Lonchocarpine increases Nrf2/ARE-mediated antioxidant enzyme expression by modulating AMPK and MAPK signaling in brain astrocytes

Biomolecules and Therapeutics

Volumn 24, Issue 6, 2016, Pages 581-588

  Jeong, Yeon Hui ^a   Park, Jin Sun ^a   Kim, Dong Hyun ^b   Kim, Hee Sun ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

AMPK; Antioxidant enzymes; Astrocytes; Lonchocarpine; MAPK; Nrf2 ARE signaling

Indexed keywords

ADENYLATE KINASE; ANTIOXIDANT; HEME OXYGENASE 1; LONCHOCARPINE; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT MEDICINAL PRODUCT; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ABRUS; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; ASTROCYTE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING; NONHUMAN; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

EID: 84996598786     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2016.141     Document Type: Article

References (36)

1. Barnham,K. J.,Masters,C. L. and Bush,A. I. (2004) Neurodegenerative diseases and oxidative stress. Nat. Rev. Drug Discov. 3,205-214.
2. Calkins,M. J.,Johnson,D. A.,Townsend,J. A.,Vargas,M. R.,Dowell,J. A.,Williamson,T. P.,Kraft,A. D.,Lee,J. M.,Li,J. and Johnson,J. A. (2009) The Nrf2/ARE pathway as a potential therapeutic target in neurodengenerative disease. Antioxid. Redox Signal. 11,497-508.
3. Carling,D.,Thornton,C.,Woods,A. and Sanders,M. J. (2012) AMPactivated protein kinase: new regulation,new roles? Biochem. J. 445,11-27.
4. Chen,K. and Maines,M. D. (2000) Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38. Cell. Mol. Biol. 46,609-617.
5. de Vries,H. E.,Witte,M.,Hondius,D.,Rozemuller,A. J.,Drukarch,B.,Hoozemans,J. and van Horssen,J. (2008) Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Rad. Biol. Med. 45,1375-1383.
6. Drukarch,B.,Schepens,E.,Stoof,J. C.,Langeveld,C. H. and Van Muiswinkel,F. L. (1998) Astrocyte-enhanced neuronal survival is mediated by scavenging of extracellular reactive oxygen species. Free Rad. Biol. Med. 25,217-220.
7. Elbirt,K. K.,Whitmarsh,A. J.,Davis,R. J.,and Bonkosky,H. L. (1998) Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases. J. Biol. Chem. 273,8922-8931.
8. Finsterwald,C.,Magistretti,P. J. and Lengacher,S. (2015) Astrocytes: New targets for the treatment of neurodegenerative diseases. Curr. Pharm. Des. 21,3570-3581.
9. Fontenele,J. B.,Leal,L. K.,Felix,F. H.,Silveira,E. R. and Viana,G. S. (2009) Studies on the anti-oedematogenic properties of a fraction rich in lonchocarpin and derricin isolated from Lonchocarpus sericeus. Nat. Prod. Res. 23,1677-1688.
10. Georgewill,O. A. and Georgewill,U. O. (2009) Evaluation of the antiinflammatory activity of extract of Abrus precatorious. East. J. Med. 14,23-25.
11. Gul,M. Z.,Ahmad,F.,Kondapi,A. K.,Qureshi,I. A. and Ghazi,I. A. (2013) Antioxidant and antiproliferative activities of Abrus precatorius leaf extracts--an in vitro study. BMC Complement. Altern. Med. 13,53.
12. Jaiswal,A. K. (2004) Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Rad. Biol. Med. 36,1199-1207.
13. Johnson,D. A. and Johnson,J. A. (2015) Nrf2- a therapeutic target for the treatment of neurodegenerative diseases. Free Rad. Biol. Med. 88,253-267.
14. Lee,E. J.,Ko,H. M.,Jeong,Y. H.,Park,E. M. and Kim,H. S. (2015) β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia. J. Neuroinflammation 12,133.
15. Li,J.,Jiang,Z.,Li,X.,Hou,Y.,Liu,F.,Li,N.,Liu,X.,Yang,L. and Chen,G. (2015) Natural therapeutic agents for neurodegenerative diseases from a traditional herbal medicine Pongamia pinnata (L.) Pierre. Bioorg. Med. Chem. Lett. 25,53-58.
16. Lima,N. M.,Andrade,J. I.,Lima,K. C.,dos Santos,F. N.,Barison,A.,Salome,K. S.,Matsuura,T. and Nunez,C. V. (2013) Chemical profile and biological activities of Deguelia duckeana A.M.G. Azevedo (Fabaceae). Nat. Prod. Res. 27,425-432.
