H. Nielsen, D. Merril, D. S. Torry, and J. A. Arroyo. 2014. Placenta growth factor induces invasion and activates p70 during rapamycin treatment in trophoblast cells. Am. J. Reprod. Immunol. 73:330–340.
    • (2014) Am. J. Reprod. Immunol , vol.73 , pp. 330-340
    • Knuth, A.1    Liu, L.2    Nielsen, H.3    Merril, D.4    Torry, D.S.5    Arroyo, J.A.6
  • 20
    • 0030462177 scopus 로고    scopus 로고
    • Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree
    • Krebs, C., L. M. Macara, R. Leiser, A. W. Bowman, I. A. Greer, and J. C. Kingdom. 1996. Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree. Am. J. Obstet. Gynecol. 175:1534–1542.
    • (1996) Am. J. Obstet. Gynecol , vol.175 , pp. 1534-1542
    • Krebs, C.1    Macara, L.M.2    Leiser, R.3    Bowman, A.W.4    Greer, I.A.5    Kingdom, J.C.6
  • 22
    • 84959299504 scopus 로고    scopus 로고
    • Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy
    • Matheson, H., J. H. Veerbeek, D. S. Charnock-Jones, G. J. Burton, and H. W. Yung. 2015. Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy. J. Physiol. doi:10.1113/JP271073.
    • (2015) J. Physiol
    • Matheson, H.1    Veerbeek, J.H.2    Charnock-Jones, D.S.3    Burton, G.J.4    Yung, H.W.5
  • 23
    • 0037659698 scopus 로고    scopus 로고
    • Stereological investigation of placental morphology in pregnancies complicated by pre-eclampsia with and without intrauterine growth restriction
    • Mayhew, T. M., C. Ohadike, P. N. Baker, I. P. Crocker, C. Mitchell, and S. S. Ong. 2003. Stereological investigation of placental morphology in pregnancies complicated by pre-eclampsia with and without intrauterine growth restriction. Placenta 24:219–226.
    • (2003) Placenta , vol.24 , pp. 219-226
    • Mayhew, T.M.1    Ohadike, C.2    Baker, P.N.3    Crocker, I.P.4    Mitchell, C.5    Ong, S.S.6
  • 24
    • 0034685949 scopus 로고    scopus 로고
    • A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle
    • Milan, D., J. T. Jeon, C. Looft, V. Amarger, A. Robic, M. Thelander, et al. 2000. A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science 288:1248–1251.
    • (2000) Science , vol.288 , pp. 1248-1251
    • Milan, D.1    Jeon, J.T.2    Looft, C.3    Amarger, V.4    Robic, A.5    Thelander, M.6
  • 25
    • 34447503808 scopus 로고    scopus 로고
    • Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
    • Miled, N., Y. Yan, W. C. Hon, O. Perisic, M. Zvelebil, Y. Inbar, et al. 2007. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239–242.
    • (2007) Science , vol.317 , pp. 239-242
    • Miled, N.1    Yan, Y.2    Hon, W.C.3    Perisic, O.4    Zvelebil, M.5    Inbar, Y.6
  • 26
    • 84942549961 scopus 로고    scopus 로고
    • LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression
    • Mura, M., T. G. Hopkins, T. Michael, N. Abd-Latip, J. Weir, E. Aboagye, et al. 2015. LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression. Oncogene 34:5025–5036.
    • (2015) Oncogene , vol.34 , pp. 5025-5036
    • Mura, M.1    Hopkins, T.G.2    Michael, T.3    Abd-Latip, N.4    Weir, J.5    Aboagye, E.6
  • 27
    • 33645306841 scopus 로고    scopus 로고
    • Placental adaptive responses and fetal programming
    • Myatt, L. 2006. Placental adaptive responses and fetal programming. J. Physiol. 572:25–30.
    • (2006) J. Physiol , vol.572 , pp. 25-30
    • Myatt, L.1
  • 28
    • 0032921924 scopus 로고    scopus 로고
    • Hypoxia limits differentiation and upregulates expression and activity of prostaglandin H synthase 2 in cultured trophoblast from term human placenta
    • Nelson, D. M., R. D. Johnson, S. D. Smith, E. Y. Anteby, and Y. Sadovsky. 1999. Hypoxia limits differentiation and upregulates expression and activity of prostaglandin H synthase 2 in cultured trophoblast from term human placenta. Am. J. Obstet. Gynecol. 180:896–902.
    • (1999) Am. J. Obstet. Gynecol , vol.180 , pp. 896-902
    • Nelson, D.M.1    Johnson, R.D.2    Smith, S.D.3    Anteby, E.Y.4    Sadovsky, Y.5
  • 29
    • 0026573750 scopus 로고
    • Intrauterine growth retardation: Definition, classification, and etiology
    • Pollack, R. N., and M. Y. Divon. 1992. Intrauterine growth retardation: definition, classification, and etiology. Clin. Obstet. Gynecol. 35:99–107.
    • (1992) Clin. Obstet. Gynecol , vol.35 , pp. 99-107
    • Pollack, R.N.1    Divon, M.Y.2
  • 30
    • 84924955930 scopus 로고    scopus 로고
    • Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors
    • Qian, X. J., Y. T. Li, Y. Yu, F. Yang, R. Deng, J. Ji, et al. 2015. Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors. Oncotarget 6:5134–5146.
