Effects of crude hydroalcoholic extract of Syzygium cumini (L.) Skeels leaves and continuous aerobic training in rats with diabetes induced by a high-fat diet and low doses of streptozotocin

Journal of Ethnopharmacology

Volumn 194, Issue , 2016, Pages 1012-1021

  Baldissera, G ^a   Sperotto, N D M ^a   Rosa, H T ^a   Henn, J G ^a   Peres, V F ^a   Moura, D J ^a   Roehrs, R ^b   Denardin, E L G ^b   Dal Lago, P ^a   Nunes, R B ^a   Saffi, J ^a  

^a UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

^b UNIVERSIDADE FEDERAL DO PAMPA   (Brazil)

Author keywords

DNA damage; Exercise; Experimental diabetes mellitus; Oxidative stress; Syzygium cumini

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CHOLESTEROL; GLUCOSE; MYRICETIN; PHENOL DERIVATIVE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; SYZYGIUM CUMINI EXTRACT; TANNIN DERIVATIVE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; ANTIDIABETIC AGENT; ANTIOXIDANT; PLANT EXTRACT;

AEROBIC EXERCISE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; COMET ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; DNA DAMAGE; ENZYME ACTIVITY; EXERCISE; FLUID INTAKE; FOOD INTAKE; FUNCTIONAL STATUS; GLUCOSE BLOOD LEVEL; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIPID DIET; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PLANT LEAF; RAT; RETENTION TIME; SYZYGIUM CUMINI; TRIACYLGLYCEROL BLOOD LEVEL; ADVERSE EFFECTS; ANIMAL; BRAZIL; CHEMICALLY INDUCED; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; METABOLISM; MYRTACEAE; PHYSIOLOGY; PROCEDURES; SYZYGIUM; TRADITIONAL MEDICINE; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; BRAZIL; CATALASE; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; DNA DAMAGE; HYPOGLYCEMIC AGENTS; LIPID PEROXIDATION; MALE; MEDICINE, TRADITIONAL; MYRTACEAE; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; STREPTOZOCIN; SUPEROXIDE DISMUTASE; SYZYGIUM; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 85001104745     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.10.056     Document Type: Article

References (59)

