Multimorbidity and functional decline in community-dwelling adults: A systematic review

Health and Quality of Life Outcomes

Volumn 13, Issue 1, 2015, Pages

  Ryan, Aine ^a   Wallace, Emma ^a   O'Hara, Paul ^b   Smith, Susan M ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b WATERFORD REGIONAL HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHRONIC DISEASE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FOLLOW UP; FUNCTIONAL ASSESSMENT; FUNCTIONAL DISEASE; HUMAN; MORBIDITY; MULTIMORBIDITY; OUTCOME ASSESSMENT; PATIENT CARE PLANNING; PHYSICAL ACTIVITY; POPULATION RESEARCH; RISK ASSESSMENT; SYSTEMATIC REVIEW (TOPIC); ADULT; AGED; COMORBIDITY; DISABLED PERSON; FEMALE; GERIATRIC ASSESSMENT; HEALTH STATUS; MALE; MENTAL HEALTH; MIDDLE AGED; PROCEDURES; QUALITY OF LIFE; STATISTICS AND NUMERICAL DATA;

ADULT; AGED; CHRONIC DISEASE; COMORBIDITY; CROSS-SECTIONAL STUDIES; DISABLED PERSONS; FEMALE; GERIATRIC ASSESSMENT; HEALTH STATUS; HUMANS; MALE; MENTAL HEALTH; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); QUALITY OF LIFE;

EID: 84944403833     PISSN: None     EISSN: 14777525     Source Type: Journal    
DOI: 10.1186/s12955-015-0355-9     Document Type: Article

References (68)

