Is pain sensitivity altered in people with Alzheimer's disease? A systematic review and meta-analysis of experimental pain research

Experimental Gerontology

Volumn 82, Issue , 2016, Pages 30-38

  Stubbs, Brendon ^a,b   Thompson, Trevor ^c   Solmi, Marco ^d,h   Vancampfort, Davy ^e,f   Sergi, Giuseppe ^d   Luchini, Claudio ^g   Veronese, Nicola ^d,h  

^a SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF GREENWICH   (United Kingdom)

^d UNIVERSITY OF PADOVA   (Italy)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f KU LEUVEN DEPARTMENT OF REHABILITATION SCIENCES   (Belgium)

^g UNIVERSITY AND HOSPITAL TRUST OF VERONA   (Italy)

^h Institute of Clinical Research and Education in Medicine (IREM)   (Italy)

Author keywords

Alzheimer's disease; Dementia pain; Experimental pain; Meta analysis; Systematic review

Indexed keywords

ALZHEIMER DISEASE; CLINICAL ASSESSMENT TOOL; CLINICAL FEATURE; DISEASE ASSOCIATION; ELECTRONIC MEDICAL RECORD; EXPERIMENTAL PAIN; FACIAL ACTION CODING SYSTEM; FACIAL EXPRESSION; HEART RATE VARIABILITY; HUMAN; MINI MENTAL STATE EXAMINATION; NOCICEPTION; NOCICEPTIVE STIMULATION; PAIN ASSESSMENT; PAIN INTENSITY; PAIN THRESHOLD; PRIORITY JOURNAL; REVIEW; SCORING SYSTEM; SEX DIFFERENCE; SYSTEMATIC REVIEW; VERBAL BEHAVIOR; HEART RATE; META ANALYSIS; PAIN; PAIN MEASUREMENT; PATHOPHYSIOLOGY;

ALZHEIMER DISEASE; HEART RATE; HUMANS; PAIN; PAIN MEASUREMENT;

EID: 84976468230     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2016.05.016     Document Type: Review

References (49)

