Genotypic diversity of porcine circovirus type 2 (PCV2) and genotype shift to PCV2d in Korean pig population

Virus Research

Volumn 228, Issue , 2017, Pages 24-29

  Kwon, Taeyong ^a   Lee, Dong Uk ^a   Yoo, Sung J ^a   Je, Sang H ^a   Shin, Jeong Y ^a   Lyoo, Young S ^a  

^a Konkuk University   (South Korea)

Author keywords

Genotype shift; PCV2d; Porcine circovirus type 2; Selection pressure

Indexed keywords

AMINO ACID; EPITOPE;

ANIMAL TISSUE; ARTICLE; CIRCOVIRIDAE INFECTION; EXPERIMENTAL PIG; GENETIC VARIABILITY; GENOTYPE; KOREA; NONHUMAN; PHYLOGENY; PORCINE CIRCOVIRUS 2; PREVALENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; VIRUS NEUTRALIZATION; ANIMAL; CIRCOVIRUS; CLASSIFICATION; GENETIC SELECTION; GENETIC VARIATION; GENETICS; MOLECULAR EVOLUTION; OPEN READING FRAME; PHYLOGEOGRAPHY; PIG; SOUTH KOREA; SWINE DISEASE; VETERINARY; VIROLOGY; WHOLE GENOME SEQUENCING;

ANIMALS; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; EVOLUTION, MOLECULAR; GENETIC VARIATION; GENOTYPE; OPEN READING FRAMES; PHYLOGENY; PHYLOGEOGRAPHY; REPUBLIC OF KOREA; SELECTION, GENETIC; SWINE; SWINE DISEASES; WHOLE GENOME SEQUENCING;

EID: 84995900135     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2016.11.015     Document Type: Article

References (44)

