Sympathetic overactivity prevails over the vascular amplifier phenomena in a chronic kidney disease rat model of hypertension

Physiological Reports

Volumn 2, Issue 11, 2014, Pages

  Ameer, Omar Z ^a   Hildreth, Cara M ^a   Phillips, Jacqueline K ^a  

^a MACQUARIE UNIVERSITY   (Australia)

Author keywords

Chronic kidney disease; Ganglion blockade; Sympathetic nervous system; Vascular amplifier

Indexed keywords

ADENOSINE; HEXAMETHONIUM; NITROPRUSSIDE SODIUM;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOPOTENTIAL AMPLIFIER; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DEPRESSOR RESPONSE; DIASTOLIC BLOOD PRESSURE; ESSENTIAL HYPERTENSION; FEMALE; GANGLION BLOCK; HEART RATE; HEMODYNAMIC PARAMETERS; KIDNEY POLYCYSTIC DISEASE; LPK RAT; MALE; MEAN ARTERIAL PRESSURE; NERVE CONDUCTION; NONHUMAN; PULSE PRESSURE; RAT; SYMPATHETIC NERVE; SYSTOLIC BLOOD PRESSURE; TRACHEOSTOMY; VASODILATATION; VASOMOTOR REFLEX;

EID: 85003561696     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12205     Document Type: Article

References (36)

