PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle

Physiological Reports

Volumn 2, Issue 7, 2014, Pages

  Bhattachariya, Anirban ^a   Turczyńska, Karolina M ^a   Grossi, Mario ^a   Nordström, Ina ^a   Buckbinder, Leonard ^b   Albinsson, Sebastian ^a   Hellstrand, Per ^a  

^a LUND UNIVERSITY   (Sweden)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Calcium; Contraction; Ion channel; PF 4594755; Stretch

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; ANGIOTENSIN II; CALCIUM; CALCIUM CHANNEL L TYPE; CIRAZOLINE; FOCAL ADHESION KINASE 2; INTEGRIN; LOSARTAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NIFEDIPINE;

ADRENERGIC STIMULATION; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DNA SYNTHESIS; GENE ACTIVATION; GENE EXPRESSION REGULATION; MUSCLE CONTRACTURE; MUSCLE DEVELOPMENT; MUSCLE GROWTH; MUSCLE STRETCHING; NONHUMAN; ORGAN CULTURE; POLYMERASE CHAIN REACTION; PORTAL VEIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

EID: 85002654040     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12080     Document Type: Article

References (33)

1. Aalkjaer, C., A. M. Heagerty, K. K. Petersen, J. D. Swales, and M. J. Mulvany. 1987. Evidence for increased media thickness, increased neuronal amine uptake, and depressed excitation-contraction coupling in isolated resistance vessels from essential hypertensives. Circ. Res. 61:181-186.
2. Albinsson, S., I. Nordström, and P. Hellstrand. 2004. Stretch of the vascular wall induces smooth muscle differentiation by promoting actin polymerization. J. Biol. Chem. 279:34849-34855.
3. Albinsson, S., A. Bhattachariya, and P. Hellstrand. 2014. Stretch-dependent smooth muscle differentiation in the portal vein—role of actin polymerization, calcium signaling, and microRNAs. Microcirculation 21:230-238.
4. Avraham, H., S.-Y. Park, K. Schinkmann, and S. Avraham. 2000. RAFTK/Pyk2-mediated cellular signalling. Cell. Signal. 12:123-133.
5. Beech, D. J. 2007. Ion channel switching and activation in smooth-muscle cells of occlusive vascular diseases. Biochem. Soc. Trans. 35:890-894.
6. Bonnette, P. C., B. S. Robinson, J. C. Silva, M. P. Stokes, A. D. Brosius, A. Baumann, et al. 2010. Phosphoproteomic characterization of PYK2 signaling pathways involved in osteogenesis. J. Proteo. 73:1306-1320.
7. Buckbinder, L., D. T. Crawford, H. Qi, H. Z. Ke, L. M. Olsonfill, K. R. Longfi, et al. 2007. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc. Natl Acad. Sci. USA 104:10619-10624.
8. Dikic, I., G. Tokiwa, S. Lev, S. A. Courtneidge, and J. Schlessinger. 1996. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383:547-550.
9. 2+ entry into contractile vascular smooth muscle following organ culture. J. Vasc. Res. 38:324-331.
10. Gadepalli, R., N. K. Singh, V. Kundumani-Sridharan, M. R. Heckle, and G. N. Rao. 2012. Novel role of proline-rich nonreceptor tyrosine kinase 2 in vascular wall remodeling after balloon injury. Arterioscler. Thromb. Vasc. Biol. 32:2652-2661.
11. Iwasaki, H., T. Yoshimoto, T. Sugiyama, and Y. Hirata. 2003. Activation of cell adhesion kinase beta by mechanical stretch in vascular smooth muscle cells. Endocrinology 144:2304-2310.
12. Johansson, B., and S. Mellander. 1975. Static and dynamic components in the vascular myogenic response to passive changes in length as revealed by electrical and mechanical recordings from the rat portal vein. Circ. Res. 36:76-83.
13. Knot, H. J., and M. T. Nelson. 1998. Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure. J. Physiol. 508:199-209.
14. Lev, S., H. Moreno, R. Martinez, P. Canoll, E. Peles, J. M. Musacchio, et al. 1995. Protein-tyrosine kinase Pyk2 Involved in Ca2+-induced regulation of ion-channel and map kinase functions. Nature 376:737-745.
