메뉴 건너뛰기




Volumn 30, Issue 6, 2016, Pages 571-584

Immune-Related Adverse Events Associated with Immune Checkpoint Inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNE CHECKPOINT INHIBITOR; IMMUNOMODULATING AGENT; IPILIMUMAB; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 RECEPTOR; TICILIMUMAB; UNCLASSIFIED DRUG; CD274 PROTEIN, HUMAN; CTLA4 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 LIGAND 1;

EID: 84995478531     PISSN: 11738804     EISSN: 1179190X     Source Type: Journal    
DOI: 10.1007/s40259-016-0204-3     Document Type: Review
Times cited : (87)

References (108)
  • 1
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: from immunosurveillance to tumor escape
    • COI: 1:CAS:528:DC%2BD38Xot1Chs70%3D, PID: 12407406
    • Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3(11):991–8. doi:10.1038/ni1102-991.
    • (2002) Nat Immunol , vol.3 , Issue.11 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2    Ikeda, H.3    Old, L.J.4    Schreiber, R.D.5
  • 2
    • 33846465547 scopus 로고    scopus 로고
    • Immunostimulatory monoclonal antibodies for cancer therapy
    • COI: 1:CAS:528:DC%2BD2sXotFOjtQ%3D%3D, PID: 17251916
    • Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer. 2007;7(2):95–106. doi:10.1038/nrc2051.
    • (2007) Nat Rev Cancer , vol.7 , Issue.2 , pp. 95-106
    • Melero, I.1    Hervas-Stubbs, S.2    Glennie, M.3    Pardoll, D.M.4    Chen, L.5
  • 3
    • 84887862839 scopus 로고    scopus 로고
    • A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
    • COI: 1:CAS:528:DC%2BC3sXhslygt7bF, PID: 24240160
    • Okazaki T, Chikuma S, Iwai Y, Fagarasan S, Honjo T. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. Nat Immunol. 2013;14(12):1212–8. doi:10.1038/ni.2762.
    • (2013) Nat Immunol , vol.14 , Issue.12 , pp. 1212-1218
    • Okazaki, T.1    Chikuma, S.2    Iwai, Y.3    Fagarasan, S.4    Honjo, T.5
  • 4
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3cXhtVCrtrbN, PID: 20525992
    • Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711–23. doi:10.1056/NEJMoa1003466.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O’Day, S.J.2    McDermott, D.F.3    Weber, R.W.4    Sosman, J.A.5    Haanen, J.B.6
  • 5
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3MXosVegtro%3D, PID: 21639810
    • Robert C, Thomas L, Bondarenko I, O’Day S, Weber J, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364(26):2517–26. doi:10.1056/NEJMoa1104621.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O’Day, S.4    Weber, J.5    Garbe, C.6
  • 6
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • COI: 1:CAS:528:DC%2BC38XhtV2rs7fN, PID: 22658127
    • Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443–54. doi:10.1056/NEJMoa1200690.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3    Gettinger, S.N.4    Smith, D.C.5    McDermott, D.F.6
  • 7
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • COI: 1:CAS:528:DC%2BC3sXht1emsbjP, PID: 23724846
    • Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med. 2013;369(2):134–44. doi:10.1056/NEJMoa1305133.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.J.5    Kefford, R.6
  • 8
    • 84936749833 scopus 로고    scopus 로고
    • Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC2MXhsFKmt7rJ, PID: 25897158
    • Gettinger SN, Horn L, Gandhi L, Spigel DR, Antonia SJ, Rizvi NA, et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol. 2015;33(18):2004–12. doi:10.1200/JCO.2014.58.3708.
    • (2015) J Clin Oncol , vol.33 , Issue.18 , pp. 2004-2012
    • Gettinger, S.N.1    Horn, L.2    Gandhi, L.3    Spigel, D.R.4    Antonia, S.J.5    Rizvi, N.A.6
  • 9
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab in advanced melanoma
    • COI: 1:CAS:528:DC%2BC2MXhtFyrsbrF, PID: 25891173
    • Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med. 2015;372(26):2521–32. doi:10.1056/NEJMoa1503093.