    • (2015) Oncotarget , vol.6 , pp. 5134-5146
    • Qian, X.J.1    Li, Y.T.2    Yu, Y.3    Yang, F.4    Deng, R.5    Ji, J.6
  • 31
    • 84903743629 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in cancer therapy
    • Rehman, G., A. Shehzad, A. L. Khan, and M. Hamayun. 2014. Role of AMP-activated protein kinase in cancer therapy. Arch. Pharm. 347:457–468.
    • (2014) Arch. Pharm , vol.347 , pp. 457-468
    • Rehman, G.1    Shehzad, A.2    Khan, A.L.3    Hamayun, M.4
  • 33
    • 34347211057 scopus 로고    scopus 로고
    • Mammalian target of rapamycin in the human placenta regulates leucine transport and is downregulated in restricted fetal growth
    • Roos, S., N. Jansson, I. Palmberg, K. Saljo, T. L. Powell, and T. Jansson. 2007. Mammalian target of rapamycin in the human placenta regulates leucine transport and is downregulated in restricted fetal growth. J. Physiol. 582:449–459.
    • (2007) J. Physiol , vol.582 , pp. 449-459
    • Roos, S.1    Jansson, N.2    Palmberg, I.3    Saljo, K.4    Powell, T.L.5    Jansson, T.6
  • 34
    • 0038112035 scopus 로고    scopus 로고
    • Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity
    • Roux, P. P., S. A. Richards, and J. Blenis. 2003. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol. Cell. Biol. 23:4796–4804.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 4796-4804
    • Roux, P.P.1    Richards, S.A.2    Blenis, J.3
  • 35
    • 84898986048 scopus 로고    scopus 로고
    • Effect of prenatal hypoxia in transgenic mouse models of preeclampsia and fetal growth restriction
    • Rueda-Clausen, C. F., J. L. Stanley, D. F. Thambiraj, R. Poudel, S. T. Davidge, and P. N. Baker. 2014. Effect of prenatal hypoxia in transgenic mouse models of preeclampsia and fetal growth restriction. Reprod. Sci. 21:492–502.
    • (2014) Reprod. Sci , vol.21 , pp. 492-502
    • Rueda-Clausen, C.F.1    Stanley, J.L.2    Thambiraj, D.F.3    Poudel, R.4    Davidge, S.T.5    Baker, P.N.6
  • 36
    • 84959271583 scopus 로고    scopus 로고
    • Effect of resveratrol on metabolic and cardiovascular function in male and female adult offspring exposed to prenatal hypoxia and a high-fat diet
    • Shah, A., L. M. Reyes, J. S. Morton, D. Fung, J. Schneider, and S. T. Davidge. 2015. Effect of resveratrol on metabolic and cardiovascular function in male and female adult offspring exposed to prenatal hypoxia and a high-fat diet. J. Physiol. doi:10.1113/JP271133.
    • (2015) J. Physiol
    • Shah, A.1    Reyes, L.M.2    Morton, J.S.3    Fung, D.4    Schneider, J.5    Davidge, S.T.6
  • 37
    • 84857373125 scopus 로고    scopus 로고
    • Rat placentation: An experimental model for investigating the hemochorial maternal-fetal interface
    • Soares, M. J., D. Chakraborty, M. A. Karim Rumi, T. Konno, and S. J. Renaud. 2012. Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface. Placenta 33:233–243.
    • (2012) Placenta , vol.33 , pp. 233-243
    • Soares, M.J.1    Chakraborty, D.2    Karim Rumi, M.A.3    Konno, T.4    Renaud, S.J.5
  • 39
    • 0028077905 scopus 로고
    • Experimental growth retardation produced by transient period of uteroplacental ischemia in pregnant Sprague-Dawley rats
    • Tanaka, M., M. Natori, H. Ishimoto, T. Miyazaki, T. Kobayashi, and S. Nozawa. 1994. Experimental growth retardation produced by transient period of uteroplacental ischemia in pregnant Sprague-Dawley rats. Am. J. Obstet. Gynecol. 171:1231–1234.
    • (1994) Am. J. Obstet. Gynecol , vol.171 , pp. 1231-1234
    • Tanaka, M.1    Natori, M.2    Ishimoto, H.3    Miyazaki, T.4    Kobayashi, T.5    Nozawa, S.6
  • 40
    • 0028287587 scopus 로고
    • Maternal hypoxia as a model for intrauterine growth retardation: Effects on insulin-like growth factors and their binding proteins
    • Tapanainen, P. J., P. Bang, K. Wilson, T. G. Unterman, H. J. Vreman, and R. G. Rosenfeld. 1994. Maternal hypoxia as a model for intrauterine growth retardation: effects on insulin-like growth factors and their binding proteins. Pediatr. Res. 36:152–158.
    • (1994) Pediatr. Res , vol.36 , pp. 152-158
    • Tapanainen, P.J.1    Bang, P.2    Wilson, K.3    Unterman, T.G.4    Vreman, H.J.5    Rosenfeld, R.G.6
  • 41
    • 79959806286 scopus 로고    scopus 로고
    • The intrauterine growth restriction phenotype: Fetal adaptations and potential implications for later life insulin resistance and diabetes
    • Thorn, S. R., P. J. Rozance, L. D. Brown, and W. W. Hay Jr. 2011. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin. Reprod. Med. 29:225–236.
    • (2011) Semin. Reprod. Med , vol.29 , pp. 225-236
    • Thorn, S.R.1    Rozance, P.J.2    Brown, L.D.3    Hay, W.W.4
  • 43
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., R. Loewith, and M. N. Hall. 2006. TOR signaling in growth and metabolism. Cell 124:471–484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.