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Angewandte Chemie - International Edition

Volumn 55, Issue 49, 2016, Pages 15277-15281

Identification of Two Distinct Sites for Antagonist and Biased Agonist Binding to the Human Chemokine Receptor CXCR3

(6) Milanos, Lampros a Saleh, Noureldin a Kling, Ralf C a Kaindl, Jonas a Tschammer, Nuska a,b Clark, Timothy a

a UNIVERSITY OF ERLANGEN NUREMBERG (Germany)

b NanoTemper Technologies GmbH (Germany)

Author keywords

allosterism; membrane proteins; molecular dynamics; protein structures; signal transduction

Indexed keywords

BINDING ENERGY; MODULATORS; MOLECULAR DYNAMICS; PROTEINS; SIGNAL TRANSDUCTION;

ALLOSTERIC MODULATORS; ALLOSTERISM; CHEMOKINE RECEPTORS; EXTRACELLULAR SIGNALS; G PROTEIN COUPLED RECEPTORS; MEMBRANE PROTEINS; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN STRUCTURES;

BINDING SITES;

ACETAMIDE DERIVATIVE; CHEMOKINE RECEPTOR CXCR3; CXCR3 PROTEIN, HUMAN; PYRIMIDINONE DERIVATIVE; RAMX3;

AGONISTS; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; HUMAN; MOLECULAR DYNAMICS; MOLECULAR LIBRARY; PHARMACOLOGY;

ACETAMIDES; BINDING SITES; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; PYRIMIDINONES; RECEPTORS, CXCR3; SMALL MOLECULE LIBRARIES;

EID: 84997796763 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201607831 Document Type: Article

Times cited : (16)

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