    • (2015) N Engl J Med , vol.372 , Issue.26 , pp. 2521-2532
    • Robert, C.1    Schachter, J.2    Long, G.V.3    Arance, A.4    Grob, J.J.5    Mortier, L.6
  • 10
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • PID: 25891304
    • Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med. 2015;372(21):2006–17. doi:10.1056/NEJMoa1414428.
    • (2015) N Engl J Med , vol.372 , Issue.21 , pp. 2006-2017
    • Postow, M.A.1    Chesney, J.2    Pavlick, A.C.3    Robert, C.4    Grossmann, K.5    McDermott, D.6
  • 11
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • COI: 1:CAS:528:DC%2BC38XhtV2rsbnJ, PID: 22658128
    • Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455–65. doi:10.1056/NEJMoa1200694.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3    Hwu, W.J.4    Topalian, S.L.5    Hwu, P.6
  • 12
    • 0031405867 scopus 로고    scopus 로고
    • Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
    • COI: 1:CAS:528:DyaK1cXjsFaqsQ%3D%3D, PID: 9430233
    • Chambers CA, Sullivan TJ, Allison JP. Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity. 1997;7(6):885–95.
    • (1997) Immunity , vol.7 , Issue.6 , pp. 885-895
    • Chambers, C.A.1    Sullivan, T.J.2    Allison, J.P.3
  • 13
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • COI: 1:CAS:528:DC%2BC3cXovFaks7s%3D, PID: 20636820
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010;236:219–42. doi:10.1111/j.1600-065X.2010.00923.x.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 14
    • 84879579673 scopus 로고    scopus 로고
    • At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC3sXhtFajs7bN, PID: 23625198
    • Intlekofer AM, Thompson CB. At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy. J Leukoc Biol. 2013;94(1):25–39. doi:10.1189/jlb.1212621.
    • (2013) J Leukoc Biol , vol.94 , Issue.1 , pp. 25-39
    • Intlekofer, A.M.1    Thompson, C.B.2
  • 15
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • COI: 1:CAS:528:DyaK2MXps1Oqtrw%3D, PID: 7584144
    • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995;3(5):541–7.
    • (1995) Immunity , vol.3 , Issue.5 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 16
    • 23844529169 scopus 로고    scopus 로고
    • Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
    • COI: 1:CAS:528:DC%2BD2MXpsFGgtb0%3D, PID: 16087865
    • Wang J, Yoshida T, Nakaki F, Hiai H, Okazaki T, Honjo T. Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Proc Natl Acad Sci. 2005;102(33):11823–8. doi:10.1073/pnas.0505497102.
    • (2005) Proc Natl Acad Sci , vol.102 , Issue.33 , pp. 11823-11828
    • Wang, J.1    Yoshida, T.2    Nakaki, F.3    Hiai, H.4    Okazaki, T.5    Honjo, T.6
  • 17
    • 28244492012 scopus 로고    scopus 로고
    • Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade
    • COI: 1:CAS:528:DC%2BD2MXht1ent7vP, PID: 16301685
    • Maker AV, Attia P, Rosenberg SA. Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol. 2005;175(11):7746–54.
    • (2005) J Immunol. , vol.175 , Issue.11 , pp. 7746-7754
    • Maker, A.V.1    Attia, P.2    Rosenberg, S.A.3
  • 18
    • 84864052441 scopus 로고    scopus 로고
    • Management of immune-related adverse events and kinetics of response with ipilimumab
    • COI: 1:CAS:528:DC%2BC38Xht1ygsr%2FK, PID: 22614989
    • Weber JS, Kahler KC, Hauschild A. Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol. 2012;30(21):2691–7. doi:10.1200/JCO.2012.41.6750.
    • (2012) J Clin Oncol , vol.30 , Issue.21 , pp. 2691-2697
    • Weber, J.S.1    Kahler, K.C.2    Hauschild, A.3
  • 19
    • 33744792341 scopus 로고    scopus 로고
    • Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
    • COI: 1:CAS:528:DC%2BD28XlvV2ksb4%3D, PID: 16710025
    • Beck KE, Blansfield JA, Tran KQ, Feldman AL, Hughes MS, Royal RE, et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol. 2006;24(15):2283–9. doi:10.1200/JCO.2005.04.5716.
