Gene transfer to rodent hearts in vivo

Methods in Molecular Biology

Volumn 1521, Issue , 2017, Pages 195-204

  del Monte, Federica ^a   Ishikawa, Kiyotake ^b   Hajjar, Roger J ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Adeno virus; Adeno associated virus; Gene delivery; Modified RNA; Mouse; Plasmid; Rat; Small animals

Indexed keywords

ANTIBIOTIC AGENT; CHOLESTEROL; DISTEAROYLPHOSPHATIDYLCHOLINE; DOUBLE STRANDED DNA; VIRUS VECTOR;

ANALGESIA; ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC PROPHYLAXIS; AORTA CLAMPING; CARDIOVASCULAR GENE THERAPY; CONTROLLED STUDY; FEMALE; GENE TRANSFER; GENETIC MANIPULATION; HEART; HEART VENTRICLE WALL; IN VIVO STUDY; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PULMONARY ARTERY; RAT; RODENT; TAIL VEIN; TISSUE SPECIFICITY; ANESTHESIA; ANIMAL; AORTA; GENE VECTOR; INJECTION; METABOLISM; PHYSIOLOGY; VEIN;

ANESTHESIA; ANIMALS; AORTA; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEART; INJECTIONS; MALE; PULMONARY ARTERY; RATS; VEINS;

EID: 85006018063     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-6588-5_13     Document Type: Chapter

References (15)

1. Hajjar RJ (2013) Potential of gene therapy as a treatment for heart failure. J Clin Invest 123(1):53-61. doi:10.1172/JCI62837
2. Gomes AC, Falcao-Pires I, Pires AL, Bras-Silva C, Leite-Moreira AF (2013) Rodent models of heart failure: an updated review. Heart Fail Rev 18(2):219-249. doi:10.1007/s10741-012-9305-3
3. Gray SJ, Samulski RJ (2008) Optimizing gene delivery vectors for the treatment of heart disease. Expert Opin Biol Ther 8(7):911-922. doi:10.1517/14712598.8.7.911
4. Lin H, Parmacek MS, Morle G, Bolling S, Leiden JM (1990) Expression of recombinant genes in myocardium in vivo after direct injection of DNA. Circulation 82(6):2217-2221
5. Barr E, Carroll J, Kalynych AM, Tripathy SK, Kozarsky K, Wilson JM, Leiden JM (1994) Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther 1(1):51-58
6. Hajjar RJ, Schmidt U, Matsui T, Guerrero JL, Lee KH, Gwathmey JK, Dec GW, Semigran MJ, Rosenzweig A (1998) Modulation of ventricular function through gene transfer in vivo. Proc Natl Acad Sci U S A 95(9):5251-5256
7. Bish LT, Morine K, Sleeper MM, Sanmiguel J, Wu D, Gao G, Wilson JM, Sweeney HL (2008) Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat. Hum Gene Ther 19(12):1359-1368. doi:10.1089/hum.2008.123
8. Turnbull IC, Eltoukhy AA, Fish KM, Nonnenmacher M, Ishikawa K, Chen J, Hajjar RJ, Anderson DG, Costa KD (2016) Myocardial delivery of lipidoidnanoparticlecarryingmodRNAinducesrapidandtransientexpression.MolTher24:66.doi:10.1038/mt.2015.193
9. Bradshaw AC, Baker AH (2013) Gene therapy for cardiovascular disease: perspectives and potential. Vascul Pharmacol 58(3):174-181. doi:10.1016/j.vph.2012.10.008
10. Tang T, Gao MH, Hammond HK (2012) Prospects for gene transfer for clinical heart failure. Gene Ther 19(6):606-612. doi:10.1038/gt.2012.36
11. Hammoudi N, Ishikawa K, Hajjar RJ (2015) Adeno-associated virus-mediated gene therapy in cardiovascular disease. Curr Opin Cardiol 30(3):228-234. doi:10.1097/HCO.0000000000000159
12. Di Pasquale E, Latronico MV, Jotti GS, Condorelli G (2012) Lentiviral vectors and cardiovascular diseases: a genetic tool for manipulating cardiomyocyte differentiation and function. Gene Ther 19(6):642-648. doi:10.1038/gt.2012.19
13. Williams PD, Kingston PA (2011) Plasmidmediated gene therapy for cardiovascular disease. Cardiovasc Res 91(4):565-576. doi:10.1093/cvr/cvr197
14. Chien KR, Zangi L, Lui KO (2015) Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. Cold Spring Harb Perspect Med 5(1):a014035. doi:10.1101/cshperspect.a014035
15. Festing MF, Altman DG (2002) Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR J 43(4):244-258