Is Pain Perception Altered in People With Depression? A Systematic Review and Meta-Analysis of Experimental Pain Research

Journal of Pain

Volumn 17, Issue 12, 2016, Pages 1257-1272

  Thompson, Trevor ^a   Correll, Christoph U ^b   Gallop, Katy ^c   Vancampfort, Davy ^d   Stubbs, Brendon ^e,f  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

^b ZUCKER HILLSIDE HOSPITAL   (United States)

^c Acaster Consulting   (United Kingdom)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^f KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Depression; depressive disorder; meta analysis; pain; systematic review

Indexed keywords

ANTIDEPRESSANT AGENT;

AGE DISTRIBUTION; DEPRESSION; EXPERIMENTAL PAIN; HUMAN; INTEROCEPTION; MENTAL PATIENT; NOCICEPTION; NOCICEPTIVE STIMULATION; PAIN; PAIN THRESHOLD; PSYCHOPHARMACOTHERAPY; REVIEW; SEX DIFFERENCE; SEX RATIO; SKIN STIMULATION; SYSTEMATIC REVIEW; META ANALYSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY;

DEPRESSION; HUMANS; PAIN PERCEPTION; PAIN THRESHOLD;

EID: 84997531205     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2016.08.007     Document Type: Review

References (77)

1. 1 Adler, G., Gattaz, W.F., Pain perception threshold in major depression. Biol Psychiatry 34 (1993), 687–689.
2. 2 Bair, M.J., Robinson, R.L., Katon, W., Kroenke, K., Depression and pain comorbidity: A literature review. Arch Intern Med 163 (2003), 2433–2445.
3. 3 Bär, K.J., Brehm, S., Boettger, M.K., Boettger, S., Wagner, G., Sauer, H., Pain perception in major depression depends on pain modality. Pain 117 (2005), 97–103.
4. 4 Bär, K.J., Greiner, W., Letsch, A., Köbele, R., Sauer, H., Influence of gender and hemispheric lateralization on heat pain perception in major depression. J Psychiatr Res 37 (2003), 345–353.
5. 5 Bär, K.J., Terhaar, J., Boettger, M.K., Boettger, S., Berger, S., Weiss, T., Pseudohypoalgesia on the skin: A novel view on the paradox of pain perception in depression. J Clin Psychopharmacol 31 (2011), 103–107.
6. 6 Bär, K.J., Wagner, G., Koschke, M., Boettger, S., Boettger, M.K., Schlösser, R., Sauer, H., Increased prefrontal activation during pain perception in major depression. Biol Psychiatry 62 (2007), 1281–1287.
7. 7 Beck, A.T., Ward, C.H., Mendelson, M., Mock, J., Erbaugh, J., An inventory for measuring depression. Arch Gen Psychiatry 4 (1961), 561–571.
8. 8 Begg, C.B., Mazumdar, M., Operating characteristics of a rank correlation test for publication bias. Biometrics 50 (1994), 1088–1101.
9. 9 Ben-Tovim, D.I., Schwartz, M.S., Hypoalgesia in depressive illness. Br J Psychiatry 138 (1981), 37–39.
10. 10 Boettger, M.K., Greiner, W., Rachow, T., Brühl, C., Bär, K.J., Sympathetic skin response following painful electrical stimulation is increased in major depression. Pain 149 (2010), 130–134.
11. 11 Borenstein, M., Hedges, L., Higgins, J., Rothstein, H.R., Introduction to Meta-Analysis. 2009, Wiley, West Sussex.
12. 12 Boureau, F., Luu, M., Doubrère, J.F., Study of experimental pain measures and nociceptive reflex in chronic pain patients and normal subjects. Pain 44 (1991), 131–138.
13. 13 Bridges, K.W., Goldberg, D.P., Somatic presentation of DSM III psychiatric disorders in primary care. J Psychosom Res 29 (1985), 563–569.
14. 14 Davis, G.C., Buchsbaum, M.S., Bunney, W.E., Analgesia to painful stimuli in affective illness. Am J Psychiatry 136 (1979), 1148–1151.
15. 15 Demyttenaere, K., Bonnewyn, A., Bruffaerts, R., Brugha, T., De Graaf, R., Alonso, J., Comorbid painful physical symptoms and depression: prevalence, work loss, and help seeking. J Affect Disord 92 (2006), 185–193.
16. 16 Dickens, C., McGowan, L., Dale, S., Impact of depression on experimental pain perception: A systematic review of the literature with meta-analysis. Psychosom Med 65 (2003), 369–375.