    • (2006) J Clin Oncol , vol.24 , Issue.15 , pp. 2283-2289
    • Beck, K.E.1    Blansfield, J.A.2    Tran, K.Q.3    Feldman, A.L.4    Hughes, M.S.5    Royal, R.E.6
  • 21
    • 84899071058 scopus 로고    scopus 로고
    • Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P. Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci Transl Med. 2014;6(230):230ra45. doi:.
    • Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P. Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci Transl Med. 2014;6(230):230ra45. doi:10.1126/scitranslmed.3008002.
  • 22
    • 84872339660 scopus 로고    scopus 로고
    • The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network
    • COI: 1:CAS:528:DC%2BC3sXhsVGmurc%3D, PID: 23341990
    • Voskens CJ, Goldinger SM, Loquai C, Robert C, Kaehler KC, Berking C, et al. The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network. PLoS One. 2013;8(1):e53745. doi:10.1371/journal.pone.0053745.
    • (2013) PLoS One , vol.8 , Issue.1
    • Voskens, C.J.1    Goldinger, S.M.2    Loquai, C.3    Robert, C.4    Kaehler, K.C.5    Berking, C.6
  • 23
    • 84882879837 scopus 로고    scopus 로고
    • The risk of rash associated with ipilimumab in patients with cancer: a systematic review of the literature and meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXhvFWhtbw%3D, PID: 23357570
    • Minkis K, Garden BC, Wu S, Pulitzer MP, Lacouture ME. The risk of rash associated with ipilimumab in patients with cancer: a systematic review of the literature and meta-analysis. J Am Acad Dermatol. 2013;69(3):e121–8. doi:10.1016/j.jaad.2012.12.963.
    • (2013) J Am Acad Dermatol , vol.69 , Issue.3 , pp. e121-e128
    • Minkis, K.1    Garden, B.C.2    Wu, S.3    Pulitzer, M.P.4    Lacouture, M.E.5
  • 24
    • 84896934432 scopus 로고    scopus 로고
    • Atypical neurological complications of ipilimumab therapy in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC2cXkslCruro%3D, PID: 24482447
    • Liao B, Shroff S, Kamiya-Matsuoka C, Tummala S. Atypical neurological complications of ipilimumab therapy in patients with metastatic melanoma. Neuro Oncol. 2014;16(4):589–93. doi:10.1093/neuonc/nou001.
    • (2014) Neuro Oncol. , vol.16 , Issue.4 , pp. 589-593
    • Liao, B.1    Shroff, S.2    Kamiya-Matsuoka, C.3    Tummala, S.4
  • 25
    • 84933678156 scopus 로고    scopus 로고
    • Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2MXlslCkuro%3D, PID: 25840693
    • Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial. Lancet Oncol. 2015;16(5):522–30. doi:10.1016/S1470-2045(15)70122-1.
    • (2015) Lancet Oncol. , vol.16 , Issue.5 , pp. 522-530
    • Eggermont, A.M.1    Chiarion-Sileni, V.2    Grob, J.J.3    Dummer, R.4    Wolchok, J.D.5    Schmidt, H.6
  • 26
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • PID: 26027431
    • Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015;373(1):23–34. doi:10.1056/NEJMoa1504030.
    • (2015) N Engl J Med , vol.373 , Issue.1 , pp. 23-34
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3    Grob, J.J.4    Cowey, C.L.5    Lao, C.D.6
  • 27
    • 77955256254 scopus 로고    scopus 로고
    • Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study
    • PID: 20147741
    • O’Day SJ, Maio M, Chiarion-Sileni V, Gajewski TF, Pehamberger H, Bondarenko IN, et al. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study. Ann Oncol. 2010;21(8):1712–7. doi:10.1093/annonc/mdq013.
    • (2010) Ann Oncol , vol.21 , Issue.8 , pp. 1712-1717
    • O’Day, S.J.1    Maio, M.2    Chiarion-Sileni, V.3    Gajewski, T.F.4    Pehamberger, H.5    Bondarenko, I.N.6
  • 28
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study
    • COI: 1:CAS:528:DC%2BC3cXhtlGgtbY%3D, PID: 20004617
    • Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 2010;11(2):155–64. doi:10.1016/S1470-2045(09)70334-1.
