Intestinal barrier dysfunction in human necrotizing enterocolitis

Journal of Pediatric Surgery

Volumn 51, Issue 12, 2016, Pages 1907-1913

  Moore, Sarah A ^a   Nighot, Prashant ^a   Reyes, Cynthia ^a   Rawat, Manmeet ^a   McKee, Jason ^a   Lemon, David ^a   Hanson, Joshua ^a   Ma, Thomas Y ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Intestinal barrier function; Necrotizing enterocolitis; Occludin; Tight junction

Indexed keywords

MANNITOL; MESSENGER RNA; MYOSIN LIGHT CHAIN KINASE; TIGHT JUNCTION PROTEIN; OCCLUDIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTESTINE MUCOSA; MALE; MEMBRANE DAMAGE; NECROTIZING ENTEROCOLITIS; NEWBORN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINAL TISSUE; SMALL INTESTINE ABSORPTION; SMALL INTESTINE RESECTION; TRANSEPITHELIAL RESISTANCE; BIOSYNTHESIS; INFANT; METABOLISM; PATHOPHYSIOLOGY; PERMEABILITY; SMALL INTESTINE; TIGHT JUNCTION;

ENTEROCOLITIS, NECROTIZING; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MYOSIN-LIGHT-CHAIN KINASE; OCCLUDIN; PERMEABILITY; RNA, MESSENGER; TIGHT JUNCTIONS;

EID: 85001129934     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2016.09.011     Document Type: Article

References (49)

