Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

ACS Medicinal Chemistry Letters

Volumn 7, Issue 12, 2016, Pages 1213-1218

  Navratilova, Iva ^a   Aristotelous, Tonia ^a   Picaud, Sarah ^b,c   Chaikuad, Apirat ^b,c   Knapp, Stefan ^b,c   Filappakopoulos, Panagis ^b,d   Hopkins, Andrew L ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

BRD4; Bromodomains; CREBBP; fragment screening; PCAF; surface plasmon resonance

Indexed keywords

BROMODOMAIN CONTAINING PROTEIN 4; BROMODOMAIN INHIBITOR; CARRIER PROTEINS AND BINDING PROTEINS; CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN 1 BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DIMETHYL SULFOXIDE; HISTONE ACETYLTRANSFERASE PCAF; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SCREENING; ENZYME INHIBITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

EID: 85003906189     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.6b00154     Document Type: Article

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