    • (2010) Lancet Oncol. , vol.11 , Issue.2 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3    Negrier, S.4    Lutzky, J.5    Thomas, L.6
  • 29
    • 58049202334 scopus 로고    scopus 로고
    • Phase I/II study of ipilimumab for patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BD1MXhs1Ggurc%3D, PID: 19018089
    • Weber JS, O’Day S, Urba W, Powderly J, Nichol G, Yellin M, et al. Phase I/II study of ipilimumab for patients with metastatic melanoma. J Clin Oncol. 2008;26(36):5950–6. doi:10.1200/JCO.2008.16.1927.
    • (2008) J Clin Oncol , vol.26 , Issue.36 , pp. 5950-5956
    • Weber, J.S.1    O’Day, S.2    Urba, W.3    Powderly, J.4    Nichol, G.5    Yellin, M.6
  • 30
    • 84940746759 scopus 로고    scopus 로고
    • Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis
    • PID: 26337719
    • Bertrand A, Kostine M, Barnetche T, Truchetet ME, Schaeverbeke T. Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis. BMC Med. 2015;13:211. doi:10.1186/s12916-015-0455-8.
    • (2015) BMC Med , vol.13 , pp. 211
    • Bertrand, A.1    Kostine, M.2    Barnetche, T.3    Truchetet, M.E.4    Schaeverbeke, T.5
  • 31
    • 84901246811 scopus 로고    scopus 로고
    • Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort
    • PID: 24885479
    • Ascierto PA, Simeone E, Sileni VC, Pigozzo J, Maio M, Altomonte M, et al. Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort. J Transl Med. 2014;12:116. doi:10.1186/1479-5876-12-116.
    • (2014) J Transl Med. , vol.12 , pp. 116
    • Ascierto, P.A.1    Simeone, E.2    Sileni, V.C.3    Pigozzo, J.4    Maio, M.5    Altomonte, M.6
  • 32
    • 84944261579 scopus 로고    scopus 로고
    • Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial sloan kettering cancer center
    • COI: 1:CAS:528:DC%2BC28Xmt1Cltbg%3D, PID: 26282644
    • Horvat TZ, Adel NG, Dang TO, Momtaz P, Postow MA, Callahan MK, et al. Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial sloan kettering cancer center. J Clin Oncol. 2015;33(28):3193–8. doi:10.1200/JCO.2015.60.8448.
    • (2015) J Clin Oncol , vol.33 , Issue.28 , pp. 3193-3198
    • Horvat, T.Z.1    Adel, N.G.2    Dang, T.O.3    Momtaz, P.4    Postow, M.A.5    Callahan, M.K.6
  • 33
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study
    • COI: 1:CAS:528:DC%2BC38XhtVynsbvP, PID: 22547592
    • Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 2012;30(17):2046–54. doi:10.1200/JCO.2011.38.4032.
    • (2012) J Clin Oncol , vol.30 , Issue.17 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6
  • 34
    • 84901641673 scopus 로고    scopus 로고
    • Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2cXotFOrs74%3D, PID: 24831977
    • Kwon ED, Drake CG, Scher HI, Fizazi K, Bossi A, van den Eertwegh AJ, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2014;15(7):700–12. doi:10.1016/S1470-2045(14)70189-5.
    • (2014) Lancet Oncol. , vol.15 , Issue.7 , pp. 700-712
    • Kwon, E.D.1    Drake, C.G.2    Scher, H.I.3    Fizazi, K.4    Bossi, A.5    van den Eertwegh, A.J.6
  • 35
    • 37349072460 scopus 로고    scopus 로고
    • Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
    • COI: 1:CAS:528:DC%2BD2sXhtlGqs7fO, PID: 18049334
    • Yang JC, Hughes M, Kammula U, Royal R, Sherry RM, Topalian SL, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother. 2007;30(8):825–30. doi:10.1097/CJI.0b013e318156e47e.