17. 17 Duval, S., Tweedie, R., Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56 (2000), 455–463.
18. 18 Dworkin, R.H., Clark, W.C., Lipsitz, J.D., Pain responsivity in major depression and bipolar disorder. Psychiatry Res 56 (1995), 173–181.
19. 19 Eccleston, C., Crombez, G., Pain demands attention: A cognitive-affective model of the interruptive function of pain. Psychol Bull 125 (1999), 356–366.
20. 20 Egger, M., Davey Smith, G., Schneider, M., Minder, C., Bias in meta-analysis detected by a simple, graphical test. BMJ 315 (1997), 629–634.
21. 21 Euteneuer, F., Schwarz, M.J., Hennings, A., Riemer, S., Stapf, T., Selberdinger, V., Rief, W., Depression, cytokines and experimental pain: Evidence for sex-related association patterns. J Affect Disord 131 (2011), 143–149.
22. 22 Fields, H.L., Pain modulation: Expectation, opioid analgesia and virtual pain. Prog Brain Res 122 (2000), 245–253.
23. 23 Fillingim, R.B., Girdler, S., Booker, D.K., Light, K.C., Harris, M.B., Maixner, W., Pain sensitivity in women with premenstrual dysphoric disorder: A preliminary report. J Womens Health 4 (1995), 367–374.
24. 24 Fishbain, D.A., Cole, B., Lewis, J.E., Gao, J., Does pain interfere with antidepressant depression treatment response and remission in patients with depression and pain? An evidence-based structured review. Pain Med 15 (2014), 1522–1539.
25. 25 Gracely, R.H., Studies of pain in human subjects. Melzack, R., Wall, P., (eds.), Textbook of Pain, 2005, Elsevier, London, 267–289.
26. 26 Hamilton, M., A rating scale for depression. J Neurol Neurosurg Psychiatry 23 (1960), 56–62.
27. 27 Han, C., Pae, C.U., Pain and depression: A neurobiological perspective of their relationship. Psychiatry Investig 12 (2015), 1–8.
28. 28 Higgins, J.P., Thompson, S.G., Deeks, J.J., Altman, D.G., Measuring inconsistency in meta-analyses. BMJ 327 (2003), 557–560.
29. 29 Higgins, J.P., Green, S., Cochrane Handbook for Systematic Reviews of Interventions. 2008, Wiley, West Sussex.
30. 30 Hirsch, J.K., Sirois, F.M., Molnar, D., Chang, E.C., Pain and depressive symptoms in primary care: Moderating role of positive and negative affect. Clin J Pain 32 (2016), 562–567.
31. 31 Katon, W., Sullivan, M.D., Depression and chronic medical illness. J Clin Psychiatry 51:Suppl (1990), 3–11 discussion: 12.
32. 32 Kirmayer, L.J., Robbins, J.M., Dworkind, M., Yaffe, M.J., Somatization and the recognition of depression and anxiety in primary care. Am J Psychiatry 150 (1993), 734–741.
33. 33 Klatzkin, R.R., Lindgren, M.E., Forneris, C.A., Girdler, S.S., Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences. Biol Psychol 84 (2010), 235–247.
34. 34 Klauenberg, S., Maier, C., Assion, H.J., Hoffmann, A., Krumova, E.K., Magerl, W., Scherens, A., Treede, R.D., Juckel, G., Depression and changed pain perception: Hints for a central disinhibition mechanism. Pain 140 (2008), 332–343.
35. 35 Kroenke, K., Spitzer, R.L., Williams, J.B., Linzer, M., Hahn, S.R., deGruy, F.V., Brody, D., Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment. Arch Fam Med 3 (1994), 774–779.
36. 36 Landis, J.R., Koch, G.G., The measurement of observer agreement for categorical data. Biometrics 33 (1977), 159–174.
37. 37 Lautenbacher, S., Krieg, J.C., Pain perception in psychiatric disorders: A review of the literature. J Psychiatr Res 28 (1994), 109–122.
38. 38 Lautenbacher, S., Roscher, S., Strian, D., Fassbender, K., Krumrey, K., Krieg, J.C., Pain perception in depression: Relationships to symptomatology and naloxone-sensitive mechanisms. Psychosom Med 56 (1994), 345–352.
39. 39 Lautenbacher, S., Spernal, J., Schreiber, W., Krieg, J.C., Relationship between clinical pain complaints and pain sensitivity in patients with depression and panic disorder. Psychosom Med 61 (1999), 822–827.
