Exercise and Hypertension: Uncovering the Mechanisms of Vascular Control

Progress in Cardiovascular Diseases

Volumn 59, Issue 3, 2016, Pages 226-234

  Sabbahi, Ahmad ^a   Arena, Ross ^a   Elokda, Ahmed ^b   Phillips, Shane A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b FLORIDA GULF COAST UNIVERSITY   (United States)

Author keywords

Aerobic exercise; Exercise; Exercise training; Hypertension; Resistance exercise

Indexed keywords

NITRIC OXIDE;

ADRENERGIC STIMULATION; AEROBIC EXERCISE; ARTERIAL STIFFNESS; ARTERIAL WALL THICKNESS; AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR DISEASE; ENDOTHELIAL DYSFUNCTION; EXERCISE; EXERCISE INTENSITY; HEART OUTPUT; HUMAN; HYPERTENSION; ISOMETRIC EXERCISE; MEAN ARTERIAL PRESSURE; POST EXERCISE HYPOTENSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RESISTANCE TRAINING; REVIEW; SHEAR STRESS; VASCULAR RESISTANCE; BLOOD PRESSURE; KINESIOTHERAPY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

BLOOD PRESSURE; EXERCISE; EXERCISE THERAPY; HUMANS; HYPERTENSION;

EID: 85001831600     PISSN: 00330620     EISSN: 18731740     Source Type: Journal    
DOI: 10.1016/j.pcad.2016.09.006     Document Type: Review

References (92)