    • (2007) J Immunother , vol.30 , Issue.8 , pp. 825-830
    • Yang, J.C.1    Hughes, M.2    Kammula, U.3    Royal, R.4    Sherry, R.M.5    Topalian, S.L.6
  • 36
    • 84880508629 scopus 로고    scopus 로고
    • Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study
    • COI: 1:STN:280:DC%2BC3srgt1Cmtg%3D%3D, PID: 23535954
    • Slovin SF, Higano CS, Hamid O, Tejwani S, Harzstark A, Alumkal JJ, et al. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. Ann Oncol. 2013;24(7):1813–21. doi:10.1093/annonc/mdt107.
    • (2013) Ann Oncol , vol.24 , Issue.7 , pp. 1813-1821
    • Slovin, S.F.1    Higano, C.S.2    Hamid, O.3    Tejwani, S.4    Harzstark, A.5    Alumkal, J.J.6
  • 37
    • 34250223096 scopus 로고    scopus 로고
    • A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
    • COI: 1:CAS:528:DC%2BD2sXivV2gtLs%3D, PID: 17363537
    • Small EJ, Tchekmedyian NS, Rini BI, Fong L, Lowy I, Allison JP. A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. Clin Cancer Res. 2007;13(6):1810–5. doi:10.1158/1078-0432.CCR-06-2318.
    • (2007) Clin Cancer Res , vol.13 , Issue.6 , pp. 1810-1815
    • Small, E.J.1    Tchekmedyian, N.S.2    Rini, B.I.3    Fong, L.4    Lowy, I.5    Allison, J.P.6
  • 38
    • 77958050577 scopus 로고    scopus 로고
    • Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
    • COI: 1:CAS:528:DC%2BC3cXht1Wju77O, PID: 20842054
    • Royal RE, Levy C, Turner K, Mathur A, Hughes M, Kammula US, et al. Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother. 2010;33(8):828–33. doi:10.1097/CJI.0b013e3181eec14c.
    • (2010) J Immunother , vol.33 , Issue.8 , pp. 828-833
    • Royal, R.E.1    Levy, C.2    Turner, K.3    Mathur, A.4    Hughes, M.5    Kammula, U.S.6
  • 39
    • 84925379870 scopus 로고    scopus 로고
    • Identification and management of toxicities from immune checkpoint-blocking drugs
    • PID: 25384885
    • Teply BA, Lipson EJ. Identification and management of toxicities from immune checkpoint-blocking drugs. Oncology (Williston). 2014;28(Suppl 3):30–8.
    • (2014) Oncology (Williston). , vol.28 , pp. 30-38
    • Teply, B.A.1    Lipson, E.J.2
  • 40
    • 84949988089 scopus 로고    scopus 로고
    • Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
    • COI: 1:STN:280:DC%2BC283it1Khtw%3D%3D, PID: 26371282
    • Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol. 2015;26(12):2375–91. doi:10.1093/annonc/mdv383.
    • (2015) Ann Oncol , vol.26 , Issue.12 , pp. 2375-2391
    • Naidoo, J.1    Page, D.B.2    Li, B.T.3    Connell, L.C.4    Schindler, K.5    Lacouture, M.E.6
  • 41
    • 84997782537 scopus 로고    scopus 로고
    • Yervoy Safety Information. Accessed 14 July 2016.
    • Yervoy Safety Information. http://www.hcp.yervoy.com. Accessed 14 July 2016.
  • 42
    • 84997682107 scopus 로고    scopus 로고
    • Lin R, Yellin MJ, Lowy I, Safferman A, Chin K, Ibrahim R. An analysis of the effectiveness of specific guidelines for the management of ipilimumab-mediated diarrhea/colitis: prevention of gastrointestinal perforation and/or colectomy. J Clin Oncol (Meeting Abstracts). 2008;26(15):Suppl 9063.
    • Lin R, Yellin MJ, Lowy I, Safferman A, Chin K, Ibrahim R. An analysis of the effectiveness of specific guidelines for the management of ipilimumab-mediated diarrhea/colitis: prevention of gastrointestinal perforation and/or colectomy. J Clin Oncol (Meeting Abstracts). 2008;26(15):Suppl 9063.
