Enhanced Behavioral Responses to Cold Stimuli following CGRPα Sensory Neuron Ablation are Dependent on TRPM8

Molecular Pain

Volumn 10, Issue , 2014, Pages

  McCoy, Eric S ^a   Zylka, Mark J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Nociception; Pain; Thermoregulation; TRPM8; TRPV1

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; DIPHTHERIA TOXIN; ENOLASE; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; ICILIN; NEUROFILAMENT PROTEIN; NEUROFILAMENT PROTEIN H; PYRIMIDINONE DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM8 PROTEIN, MOUSE;

ADVERSE EFFECTS; ANIMAL; BODY WEIGHT; CELL COUNT; COLD; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENETICS; HEAT; HUMAN; HYPERALGESIA; MALE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PERCEPTIVE THRESHOLD; SENSORY NERVE CELL; SPINAL GANGLION; THERMOREGULATION; TRANSGENIC MOUSE;

ANIMALS; BODY TEMPERATURE REGULATION; BODY WEIGHT; CALCITONIN GENE-RELATED PEPTIDE; CELL COUNT; COLD TEMPERATURE; DIPHTHERIA TOXIN; GANGLIA, SPINAL; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; HOT TEMPERATURE; HUMANS; HYPERALGESIA; MALE; MICE; MICE, TRANSGENIC; NEUROFILAMENT PROTEINS; PHOSPHOPYRUVATE HYDRATASE; PYRIMIDINONES; SENSORY RECEPTOR CELLS; SENSORY THRESHOLDS; TRPM CATION CHANNELS;

EID: 84996528911     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-10-69     Document Type: Article

References (22)

1. Basbaum AI Bautista DM Scherrer G Julius D: Cellular and molecular mechanisms of pain. Cell 2009, 139:267–284.
2. Schutz B Mauer D Salmon AM Changeux JP Zimmer A: Analysis of the cellular expression pattern of beta-CGRP in alpha-CGRP-deficient mice. J Comp Neurol 2004, 476:32–43.
3. McCoy ES Taylor-Blake B Street SE Pribisko AL Zheng J Zylka MJ: Peptidergic CGRPalpha primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold. Neuron 2013, 78:138–151.
4. Hasegawa H Abbott S Han BX Qi Y Wang F: Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. J Neurosci 2007, 27:14404–14414.
5. Minett MS Nassar MA Clark AK Passmore G Dickenson AH Wang F Malcangio M Wood JN: Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nat Commun 2012, 3:791.
6. Knowlton WM Bifolck-Fisher A Bautista DM McKemy DD: TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain 2010, 150:340–350.
7. McCoy ES Taylor-Blake B Zylka MJ: CGRPalpha-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch. PLoS One 2012, 7:e36355.
8. Cain DM Khasabov SG Simone DA: Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: An in vivo study. J Neurophysiol 2001, 85:1561–1574.
9. Kobayashi K Fukuoka T Obata K Yamanaka H Dai Y Tokunaga A Noguchi K: Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J Comp Neurol 2005, 493:596–606.
10. Bautista DM Siemens J Glazer JM Tsuruda PR Basbaum AI Stucky CL Jordt SE Julius D: The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 2007, 448:204–208.
11. Dhaka A Murray AN Mathur J Earley TJ Petrus MJ Patapoutian A: TRPM8 is required for cold sensation in mice. Neuron 2007, 54:371–378.
12. Colburn RW Lubin ML Stone DJ Jr Wang Y Lawrence D D'Andrea MR Brandt MR Liu Y Flores CM Qin N: Attenuated cold sensitivity in TRPM8 null mice. Neuron 2007, 54:379–386.
13. Knowlton WM Daniels RL Palkar R McCoy DD McKemy DD: Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS One 2011, 6:e25894.
14. Feketa W Balasubramanian A Flores CM Player MR Marrelli SP: Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. Am J Physiol Regul Integr Comp Physiol 2013, 305:R1040–1050.
15. Wahren LK Torebjork E Jorum E: Central suppression of cold-induced C fibre pain by myelinated fibre input. Pain 1989, 38:313–319.
16. Yarnitsky D Ochoa JL: Release of cold-induced burning pain by block of cold-specific afferent input. Brain 1990, 113(Pt 4):893–902.
17. Chakour MC Gibson SJ Bradbeer M Helme RD: The effect of age on A delta- and C-fibre thermal pain perception. Pain 1996, 64:143–152.
18. Wang JJ Ho ST Hu OY Chu KM: An innovative cold tail-flick test: The cold ethanol tail-flick test. Anesth Analg 1995, 80:102–107.
19. Garrison SR Dietrich A Stucky CL: TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons. J Neurophysiol 2012, 107:913–922.
20. Brenner DS Golden JP Gereau RW: A novel behavioral assay for measuring cold sensation in mice. PLoS One 2012, 7:e39765.
21. Gentry C Stoakley N Andersson DA Bevan S: The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity. Mol Pain 2010, 6:4.
22. Westerberg R Tvrdik P Unden AB Mansson JE Norlen L Jakobsson A Holleran WH Elias PM Asadi A Flodby P Toftgård R Capecchi MR Jacobsson A: Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem 2004, 279:5621–5629.