1. 1. Mozaffarian, D., Benjamin, E.J., Go, A.S., et al. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation 131:4 (2015), e29–e322, 10.1161/CIR.0000000000000152.
2. 2. Pescatello, L.S., MacDonald, H.V., Lamberti, L., Johnson, B.T., Exercise for hypertension: aprescription update integrating existing recommendations with emerging research. Curr Hypertens Rep, 17(11), 2015, 10.1007/s11906–015-0600-y.
3. 3. Lim, S.S., Vos, T., Flaxman, A.D., et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:9859 (2012), 2224–2260, 10.1016/S0140-6736(12)61766-8.
4. 4. Rapsomaniki, E., Timmis, A., George, J., et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet 383:9932 (2014), 1899–1911, 10.1016/S0140-6736(14)60685-1.
5. 5. Arena, R., Daugherty, J., Bond, S., Lavie, C.J., Phillips, S., Borghi-Silva, A., The combination of obesity and hypertension: a highly unfavorable phenotype requiring attention. Curr Opin Cardiol 31:4 (2016), 394–401, 10.1097/HCO.0000000000000294 [Publish Ah].
6. 6. Churilla, J.R., Ford, E.S., Comparing physical activity patterns of hypertensive and nonhypertensive US adults. Am J Hypertens 23:9 (2010), 987–993, 10.1038/ajh.2010.88.
7. 7. Green, D.J., Exercise training as vascular medicine: direct impacts on the vasculature in humans. Exerc Sport Sci Rev 37:4 (2009), 196–202, 10.1097/JES.0b013e3181b7b6e3.
8. 8. Naci, H., Ioannidis, J.P.A., Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study. BMJ, 347, 2013, f5577, 10.1136/bjsports-2015-f5577rep.
9. 9. Hambrecht, R., Walther, C., Möbius-Winkler, S., et al. Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: arandomized trial. Circulation 109:11 (2004), 1371–1378, 10.1161/01.CIR.0000121360.31954.1F.
10. 10. Whelton, P.K., He, J., Appel, L.J., et al. Primary prevention of hypertension: clinical and public health advisory from the national high blood pressure education program. JAMA 288:15 (2002), 1882–1888, 10.1001/jama.288.15.1882.
11. 11. Chobanian, A.V., Bakris, G.L., Black, H.R., et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 289:19 (2003), 2560–2571.
12. 12. Pescatello, L.S., Franklin, B.A., Fagard, R., Farquhar, W.B., Kelley, G.A., Ray, C.A., Exercise and hypertension. Med Sci Sports Exerc 36:3 (2004), 533–553, 10.1249/01.MSS.0000115224.88514.3A.
13. 13. Eckel, R.H., Jakicic, J.M., Ard, J.D., et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of cardiology/American Heart Association task force on practice guidelines. Circulation 129 (2014), S76–S99, 10.1161/01.cir.0000437740.48606.d1 [Suppl.].
14. 14. Brook, R.D., Appel, L.J., Rubenfire, M., et al. Beyond medications and diet: alternative approaches to lowering blood pressure: a scientific statement from the American Heart Association. Hypertension 61:6 (2013), 1360–1383, 10.1161/HYP.0b013e318293645f.
15. 15. Sharman, J.E., Stowasser, M., Australian association for exercise and sports science position statement on exercise and hypertension. J Sci Med Sport 12:2 (2009), 252–257, 10.1016/j.jsams.2008.10.009.
16. 16. James, P.A., Oparil, S., Carter, B.L., et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (jnc 8). JAMA 311:5 (2014), 507–520, 10.1001/jama.2013.284427.
17. 17. Mancia, G., Fagard, R., Narkiewicz, K., et al. 2013 ESH/ESC practice guidelines for the Management of Arterial Hypertension. Blood Press 23:1 (2014), 3–16, 10.3109/08037051.2014.868629.
18. 18. Mu, L., Cohen, A.J., Mukamal, K.J., Prevalence and predictors of resistance and aerobic exercise among hypertensive adults in the United States. J Hum Hypertens 29:6 (2015), 394–395, 10.1038/jhh.2014.104.
19. 19. FitzGerald, W.A., Labile hypertension, jogging, and diet: clues to the etiology of essential hypertension?. Med Hypotheses 14:3 (1984), 321–333, 10.1016/0306-9877(87)90136-8.
20. 20. Eicher, J.D., Maresh, C.M., Tsongalis, G.J., Thompson, P.D., Pescatello, L.S., The additive blood pressure lowering effects of exercise intensity on post-exercise hypotension. Am Heart J 160:3 (2010), 513–520, 10.1016/j.ahj.2010.06.005.