  • 43
    • 84876678621 scopus 로고    scopus 로고
    • Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: detailed safety analysis from a phase 3 trial in patients with advanced melanoma
    • COI: 1:CAS:528:DC%2BC3sXmsFWmsr4%3D, PID: 23400564
    • Weber JS, Dummer R, de Pril V, Lebbe C, Hodi FS, Investigators MDX. Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: detailed safety analysis from a phase 3 trial in patients with advanced melanoma. Cancer. 2013;119(9):1675–82. doi:10.1002/cncr.27969.
    • (2013) Cancer , vol.119 , Issue.9 , pp. 1675-1682
    • Weber, J.S.1    Dummer, R.2    de Pril, V.3    Lebbe, C.4    Hodi, F.S.5    Investigators, M.D.X.6
  • 44
    • 84922584243 scopus 로고    scopus 로고
    • Long-term follow-up of ipilimumab-induced hypophysitis, a common adverse event of the anti-CTLA-4 antibody in melanoma
    • COI: 1:CAS:528:DC%2BC2MXksFehtrk%3D, PID: 25416723
    • Albarel F, Gaudy C, Castinetti F, Carre T, Morange I, Conte-Devolx B, et al. Long-term follow-up of ipilimumab-induced hypophysitis, a common adverse event of the anti-CTLA-4 antibody in melanoma. Eur J Endocrinol. 2015;172(2):195–204. doi:10.1530/EJE-14-0845.
    • (2015) Eur J Endocrinol , vol.172 , Issue.2 , pp. 195-204
    • Albarel, F.1    Gaudy, C.2    Castinetti, F.3    Carre, T.4    Morange, I.5    Conte-Devolx, B.6
  • 45
    • 84884721380 scopus 로고    scopus 로고
    • Efficacy and safety of ipilimumab in metastatic melanoma patients surviving more than 2 years following treatment in a phase III trial (MDX010-20)
    • COI: 1:STN:280:DC%2BC3sfpsVanuw%3D%3D, PID: 23942774
    • McDermott D, Haanen J, Chen TT, Lorigan P, O’Day S, Investigators MDX. Efficacy and safety of ipilimumab in metastatic melanoma patients surviving more than 2 years following treatment in a phase III trial (MDX010-20). Ann Oncol. 2013;24(10):2694–8. doi:10.1093/annonc/mdt291.
    • (2013) Ann Oncol , vol.24 , Issue.10 , pp. 2694-2698
    • McDermott, D.1    Haanen, J.2    Chen, T.T.3    Lorigan, P.4    O’Day, S.5    Investigators, M.D.X.6
  • 46
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • COI: 1:CAS:528:DC%2BC3sXjvVart74%3D, PID: 23295794
    • Ribas A, Kefford R, Marshall MA, Punt CJ, Haanen JB, Marmol M, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol. 2013;31(5):616–22. doi:10.1200/JCO.2012.44.6112.
    • (2013) J Clin Oncol , vol.31 , Issue.5 , pp. 616-622
    • Ribas, A.1    Kefford, R.2    Marshall, M.A.3    Punt, C.J.4    Haanen, J.B.5    Marmol, M.6
  • 47
    • 76049092889 scopus 로고    scopus 로고
    • Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma
    • COI: 1:CAS:528:DC%2BC3cXhs1aru70%3D, PID: 20086001
    • Kirkwood JM, Lorigan P, Hersey P, Hauschild A, Robert C, McDermott D, et al. Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma. Clin Cancer Res. 2010;16(3):1042–8. doi:10.1158/1078-0432.CCR-09-2033.
    • (2010) Clin Cancer Res , vol.16 , Issue.3 , pp. 1042-1048
    • Kirkwood, J.M.1    Lorigan, P.2    Hersey, P.3    Hauschild, A.4    Robert, C.5    McDermott, D.6
  • 48
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • PID: 25891174
    • Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372(21):2018–28. doi:10.1056/NEJMoa1501824.
    • (2015) N Engl J Med , vol.372 , Issue.21 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3    Leighl, N.4    Balmanoukian, A.S.5    Eder, J.P.6
  • 49
    • 84938205998 scopus 로고    scopus 로고
    • Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
    • COI: 1:CAS:528:DC%2BC2MXhtFSjtr3L, PID: 26115796
    • Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol. 2015;16(8):908–18. doi:10.1016/S1470-2045(15)00083-2.
