Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: Involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway

Journal of Ethnopharmacology

Volumn 194, Issue , 2016, Pages 850-860

  Chen, Yuping ^a,b,c   Wu, Yunhao ^a,b   Gan, Xiaoyang ^a,b   Liu, Kai ^a,b   Lv, Xing ^a,b   Shen, Hongsheng ^a,b   Dai, Guoying ^a,b   Xu, Huiqin ^a,b  

^a Key Laboratory of Traditional Chinese Medicine Processing of Jiangsu Province   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Advanced glycation end products; Cornus officinalis; Diabetic testicular damage; Iridoid glycoside; P38 MAPK

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; BIOLOGICAL MARKER; CATALASE; CORNUS OFFICINALIS EXTRACT; CREATININE; FOLLITROPIN; GLUCOSE; GONADORELIN; HERBACEOUS AGENT; INSULIN; IRIDOID; LACTATE DEHYDROGENASE; LOGANIN; LUTEINIZING HORMONE; MALONALDEHYDE; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MORRONISIDE; NITROGEN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TESTOSTERONE; UNCLASSIFIED DRUG; UREA; AGER PROTEIN, RAT; PLANT EXTRACT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORNUS; CORNUS OFFICINALIS; CREATININE BLOOD LEVEL; DOWN REGULATION; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME INHIBITION; FOLLITROPIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HISTOLOGY; HORMONE BLOOD LEVEL; HYPERPHAGIA; INSULIN BLOOD LEVEL; KIDNEY FUNCTION; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID DIET; LOW DRUG DOSE; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; POLYDIPSIA; POLYURIA; PROTEIN URINE LEVEL; SIGNAL TRANSDUCTION; SPERMATOCYTE; SPERMATOZOON COUNT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TESTIS FUNCTION; TESTIS INJURY; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; UREA NITROGEN BLOOD LEVEL; URINARY EXCRETION; WEIGHT REDUCTION; ANIMAL; CHEMISTRY; COMPLICATION; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; RAT; TESTICULAR DISEASES;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANIMALS; CORNUS; DIABETES MELLITUS, EXPERIMENTAL; DRUGS, CHINESE HERBAL; GLYCOSYLATION END PRODUCTS, ADVANCED; IRIDOID GLYCOSIDES; MALE; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLANT EXTRACTS; RATS; TESTICULAR DISEASES;

EID: 85004178574     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.10.079     Document Type: Article

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