21. 21. Ashor, A.W., Lara, J., Siervo, M., et al. Exercise modalities and endothelial function: asystematic review and dose–response meta-analysis of randomized controlled trials. Sports Med 45:2 (2015), 279–296, 10.1007/s40279-014-0272-9.
22. 22. Cornelissen, V.A., Smart, N.A., Exercise training for blood pressure: a systematic review and meta-analysis. J Am Heart Assoc 2:1 (2013), 1–9, 10.1161/JAHA.112.004473.
23. 23. Ciolac, E.G., Guimarães, G.V., D'Avila, V.M., Bortolotto, L.a., Doria, E.L., Bocchi, E.a., Acute aerobic exercise reduces 24-h ambulatory blood pressure levels in long-term-treated hypertensive patients. Clinics (Sao Paulo) 63:6 (2008), 753–758, 10.1590/S1807–59322008000600008.
24. 24. Oliveira, J., Mesquita-Bastos, J., Argel de Melo, C., Ribeiro, F., Postaerobic exercise blood pressure reduction in very old persons with hypertension. J Geriatr Phys Ther 39:1 (2015), 8–13, 10.1519/JPT.0000000000000049.
25. 25. Dimeo, F., Pagonas, N., Seibert, F., Arndt, R., Zidek, W., Westhoff, T.H., Aerobic exercise reduces blood pressure in resistant hypertension. Hypertension 60:3 (2012), 653–658, 10.1161/HYPERTENSIONAHA.112.197780.
26. 26. Kessler, H.S., Sisson, S.B., Short, K.R., The potential for high-intensity interval training to reduce cardiometabolic disease risk. Sports Med 42:6 (2012), 489–509.
27. 27. Guidry, M.A., Blanchard, B.E., Thompson, P.D., et al. The influence of short and long duration on the blood pressure response to an acute bout of dynamic exercise. Am Heart J 151:6 (2006), 1322.e5–1322.e12, 10.1016/j.ahj.2006.03.010.
28. 28. Bhammar, D.M., Angadi, S.S., Gaesser, G.A., Effects of fractionized and continuous exercise on 24-h ambulatory blood pressure. Med Sci Sports Exerc 44:12 (2012), 2270–2276, 10.1249/MSS.0b013e3182663117.
29. 29. Park, S., Rink, L.D., Wallace, J.P., Accumulation of physical activity leads to a greater blood pressure reduction than a single continuous session, in prehypertension. J Hypertens 24:9 (2006), 1761–1770, 10.1097/01.hjh.0000242400.37967.54.
30. 30. Hagberg, J., Park, J., Brown, M., The role of exercise training in the treatment of hypertension. Sports Med 30:3 (2000), 193–206, 10.2165/00007256-200030030-00004.
31. 31. Liu, S., Goodman, J., Nolan, R., Lacombe, S., Thomas, S.G., Blood pressure responses to acute and chronic exercise are related in prehypertension. Med Sci Sports Exerc, 44(9), 2012, 10.1249/MSS.0b013e31825408fb.
32. 32. Pescatello, L.S., MacDonald, H.V., Ash, G.I., et al. Assessing the existing professional exercise recommendations for hypertension: areview and recommendations for future research priorities. Mayo Clin Proc 90:6 (2015), 801–812, 10.1016/j.mayocp.2015.04.008.
33. 33. Blumenthal, J., Siegel, W., Appelbaum, M., Failure of exercise to reduce blood pressure in patients with mild hypertension: results of a randomized controlled trial. JAMA 266:15 (1991), 2098–2104, 10.1001/jama.1991.03470150070033.
34. 34. Harris, K.A., Holly, R.G., Physiological response to circuit weight training in borderline hypertensive subjects. Med Sci Sports Exerc, 19(3), 1987.
35. 35. Conceição, M.S., Bonganha, V., Vechin, F.C., et al. Sixteen weeks of resistance training can decrease the risk of metabolic syndrome in healthy postmenopausal women. Clin Interv Aging 8 (2013), 1221–1228, 10.2147/CIA.S44245.
36. 36. Yoshizawa, M., Maeda, S., Miyaki, a., et al. Effect of 12 weeks of moderate-intensity resistance training on arterial stiffness: a randomised controlled trial in women aged 32–59 years. Br J Sports Med 43 (2009), 615–618, 10.1136/bjsm.2008.052126.
37. 37. Moraes, M.R., Bacurau, R.F., Casarini, D.E., et al. Chronic conventional resistance exercise reduces blood pressure in stage 1 hypertensive men. J Strength Cond Res 26:4 (2012), 1122–1129, 10.1519/JSC.0b013e31822dfc5e.
38. 38. Mota, M.R., Oliveira, R.J., Terra, D.F., et al. Acute and chronic effects of resistance exercise on blood pressure in elderly women and the possible influence of ACE I/D polymorphism. Int J Gen Med 6 (2013), 581–587, 10.2147/IJGM.S40628.