1. Abdulla, A., Bone, M., Adams, N., Elliott, A.M., Jones, D., Knaggs, R., Martin, D., Sampson, E.L., Schofield, P., Evidence-based clinical practice guidelines on management of pain in older people. Age Ageing 42 (2013), 151–153.
2. Achterberg, W.P., Pieper, M.J.C., van Dalen-Kok, A.H., de Waal, M.W.M., Husebo, B.S., Lautenbacher, S., Kunz, M., Scherder, E.J.A., Corbett, A., Pain management in patients with dementia. Clin. Interv. Aging 8 (2013), 1471–1482.
3. Anon., Pharmacological management of persistent pain in older persons. J. Am. Geriatr. Soc. 57 (2009), 1331–1346.
4. Beach, P.A., Huck, J.T., Miranda, M.M., Bozoki, A.C., Autonomic, behavioral, and subjective pain responses in Alzheimer's disease. Pain Med. 16 (2015), 1930–1942.
5. Beach, P.A., Huck, J.T., Miranda, M.M., Foley, K.T., Bozoki, A.C., Effects of Alzheimer's disease on the facial expression of pain. Clin. J. Pain, 2015.
6. Begg, C.B., Mazumdar, M., Operating characteristics of a rank correlation test for publication bias. Biometrics 50 (1994), 1088–1101.
7. Benedetti, F., Vighetti, S., Ricco, C., Lagna, E., Bergamasco, B., Pinessi, L., Rainero, I., Pain threshold and tolerance in Alzheimer's disease. Pain 80 (1999), 377–382 ((03043959) 376 pp.).
8. Benedetti, F., Arduino, C., Costa, S., Vighetti, S., Tarenzi, L., Rainero, I., Asteggiano, G., Loss of expectation-related mechanisms in Alzheimer's disease makes analgesic therapies less effective. Pain 121 (2006), 133–144.
9. Cole, L.J., Farrell, M.J., Duff, E., Barber, J.B., Egan, G.F., Gibson, S.J., Pain sensitivity and fmri pain-related brain activity in Alzheimer's disease. Brain 129 (2006), 2957–2965 (2959 pp.).
10. Cole, L.J., Gavrilescu, M., Johnston, L.A., Gibson, S.J., Farrell, M.J., Egan, G.F., The impact of Alzheimer's disease on the functional connectivity between brain regions underlying pain perception. Eur. J. Pain 15 (2011), e1–e11.
11. Corbett, A., Husebo, B., Malcangio, M., Staniland, A., Cohen-Mansfield, J., Aarsland, D., Ballard, C., Assessment and treatment of pain in people with dementia. Nat. Rev. Neurol. 8 (2012), 264–274.
12. Corbett, A., Husebo, B.S., Achterberg, W.P., Aarsland, D., Erdal, A., Flo, E., The importance of pain management in older people with dementia. Br. Med. Bull. 111 (2014), 139–148.
13. Defrin, R., Amanzio, M., de Tommaso, M., Dimova, V., Filipovic, S., Finn, D.P., Gimenez-Llort, L., Invitto, S., Jensen-Dahm, C., Lautenbacher, S., Oosterman, J.M., Petrini, L., Pick, C.G., Pickering, G., Vase, L., Kunz, M., Experimental pain processing in individuals with cognitive impairment: current state of the science. Pain 156 (2015), 1396–1408 (03043959). (1313 pp.).
14. Duval, S., Tweedie, R., Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56 (2000), 455–463.
15. Egger, M., Davey Smith, G., Schneider, M., Minder, C., Bias in meta-analysis detected by a simple, graphical test. BMJ 315 (1997), 629–634.
16. Femminella, G.D., Rengo, G., Komici, K., Iacotucci, P., Petraglia, L., Pagano, G., de Lucia, C., Canonico, V., Bonaduce, D., Leosco, D., Ferrara, N., Autonomic dysfunction in Alzheimer's disease: tools for assessment and review of the literature. J. Alzheimers Dis. 42 (2014), 369–377.
17. Folstein, M.F., Folstein, S.E., McHugh, P.R., Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12 (1975), 189–198.
18. Gibson, S.J., Voukelatos, X., Ames, D., Flicker, L., Helme, R.D., An examination of pain perception and cerebral event-related potentials following carbon dioxide laser stimulation in patients with Alzheimer's disease and age-matched control volunteers. Pain Res. Manag. 6 (2001), 126–132.
19. Gracely, R.H., Studies of pain in human subjects. Melzack, R., Wall, P., (eds.) Textbook of Pain, fifth ed., 2005, Elsevier, London, 267–289.
20. Higgins, J.P.T., Thompson, S.G., Deeks, J.J., Altman, D.G., Measuring inconsistency in meta-analyses. BMJ 327 (2003), 557–560.
21. Hoffmann, F., van den Bussche, H., Wiese, B., Glaeske, G., Kaduszkiewicz, H., Diagnoses indicating pain and analgesic drug prescription in patients with dementia: a comparison to age- and sex-matched controls. BMC Geriatr., 14, 2014, 20.
22. Hunt, L.J., Covinsky, K.E., Yaffe, K., Stephens, C.E., Miao, Y., Boscardin, W.J., Smith, A.K., Pain in community-dwelling older adults with dementia: results from the national health and aging trends study. J. Am. Geriatr. Soc. 63 (2015), 1503–1511 (1509 pp.).
23. Husebo, B.S., BC, AD, Pain treatment of agitation in patients with dementia: a systematic review. Int. J. Geriatr. Psychiatry 26 (2011), 1012–1018.
24. Ioannidis, J.P., Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. CMAJ 181 (2009), 488–493.
25. Jensen-Dahm, C., Werner, M.U., Dahl, J.B., Jensen, T.S., Ballegaard, M., Hejl, A.-M., Waldemar, G., Quantitative sensory testing and pain tolerance in patients with mild to moderate Alzheimer disease compared to healthy control subjects. Pain 155 (2014), 1439–1445.