40. 40 Leino, P., Magni, G., Depressive and distress symptoms as predictors of low back pain, neck-shoulder pain, and other musculoskeletal morbidity: A 10-year follow-up of metal industry employees. Pain 53 (1993), 89–94.
41. 41 López-Solà, M., Pujol, J., Hernández-Ribas, R., Harrison, B.J., Contreras-Rodríguez, O., Soriano-Mas, C., Deus, J., Ortiz, H., Menchón, J.M., Vallejo, J., Cardoner, N., Effects of duloxetine treatment on brain response to painful stimulation in major depressive disorder. Neuropsychopharmacology 35 (2010), 2305–2317.
42. 42 Marazziti, D., Castrogiovanni, P., Rossi, A., Rosa, C., Ghione, S., Di Muro, A., Panattoni, E., Cassano, G.B., Pain threshold is reduced in depression. Int J Neuropsychopharmacol 1 (1998), 45–48.
43. 43 Melzack, R., Wall, P., (eds.) Textbook of Pain, 2005, Elsevier, London.
44. 44 Meyer, R.A., Ringkamp, M., Campbell, J.N., Raja, S.N., Peripheral mechanisms of cutaneous nociception. Melzack, R., Wall, P., (eds.), Textbook of Pain, 2005, Elsevier, London, 3–34.
45. 45 Mialet, J.P., Pope, H.G., Yurgelun-Todd, D., Impaired attention in depressive states: A non-specific deficit. Psychol Med 26 (1996), 1009–1020.
46. 46 Mitchell, A.J., Vaze, A., Rao, S., Clinical diagnosis of depression in primary care: A meta-analysis. Lancet 374 (2009), 609–619.
47. 47 Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., PRISMA Group: Preferred Reporting Items for Systematic reviews and Meta-Analyses: The PRISMA statement. BMJ, 339, 2009, b2535.
48. 48 Muhtz, C., Rodriguez-Raecke, R., Hinkelmann, K., Moeller-Bertram, T., Kiefer, F., Wiedemann, K., May, A., Otte, C., Cortisol response to experimental pain in patients with chronic low back pain and patients with major depression. Pain Med 14 (2013), 498–503.
49. 49 Neziri, A.Y., Curatolo, M., Nüesch, E., Scaramozzino, P., Andersen, O.K., Arendt-Nielsen, L., Jüni, P., Factor analysis of responses to thermal, electrical, and mechanical painful stimuli supports the importance of multi-modal pain assessment. Pain 152 (2011), 1146–1155.
50. 50 Normand, E., Potvin, S., Gaumond, I., Cloutier, G., Corbin, J.F., Marchand, S., Pain inhibition is deficient in chronic widespread pain but normal in major depressive disorder. J Clin Psychiatry 72 (2011), 219–224.
51. 51 Otto, M.W., Dougher, M.J., Yeo, R.A., Depression, pain, and hemispheric activation. J Nerv Ment Dis 177 (1989), 210–218.
52. 52 Piñerua-Shuhaibar, L., Prieto-Rincon, D., Ferrer, A., Bonilla, E., Maixner, W., Suarez-Roca, H., Reduced tolerance and cardiovascular response to ischemic pain in minor depression. J Affect Disord 56 (1999), 119–126.
53. 53 Pinheiro, M.B., Ferreira, M.L., Refshauge, K., Ordoñana, J.R., Machado, G.C., Prado, L.R., Maher, C.G., Ferreira, P.H., Symptoms of depression and risk of new episodes of low back pain. A systematic review and meta-analysis. Arthritis Care Res (Hoboken) 67 (2015), 1591–1603.
54. 54 Probst, T., Neumeier, S., Altmeppen, J., Angerer, M., Loew, T., Pieh, C., Depressed mood differentially mediates the relationship between pain intensity and pain disability depending on pain duration: A moderated mediation analysis in chronic pain patients. Pain Res Manag, 1-7, 2016, 2016.
55. 55 Rijavec, N., Grubic, V.N., Depression and pain: Often together but still a clinical challenge: A review. Psychiatr Danub 24 (2012), 346–352.
56. 56 Rodriguez-Raecke, R., Ihle, K., Ritter, C., Muhtz, C., Otte, C., May, A., Neuronal differences between chronic low back pain and depression regarding long-term habituation to pain. Eur J Pain 18 (2014), 701–711.
57. 57 Schaible, H.G., Basic mechanisms of deep somatic pain. Melzack, R., Wall, P., (eds.), Textbook of Pain, 2005, Elsevier, London, 621–633.