39. 39. Nascimento Dda, C., Tibana, R.A., Benik, F.M., et al. Sustained effect of resistance training on blood pressure and hand grip strength following a detraining period in elderly hypertensive women: a pilot study. Clin Interv Aging 9 (2014), 219–225, 10.2147/CIA.S56058.
40. 40. Collier, S.R., Kanaley, J.A., Carhart, R., et al. Effect of 4 weeks of aerobic or resistance exercise training on arterial stiffness, blood flow and blood pressure in pre- and stage-1 hypertensives. J Hum Hypertens 22:10 (2008), 678–686, 10.1038/jhh.2008.36.
41. 41. Kaess, B.M., Larson, M.G., Hamburg, N.M., Vita, J.A., Levy, D., Benjamin, E.J., Aortic stiffness, blood pressure progression, and incident hypertension. JAMA 308:9 (2012), 875–881 [doi:Genetic Epidemiology of Bland Incident Hypertension].
42. 42. Jurva, J.W., Phillips, S.A., Syed, A.Q., et al. The effect of exertional hypertension evoked by weight lifting on vascular endothelial function. J Am Coll Cardiol 48:3 (2006), 588–589, 10.1016/j.jacc.2006.05.004.
43. 43. Phillips, S.A., Das, E., Wang, J., Pritchard, K., Gutterman, D.D., Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion. J Appl Physiol 110:4 (2011), 1013–1020, 10.1152/japplphysiol.00438.2010.
44. 44. Franklin, N.C., Ali, M., Goslawski, M., Wang, E., Phillips, S.A., Reduced vasodilator function following acute resistance exercise in obese women. Front Physiol, 5, 2014, 10.3389/fphys.2014.00253.
45. 45. Franklin, N.C., Robinson, A.T., Bian, J.-T., et al. Circuit resistance training attenuates acute exertion-induced reductions in arterial function but not inflammation in obese women. Metab Syndr Relat Disord 13:5 (2015), 227–234, 10.1089/met.2014.0135.
46. 46. Thijssen, D.H.J., Maiorana, A., Green, D.J., Aerobic Exercise Training: Effects on Vascular Function and Structure. Pescatello, L.S., (eds.) Effects of Exercise on Hypertension, Molecular and Translational Medicine, 2015, Springer International Publishing, Switzerland.
47. 47. Gielen, S., Schuler, G., Adams, V., Cardiovascular effects of exercise training: molecular mechanisms. Circulation 122:12 (2010), 1221–1238, 10.1161/CIRCULATIONAHA.110.939959.
48. 48. Phillips, S.A., Mahmoud, A.M., Brown, M.D., Haus, J.M., Exercise interventions and peripheral arterial function: implications for cardio-metabolic disease. Prog Cardiovasc Dis 57:5 (2015), 521–534, 10.1016/j.pcad.2014.12.005.
49. 49. Vanhoutte, P.M., Shimokawa, H., Tang, E.H.C., Feletou, M., Endothelial dysfunction and vascular disease. Acta Physiol, 2009, 193–222, 10.1111/j.1748–1716.2009.01964.x.
50. 50. Panza, J.A., Casino, P.R., Kilcoyne, C.M., Quyyumi, A.A., Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 87:5 (1993), 1468–1474, 10.1161/01.CIR.87.5.1468.
51. 51. Thijssen, D.H.J., Maiorana, A.J., O'Driscoll, G., Cable, N.T., Hopman, M.T.E., Green, D.J., Impact of inactivity and exercise on the vasculature in humans. Eur J Appl Physiol 108:5 (2010), 845–875, 10.1007/s00421-009-1260-x.
52. 52. Taddei, S., Virdis, a., Ghiadoni, L., Magagna, A., Salvetti, A., Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 97:22 (1998), 2222–2229, 10.1161/01.CIR.97.22.2222.
53. 53. Laufs, U., Wassmann, S., Czech, T., et al. Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arterioscler Thromb Vasc Biol 25:4 (2005), 809–814, 10.1161/01.ATV.0000158311.24443.af.
54. 54. Durand, M.J., Phillips, S.A., Widlansky, M.E., Otterson, M.F., Gutterman, D.D., The vascular renin-angiotensin system contributes to blunted vasodilation induced by transient high pressure in human adipose microvessels. Am J Physiol Heart Circ Physiol 307:1 (2014), H25–H32, 10.1152/ajpheart.00055.2014.
55. 55. Maeda, S., Otsuki, T., Iemitsu, M., et al. Effects of leg resistance training on arterial function in older men. Br J Sports Med 40:10 (2006), 867–869, 10.1136/bjsm.2006.029538.
