Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 305, Issue 9, 2013, Pages

  Feketa, Viktor V ^a   Balasubramanian, Adithya ^a   Flores, Christopher M ^b   Player, Mark R ^b   Marrelli, Sean P ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Dihydrocapsaicin; Electromyography; Pharmacological hypothermia; Physical cooling; Shivering; Therapeutic hypothermia; Transient receptor potential

Indexed keywords

DIHYDROCAPSAICIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; VANILLOID RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACK MUSCLE; COLD EXPOSURE; COLD SENSITIVITY; CONTROLLED STUDY; COOLING; CORE TEMPERATURE; ELECTROCARDIOGRAPHY; ELECTROMYOGRAPHY; ENVIRONMENTAL TEMPERATURE; GENE DELETION; HEAT LOSS; HYPOTHERMIA; INDUCED HYPOTHERMIA; MOUSE; MUSCLE CONTRACTION; NEUROPROTECTION; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; RESTING HEART RATE; SHIVERING; TACHYCARDIA; VASOCONSTRICTION;

DIHYDROCAPSAICIN; ELECTROMYOGRAPHY; PHARMACOLOGICAL HYPOTHERMIA; PHYSICAL COOLING; SHIVERING; THERAPEUTIC HYPOTHERMIA; TRANSIENT RECEPTOR POTENTIAL;

ANIMALS; BENZIMIDAZOLES; CAPSAICIN; HEART RATE; HYPOTHERMIA, INDUCED; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SHIVERING; TACHYCARDIA; TIME FACTORS; TRPM CATION CHANNELS; TRPV CATION CHANNELS;

EID: 84886996242     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00296.2013     Document Type: Article

References (39)