1. Abdala, A. P., F. D. McBryde, N. Marina, E. B. Hendy, Z. J. Engelman, M. Fudim, et al. 2012. Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat. J. Physiol. 590: 4269-4277.
2. Adams, M. A., A. Bobik, and P. I. Korner. 1989. Differential development of vascular and cardiac hypertrophy in genetic hypertension. Relation to sympathetic function. Hypertension 14:191-202.
3. Adams, M. A., A. Bobik, and P. I. Korner. 1990. Enalapril can prevent vascular amplifier development in spontaneously hypertensive rats. Hypertension 16:252-260.
4. Bevan, R. D. 1984. Trophic effects of peripheral adrenergic nerves on vascular structure. Hypertension, 6: III19-III26.
5. Biancardi, V. C., C. T. Bergamaschi, O. U. Lopes, and R. R. Campos. 2007. Sympathetic activation in rats with L-NAME-induced hypertension. Braz. J. Med. Biol. Res. 40:401-408.
6. Black, M. J., P. Kanellakis, and A. Bobik. 1997. Role of angiotensin II in early cardiovascular growth and vascular amplifier development in spontaneously hypertensive rats. J. Hypertens. 15:945-954.
7. Diedrich, A., J. Jordan, J. Tank, J. R. Shannon, R. Robertson, F. C. Luft, et al. 2003. The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade. J. Hypertens. 21:1677-1686.
8. Fink, G. D., and J. M. Ploucha. 1986. Contribution of the autonomic nervous system and vasopressin to elevated vascular resistance in the spontaneously hypertensive rat. J. Hypertens. 4(Suppl. 6):S594-S596.
9. Folkow, B., and G. Karlstrom. 1984. Age-and pressure-dependent changes of systemic resistance vessels concerning the relationships between geometric design, wall distensibility, vascular reactivity and smooth muscle sensitivity. Acta Physiol. Scand. 122:17-33.
10. Franklin, S. S., S. A. Khan, N. D. Wong, M. G. Larson, and D. Levy. 1999. Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart study. Circulation 100:354-360.
11. Grassi, G., F. Quarti-Trevano, G. Seravalle, F. Arenare, M. Volpe, S. Furiani, et al. 2011. Early sympathetic activation in the initial clinical stages of chronic renal failure. Hypertension 57:846-851.
12. Harrison, J. L., C. M. Hildreth, S. M. Callahan, A. K. Goodchild, and J. K. Phillips. 2010. Cardiovascular autonomic dysfunction in a novel rodent model of polycystic kidney disease. Auton. Neurosci. 152:60-66.
13. Head, G. A. 2003. The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade. J. Hypertens. 21:1619-1621.
14. Hildreth, C. M., D. S. Kandukuri, A. K. Goodchild, and J. K. Phillips. 2013. Temporal development of baroreceptor dysfunction in a rodent model of chronic kidney disease. Clin. Exp. Pharmacol. Physiol. 40:458-465.
15. Johansson, M., M. Elam, B. Rundqvist, G. Eisenhofer, H. Herlitz, G. Lambert, et al. 1999. Increased sympathetic nerve activity in renovascular hypertension. Circulation 99:2537-2542.
16. Judy, W. V., A. M. Watanabe, D. P. Henry, H. R. Besch, W. R. Murphy Jr, and G. M. Hockel. 1976. Sympathetic nerve activity: role in regulation of blood pressure in the spontaenously hypertensive rat. Circ. Res., 38:21-29.
17. Klein, I. H., G. Ligtenberg, P. L. Oey, H. A. Koomans, and P. J. Blankestijn. 2001. Sympathetic activity is increased in polycystic kidney disease and is associated with hypertension. J. Am. Soc. Nephrol. 12:2427-2433.
18. Li, Q., W. E. Dale, E. M. Hasser, and E. H. Blaine. 1996. Acute and chronic angiotensin hypertension: neural and nonneural components, time course, and dose dependency. Am. J. Physiol. 271:R200-R207.
19. London, G. M., and A. Guerin. 1999. Influence of arterial pulse and reflective waves on systolic blood pressure and cardiac function. J. Hypertens. Suppl. 17:S3-S6.
20. McCooke, J. K., R. Appels, R. A. Barrero, A. Ding, J. E. Ozimek-Kulik, M. I. Bellgard, et al. 2012. A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8. BMC Genom. 13:1471-2164.
21. Moretti, J. L., S. L. Burke, R. G. Evans, G. W. Lambert, and G. A. Head. 2009. Enhanced responses to ganglion blockade do not reflect sympathetic nervous system contribution to angiotensin II-induced hypertension. J. Hypertens. 27:1838-1848.
22. Murphy, C. A., R. P. Sloan, and M. M. Myers. 1991. Pharmacologic responses and spectral analyses of spontaneous fluctuations in heart rate and blood pressure in SHR rats. J. Auton. Nerv. Syst. 36:237-250.
23. Ng, K., C. M. Hildreth, J. K. Phillips, and A. P. Avolio. 2011. Aortic stiffness is associated with vascular calcification and remodeling in a chronic kidney disease rat model. Am. J. Physiol. Renal. Physiol. 300:F1431-F1436.
24. Osborn, J. W., Jr, M. M. Skelton, and A. W. Cowley, Jr. 1987. Hemodynamic effects of vasopressin compared with angiotensin II in conscious rats. Am. J. Physiol., 252:H628-H637.
25. Phillips, J. K., D. Hopwood, R. A. Loxley, K. Ghatora, J. D. Coombes, Y. S. Tan, et al. 2007. Temporal relationship between renal cyst development, hypertension and cardiac hypertrophy in a new rat model of autosomal recessive polycystic kidney disease. Kidney Blood Press. Res. 30:129-144.
26. Salman, I. M., C. M. Hildreth, O. Z. Ameer, and J. K. Phillips. 2014. Differential contribution of afferent and central pathways to the development of baroreflex dysfunction in chronic kidney disease. Hypertension 63:804-810.
27. Santajuliana, D., B. J. Hornfeldt, and J. W. Osborn. 1996. Use of ganglionic blockers to assess neurogenic pressor activity in conscious rats. J. Pharmacol. Toxicol. Methods 35:45-54.
28. Shannon, J. R., N. L. Flattem, J. Jordan, G. Jacob, B. K. Black, I. Biaggioni, et al. 2000. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N. Engl. J. Med. 342:541-549.
29. Shimokawa, A., T. Kunitake, M. Takasaki, and H. Kannan. 1998. Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats. J. Auton. Nerv. Syst. 72:46-54.
30. Smid, S. D., D. B. Frewin, C. L. Wyartt, and R. J. Head. 1995. Functional tolerance to alpha-adrenergic receptor blockade in the spontaneously hypertensive rat highlights the multifunctional role of vascular angiotensin II in the development of hypertension. J. Vasc. Res. 32:247-253.
31. Stauss, H. M. 2007. Identification of blood pressure control mechanisms by power spectral analysis. Clin. Exp. Pharmacol. Physiol. 34:362-368.
32. Stauss, H. M., R. Mrowka, B. Nafz, A. Patzak, T. Unger, and P. B. Persson. 1995. Does low frequency power of arterial blood pressure reflect sympathetic tone? J. Auton. Nerv. Syst. 54:145-154.
33. Vanness, J. M., C. Hinojosa-Laborde, T. Craig, and J. R. Haywood. 1999. Effect of sinoaortic deafferentation on renal wrap hypertension. Hypertension 33:476-481.
34. Wang, G. F., X. J. Mao, and Z. J. Chen. 2014. Urethane suppresses renal sympathetic nerve activity in Wistar rats. Eur. Rev. Med. Pharmacol. Sci. 18:1454-1457.
35. Wright, C. E., and J. A. Angus. 1999. Enhanced total peripheral vascular responsiveness in hypertension accords with the amplifier hypothesis. J. Hypertens. 17:1687-1696.
36. Zoccali, C., F. Mallamaci, S. Parlongo, S. Cutrupi, F. A. Benedetto, G. Tripepi, et al. 2002. Plasma norepinephrine predicts survival and incident cardiovascular events in patients with end-stage renal disease. Circulation 105:1354-1359.