1. Allan, G.M., McNeilly, F., Kennedy, S., Daft, B., Clarke, E.G., Ellis, J.A., Haines, D.M., Meehan, B.M., Adair, B.M., Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. J. Vet. Diagn. Invest. 10 (1998), 3–10.
2. An, D.J., Roh, I.S., Song, D.S., Park, C.K., Park, B.K., Phylogenetic characterization of porcine circovirus type 2 in PMWS and PDNS Korean pigs between 1999 and 2006. Virus Res. 129 (2007), 115–122.
3. Beach, N.M., Meng, X.J., Efficacy and future prospects of commercially available and experimental vaccines against porcine circovirus type 2 (PCV2). Virus Res. 164 (2012), 33–42.
4. Chiou, M.-T., Lin, C.-N., Yang, C.-Y., Su, G.-S., Lin, C.-F., Chang, T.-C., Genotypic change and phylogenetic analysis of porcine circovirus type 2 in taiwanese pig herds. J. Vet. Med. Sci. 74 (2012), 1303–1310.
5. Choi, C., Chae, C., In-situ hybridization for the detection of porcine circovirus in pigs with postweaning multisystemic wasting syndrome. J. Comp. Pathol. 121 (1999), 265–270.
6. Cortey, M., Olvera, A., Grau-Roma, L., Segales, J., Further comments on porcine circovirus type 2 (PCV2) genotype definition and nomenclature. Vet. Microbiol. 149 (2011), 522–523.
7. Cortey, M., Pileri, E., Sibila, M., Pujols, J., Balasch, M., Plana, J., Segales, J., Genotypic shift of porcine circovirus type 2 from PCV-2a to PCV-2b in Spain from 1985 to 2008. Vet. J. 187 (2011), 363–368.
8. Dupont, K., Nielsen, E.O., Baekbo, P., Larsen, L.E., Genomic analysis of PCV2 isolates from danish archives and a current PMWS case-control study supports a shift in genotypes with time. Vet. Microbiol. 128 (2008), 56–64.
9. Eddicks, M., Fux, R., Szikora, F., Eddicks, L., Majzoub-Altweck, M., Hermanns, W., Sutter, G., Palzer, A., Banholzer, E., Ritzmann, M., Detection of a new cluster of porcine circovirus type 2b strains in domestic pigs in Germany. Vet. Microbiol. 176 (2015), 337–343.
10. Gagnon, C.A., Tremblay, D., Tijssen, P., Venne, M.H., Houde, A., Elahi, S.M., The emergence of porcine circovirus 2b genotype (PCV-2b) in swine in Canada. Can. Vet. J. 48 (2007), 811–819.
11. Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Kehrli, M.E. Jr., Cheung, A.K., Postweaning multisystemic wasting syndrome produced in gnotobiotic pigs following exposure to various amounts of porcine circovirus type 2a or type 2b. Vet. Microbiol. 153 (2011), 229–239.
12. Grau-Roma, L., Crisci, E., Sibila, M., Lopez-Soria, S., Nofrarias, M., Cortey, M., Fraile, L., Olvera, A., Segales, J., A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence. Vet. Microbiol. 128 (2008), 23–35.
13. Guo, L.J., Lu, Y.H., Wei, Y.W., Huang, L.P., Liu, C.M., Porcine circovirus type 2 (PCV2): genetic variation and newly emerging genotypes in China. Virol. J., 7, 2010, 273.
14. Guo, L., Lu, Y., Huang, L., Wei, Y., Liu, C., Identification of a new antigen epitope in the nuclear localization signal region of porcine circovirus type 2 capsid protein. Intervirology 54 (2011), 156–163.
15. Guo, L., Fu, Y., Wang, Y., Lu, Y., Wei, Y., Tang, Q., Fan, P., Liu, J., Zhang, L., Zhang, F., Huang, L., Liu, D., Li, S., Wu, H., Liu, C., A porcine circovirus type 2 (PCV2) mutant with 234 amino acids in capsid protein showed more virulence in vivo, compared with classical PCV2a/b strain. PLoS One, 7, 2012, e41463.
16. Harding, J.C., Ellis, J.A., McIntosh, K.A., Krakowka, S., Dual heterologous porcine circovirus genogroup 2a/2b infection induces severe disease in germ-free pigs. Vet. Microbiol. 145 (2010), 209–219.
17. Hesse, R., Kerrigan, M., Rowland, R.R., Evidence for recombination between PCV2a and PCV2b in the field. Virus Res. 132 (2008), 201–207.
18. Huang, L.P., Lu, Y.H., Wei, Y.W., Guo, L.J., Liu, C.M., Identification of one critical amino acid that determines a conformational neutralizing epitope in the capsid protein of porcine circovirus type 2. BMC Microbiol., 11, 2011, 188.
19. Kim, J.H., Lyoo, Y.S., Genetic characterization of porcine circovirus-2 field isolates from PMWS pigs. J. Vet. Sci. 3 (2002), 31–39.
20. Kim, Y., Kim, J., Kang, K., Lyoo, Y.S., Characterization of the recombinant proteins of porcine circovirus type2 field isolate expressed in the baculovirus system. J. Vet. Sci. 3 (2002), 19–23.
21. Kim, H.-H., Park, S.-I., Hyun, B.-H., Park, S.-J., Jeong, Y.-J., Shin, D.-J., Chun, Y.-H., Hosmillo, M., Lee, B.-J., Kang, M.-I., Cho, K.-O., Genetic diversity of porcine circovirus type 2 in korean pigs with postweaning multisystemic wasting syndrome during 2005–2007. J. Vet. Med. Sci. 71 (2009), 349–353.
22. Kim, H.K., Luo, Y., Moon, H.J., Park, S.J., Keum, H.O., Rho, S., Park, B.K., Phylogenetic and recombination analysis of genomic sequences of PCV2 isolated in Korea. Virus Genes 39 (2009), 352–358.
