The Impact of Health Care Appointment Non-Adherence on Graft Outcomes in Kidney Transplantation

American Journal of Nephrology

Volumn 45, Issue 1, 2017, Pages 91-98

  Taber, David J ^a,d   Fleming, James N ^c   Fominaya, Cory E ^d   Gebregziabher, Mulugeta ^b   Hunt, Kelly J ^b   Srinivas, Titte R ^b   Baliga, Prabhakar K ^a   McGillicuddy, John W ^a   Egede, Leonard E ^d  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Division of Biostatistics   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Acute rejection; Graft survival; Kidney transplant; Non adherence

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; MAMMALIAN TARGET OF RAPAMYCIN; MYCOPHENOLIC ACID; PREDNISONE; TACROLIMUS; IMMUNOSUPPRESSIVE AGENT;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; COHORT ANALYSIS; DELAYED GRAFT FUNCTION; FEMALE; GRAFT FAILURE; HEALTH CARE; HUMAN; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT REFUSAL; AGED; CHRONIC KIDNEY FAILURE; GRAFT REJECTION; GRAFT SURVIVAL; HOSPITAL MANAGEMENT; LONGITUDINAL STUDY; MEDICATION COMPLIANCE; MIDDLE AGED; PATIENT ATTENDANCE; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; STATISTICS AND NUMERICAL DATA; SURVIVAL RATE; UNITED STATES; VETERAN;

AGED; APPOINTMENTS AND SCHEDULES; DELAYED GRAFT FUNCTION; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; LONGITUDINAL STUDIES; MALE; MEDICATION ADHERENCE; MIDDLE AGED; NO-SHOW PATIENTS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; UNITED STATES; VETERANS;

EID: 85001610269     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000453554     Document Type: Article

References (30)

1. Sellares J, de Freitas DG, Mengel M, Reeve J, Einecke G, et al: Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am J Transplant 2012; 12: 388-399
2. Einecke G, Sis B, Reeve J, Mengel M, Campbell PM, et al: Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am J Transplant 2009; 9: 2520-2531
3. Gaynor JJ, Ciancio G, Guerra G, Sageshima J, Hanson L, et al: Graft failure due to noncompliance among 628 kidney transplant recipients with long-term follow-up: a single-center observational study. Transplantation 2014; 97: 925-933
4. Dew MA, DiMartini AF, Vito Dabbs A, Myaskovsky L, Steel J, et al: Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation 2007; 83: 858-873
5. Butler JA, Roderick P, Mullee M, Mason JC, Peveler RC: Frequency and impact of nonadherence to immunosuppressants after renal transplantation: a systematic review. Transplantation 2004; 77: 769-776
6. Chisholm MA, Kwong WJ, Spivey CA: Associations of characteristics of renal transplant recipients with clinicians' perceptions of adherence to immunosuppressant therapy. Transplantation 2007; 84: 1145-1150
7. Pullalarevu R, Taber D, Chokkalingam A, Browning R, Kamel M, et al: Non-adherence is associated with increased risk of rejection and graft loss. Am J Transplant 2016; 16: 321
8. Doyle IC, Maldonado AQ, Heldenbrand S, Tichy EM, Trofe-Clark J: Nonadherence to therapy after adult solid organ transplantation: a focus on risks and mitigation strategies. Am J Health Syst Pharm 2016; 73: 909-920
9. Cutler DM, Everett W: Thinking outside the pillbox-medication adherence as a priority for health care reform. N Engl J Med 2010; 362: 1553-1555
10. Lehmann A, Aslani P, Ahmed R, Celio J, Gauchet A, et al: Assessing medication adherence: options to consider. Int J Clin Pharm 2014; 36: 55-69
11. Stewart K, Mc Namara KP, George J: Challenges in measuring medication adherence: experiences from a controlled trial. Int J Clin Pharm 2014; 36: 15-19
12. Sattler EL, Lee JS, Perri M 3rd: Medication (re)fill adherence measures derived from pharmacy claims data in older Americans: a review of the literature. Drugs Aging 2013; 30: 383-399
13. Taber DJ, Gebregziabher M, Payne EH, Srinivas T, Baliga PK, Egede LE: Overall graft loss versus death-censored graft loss: unmasking the magnitude of racial disparities in outcomes among US kidney transplant recipients. Transplantation 2016, Epub ahead of print
14. Karve S, Cleves MA, Helm M, Hudson TJ, West DS, Martin BC: An empirical basis for standardizing adherence measures derived from administrative claims data among diabetic patients. Med Care 2008; 46: 1125-1133
15. Kim N, Agostini JV, Justice AC: Refill adherence to oral hypoglycemic agents and glycemic control in veterans. Ann Pharmacother 2010; 44: 800-808
16. Pabst S, Bertram A, Zimmermann T, Schiffer M, Zwaan M: Physician reported adherence to immunosuppressants in renal transplant patients: prevalence, agreement, and correlates. J Psychosom Res 2015; 79: 364-371
17. Massey EK, Tielen M, Laging M, et al: Discrepancies between beliefs and behavior: a prospective study into immunosuppressive medication adherence after kidney transplantation. Transplantation 2015; 99: 375-380
18. Steiner JF, Prochazka AV: The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol 1997; 50: 105-116
19. Pinsky BW, Takemoto SK, Lentine KL, Burroughs TE, Schnitzler MA, Salvalaggio PR: Transplant outcomes and economic costs associated with patient noncompliance to immunosuppression. Am J Transplant 2009; 9: 2597-2606
20. Van Wijk BL, Klungel OH, Heerdink ER, Boer A: The association between compliance with antihypertensive drugs and modification of antihypertensive drug regimen. J Hypertens 2004; 22: 1831-1837
21. Su GC, Greanya ED, Partovi N, Yoshida EM, Shapiro RJ, Levy RD: Assessing medication adherence in solid-organ transplant recipients. Exp Clin Transplant 2013; 11: 475-481
22. Chisholm MA, Vollenweider LJ, Mulloy LL, et al: Renal transplant patient compliance with free immunosuppressive medications. Transplantation 2000; 70: 1240-1244
23. Hilbrands LB, Hoitsma AJ, Koene RA: Medication compliance after renal transplantation. Transplantation 1995; 60: 914-920
24. Liu WJ, Zaki M: Medication compliance among renal transplant patients: a Hospital Kuala Lumpur experience. Med J Malaysia 2004; 59: 649-658
25. Kobus G, Malyszko J, Malyszko JS, Puza E, Bachorzewska-Gajewska H, Mysliwiec M: Compliance with lifestyle recommendations in kidney allograft recipients. Transplant Proc 2011; 43: 2930-2934
26. Yavuz A, Tuncer M, Erdogan O, et al: Is there any effect of compliance on clinical parameters of renal transplant recipients? Transplant Proc 2004; 36: 120-121
27. Kiley DJ, Lam CS, Pollak R: A study of treatment compliance following kidney transplantation. Transplantation 1993; 55: 51-56
28. Dew MA, Dabbs AD, Myaskovsky L, et al: Meta-analysis of medical regimen adherence outcomes in pediatric solid organ transplantation. Transplantation 2009; 88: 736-746
29. Kizer KW: The 'new VA': a national laboratory for health care quality management. Am J Med Qual 1999; 14: 3-20
30. Sterne JA, White IR, Carlin JB, Spratt M, Royston P, et al: Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 2009; 338:b2393