1. Anandharajan, R., Jaiganesh, S., Shankernarayanan, N.P., Viswakarma, R.A., Balakrishnan, A., In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARgamma in L6 myotubes. Phytomedicine 13 (2006), 434–441.
2. Ayyanar, M., Subash-Babu, P., Syzygium cumini (L.) Skeels: a review of its phytochemical constituents and traditional uses. Asian Pac. J. Trop. Biomed. 2 (2012), 240–246.
3. Baliga, M.S., Fernandes, S., Thilakchand, K.R., D'Souza, P., Rao, S., Scientific validation of the antidiabetic effects of Syzygium jambolanum DC (Black Plum), a traditional medicinal plant of India. J. Altern. Complement. Med. 19 (2013), 191–197.
4. Bartolome, A., Mandapa, K., David, K.J., Sevilla, F., Villanueva, J., SOS-red fluorescent protein (RFP) bioassay system for monitoring of antigenotoxic activity in plant extracts. Biosens. Bioelectron. 21 (2006), 2114–2120.
5. Batista, M.L. Jr, Santos, R.V.T., Oliveira, E.M., Seelaender, M.C.L., Costa Rosa, L.F.B.P., Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats. J. Appl. Physiol. 102 (2007), 2033–2039.
6. Benherlal, P.S., Arumughan, C., Studies on modulation of DNA integrity in Fenton's system by phytochemicals. Mutat. Res. 648 (2008), 1–8.
7. Blasiak, J., Arabski, M., Krupa, R., Wozniak, K., Zadrozny, M., Kasznicki, J., Zurawska, M., Drzewoski, J., DNA damage and repair in type 2 diabetes mellitus. Mutat. Res. 554 (2004), 297–304.
8. Bonfanti, G., Bitencourt, P.R., Bona, K.S., Silva, P.S., Jantsch, L.B., Pigatto, A.S., Boligon, A., Athayde, M.L., Gonçalves, T.L., Moretto, M.B., Syzygium jambos and Solanum guaraniticum show similar antioxidant properties but induce different enzymatic activities in the brain of rats. Molecules 18 (2013), 9179–9194.
9. Borghouts, L.B., Keizer, H.A., Exercise and insulin sensitivity: a review. Int. J. Sports Med. 21 (2000), 1–12.
10. Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976), 248–254.
11. British-Pharmacopoeia, British-Pharmacopoeia-Cd-Rom. 2007, Her Majesty's Stationery Office, London (Version 11.0 ed).
12. Cascaes, M.M., Guilhon, G.M.S.P., Andrade, E.H.A., Zoghbi, M.G.B., Santos, L.S., Constituents and pharmacological activities of Myrcia (Myrtaceae): a review of an aromatic and medicinal group of plants. Int. J. Mol. Sci. 16 (2015), 23881–23904.
13. Chance, B., Sies, H., Boveris, A., Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59 (1979), 527–605.
14. Chandran, R., Parimelazhagan, T., Shanmugam, S., Thankarajan, S., Antidiabetic activity of Syzygium calophyllifolium in streptozotocin-nicotinamide induced type-2 diabetic rats. Biomed. Pharmacother. 82 (2016), 547–554.
15. Chang, C.J., Tzeng, T.F., Liou, S.S., Chang, Y.S., Liu, I.M., Myricetin increases hepatic peroxisome proliferator-activated receptor α protein expression and decreases plasma lipids and adiposity in rats. J. Evid. Based Complement. Altern. Med., 2012, 1–11.
16. Choi, H.N., Kang, M.J., Lee, S.J., Kim, J.I., Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose diet. Nutr. Res. Pr. 8 (2014), 544–549.
17. Ding, Y., Zhang, Z.F., Dai, X.Q., Li, Y., Myricetin protects against cytokine-induced cell death in RIN-m5f beta cells. J. Med. Food 15 (2012), 733–740.
18. Dotzert, M.S., Murray, M.R., McDonald, M.W., Olver, T.D., Velenosi, T.J., Hennop, A., Noble, E.G., Urquhart, B.L., Melling, C.W.J., Metabolomic response of skeletal muscle to aerobic exercise training in insulin resistant type 1 diabetic rats. Sci. Rep. 20 (2016), 1–10.
19. Emter, C.A., McCune, S.A., Sparagna, G.C., Radin, M.J., Moore, R.L., Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats. Am. J. Physiol. Heart Circ. Physiol. 289 (2005), H2030–H2038.
20. Eshwarappa, R.S.B., Iyer, R.S., Subbaramaiah, S.R., Richard, S.A., Dhananjaya, B.L., Antioxidant activity of Syzygium cumini leaf gall extracts. Bioimpacts 4 (2014), 101–107.