23. Kim, D., Ha, Y., Oh, Y., Chae, C., Prevalence of porcine circovirus types 2a and b in pigs with and without post-weaning multi-systemic wasting syndrome. Vet. J. 188 (2011), 115–117.
24. Lyoo, Y.S., Kim, J.-H., Park, C.-K., Identification of porcine circovirus with genetic variation from lymph nodes collected in pigs with PMWS. Korean J. Vet. Res. 39 (1999), 353–358.
25. Mahe, D., Blanchard, P., Truong, C., Arnauld, C., Le Cann, P., Cariolet, R., Madec, F., Albina, E., Jestin, A., Differential recognition of ORF2 protein from type 1 and type 2 porcine circoviruses and identification of immunorelevant epitopes. J. Gen. Virol. 81 (2000), 1815–1824.
26. Nguyen, V.G., Kim, H.K., Moon, H.J., Park, S.J., Keum, H.O., Rho, S., Han, J.Y., Park, B.K., Population dynamics and ORF3 gene evolution of porcine circovirus type 2 circulating in Korea. Arch. Virol 157 (2012), 799–810.
27. Olvera, A., Cortey, M., Segales, J., Molecular evolution of porcine circovirus type 2 genomes: phylogeny and clonality. Virology 357 (2007), 175–185.
28. Opriessnig, T., Meng, X.J., Halbur, P.G., Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J. Vet. Diagn. Invest. 19 (2007), 591–615.
29. Opriessnig, T., Ramamoorthy, S., Madson, D.M., Patterson, A.R., Pal, N., Carman, S., Meng, X.J., Halbur, P.G., Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection. J. Gen. Virol. 89 (2008), 2482–2491.
30. Opriessnig, T., Xiao, C.T., Gerber, P.F., Halbur, P.G., Matzinger, S.R., Meng, X.J., Mutant USA strain of porcine circovirus type 2 (mPCV2) exhibits similar virulence to the classical PCV2a and PCV2b strains in caesarean-derived, colostrum-deprived pigs. J. Gen. Virol. 95 (2014), 2495–2503.
31. Ouardani, M., Wilson, L., Jette, R., Montpetit, C., Dea, S., Multiplex PCR for detection and typing of porcine circoviruses. J. Clin. Microbiol. 37 (1999), 3917–3924.
32. Pond, S.L., Frost, S.D., Datamonkey: rapid detection of selective pressure on individual sites of codon alignments. Bioinformatics 21 (2005), 2531–2533.
33. Rose, N., Opriessnig, T., Grasland, B., Jestin, A., Epidemiology and transmission of porcine circovirus type 2 (PCV2). Virus Res. 164 (2012), 78–89.
34. Saha, D., Lefebvre, D.J., Ooms, K., Huang, L., Delputte, P.L., Van Doorsselaere, J., Nauwynck, H.J., Single amino acid mutations in the capsid switch the neutralization phenotype of porcine circovirus 2. J. Gen. Virol. 93 (2012), 1548–1555.
35. Salgado, R.L., Vidigal, P.M., de Souza, L.F., Onofre, T.S., Gonzaga, N.F., Eller, M.R., Bressan, G.C., Fietto, J.L., Almeida, M.R., Silva, A. Junior, Identification of an emergent porcine circovirus-2 in vaccinated pigs from a brazilian farm during a postweaning multisystemic wasting syndrome outbreak. Genome Announc., 2014, 2.
36. Seo, H.W., Park, C., Kang, I., Choi, K., Jeong, J., Park, S.J., Chae, C., Genetic and antigenic characterization of a newly emerging porcine circovirus type 2b mutant first isolated in cases of vaccine failure in Korea. Arch. Virol 159 (2014), 3107–3111.
37. Shang, S.B., Jin, Y.L., Jiang, X.T., Zhou, J.Y., Zhang, X., Xing, G., He, J.L., Yan, Y., Fine mapping of antigenic epitopes on capsid proteins of porcine circovirus, and antigenic phenotype of porcine circovirus type 2. Mol. Immunol. 46 (2009), 327–334.
38. Tamura, K., Stecher, G., Peterson, D., Filipski, A., Kumar, S., MEGA6: molecular evolutionary genetics analysis version 6.0. Mol. Biol. Evol. 30 (2013), 2725–2729.
39. Thompson, J.D., Higgins, D.G., Gibson, T.J., CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22 (1994), 4673–4680.
40. Wang, F., Guo, X., Ge, X., Wang, Z., Chen, Y., Cha, Z., Yang, H., Genetic variation analysis of Chinese strains of porcine circovirus type 2. Virus Res. 145 (2009), 151–156.
41. Wei, C., Zhang, M., Chen, Y., Xie, J., Huang, Z., Zhu, W., Xu, T., Cao, Z., Zhou, P., Su, S., Zhang, G., Genetic evolution and phylogenetic analysis of porcine circovirus type 2 infections in southern China from 2011 to 2012. Infect. Genet. Evol. 17 (2013), 87–92.
42. Xiao, C.T., Halbur, P.G., Opriessnig, T., Complete genome sequence of a novel porcine circovirus type 2b variant present in cases of vaccine failures in the United States. J. Virol., 86, 2012, 12469.
43. Xiao, C.T., Halbur, P.G., Opriessnig, T., Global molecular genetic analysis of porcine circovirus type 2 (PCV2) sequences confirms the presence of four main PCV2 genotypes and reveals a rapid increase of PCV2d. J. Gen. Virol. 96 (2015), 1830–1841.
44. Zhai, S.L., Chen, S.N., Wei, Z.Z., Zhang, J.W., Huang, L., Lin, T., Yue, C., Ran, D.L., Yuan, S.S., Wei, W.K., Long, J.X., Co-existence of multiple strains of porcine circovirus type 2 in the same pig from China. Virol. J., 8, 2011, 517.