1. Fortin M, Bravo G, Hudon C, Vanasse A, Lapointe L. Prevalence of multimorbidity among adults seen in family practice. Ann Fam Med. 2005;3(3):223-8.
2. Van den Aker M, Buntinx F, Metsemakers JF, Roos S, Knottnerus JA. Multimorbidity in general practice: prevalence, incidence and determinants of co-occurring and recurrent disease. J Clin Epidemiol. 1998;51(5):365-75.
3. Uijen AAA, Van de Lisdonk EH. Multimorbidity in Primary care: prevalence and trend over the past 20years. Eur J Gen Pract. 2008;14(suppl):28-32.
4. WHO. Global status report on noncommunicable diseases 2010: description of the global burden of NCDs, their risk factors and determinants. Geneva: World Health Organization; 2011. http://www.who.int/nmh/publications/ncd_report2010/en.
5. Inouye SK, Wagner R, Acampora D, Horowitz RI, Cooney LM, Hurst LD, et al. A predictive index for functional decline in hospitaliszed elderly patients. J Gen Intern Med. 1993;8:645-52.
6. Hebert R. Functional decline in old age. Can Med Assoc J. 1997;157:1037-45.
7. Campbell SE, Seymour DG, Primrose WR, for the ACMEplus Project. A systematic literature review of factors affecting outcome in older medical patients admitted to hospital. Age Aging. 2004;33:110-5.
8. Koyano W, Shibata H, Haga H, Suyama Y. Prevalence and outcome of low ADL and incontinence among the elderly: five years follow-up in a Japanese urban community. Arch Gerontol Geriatr. 1986;5(3):197-206.
9. Ní Mhaoláin AM, Gallagher D, O'Connell H, Chin AV, Bruce I, Hamilton F, et al. Subjective well-being amongst community-dwelling elders: what determines satisfaction with life? Findings from the Dublin Healthy Aging Study. Int Psychogeriatr. 2012;24(2):316-23.
10. Taylor AW, Price K, Gill TK, Adams R, Pilkington R, Carrangis N, et al. Multimorbidity - not just an older person's issue. BMC Public Health. 2010;10:718. doi: 10.1186/1471-2458-10-718.
11. Wolff J, Starfield B, Anderson G. Prevalence, expenditure and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002;62:2269-76.
12. Hoffman C, Rice D, Sung HY. Persons with chronic conditions. Their prevalence and costs. JAMA. 1996;276:1473-79.
13. Barnett K, Mercer S, Norbury M, Watt G, Wkye S, Guthrie B. Epidemiology of Multimorbidity and implications for health care, research, and medical education: a cross sectional study. Lancet. 2012;380(9836):37-43.
14. Van Den Bussche H, Shon G, Kolonko T, Wegscheider K, Glaeske G, Koller D. Patterns of ambulatory medical care utilisation in elderly patients with special reference to chronic diseases and multimorbidity- results from a claims data based observational study in Germany. BMC Geriatr. 2011;11:54.
15. Fortin M, Bravo G, Hudon C, Lapointe L, Almirall J, Dubois MF, et al. Relationship between multimorbidity and health-related quality of life of patients in primary care. Qual Life Res. 2006;15:83-91.
16. Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, et al. Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011;10(4):430-9.
17. Ambrose-Liu TYL, Ashe MC, Marra C and The Physical Activity and Chronic Conditions Research Team. Among older adults with multiple chronic conditions, physical activity is independently and inversely associated with health care utilization. British Journal of Sports Medicine. 2008; doi: 10.1136/bjsm.2008.046458.
18. Kadam UT, Croft PR, North Staffordshire GP Consortium Group. Clinical multimorbidity and physical function in older adults: a record and health status linkage study in general practice. Fam Pract. 2007;24(5):412-9.
19. Smith SM, Soubhi H, Fortin M, Hudon C, O'Dowd T. Interventions for improving outcomes in patients with multimorbidity in primary care and community settings. Cochrane Database Syst Rev. 2012;4:CD006560.
20. Fortin M, Lapointe L, Hudon C, Vanasse A, Ntetu AL, Maltais D. Multimorbidity and quality of life in primary care: a systematic review. Health Qual Life Outcomes. 2004;2:51.
21. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1.
22. National Academy Press. Primary care: America's health in a new era. Washington, DC: National Academy Press; 1996.
23. Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
24. Baker JG, Johnston MV. Prevalence and identification of problems in daily functioning in a primary medicine clinic. Disabil Rehabil. 2000;22(16):716-24.
25. Baker TA, Whitfield KE. Physical functioning in older blacks: an exploratory study identifying psychosocial and clinical predictors. J Natl Med Assoc. 2006;98(7):1114-20.