1. Almeida MC, Hew-Butler T, Soriano RN, Rao S, Wang W, Wang J, Tamayo N, Oliveira DL, Nucci TB, Aryal P, Garami A, Bautista D, Gavva NR, Romanovsky AA. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci 32: 2086-2099, 2012.
2. American Heart Association. American Heart Association Guidelines for Cardiopulmonary Resuscitation, and Emergency Cardiovascular Care. Circulation 112: IV1-IV203, 2005.
3. Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448: 204-208, 2007.
4. Cao Z, Balasubramanian A, Marrelli SP. Hijacking the thermoregulatory system to promote therapeutic hypothermia in the treatment of acute cerebral ischemic stroke. In: First Annual Cardiovascular Research Symposium. Houston, Texas, USA: Baylor College of Medicine, 2013, p. 67.
5. Chanda S, Mould A, Esmail A, Bley K. Toxicity studies with pure trans-capsaicin delivered to dogs via intravenous administration. Regul Toxicol Pharmacol 43: 66-75, 2005.
6. Choi HA, Badjatia N, Mayer SA. Hypothermia for acute brain injury-mechanisms and practical aspects. Nat Rev Neurol 8: 214-222, 2012.
7. Colburn RW, Lubin Lou M, Stone DJ, Wang Y, Lawrence D, D'Andrea MR, Brandt MR, Liu Y, Flores CM, Qin N. Attenuated cold sensitivity in TRPM8-null mice. Neuron 54: 379-386, 2007.
8. Daniele O, Caravaglios G, Fierro B, Natalè E. Stroke and cardiac arrhythmias. J Stroke Cerebrovasc Dis 11: 28-33, 2002.
9. Dhaka A, Murray AN, Mathur J, Earley TJ, Petrus MJ, Patapoutian A. TRPM8 is required for cold sensation in mice. Neuron 54: 371-378, 2007.
10. Fosgerau K, Ristagno G, Jayatissa M, Axelsen M, Gotfredsen JW, Weber UJ, Køber L, Torp-Pedersen C, Videbaek C. Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin BMC. Cardiovasc Disord 10: 39, 2010.
11. Fosgerau K, Weber UJ, Gotfredsen JW, Jayatissa M, Buus C, Kristensen NB, Vestergaard M, Teschendorf P, Schneider A, Hansen P, Raunsø J, Køber L, Torp-Pedersen C, Videbaek C. Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. BMC Cardiovasc Disord 10: 51, 2010.
12. Gavva NR, Davis C, Lehto SG, Rao S, Wang W, Zhu DXD. Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation. Mol Pain 8: 36, 2012.
13. Gordon CJ. Thermal physiology of laboratory mice. Defining thermoneutrality. J Thermal Biol 37: 654-685, 2012.
14. Hancock JC, Hoover DB. Capsaicin-evoked bradycardia in anesthetized guinea pigs is mediated by endogenous tachykinins. Regul Pept 147: 19-24, 2008.
15. Hori T. Capsaicin and central control of thermoregulation. Pharmacol Ther 26: 389-416, 1984.
16. Karashima Y, Damann N, Prenen J, Talavera K, Segal A, Voets T, Nilius B. Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci 27: 9874-9884, 2007.
17. Karashima Y, Talavera K, Everaerts W, Janssens A, Kwan KY, Vennekens R, Nilius B, Voets T. TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci USA 106: 1273-1278, 2009.
18. Knowlton WM, Daniels RL, Palkar R, McCoy DD, McKemy DD. Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLos One 6: e25894, 2011.
19. Kozyreva TV, Kozaruk VP, Tkachenko EY, Khramova GM. Agonist of TRPM8 channel, menthol, facilitates the initiation of thermoregulatory responses to external cooling. J Therm Biol 35: 428-434, 2010.
20. Lay C, Badjatia N. Therapeutic hypothermia after cardiac arrest. Curr Atheroscler Rep 12: 336-342, 2010.
21. Lee P, Swarbrick MM, Ho KKY. Brown adipose tissue in adult humans: a metabolic renaissance. Endocr Rev 34: 413-438, 2013.
22. 2 release from endoplasmic reticulum and Golgi. J Biol Chem 282: 3325-36, 2007.
23. McAllen RM, Tanaka M, Ootsuka Y, McKinley MJ. Multiple thermoregulatory effectors with independent central controls. Eur J Appl Physiol 109: 27-33, 2010.
24. McCoy DD, Knowlton WM, McKemy DD. Scraping through the ice: uncovering the role of TRPM8 in cold transduction. Am J Physiol Regul Integr Comp Physiol 300: R1278-R1287, 2011.
25. McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416: 52-58, 2002.
26. Morrison SF, Nakamura K. Central neural pathways for thermoregulation. Front Biosci 16: 74-104, 2011.
27. Muzzi M, Felici R, Cavone L, Gerace E, Minassi A, Appendino G, Moroni F, Chiarugi A. Ischemic neuroprotection by TRPV1 receptorinduced hypothermia. J Cereb Blood Flow Metab 32: 978-982, 2012.
28. channels TRAAK and TREK-1 control both warm and cold perception. EMBO J 28: 1308-1318, 2009.
29. Parks DJ, Parsons WH, Colburn RW, Meegalla SK, Ballentine SK, Illig CR, Qin N, Liu Y, Hutchinson TL, Lubin Lou M, Stone DJ, Baker JF, Schneider CR, Ma J, Damiano BP, Flores CM, Player MR. Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem 8: 233-247, 2010.
30. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson D, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A. A TRP channel that senses cold stimuli and menthol. Cell 108: 705-715, 2002.
31. Romanovsky AA, Almeida MC, Garami A, Steiner AA, Norman MH, Morrison SF, Nakamura K, Burmeister JJ, Nucci TB. The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev 61: 228-261, 2009.
32. Romanovsky AA. Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system. Am J Physiol Regul Integr Comp Physiol 292: R37-R46, 2007.
33. Sessler DI. Thermoregulatory defense mechanisms. Crit Care Med 37: S203-S210, 2009.
34. Tajino K, Hosokawa H, Maegawa S, Matsumura K, Dhaka A, Kobayashi S. Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. PLos One 6: e17504, 2011.
35. Tajino K, Matsumura K, Kosada K, Shibakusa T, Inoue K, Fushiki T, Hosokawa H, Kobayashi S. Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses. Am J Physiol Regul Integr Comp Physiol 293: R2128-R2135, 2007.
36. Toda N, Usui H, Nishino N, Fujiwara M. Cardiovascular effects of capsaicin in dogs and rabbits. J Pharmacol Exp Ther 181: 512-521, 1972.
37. Varga K, Lake KD, Huangfu D, Guyenet PG, Kunos G. Mechanism of the hypotensive action of anandamide in anesthetized rats. Hypertension 28: 682-686, 1996.
38. Van der Worp HB, Sena ES, Donnan a G, Howells DW, Macleod MR. Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain 130: 3063-3074, 2007.
39. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci USA 108: 18114-18119, 2011.