NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade

Journal for ImmunoTherapy of Cancer

Volumn 3, Issue 1, 2015, Pages

  Kohlhapp, Frederick J ^a,b   Broucek, Joseph R ^b   Hughes, Tasha ^b   Huelsmann, Erica J ^b   Lusciks, Jevgenijs ^b   Zayas, Janet P ^b   Dolubizno, Hubert ^b   Fleetwood, Vidyaratna A ^b   Grin, Alisa ^b   Hill, Graham E ^b   Poshepny, Joseph L ^b   Nabatiyan, Arman ^b   Ruby, Carl E ^b   Snook, Joshua D ^c   Rudra, Jai S ^c   Schenkel, Jason M ^d   Masopust, David ^d   Zloza, Andrew ^a,b,e   Kaufman, Howard L ^a,e  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^e ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

CD8+ T cells; CTLA 4; Immunotherapy; Interleukin 2; NK cells

Indexed keywords

9H10 MONOCLONAL ANTIBODY; ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CALCIUM; CREATININE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOSE; IMMUNOGLOBULIN G; INTERLEUKIN 2; INTERLEUKIN 2 ANTIBODY; IPILIMUMAB; MONOCLONAL ANTIBODY; PHOSPHORUS; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; LOW DRUG DOSE; MELANOMA; MOUSE; NATURAL KILLER CELL; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

EID: 84998981036     PISSN: None     EISSN: 20511426     Source Type: Journal    
DOI: 10.1186/s40425-015-0063-3     Document Type: Article

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