58. 58 Schwier, C., Kliem, A., Boettger, M.K., Bär, K.J., Increased cold-pain thresholds in major depression. J Pain 11 (2010), 287–290.
59. 59 Simon, G.E., VonKorff, M., Piccinelli, M., Fullerton, C., Ormel, J., An international study of the relation between somatic symptoms and depression. N Engl J Med 341 (1999), 1329–1335.
60. 60 Spernal, J., Krieg, J.C., Lautenbacher, S., Pain thresholds as a putative functional test for cerebral laterality in major depressive disorder and panic disorder. Neuropsychobiology 48 (2003), 146–151.
61. 61 Strigo, I.A., Matthews, S.C., Simmons, A.N., Right anterior insula hypoactivity during anticipation of homeostatic shifts in major depressive disorder. Psychosom Med 72 (2010), 316–323.
62. 62 Strigo, I.A., Simmons, A.N., Matthews, S.C., Craig, A.D., Paulus, M.P., Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: Evidence of “emotional allodynia”. Psychosom Med 70 (2008), 338–344.
63. 63 Strigo, I.A., Simmons, A.N., Matthews, S.C., Craig, A.D., Paulus, M.P., Major depressive disorder is associated with altered functional brain response during anticipation and processing of heat pain. Arch Gen Psychiatry 65 (2008), 1275–1284.
64. 64 Stroup, D.F., Berlin, J.A., Morton, S.C., Olkin, I., Williamson, G.D., Rennie, D., Moher, D., Becker, B.J., Sipe, T.A., Thacker, S.B., Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283 (2000), 2008–2012.
65. 65 Stubbs, B., Thompson, T., Acaster, S., Vancampfort, D., Gaughran, F., Correll, C.U., Decreased pain sensitivity among people with schizophrenia: A meta-analysis of experimental pain induction studies. Pain 156 (2015), 2121–2131.
66. 66 Stubbs, B., Thompson, T., Solmi, M., Vancampfort, D., Sergi, G., Luchini, C., Veronese, N., Is pain sensitivity altered in people with Alzheimer's disease? A systematic review and meta-analysis of experimental pain research. Exp Gerontol 82 (2016), 30–38.
67. 67 Suarez-Roca, H., Piñerua-Shuhaibar, L., Morales, M.E., Maixner, W., Increased perception of post-ischemic paresthesias in depressed subjects. J Psychosom Res 55 (2003), 253–257.
68. 68 Terhaar, J., Boettger, M.K., Schwier, C., Wagner, G., Israel, A.K., Bär, K.J., Increased sensitivity to heat pain after sad mood induction in female patients with major depression. Eur J Pain 14 (2010), 559–563.
69. 69 Terhaar, J., Viola, F.C., Franz, M., Berger, S., Bär, K.J., Weiss, T., Differential processing of laser stimuli by Aδ and C fibres in major depression. Pain 152 (2011), 1796–1802.
70. 70 Thompson, T., Keogh, E., French, C.C., Davis, R., Anxiety sensitivity and pain: Generalisability across noxious stimuli. Pain 134 (2008), 187–196.
71. 71 Trivedi, M.H., The link between depression and physical symptoms. Prim Care Companion J Clin Psychiatry 6:Suppl 1 (2004), 12–16.
72. 72 von Knorring, L., Espvall, M., Experimentally induced pain in patients with depressive disorders. Acta Psychiatr Scand Suppl 255 (1974), 121–133.
73. 73 Vos, T., Barber, R.M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., Duan, L., Erskine, H., Feigin, V.L., Ferrari, A.J., Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 386 (2015), 743–800.
74. 74 Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available at: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
75. 75 Wolff B: in Wall PD, Melzack R (eds): Textbook of Pain. Edinburgh, Churchill Livingstone, 1984, pp 186.
76. 76 Zambito Marsala, S., Pistacchi, M., Tocco, P., Gioulis, M., Fabris, F., Brigo, F., Tinazzi M: Pain perception in major depressive disorder: A neurophysiological case–control study. J Neurol Sci 357 (2015), 19–21.
77. 77 Zhang, L., Zhang, Y., Zhao, Z.Q., Anterior cingulate cortex contributes to the descending facilitatory modulation of pain via dorsal reticular nucleus. Eur J Neurosci 22 (2005), 1141–1148.