Role of primary T-cell immunodeficiency and hepatitis B coinfection on spontaneous clearance of hepatitis C: The BC Hepatitis Testers Cohort

Journal of Viral Hepatitis

Volumn 24, Issue 5, 2017, Pages 421-429

  Islam, N ^a,b   Krajden, M ^a,b   Gilbert, M ^b,c   Gustafson, P ^a   Yu, A ^b   Kuo, M ^b   Chong, M ^b   Alvarez, M ^b   Wong, J ^a,b   Tyndall, M W ^a,b   Janjua, N Z ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CENTRE FOR DISEASE CONTROL   (Canada)

^c ONTARIO HIV TREATMENT NETWORK   (Canada)

Author keywords

genotype; hepatitis B virus; hepatitis C virus; spontaneous resolution; T cell immunodeficiency

Indexed keywords

ADULT; ARTICLE; CANADA; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HEPATITIS B; HEPATITIS C; HUMAN; IMMUNE DEFICIENCY; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PRIMARY T CELL IMMUNODEFICIENCY; SEROCONVERSION; SEX DIFFERENCE; VIRAL CLEARANCE; AGED; BLOOD; BRITISH COLUMBIA; COMPLICATION; HEPACIVIRUS; ISOLATION AND PURIFICATION; MIDDLE AGED; POLYMERASE CHAIN REACTION; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

VIRUS RNA;

ADULT; AGED; AGED, 80 AND OVER; BRITISH COLUMBIA; COINFECTION; FEMALE; HEPACIVIRUS; HEPATITIS B; HEPATITIS C; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RNA, VIRAL; YOUNG ADULT;

EID: 85005931187     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12650     Document Type: Article

References (46)

1. Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013;57:1333–1342.
2. Gerlach JT, Diepolder HM, Zachoval R, et al. Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance. Gastroenterology. 2003;125:80–88.
3. Grebely J, Raffa JD, Mmath CL, Krajden M, Conway B, Tyndall MW. Factors associated with spontaneous clearance of hepatitis C virus among illicit drug users. Can J Gastroenterol. 2007;21:447–451.
4. Jauncey M, Micallef JM, Gilmour S, et al. Clearance of hepatitis C virus after newly acquired infection in injection drug users. J Infect Dis. 2004;190:1270–1274.
5. Micallef JM, Kaldor JM, Dore GJ. Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. J Viral Hepat. 2006;13:34–41.
6. Seeff LB. Natural history of chronic hepatitis C. Hepatology. 2002;36(5 Suppl 1):S35–S46.
7. Thomas DL, Astemborski J, Rai RM, et al. The natural history of hepatitis C virus infection: host, viral, and environmental factors. JAMA. 2000;284:450–456.
8. Villano SA, Vlahov D, Nelson KE, Cohn S, Thomas DL. Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection. Hepatology. 1999;29:908–914.
9. Grebely J, Prins M, Hellard M, et al. Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine. Lancet Infect Dis. 2012;12:408–414.
10. Schulze Zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, et al. Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. J Exp Med. 2012;209:61–75.
11. Kong F, Pan Y, Chi X, et al. Factors associated with spontaneous clearance of hepatitis C virus in Chinese population. Biomed Res Int. 2014;2014:527030.
12. Zhang M, Rosenberg PS, Brown DL, et al. Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia. Blood. 2006;107:892–897.
13. Chang KM, Thimme R, Melpolder JJ, et al. Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection. Hepatology. 2001;33:267–276.
14. Day CL, Lauer GM, Robbins GK, et al. Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection. J Virol. 2002;76:12584–12595.
15. Grakoui A, Shoukry NH, Woollard DJ, et al. HCV persistence and immune evasion in the absence of memory T cell help. Science. 2003;302:659–662.
16. Thimme R, Bukh J, Spangenberg HC, et al. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Natl Acad Sci USA. 2002;99:15661–15668.
17. Piasecki BA, Lewis JD, Reddy KR, et al. Influence of alcohol use, race, and viral coinfections on spontaneous HCV clearance in a US veteran population. Hepatology. 2004;40:892–899.
18. van den Berg CH, Grady BP, Schinkel J, et al. Female sex and IL28B, a synergism for spontaneous viral clearance in hepatitis C virus (HCV) seroconverters from a community-based cohort. PLoS ONE. 2011;6:e27555.
19. Melendez-Morales L, Konkle BA, Preiss L, et al. Chronic hepatitis B and other correlates of spontaneous clearance of hepatitis C virus among HIV-infected people with hemophilia. AIDS. 2007;21:1631–1636.
20. British Columbia Ministry of Health [creator]. Client Roster (Client Registry System/Enterprise Master Patient Index). British Columbia Ministry of Health [publisher]. Data Extract. MOH (2013). 2014. http://www.health.gov.bc.ca/data/
21. British Columbia Ministry of Health [creator]. Medical Services Plan (MSP) Payment Information File. British Columbia Ministry of Health [publisher]. Data Extract. MOH (2013). 2014. http://www.health.gov.bc.ca/data/
22. British Columbia Ministry of Health [creator]. Discharge Abstract Database (Hospital Separations). British Columbia Ministry of Health [publisher]. Data Extract. MOH (2013). 2014. http://www.health.gov.bc.ca/data/
23. British Columbia Ministry of Health [creator]. PharmaCare. British Columbia Ministry of Health [publisher]. Data Extract. MOH (2013). 2014. http://www.health.gov.bc.ca/data/
24. British Columbia Ministry of Health [creator]. PharmaNet. British Columbia Ministry of Health [publisher]. Data Extract. MOH (2013). 2014. http://www.health.gov.bc.ca/data/
25. Janjua NZ, Kuo M, Chong M, et al. Assessing hepatitis C burden and treatment effectiveness through the British Columbia Hepatitis Testers Cohort (BC-HTC): design and characteristics of linked and unlinked participants. PLoS ONE. 2016;11:e0150176.
26. Janjua NZ, Yu A, Kuo M, et al. Twin epidemics of new and prevalent hepatitis C infections in Canada: BC Hepatitis Testers Cohort. BMC Infect Dis. 2016;16:334.
27. Sacks-Davis R, Grebely J, Dore GJ, et al. Hepatitis C virus reinfection and spontaneous clearance of reinfection–the InC3 study. J Infect Dis. 2015;212:1407–1419.
28. International Union of Immunological Societies Expert Committee on Primary Immunodeficiencies, Notarangelo LD, Fischer A, et al. Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol. 2009;124:1161–1178.
29. BC Centre for Disease Control. STI/HIV Prevention and Control. Communicable Disease Control Manual. Vancouver, BC: BC Centre for Disease Control; 2013.
30. Pampalon R, Hamel D, Gamache P, Philibert MD, Raymond G, Simpson A. An area-based material and social deprivation index for public health in Quebec and Canada. Can J Public Health. 2012;103(8 Suppl 2):S17–S22.
31. Omland LH, Osler M, Jepsen P, et al. Socioeconomic status in HCV infected patients – risk and prognosis. Clin Epidemiol. 2013;5:163–172.
32. Raison CL, Broadwell SD, Borisov AS, et al. Depressive symptoms and viral clearance in patients receiving interferon-α and ribavirin for hepatitis C. Brain Behav Immun. 2005;19:23–27.
33. Seaberg EC, Witt MD, Jacobson LP, et al. Spontaneous clearance of the hepatitis C virus among men who have sex with men. Clin Infect Dis. 2015;61:1381–1388.
34. Liaw YF, Yeh CT, Tsai SL. Impact of acute hepatitis B virus superinfection on chronic hepatitis C virus infection. Am J Gastroenterol. 2000;95:2978–2980.
35. Frese M, Pietschmann T, Moradpour D, Haller O, Bartenschlager R. Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway. J Gen Virol. 2001; 82(Pt 4):723–733.
36. Lehmann M, Meyer MF, Monazahian M, Tillmann HL, Manns MP, Wedemeyer H. High rate of spontaneous clearance of acute hepatitis C virus genotype 3 infection. J Med Virol. 2004;73:387–391.
37. Blanco J-R, Rivero-Juarez A. HCV genotype 3: a wolf in sheep's clothing. Expert Rev Anti Infect Ther. 2016;00:1–4.
38. Grebely J, Page K, Sacks-Davis R, et al. The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. Hepatology. 2014;59:109–120.
39. Harris HE, Eldridge KP, Harbour S, Alexander G, Teo CG, Ramsay ME. Does the clinical outcome of hepatitis C infection vary with the infecting hepatitis C virus type? J Viral Hepat. 2007;14:213–220.
40. Thomson EC, Fleming VM, Main J, et al. Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men. Gut. 2011;60:837–845.
41. Mekky RY, Abdelaziz AI. Sex hormones and HCV: an unresolved mystery. Expert Rev Gastroenterol Hepatol. 2013;7:69–75.
42. Hayashida K, Shoji I, Deng L, Jiang DP, Ide YH, Hotta H. 17beta-estradiol inhibits the production of infectious particles of hepatitis C virus. Microbiol Immunol. 2010;54:684–690.
43. Langer C, Gansz B, Goepfert C, et al. Testosterone up-regulates scavenger receptor BI and stimulates cholesterol efflux from macrophages. Biochem Biophys Res Commun. 2002;296:1051–1057.
44. Thomas DL, Thio CL, Martin MP, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461:798–801.
45. Aitken CK, Lewis J, Tracy SL, et al. High incidence of hepatitis C virus reinfection in a cohort of injecting drug users. Hepatology. 2008;48:1746–1752.
46. Janjua N, Kuo M, Yu A, et al. Assessing Injection Drug Use from Diagnostic Codes in Administrative Healthcare Data: the British Columbia Hepatitis Testers Cohort. 25th Annual Canadian Conference on HIV/AIDS Research (CAHR 2016). Winnipeg, Manitoba 2016.