26. Bayliss M, Rendas-Baum R, White MK, Maruish M, Bjorner J, Tunis SL. Health-related quality of life (HRQL) for individuals with self-reported chronic physical and/or mental health conditions: panel survey of an adult sample in the United States. Health Qual Life Outcomes. 2012;10:154.
27. Bayliss Ellis JL, Shoup JA, Zeng C, McQuillan DB, Steiner JF. Association of patient-centered outcomes with patient-reported and ICD-9-based morbidity measures. Ann Fam Med. 2012;10(2):126-33.
28. Brettschneider C, Leicht H, Bickel H, Dahlhaus A, Fuchs A, Gensichen J, et al. Relative impact of multimorbid chronic conditions on health-related quality of life--results from the MultiCare Cohort Study. PLoS One. 2013;8(6), e66742.
29. Agborsangaya CB, Lau D, Lahtinen M, Cooke T, Johnson JA. Health-related quality of life and healthcare utilization in multimorbidity: results of a cross-sectional survey. Qual Life Res. 2013;22(4):791-9.
30. Cesari M, Onder G, Russo A, Zamboni V, Barillaro C, Ferrucci L, et al. Comorbidity and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study). Gerontology. 2006;52(1):24-32.
31. Chen HY, Baumgardner DJ, Rice JP. Health-related quality of life among adults with multiple chronic conditions in the United States, Behavioral Risk Factor Surveillance System, 2007. Prev Chronic Dis. 2011;8(1):A09.
32. Cheng L, Cumber S, Dumas C, Winter R, Nguyen KM, Nieman LZ. Health related quality of life in pregeriatric patients with chronic diseases at urban, public supported clinics. Health Qual Life Outcomes. 2003;1:63.
33. Formiga F, Pujol R, Perez-Castejon JM, Ferrer A, Henriquez E. Low comorbidity and male sex in nonagenarian community-dwelling people are associated with better functional and cognitive abilities: the NonaSantfeliu study. J Am Geriatr Soc. 2005;53(10):1836-7.
34. Fortin M, Dubois MF, Hudon C, Soubhi H, Almirall J. Multimorbidity and quality of life: a closer look. Health Qual Life Outcomes. 2007;5:52.
35. Goins RT, Pilkerton CS. Comorbidity among older American Indians: the native elder care study. J Cross Cult Gerontol. 2010;25(4):343-54.
36. Griffith L, Raina P, Wu H, Zhu B, Stathokostas L. Population attributable risk for functional disability associated with chronic conditions in Canadian older adults. Age Ageing. 2010;39(6):738-45.
37. Heyworth IT, Hazell ML, Linehan MF, Frank TL. How do common chronic conditions affect health-related quality of life? Br J Gen Pract. 2009;59(568):e353-8.
38. Hunger M, Thoron B, Chunk M, During A, Men P, Peters A, et al. Multimorbidity and health-related quality of life in the older population: results from the German KORA-age study. Health Qual Life Outcomes. 2011;9:53.
39. Jayasinghe UW, Proudfoot J, Barton CA, Amoroso C, Holton C, Davies GP, et al. Quality of life of Australian chronically-ill adults: patient and practice characteristics matter. Health Qual Life Outcomes. 2009;7:50.
40. Joshi K, Kumar R, Avasthi A. Morbidity profile and its relationship with disability and psychological distress among elderly people in Northern India. Int J Epidemiol. 2003;32(6):978-87.
41. Kadam UT, Croft PR. Clinical multimorbidity and physical function in older adults: a record and health status linkage study in general practice. Fam Pract. 2007;24(5):412-9.
42. Kadam UT, Schellevis FG, Lewis M, van der Windt DA, de Vet HC, Bouter LM, et al. Does age modify the relationship between morbidity severity and physical health in English and Dutch family practice populations? Qual Life Res. 2009;18(2):209-20.
43. Keles H, Ekici A, Ekici M, Bulcun E, Altinkaya V. Effect of chronic diseases and associated psychological distress on health-related quality of life. Intern Med J. 2007;37(1):6-11.
44. Kim KI, Lee JH, Kim CH. Impaired health-related quality of life in elderly women is associated with multimorbidity: results from the Korean National Health and Nutrition Examination Survey. Gend Med. 2012;9(5):309-18.
45. Lawson KD, Mercer SW, Wyke S, Grieve E, Guthrie B, Watt GC, et al. Double trouble: the impact of multimorbidity and deprivation on preference-weighted health related quality of life a cross sectional analysis of the Scottish Health Survey. Int J Equity Health. 2013;12:67.
46. Michelson H, Bolund C, Brandberg Y. Multiple chronic health problems are negatively associated with health related quality of life (HRQoL) irrespective of age. Qual Life Res. 2000;9(10):1093-104.
