Recovery of cardiac function in cardiomyopathy caused by titin truncation

JAMA Cardiology

Volumn 1, Issue 2, 2016, Pages 234-235

  Felkin, Leanne E ^a   Walsh, Roddy ^a,b   Ware, James S ^a   Yacoub, Magdi H ^a   Birks, Emma J ^c   Barton, Paul J R ^b   Cook, Stuart A ^d  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF LOUISVILLE   (United States)

^d DEPARTMENT OF CARDIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIN; TTN PROTEIN, HUMAN;

ADULT; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CONVALESCENCE; FEMALE; GENE SEQUENCE; GENETIC VARIABILITY; HEART FUNCTION; HUMAN; LEFT VENTRICULAR ASSIST DEVICE; LETTER; MALE; NEXT GENERATION SEQUENCING; TTN GENE; DNA SEQUENCE; GENETICS; HEART VALVE REPLACEMENT; HEART VENTRICLE; MIDDLE AGED; PATHOPHYSIOLOGY; PROGNOSIS; SURVIVAL ANALYSIS; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; CARDIOMYOPATHY, DILATED; CONNECTIN; FEMALE; HEART VALVE PROSTHESIS IMPLANTATION; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; SEQUENCE ANALYSIS, DNA; SURVIVAL ANALYSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84999676397     PISSN: 23806583     EISSN: 23806591     Source Type: Journal    
DOI: 10.1001/jamacardio.2016.0208     Document Type: Letter

References (7)

1. Herman DS, Lam L, Taylor MR, et al. Truncations of titin causing dilated cardiomyopathy. N Engl J Med. 2012; 366(7):619-628.
2. Roberts AM, Ware JS, Herman DS, et al. Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med. 2015; 7(270):270ra6.
3. Merlo M, Stolfo D, Anzini M, et al. Persistent recovery of normal left ventricular function and dimension in idiopathic dilated cardiomyopathy during long-term follow-up: does real healing exist? J Am Heart Assoc. 2015; 4(1):e001504.
4. Birks EJ, Tansley PD, Hardy J, et al. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med. 2006; 355(18):1873-1884.
5. Birks EJ, George RS, Hedger M, et al. Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: a prospective study. Circulation. 2011; 123(4):381-390.
6. Mann DL, Barger PM, Burkhoff D. Myocardial recovery and the failing heart: myth, magic, or molecular target? J Am Coll Cardiol. 2012; 60(24):2465-2472.
7. The Exome Aggregation Consortium: ExAc browser (beta). http://exac.broadinstitute.org/. Accessed January 21, 2015.