26. Jensen-Dahm, C., Gasse, C., Astrup, A., Mortensen, P.B., Waldemar, G., Frequent use of opioids in patients with dementia and nursing home residents: a study of the entire elderly population of Denmark. Alzheimers Dement. 11 (2015), 691–699.
27. Jensen-Dahm, C., Werner, M.U., Jensen, T.S., Ballegaard, M., Andersen, B.B., Høgh, P., Waldemar, G., Discrepancy between stimulus response and tolerance of pain in Alzheimer disease. Neurology 84 (2015), 1575–1581 (1577 pp.).
28. Jones, A.K., Kulkarni, B., Derbyshire, S.W., Pain mechanisms and their disorders. Br. Med. Bull. 65 (2003), 83–93.
29. Kunz, M., Behavioural/facial markers of pain, EmoCon, CogniCon. Pickering, G., Gibson, S., (eds.) Pain, Emotion and Cognition: A Complex Nexus, 2015, 123–133.
30. Kunz, M., Scharmann, S., Hemmeter, U., Schepelmann, K., Lautenbacher, S., The facial expression of pain in patients with dementia. Pain 133 (2007), 221–228 ((03043959) 228 pp.).
31. Kunz, M., Mylius, V., Scharmann, S., Schepelman, K., Lautenbacher, S., Influence of dementia on multiple components of pain. Eur. J. Pain 13 (2009), 317–325 (319 pp.).
32. Lints-Martindale, A.C., Hadjistavropoulos, T., Barber, B., Gibson, S.J., A psychophysical investigation of the facial action coding system as an index of pain variability among older adults with and without Alzheimer's disease. Pain Med. 8 (2007), 678–689.
33. Lobo, A., Launer, L.J., Fratiglioni, L., Andersen, K., Di Carlo, A., Breteler, M.M., Copeland, J.R., Dartigues, J.F., Jagger, C., Martinez-Lage, J., Soininen, H., Hofman, A., Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic diseases in the elderly research group. Neurology 54 (2000), S4–S9.
34. McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M., Clinical diagnosis of Alzheimer's disease: report of the nincds − adrda work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology, 77, 2011, 333.
35. Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Preferred reporting items for systematic reviews and meta-analyses: the prisma statement. PLoS Clin. Trials 6 (2009), 1–6.
36. Monroe, T.B., Herr, K.A., Mion, L.C., Cowan, R.L., Ethical and legal issues in pain research in cognitively impaired older adults. Int. J. Nurs. Stud. 50 (2013), 1283–1287.
37. Nelson, P.T., Braak, H., Markesbery, W.R., Neuropathology and cognitive impairment in Alzheimer's disease: a complex but coherent relationship. J. Neuropathol. Exp. Neurol. 68 (2009), 1–14.
38. Pieper, M.J.C., van Dalen-Kok, A.H., Francke, A.L., van der Steen, J.T., Scherder, E.J.A., Husebø, B.S., Achterberg, W.P., Interventions targeting pain or behaviour in dementia: a systematic review. Ageing Res. Rev. 12 (2013), 1042–1055.
39. Prkachin, K.M., The consistency of facial expressions of pain: a comparison across modalities. Pain 51:3 (1992), 297–306.
40. Rainero, I., Vighetti, S., Bergamasco, B., Pinessi, L., Benedetti, F., Autonomic responses and pain perception in Alzheimer's disease. Eur. J. Pain 4 (2000), 267–274.
41. Sampson, E.L., White, N., Lord, K., Leurent, B., Vickerstaff, V., Scott, S., Jones, L., Pain, agitation, and behavioural problems in people with dementia admitted to general hospital wards: a longitudinal cohort study. Pain 156 (2015), 675–683 (03043959, 679 pp.).
42. Scherder, E.J.A., Sergeant, J.A., Swaab, D.F., Pain processing in dementia and its relation to neuropathology. Lancet Neurol. 2 (2003), 677–686.
43. Sternbach, R.A., Psychophysiology of pain. Int. J. Psychiatry Med. 6 (1975), 63–73.
44. Stroup, D.F., Berlin, J.A., Morton, S.C., Olkin, I., Williamson, G.D., Rennie, D., Moher, D., Becker, B.J., Sipe, T.A., Thacker, S.B., Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (moose) group. JAMA 283 (2000), 2008–2012.
45. Stubbs, B., Binnekade, T., Eggermont, L., Sepehry, A.A., Patchay, S., Schofield, P., Pain and the risk for falls in community-dwelling older adults: systematic review and meta-analysis. Arch. Phys. Med. Rehabil. 95 (2014), 175–187.e179.
46. Uthaikhup, S., Prasert, R., Paungmali, A., Boontha, K., Altered pain sensitivity in elderly women with chronic neck pain. PLoS One 10 (2015), 1–9.
47. van Kooten, J., Delwel, S., Binnekade, T.T., Smalbrugge, M., van der Wouden, J.C., Perez, R.S.G.M., Rhebergen, D., Zuurmond, W.W.A., Stek, M.L., Lobbezoo, F., Hertogh, C.M.P.M., Scherder, E.J.A., Pain in dementia: prevalence and associated factors: protocol of a multidisciplinary study. BMC Geriatr. 15 (2015), 29–38 (10 pp.).
48. Wells, G., Shea, B., O'Connell, D., Peterson Jea: The newcastle-ottawa scale (nos) for assessing the quality of nonrandomised studies in meta-analyses. 2007.
49. Wolff, B., Methods of tesCng pain mechanisms in normal man. Wall, P.D., M. R, (eds.) Textbook of Pain, 1984, Churchill Livingstone, Edinburgh, 186–194.