47. Mujica-Mota RE, Roberts M, Abel G, Elliott M, Lyratzopoulos G, Roland M, et al. Common patterns of morbidity and multi-morbidity and their impact on health-related quality of life: evidence from a national survey. Qual Life Res. 2015;24(4):909-18.
48. Noel PH, Parchman ML, Williams Jr JW, Cornell JE, Shuko L, Zeber JE, et al. The challenges of multimorbidity from the patient perspective. J Gen Intern Med. 2007;22 Suppl 3:419-24.
49. Parker L, Moran GM, Roberts LM, Calvert M, McCahon D. The burden of common chronic disease on health-related quality of life in an elderly community-dwelling population in the UK. Fam Pract. 2014;31(5):557-63.
50. Rijken M, van Kerkhof M, Dekker J, Schellevis FG. Comorbidity of chronic diseases: effects of disease pairs on physical and mental functioning. Qual Life Res. 2005;14(1):45-55.
51. Wensing M, Vingerhoets E, Grol R. Functional status, health problems, age and comorbidity in primary care patients. Qual Life Res. 2001;10(2):141-8.
52. Abizanda P, Romero L, Sanchez-Jurado PM, Martinez-Reig M, Alfonso-Silguero SA, Rodriguez-Manas L. Age, frailty, disability, institutionalization, multimorbidity or comorbidity. Which are the main targets in older adults? J Nutr Health Aging. 2014;18(6):622-7.
53. Aarts S, den Akker M, Bosma H, Tan F, Verhey F, Metsemakers J, et al. The effect of multimorbidity on health related functioning: temporary or persistent? Results from a longitudinal cohort study. J Psychosom Res. 2012;73(3):211-7.
54. Bayliss EA, Bayliss MS, Ware Jr JE, Steiner JF. Predicting declines in physical function in persons with multiple chronic medical conditions: what we can learn from the medical problem list. Health Qual Life Outcomes. 2004;2:47.
55. Byles JE, D'Este C, Parkinson L, O'Connell R, Treloar C. Single index of multimorbidity did not predict multiple outcomes. J Clin Epidemiol. 2005;58(10):997-1005.
56. Drewes YM, den Elzen WP, Mooijaart SP, de Craen AJ, Assendelft WJ, Gussekloo J. The effect of cognitive impairment on the predictive value of multimorbidity for the increase in disability in the oldest old: the Leiden 85-plus Study. Age Ageing. 2011;40(3):352-7.
57. Kiely DK, Morris JN, Morris SA, Cupples LA, Ooi WL, Sherwood S. The effect of specific medical conditions on functional decline. J Am Geriatr Soc. 1997;45(12):1459-63.
58. Nikolova R, Demers L, Beland F, Giroux F. Transitions in the functional status of disabled community-living older adults over a 3-year follow-up period. Arch Gerontol Geriatr. 2011;52(1):12-7.
59. Prior JA, Jordan KP, Kadam UT. Influence of chronic diseases on long-term change in physical health: a consultation-survey linkage cohort study in general practice. Qual Life Res. 2012;21(4):581-91.
60. Rigler SK, Studenski S, Wallace D, Reker DM, Duncan PW. Co-morbidity adjustment for functional outcomes in community-dwelling older adults. Clin Rehabil. 2002;16(4):420-8.
61. Whelan BJ, Savva GM. Design and methodology of the Irish Longitudinal Study on Ageing. J Am Geriatr Soc. 2013;61 Suppl 2:S265-8.
62. Kahlon S, Pederson J, Majumdar SR, Belga S, Lau D, Fradette M, et al. Association between frailty and 30-day outcomes after discharge from hospital. CMAJ. 2015;187(11):799-804.
63. Noel PH, Frueh BC, Larme AC, Pugh JA. Collaborative care needs and preferences of primary care patients with multimorbidity. Health Expect. 2005;8(1):54-63.
64. Mair FS, May CR. Thinking about the burden of treatment. BMJ (Clinical research ed). 2014;349:g6680.
65. Garvey J, Connolly D, Boland F, Smith SM. OPTIMAL, an occupational therapy led self-management support programme for people with multimorbidity in primary care: a randomized controlled trial. BMC Fam Pract. 2015;16:59.
66. Gitlin LN, Winter L, Dennis MP, Corcoran M, Schinfeld S, Hauck WW. A randomized trial of a multicomponent home intervention to reduce functional difficulties in older adults. J Am Geriatr Soc. 2006;54(5):809-16.
67. Wallace E, Salisbury C, Guthrie B, Lewis C, Fahey T, Smith SM. Managing patients with multimorbidity in primary care. BMJ (Clinical research ed). 2015;350:h176.
68. Smith SM, Bayliss EA, Mercer SW, Gunn J, Vestergaard M, Wyke S, et al. How to design and evaluate interventions to improve outcomes for patients with multimorbidity. Journal of Comorbidity. 2013;3:10-7.