1. [1] Lemons, J.A., Bauer, C.R., Oh, W., et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January through December 1996. Pediatrics, 107, 2001, E1.
2. [2] Claud, E.C., Walker, W.A., Bacterial colonization, probiotic and necrotizing enterocolitis. J Clin Gastroenterol 42 (2008), S46–S52.
3. [3] Guthrie, S.O., Gordon, P.V., Thomas, V., et al. Necrotizing enterocolitis among infants in the United States. Perinatology 23 (2003), 278–285.
4. [4] Bolisetty, S., Lui, K., Oei, J., et al. A regional study of underlying congenital diseases in term infants with necrotizing enterocolitis. Acta Pediatr 89 (2007), 1226–1230.
5. [5] McElhinney, D.B., Hindrick, H.L., Bush, D.M., et al. Necrotizing enterocolitis in neonates with congenital heart disease: risk factors and outcomes. Pediatrics 106 (2000), 1080–1087.
6. [6] Holman, R.C., Stoll, B.J., Curns, A.T., et al. Necrotizing enterocolitis hospitalizations among neonates in the United States. Paediatr Perinat Epidemiol 20 (2006), 498–506.
7. [7] Henry, M.C., Moss, R.L., Necrotizing enterocolitis. Annu Rev Med 60 (2009), 111–124.
8. [8] Chan, K., Ohlsson, A., Synnes, A., et al. Survival, morbidity, and resource use of infants of 25 weeks’ gestational age or less. Am J Obstet Gynecol 185 (2001), 220–226.
9. [9] Hintz, S.R., Kendrick, D.E., Stoll, B.J., et al. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics 115 (2005), 696–703.
10. [10] Neu, J., Walk, W.A., Necrotizing enterocolitis. N Engl J Med 364 (2011), 255–264.
11. [11] Obladen, M., Necrotizing enterocolitis – 150 years of fruitless search for the cause. Neonatology 96 (2009), 203–210.
12. [12] Halpern, M.D., Denning, P.W., The role of intestinal epithelial barrier function in the development of NEC. Tissue Barriers, 3(1–2), 2015, e1000707 [1-10].
13. [13] Zani, A., Pierro, A., Necrotizing enterocolitis: controversies and challenges. F1000Res 4 (2015), 1–10.
14. [14] Patel, R.M., Denning, P.W., Intestinal microbiota and its relationship with necrotizing enterocolitis. Pediatr Res 78:3 (2015), 232–238.
15. [15] Sampath, V., SIGIRR genetic variants in premature infants with necrotizing enterocolitis. Pediatrics 135:6 (2015), e1530–e1534.
16. [16] Ma, T.Y., Anderson, J.M., Tight junctions and the intestinal barrier. Physiology of the gastrointestinal tract, 2006, Elsevier Academic Press, Burlington, MA.
17. [17] Utech, M., Brüwer, M., Nusrat, A., Tight junctions and cell–cell interactions. Methods Mol Biol 341 (2006), 185–195.
18. [18] Hollander, D., Intestinal permeability, leaky gut, and intestinal disorders. Curr Gastroenterol Rep 1 (1999), 410–416.
19. [19] Turner, J.R., Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9 (2009), 799–809.
20. [20] Linskens, R.K., Huijsdens, X.W., Savelkoul, P.H., et al. The bacterial flora in inflammatory bowel disease: current insights in pathogenesis and the influence of antibiotics and probiotics. Scand J Gastroenterol Suppl(234), 2001, 29–40.
21. [21] Madara, J.L., Parkos, C., Colgan, S., et al. The movement of solutes and cells across tight junctions. Ann N Y Acad Sci 664 (1992), 47–60.
22. [22] Madara, J.L., Pappenheimer, J.R., Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J Membr Biol 100:2 (1987), 149–164.
23. [23] Shen, L., Turner, J.R., Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. Am J Physiol Gastrointest Liver Physiol 290 (2006), G577–G582.
24. [24] Westerbeek, E.A., van den Berg, A., Lafeber, H.N., et al. The intestinal bacterial colonisation in preterm infants: a review of the literature. Clin Nutr 25:3 (2006), 361–368.
25. [25] QH, Y., Yang, Q., Diversity of tight junctions (TJs) between gastrointestinal epithelial cells and their function in maintaining the mucosal barrier. Cell Biol Int 33 (2009), 78–82.
26. [26] Furuse, M., Hirase, T., Itoh, M., et al. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 123:6 Pt 2 (1993), 1777–1788.
27. [27] Colegio, O.R., Van Itallie, C., Rahner, C., et al. Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 284 (2003), C1346–C1354.
28. [28] McCarthy, K.M., Skare, I.B., Stankewich, M.C., et al. Occludin is a functional component of the tight junction. J Cell Sci 109:Pt 9 (1996), 2287–2298.
29. [29] Al-Sadi, R., Khatib, K., Guo, S., et al. Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 300:6 (2011), G1054–G1064.
30. [30] Al-Sadi, R., Guo, S., Dokladny, K., et al. Mechanism of interleukin-1β induced-increase in mouse intestinal permeability in vivo. J Interferon Cytokine Res 32:10 (2012), 474–484.
31. [31] Ye, D., Ma, T.Y., Cellular and molecular mechanisms that mediate basal and tumor necrosis factor-α-induced regulation of myosin light chain kinase gene activity. J Cell Mol Med 12:4 (2008), 1331–1346.
32. [32] Venkatraman, A., Ramakrishna, B.S., Pulimood, A.B., et al. Increased permeability in dextran sulphate colitis in rats: time course of development and effect of butyrate. Scand J Gastroenterol 35:10 (2000), 1053–1059.
33. [33] Sturm, A., Dignass, A.U., Epithelial restitution and wound healing in inflammatory bowel disease. World J Gastroenterol 14:3 (2008), 348–353.
34. [34] Weaver, L.T., Laker, M.F., Nelson, R., Intestinal permeability in the newborn. Arch Dis Child 59:3 (1984), 236–241.
35. [35] van Elburg, R.M., Fetter, W., Bunkers, C.M., et al. Intestinal permeability in relation to birth weight and gestational and postnatal age. Arch Dis Child Fetal Neonatal Ed 88:1 (2003), F52–F55.
36. [36] Bergmann, K.R., Liu, S.X., Tian, R., et al. Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis. Am J Pathol 182:5 (2013), 1595–1606.
37. [37] Sevastiadou, S., Malamitsi-Puchner, A., Costalos, C., et al. The impact of oral glutamine supplementation on the intestinal permeability and incidence of necrotizing enterocolitis/septicemia in premature neonates. J Matern Fetal Neonatal Med 24:10 (2011), 1294–1300.
38. [38] Piena-Spoel, M., Albers, M.J., ten Kate, J., et al. Intestinal permeability in newborns with necrotizing enterocolitis and controls: does the sugar absorption test provide guidelines for the time to (re-)introduce enteral nutrition?. J Pediatr Surg 36:4 (2001), 587–592.
39. [39] Nighot, P.K., Blikslager, A.T., ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction. Am J Physiol Gastrointest Liver Physiol 299 (2010), G449–G456.
40. [40] Ye, D., Ma, I., Ma, T.Y., Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 290 (2006), G496–G504.
41. [41] Clark, J.A., Doelle, S.M., Halpern, M.D., et al. Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment. Am J Physiol Gastrointest Liver Physiol 291:5 (2006), G938–G949.
42. [42] Shiou, S.R., Yu, Y., Chen, S., et al. Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis. J Biol Chem 286:14 (2011), 12123–12132.
43. [43] Rentea, R.M., Liedel, J.L., Welak, S.R., et al. Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model. J Pediatr Surg 47:6 (2012), 1135–1142.
44. [44] Ma, T.Y., Boivin, M.A., Ye, D., et al. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 288:3 (2005), G422–G430.
45. [45] Su, L., Shen, L., Clayburgh, D.R., et al. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology 136:2 (2009), 551–563.
46. [46] Nighot, P., Al-Sadi, R., Rawat, M.T., et al. Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis. Am J Physiol Gastrointest Liver Physiol 309:12 (2015), G988–G997.
47. [47] Stratiki, Z., Costalos, C., Sevastiadou, S., et al. The effect of a bifidobacter supplemented bovine milk on intestinal permeability of preterm infants. Early Hum Dev 83:9 (2007), 575–579.
48. [48] Alfaleh, K., Bassler, D., Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev, 23(1), 2008, CD005496.
49. [49] Martin, C.R., Walker, W.A., Probiotics: role in pathophysiology and prevention in necrotizing enterocolitis. Semin Perinatol 32:2 (2008), 127–137.