56. 56. Hambrecht, R., Adams, V., Erbs, S., et al. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 107:25 (2003), 3152–3158, 10.1161/01.CIR.0000074229.93804.5C.
57. 57. Ras, R.T., Streppel, M.T., Draijer, R., Zock, P.L., Flow-mediated dilation and cardiovascular risk prediction: a systematic review with meta-analysis. Int J Cardiol 168:1 (2013), 344–351, 10.1016/j.ijcard.2012.09.047.
58. 58. Landmesser, U., Hornig, B., Drexler, H., Endothelial function: acritical determinant in atherosclerosis?. Circulation 109:21 Suppl. 1 (2004), II-27–II-33, 10.1161/01.CIR.0000129501.88485.1f.
59. 59. Adams, V., Linke, A., Kränkel, N., et al. Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease. Circulation 111:5 (2005), 555–562, 10.1161/01.CIR.0000154560.88933.7E.
60. 60. Van Guilder, G.P., Westby, C.M., Greiner, J.J., Stauffer, B.L., DeSouza, C.A., Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise. Hypertension 50:2 (2007), 403–409, 10.1161/HYPERTENSIONAHA.107.088294.
61. 61. Spence, A.L., Carter, H.H., Naylor, L.H., Green, D.J., A prospective randomized longitudinal study involving 6 months of endurance or resistance exercise. Conduit artery adaptation in humans. J Physiol 591 (2013), 1265–1275, 10.1113/jphysiol.2012.247387.
62. 62. Lorenz, M.W., Markus, H.S., Bots, M.L., Rosvall, M., Sitzer, M., Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 115:4 (2007), 459–467, 10.1161/CIRCULATIONAHA.106.628875.
63. 63. Rowley, N.J., Dawson, E.A., Hopman, M.T.E., et al. Conduit diameter and wall remodeling in elite athletes and spinal cord injury. Med Sci Sports Exerc 44:5 (2012), 844–849, 10.1249/MSS.0b013e31823f6887.
64. 64. Miyachi, M., Tanaka, H., Yamamoto, K., Yoshioka, A., Takahashi, K., Onodera, S., Effects of one-legged endurance training on femoral arterial and venous size in healthy humans. J Appl Physiol 90 (2001), 2439–2444.
65. 65. Higashi, Y., Sasaki, S., Kurisu, S., et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation 100:11 (1999), 1194–1202, 10.1161/01.CIR.100.11.1194.
66. 66. Linke, A., Schoene, N., Gielen, S., et al. Endothelial dysfunction in patients with chronic heart failure: systemic effects of lower-limb exercise training. J Am Coll Cardiol 37:2 (2001), 392–397, 10.1016/S0735-1097(00)01108-6.
67. 67. Laughlin, M.H., Endothelium-mediated control of coronary vascular tone after chronic exercise training. Med Sci Sports Exerc 27:8 (1995), 1135–1144 [ http://journals.lww.com/acsm-msse/Fulltext/1995/08000/Endothelium_mediated_control_of_coronary_vascular.6.aspx].
68. 68. Tinken, T.M., Thijssen, D.H., Black, M.A., Cable, N.T., Green, D.J., Time course of change in vasodilator function and capacity in response to exercise training in humans. J Physiol 586 (2008), 5003–5012, 10.1113/jphysiol.2008.158014.
69. 69. Naylor, L.H., Weisbrod, C.J., O'Driscoll, G., Green, D.J., Measuring peripheral resistance and conduit arterial structure in humans using Doppler ultrasound. J Appl Physiol 98:February 2005 (2005), 2311–2315, 10.1152/japplphysiol.01047.2004.
70. 70. Green, D.J., Rowley, N., Spence, A., et al. Why isn't flow-mediated dilation enhanced in athletes?. Med Sci Sports Exerc 45:1 (2013), 75–82, 10.1249/MSS.0b013e318269affe.
71. 71. Lefferts, W.K., Augustine, J.A., Heffernan, K.S., Effect of acute resistance exercise on carotid artery stiffness and cerebral blood flow pulsatility. Front Physiol 5 (2014), 1–10, 10.3389/fphys.2014.00101.
72. 72. Tanaka, H., Effects of Regular Exercise on Arterial Stiffness. Pescatello, L.S., (eds.) Effects of Exercise on Hypertension, Molecular and Translational Medicine, 2015, Springer International Publishing, 10.1007/978-3-319-17076-3_8.
73. 73. Tanaka, H., Dinenno, F.A., Monahan, K.D., Clevenger, C.M., DeSouza, C.A., Seals, D.R., Aging, habitual exercise, and dynamic arterial compliance. Circulation 102:11 (2000), 1270–1275, 10.1161/01.CIR.102.11.1270.
74. 74. Levy, D., Larson, M., Vasan, R., Kannel, W., Ho, K., The progression from hypertension to congestive heart failure. JAMA 275:20 (1996), 1557–1562, 10.1001/jama.1996.03530440037034.