21. Esterbauer, H., Cheeseman, K.H., Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzym. 186 (1990), 407–421 (adapted).
22. Franzke, B., Halper, B., Hofmann, M., Oesen, S., Jandrasits, W., Baierl, A., Tosevska, A., Strasser, E.M., Wessner, B., Wagner, K.H., Vienna Active Ageing Study Group, The impact of six months strength training, nutritional supplementation or cognitive training on DNA damage in institutionalised elderly. Mutagenesis 30 (2015), 147–153.
23. Grenier, D., Chen, H., Ben Lagha, A., Fournier-Larente, J., Morin, M.P., Dual action of myricetin on Porphyromonas gingivalis and the inflammatory response of host cells: a promising therapeutic molecule for periodontal diseases. PLoS ONE 10 (2015), 1–14.
24. Hertog, M.G.L., Hollman, P.C.H., Venema, D.P., Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruits. J. Agric. Food Chem. 40 (1992), 1591–1598.
25. Isolan, G.R., Santis-isolan, P.M.B., Dobrowolski, S., Cioato, M.G., Meyer, F.S., Antunes, A.C.M., Pereira, A.H., Falcetta, F., Mousquer, P., Considerações técnicas no treinamento de anastomoses microvasculares em laboratório de microcirurgia. J. Bras. Neurocir. 21 (2010), 8–17.
26. Jensen, J., Rustad, P.I., Kolnes, A.J., Lai, Y.C., The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front. Physiol. 2 (2011), 1–11.
27. Kaneria, M., Chanda, S., Evaluation of antioxidant and antimicrobial capacity of Syzygium cumini L. leaves extracted sequentially in different solventes. J. Food Biochem. 37 (2011), 168–176.
28. Kanter, M., Aksu, F., Takir, M., Kostek, O., Kanter, B., Oymagil, A., Effects of low intensity exercise against apoptosis and oxidative stress in streptozotocin-induced diabetic rat heart. Exp. Clin. Endocrinol. Diabetes, 2016, 1–8.
29. Kim, K.S., Paik, I.Y., Woo, J.H., Kanget, B.Y., The effect of training type on oxidative DNA damage and antioxidant capacity during three-dimensional space exercise. Med. Princ. Pract. 19 (2010), 133–141.
30. LeBel, C.P., Ischiropoulos, H., Bondy, S.C., Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5 (1992), 227–231.
31. Mahmoud, H., Marzouk, M.S., Moharram, F.A., El-Gindi, M.R., Hassan, A.M., Acylated flavonol glycosides from Eugenia jambolana leaves. Phytochem 58 (2001), 1239–1244.
32. Marinho, R., Moura, L.P., Rodrigues, B.A., Pauli, L.S.S., da Silva, A.S.R., Ropelle, E.C.C., Souza, C.T., Cintra, D.E.C., Ropelle, E.R., Pauli, J.R., Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice. Einstein 12 (2014), 82–89.
33. Mastaloudis, A., Yu, T.W., O'Donnell, R.P., Frei, B., Dashwood, R.H., Traber, M.G., Endurance exercise results in DNA damage as detected by the comet assay. Free Radic. Biol. Med 36 (2004), 966–975.
34. McCord, J.M., Fridovich, I., Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem. 244 (1969), 6049–6055.
35. Mendes, V., Vilaça, R., Freitas, V., Ferreira, P.M., Mateus, N., Costa, V., Effect of myricetin, pyrogallol, and phloroglucinol on yeast resistance to oxidative Stress. Oxid. Med. Cell. Longev., 2015, 1–10.
36. Mohamed, A.A., Ali, S.I., El-Baz, F.K., Antioxidant and antibacterial activities of crude extracts and essential oils of Syzygium cumini leaves. PLoS ONE 8 (2013), 1–7.
37. Olson, A.L., Regulation of GLUT4 and insulin-dependent glucose flux. ISRN Mol. Biol., 2012, 1–12.
38. Pandey, K.B., Mishra, N., Rizvi, S.I., Myricetin may provide protection against oxidative stress in type 2 diabetic erythrocytes. Z. Nat. 64 (2009), 626–630.
39. Rech, A., Radaelli, R., Assis, A.M., Fernandes, J.R., Longoni, A., Vozari-Hampe, M.M., Pinto, R.S., Matté, C., The effects of strength, aerobic, and concurrent exercise on skeletal muscle damage in rats. Muscle Nerve 50 (2014), 79–86.
40. Richter, E.A., Hargreaves, M., Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol. Rev. 93 (2013), 993–1017.