15. Malmqvist, U., and A. Arner. 1990. Isoform distribution and tissue contents of contractile and cytoskeletal proteins in hypertrophied smooth muscle from rat portal vein. Circ. Res. 66:832-845.
16. Mederos y Schnitzler, M., U. Storch, S. Meibers, P. Nurwakagari, A. Breit, K. Essin, et al. 2008. Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J. 27:3092-3103.
17. Miralles, F., G. Posern, A. I. Zaromytidou, and R. Treisman. 2003. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113:329-342.
18. Owens, G. K. 1995. Regulation of differentiation of vascular smooth muscle cells. Physiol. Rev. 75:487-517.
19. Perez, J., R. A. Torres, P. Rocic, M. J. Cismowski, D. S. Weber, V. M. Darley-Usmar, et al. 2011. PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation. Am. J. Physiol.-Cell Physiol. 301: C242-C251.
20. Ren, J., S. Albinsson, and P. Hellstrand. 2010. Distinct effects of voltage-and store-dependent calcium influx on stretch-induced differentiation and growth in vascular smooth muscle. J. Biol. Chem. 285:31829-31839.
21. Sabri, A., G. Govindarajan, T. M. Griffin, K. L. Byron, A. M. Samarel, and P. A. Lucchesi. 1998. Calcium-and protein kinase C-dependent activation of the tyrosine kinase PYK2 by angiotensin II in vascular smooth muscle. Circ. Res. 83:841-851.
22. Sekimoto, H., J. Eipper-Mains, S. Pond-Tor, and C. M. Boney. 2005. alpha v beta 3 Integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells. Mol. Endocrinol. 19:1859-1867.
23. Shen, X. C., G. Xi, Y. Radhakrishnan, and D. R. Clemmons. 2010. Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells. Cell. Mol. Life Sci. 67:3893-3903.
24. Spencer, N. J., and I. A. Greenwood. 2003. Characterization of properties underlying rhythmicity in mouse portal vein. Auton. Neurosci.-Basic 104:73-82.
25. Swärd, K., M. Josefsson, M. L. Lydrup, and P. Hellstrand. 1993. Effects of metabolic inhibition on cytoplasmic calcium and contraction in smooth muscle of rat portal vein. Acta Physiol. Scand. 148:265-272.
26. Walsh, M. P., and W. C. Cole. 2013. The role of actin filament dynamics in the myogenic response of cerebral resistance arteries. J. Cereb. Blood Flow Metab. 33:1-12.
27. Wamhoff, B. R., D. K. Bowles, O. G. McDonald, S. Sinha, A. P. Somlyo, A. V. Somlyo, et al. 2004. L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/ myocardin/SRF-dependent mechanism. Circ. Res. 95:406-414.
28. Wamhoff, B. R., D. K. Bowles, and G. K. Owens. 2006. Excitation-transcription coupling in arterial smooth muscle. Circ. Res. 98:868-878.
29. Wang, Z., D. Z. Wang, D. Hockemeyer, J. McAnally, A. Nordheim, and E. N. Olson. 2004. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428:185-189.
30. Ying, Z., F. R. Giachini, R. C. Tostes, and R. C. Webb. 2009. PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA. Arterioscler. Thromb. Vasc. Biol. 29:1657-1663.
31. Zeidan, A., I. Nordström, K. Dreja, U. Malmqvist, and P. Hellstrand. 2000. Stretch-dependent modulation of contractility and growth in smooth muscle of rat portal vein. Circ. Res. 87:228-234.
32. Zeidan, A., I. Nordström, S. Albinsson, U. Malmqvist, K. Swärd, and P. Hellstrand. 2003. Stretch-induced contractile differentiation of vascular smooth muscle: sensitivity to actin polymerization inhibitors. Am. J. Physiol.-Cell Physiol. 284:C1387-C1396.
33. Zhang, Z., M. Wang, X. H. Fan, J. H. Chen, Y. Y. Guan, and Y. B. Tang. 2012. Upregulation of TRPM7 channels by angiotensin II triggers phenotypic switching of vascular smooth muscle cells of ascending aorta. Circ. Res. 111:1137-1146.