75. 75. Monahan, K.D., Dinenno, F.A., Seals, D.R., Clevenger, C.M., Desouza, C.A., Tanaka, H., Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance. Am J Physiol Heart Circ Physiol 281:1 (2001), H284–H289, 10.1161/01.hyp.26.1.48.
76. 76. Monahan, K.D., Tanaka, H., Dinenno, F.A., Seals, D.R., Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity. Circulation 104:14 (2001), 1627–1632, 10.1161/hc3901.096670.
77. 77. Aizawa, K., Petrella, R.J., Acute and chronic impact of dynamic exercise on arterial stiffness in older hypertensives. Open Cardiovasc Med J 2 (2008), 3–8, 10.2174/1874192400802010003.
78. 78. Ferrier, K.E., Waddell, T.K., Gatzka, C.D., Cameron, J.D., Dart, A.M., Kingwell, B.A., Aerobic exercise training does not modify large-artery compliance in isolated systolic hypertension. Hypertension 38 (2001), 222–226, 10.1161/01.HYP.38.2.222.
79. 79. DeVan, A.E., Anton, M.M., Cook, J.N., et al. Acute effects of resistance exercise on arterial compliance. J Appl Physiol 98 (2005), 2287–2291, 10.1152/japplphysiol.00002.2005.
80. 80. Collier, S.R., Frechette, V., Sandberg, K., et al. Sex differences in resting hemodynamics and arterial stiffness following 4 weeks of resistance versus aerobic exercise training in individuals with pre-hypertension to stage 1 hypertension. Biol Sex Differ, 2(1), 2011, 9, 10.1186/2042-6410-2-9.
81. 81. Cortez-Cooper, M.Y., Anton, M.M., DeVan, A.E., Neidre, D.B., Cook, J.N., Tanaka, H., The effects of strength training on central arterial compliance in middle-aged and older adults. Eur J Cardiovasc Prev Rehabil 15:2 (2008), 149–155.
82. 82. Fadel, P.J., Raven, P.B., Human investigations into the arterial and cardiopulmonary baroreflexes during exercise. Exp Physiol 97:1 (2012), 39–50, 10.1113/expphysiol.2011.057554.
83. 83. Fisher, J.P., Paton, J.F.R., The sympathetic nervous system and blood pressure in humans: implications for hypertension. J Hum Hypertens 26:8 (2012), 463–475, 10.1038/jhh.2011.66.
84. 84. Heusser, K., Tank, J., Engeli, S., et al. Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients. Hypertension 55:3 (2010), 619–626, 10.1161/HYPERTENSIONAHA.109.140665.
85. 85. Laterza, M.C., De Matos, L.D.N.J., Trombetta, I.C., et al. Exercise training restores baroreflex sensitivity in never-treated hypertensive patients. Hypertension 49:6 (2007), 1298–1306, 10.1161/HYPERTENSIONAHA.106.085548.
86. 86. Monahan, K.D., Dinenno, F.A., Tanaka, H., Clevenger, C.M., DeSouza, C.A., Seals, D.R., Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men. J Physiol 529:1 (2000), 263–271, 10.1111/j.1469-7793.2000.00263.x.
87. 87. Ferreira, J.B., Plentz, R.D.M., Stein, C., Casali, K.R., Arena, R., Lago, P.D., Inspiratory muscle training reduces blood pressure and sympathetic activity in hypertensive patients: a randomized controlled trial. Int J Cardiol 166:1 (2013), 61–67, 10.1016/j.ijcard.2011.09.069.
88. 88. Deley, G., Picard, G., Taylor, J.A., Arterial baroreflex control of cardiac vagal outflow in older individuals can be enhanced by aerobic exercise training. Hypertension 53:5 (2009), 826–832, 10.1161/HYPERTENSIONAHA.109.130039.
89. 89. Pratt, M., Perez, L.G., Goenka, S., et al. Can population levels of physical activity be increased? Global evidence and experience. Prog Cardiovasc Dis 57:4 (2015), 356–367, 10.1016/j.pcad.2014.09.002.
90. 90. Arena, R., Harrington, R.A., Després, J.P., A message from modern-day healthcare to physical activity and fitness: welcome home!. Prog Cardiovasc Dis 57:4 (2015), 293–295, 10.1016/j.pcad.2014.11.001.
91. 91. Sallis, R., Franklin, B., Joy, L., Ross, R., Sabgir, D., Stone, J., Strategies for promoting physical activity in clinical practice. Prog Cardiovasc Dis 57:4 (2015), 375–386, 10.1016/j.pcad.2014.10.003.
92. 92. Carlson, S.A., Fulton, J.E., Pratt, M., Yang, Z., Adams, E.K., Inadequate physical activity and health care expenditures in the United States. Prog Cardiovasc Dis 57:4 (2015), 315–323, 10.1016/j.pcad.2014.08.002.