17. Liu,X. M.,Peyton,K. J.,Shebib,A. R.,Wang,H.,Korthuis,R. J. and Durante,W. (2011) Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival. Am. J. Physiol. Heart Circ. Physiol. 300,H84-93.
18. Martínez de Morentin,P. B.,González,C. R. and López,M. (2010) AMP-activated protein kinase: ‘a cup of tea’ against cholesterolinduced neurotoxicity. J. Pathol. 222,329-334.
19. Mo,C.,Wang,L.,Zhang,J.,Numazawa,S.,Tang,H.,Tang,X.,Han,X.,Li,J.,Yang,M.,Wang,Z.,Wei,D. and Xiao,H. (2014) The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice. Antioxid. Redox Signal. 20,574-588.
20. Niture,S. K.,Kaspar,J. W.,Shen,J. and Jaiswal,A. K. (2010) Nrf2 signaling and cell survival. Toxicol. App. Pharmacol. 244,37-42.
21. Park,J. S.,Jung,J. S.,Jeong,Y. H.,Hyun,J. W.,Le,T. K.,Kim,D. H.,Choi,E. C. and Kim,H. S. (2011) Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression. J. Neurochem. 119,909-919.
22. Park,J. S.,Park,E. M.,Kim,D. H.,Jung,K.,Jung,J. S.,Lee,E. J.,Hyun,J. W.,Kang,J. L. and Kim,H. S. (2009) Anti-inflammatory mechanism of ginseng saponins in activated microglia. J. Neuroimmunol. 209,40-49.
23. Premanand,R. and Ganesh,T. (2010) Neuroprotective effects of Abrus precatorius Linn. aerial extract on hypoxic neurotoxicity induced rats. Int. J. Chem. Pharmac. Sci. 1,9-15.
24. Reyes-Chilpa,R.,Baggio,C. H.,Alavez-Solano,D.,Estrada-Muniz,E.,Kauffman,F. C.,Sanchez,R. I. and Mesia-Vela,S. (2006) Inhibition of gastric H+,K+-ATPase activity by flavonoids,coumarins and xanthones isolated from Mexican medicinal plants. J. Ethnopharmacol. 105,167-172.
25. Ronnett,G. V.,Ramamurthy,S.,Kleman,A. M.,Landree,L. E. and Aja,S. (2009) AMPK in the brain: its roles in energy balance and neuroprotection. J. Neurochem. 109 Suppl 1,17-23.
26. Ryter,S. W.,Alam,J.,Choi,A. M. (2006) Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 86,583-650.
27. Ryter,S. W.,Xi,S.,Hartsfield,C. L.,and Choi A.M. (2002) Mitogen activated protein kinase (MAPK) pathway regulates heme oxygenase-1 gene expression by hypoxia in vascular cells. Antioxid. Redox. Signal. 4,587-592.
28. Sofroniew,M. V. and Vinters,H. V. (2010) Astrocytes: biology and pathology. Acta. Neuropathol. 119,7-35.
29. Syapin,P. (2008) Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders. Brit. J. Pharmacol. 155,623-640.
30. Vargas,M. R.,Johnson,D. A.,Sirkis,D. W.,Messing,A. and Johnson,J. A. (2008) Nrf2 in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J. Neurosci. 28,13574-13581.
31. Vargas,M. R. and Johnson,J. A. (2009) The Nrf2-ARE cytoprotective pathway in astrocytes. Expert. Rev. Mol. Med. 11,e17.
32. Vari,R.,D’Archivio,M.,Filesi,C.,Carotenuto,S.,Scazzocchio,B.,Santangelo,C.,Giovannini,C. and Masella,R. (2011) Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages. J. Nutr. Biochem. 22,409-417.
33. Vingtdeux,V.,Giliberto,L.,Zhao,H.,Chandakkar,P.,Wu,Q.,Simon,J. E.,Janle,E. M.,Lobo,J.,Ferruzzi,M. G.,Davies,P. and Marambaud,P. (2010) AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J. Biol. Chem. 285,9100-9113.
34. Xu,C.,Yuan,X.,Pan,Z.,Shen,G.,Kim,J. H.,Yu,S.,Khor,T. O.,Li,W.,Ma,J. and Kong,A. N. (2006) Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol. Cancer Ther. 5,1918-1926.
35. Zang,M.,Zuccollo,A.,Hou,X.,Nagata,D.,Walsh,K.,Herscovitz,H.,Brecher,P.,Ruderman,N. B. and Cohen,R. A. (2004) AMPactivated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J. Biol. Chem. 279,47898-47905.
36. Zimmermann,K.,Baldinger,J.,Mayerhofer,B.,Atanasov,A. G.,Dirsch,V. M. and Heiss,E. H. (2015) Activated AMPK boosts the Nrf2/HO-1 signaling axis-A role for the unfolded protein response. Free Rad. Biol. Med. 88,417-426.