41. Sanches, J.R., França, L.M., Chagas, V.T., Gaspar, R.S., Dos Santos, K.A., Gonçalves, L.M., Sloboda, D.M., Holloway, A.C., Dutra, R.P., Carneiro, E.M., Cappelli, A.P., Paes, A.M., Polyphenol-rich extract of Syzygium cumini leaf dually improves peripheral insulin sensitivity and pancreatic islet function in monosodium l-glutamate-induced obese rats. Front. Pharm., 2016, 7.
42. Schoenfelder, T., Warmlin, C.Z., Manfredini, M.S., Pavei, L.L., Réus, J.V., Tristão, T.C., Fernandes, M.S., Costa-Campos, L., Hypoglycemic and hypolipidemic effect of leaves from Syzygium cumini (L.) Skeels myrtaceae in diabetic rats. Braz. J. Pharm. 20 (2010), 222–227.
43. Sharma, B., Balomajumder, C., Roy, P., Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem. Toxicol. 46 (2008), 2376–2383.
44. Sharma, S.B., Nasir, A., Prabhu, K.M., Murthy, P.S., Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus. J. Ethnopharmacol. 104 (2006), 367–373.
45. Singh, N.P., McCoy, M.T., Tice, R.R., Schneider, E.L., A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell. Res. 175 (1988), 184–191.
46. Srinivasan, K., Viswanad, B., Asrat, L., Kaul, C.L., Ramarao, P., Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharm. Res. 52 (2005), 313–320.
47. Srivastava, S., Chandra, D., Pharmacological potentials of Syzygium cumini: a review. J. Sci. Food Agric. 93 (2013), 2084–2093.
48. Timbola, A.K., Szpoganicz, B., Branco, A., Monache, F.D., Pizzolatti, M.G., A new flavonoid from leaves of Eugenia jambolana. Fitoterapia 73 (2002), 174–176.
49. Tripathi, A.K., Kohli, S., Pharmacognostical standardization and antidiabetic activity of activity of Syzygium cumini (Linn.) barks (Myrtaceae) on streptozotocin-induced diabetic rats [abstract]. J. Complement. Integr. Med. 11 (2014), 71–81.
50. Tripathi, P., Patel, R.K., Tripathi, R., Kanzariya, N.R., Investigation of antigenotoxic potential os Syzygium cumini (SCE) on cyclophosphamide-induced genotoxicity and oxidative stress in mice. Drug. Chem. Toxicol. 36 (2013), 396–402.
51. Tzeng, T.F., Liou, S.S., Liu, I.M., Myricetin ameliorates defective post-receptor insulin signaling via beta-endorphin signaling in the skeletal muscles of fructose-fed rats. Evid. Based Complement. Altern. Med., 2011, 1–9.
52. Venkatasamy, V.V., Pericherla, S., Manthuruthil, S., Mishra, S., Hanno, R., Effect of physical activity on insulin resistance, inflammation and oxidative stress in diabetes mellitus. J. Clin. Diagn. Res. 7 (2013), 1764–1766.
53. Vuković, R., Blažetić, S., Oršolić, I., Heffer, M., Vari, S.G., Gajdoš, M., Krivošíková, Z., Kramárová, P., Kebis, A., Has-Schön, E., Impact of ovariectomy, high fat diet, and lifestyle modifications on oxidative/antioxidative status in the rat liver. Croat. Med. J. 55 (2014), 218–227.
54. Wang, H., Joseph, J.A., Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic. Biol. Med. 27 (1999), 612–616.
55. Zhang, M., Lv, X.Y., Li, J., Xu, Z.G., Chen, L., The characterization of high-fat diet and multiple low-dose of streptozotocin induced type 2 diabetes rat model. Exp. Diabetes Res., 2008, 1–9.
56. Zhang, Y.J., Gan, R.Y., Li, S., Zhou, Y., Li, A.N., Xu, D.P., Li, H.B., Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules 20 (2015), 21138–21156.
57. Zhao, F.Q., Keating, A.F., Functional properties and genomics of glucose transporters. Curr. Genom. 8 (2007), 113–128.
58. Zheng, N., Wang, Z., Chen, F., Lin, J., Evaluation to the antioxidant activity of total flavonoids extract from Syzygium jambos seeds and optimization by response surface methodology. Afr. J. Pharm. Pharmac 5 (2011), 2411–2419.
59. Zou, D., Liu, P., Chen, K., Xie, Q., Liang, X., Bai, Q., Zhou, Q., Liu, K., Zhang, T., Zhu, J., Mi, M., Protective effects of myricetin on acute hypoxia-induced exercise intolerance and mitochondrial impairments in rats. PLoS ONE 10 (2015), 1–17.