    • (2015) Lancet Oncol. , vol.16 , Issue.8 , pp. 908-918
    • Ribas, A.1    Puzanov, I.2    Dummer, R.3    Schadendorf, D.4    Hamid, O.5    Robert, C.6
  • 50
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
    • COI: 1:CAS:528:DC%2BC2cXhtFGlsb%2FN, PID: 25034862
    • Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet. 2014;384(9948):1109–17. doi:10.1016/S0140-6736(14)60958-2.
    • (2014) Lancet , vol.384 , Issue.9948 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3    Hodi, F.S.4    Hamid, O.5    Kefford, R.6
  • 51
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC28XjsFyitL0%3D, PID: 26412456
    • Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373(17):1627–39. doi:10.1056/NEJMoa1507643.
    • (2015) N Engl J Med , vol.373 , Issue.17 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3    Spigel, D.R.4    Steins, M.5    Ready, N.E.6
  • 52
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC2MXht12qu7%2FJ, PID: 26028407
    • Brahmer J, Reckamp KL, Baas P, Crino L, Eberhardt WE, Poddubskaya E, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015;373(2):123–35. doi:10.1056/NEJMoa1504627.
    • (2015) N Engl J Med , vol.373 , Issue.2 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3    Crino, L.4    Eberhardt, W.E.5    Poddubskaya, E.6
  • 53
    • 84946607195 scopus 로고    scopus 로고
    • Nivolumab versus everolimus in advanced renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BC28XjsFyhsrg%3D, PID: 26406148
    • Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med. 2015;373(19):1803–13. doi:10.1056/NEJMoa1510665.
    • (2015) N Engl J Med , vol.373 , Issue.19 , pp. 1803-1813
    • Motzer, R.J.1    Escudier, B.2    McDermott, D.F.3    George, S.4    Hammers, H.J.5    Srinivas, S.6
  • 54
    • 84929572937 scopus 로고    scopus 로고
    • Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial
    • COI: 1:CAS:528:DC%2BC2MXpvFahsbY%3D, PID: 25452452
    • Motzer RJ, Rini BI, McDermott DF, Redman BG, Kuzel TM, Harrison MR, et al. Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial. J Clin Oncol. 2015;33(13):1430–7. doi:10.1200/JCO.2014.59.0703.
    • (2015) J Clin Oncol , vol.33 , Issue.13 , pp. 1430-1437
    • Motzer, R.J.1    Rini, B.I.2    McDermott, D.F.3    Redman, B.G.4    Kuzel, T.M.5    Harrison, M.R.6
  • 55
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
    • COI: 1:CAS:528:DC%2BC2MXjtFShs7s%3D, PID: 25704439
    • Rizvi NA, Mazieres J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 2015;16(3):257–65. doi:10.1016/S1470-2045(15)70054-9.
    • (2015) Lancet Oncol. , vol.16 , Issue.3 , pp. 257-265
    • Rizvi, N.A.1    Mazieres, J.2    Planchard, D.3    Stinchcombe, T.E.4    Dy, G.K.5    Antonia, S.J.6
  • 56
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2MXkvVWgsLk%3D, PID: 25795410
    • Weber JS, D’Angelo SP, Minor D, Hodi FS, Gutzmer R, Neyns B, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2015;16(4):375–84. doi:10.1016/S1470-2045(15)70076-8.
    • (2015) Lancet Oncol. , vol.16 , Issue.4 , pp. 375-384
    • Weber, J.S.1    D’Angelo, S.P.2    Minor, D.3    Hodi, F.S.4    Gutzmer, R.5    Neyns, B.6
  • 57
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • COI: 1:CAS:528:DC%2BC2MXisFGqsLg%3D, PID: 25399552
    • Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320–30. doi:10.1056/NEJMoa1412082.
    • (2015) N Engl J Med , vol.372 , Issue.4 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3    Dutriaux, C.4    Maio, M.5    Mortier, L.6
  • 58
    • 84886443514 scopus 로고    scopus 로고
    • CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients
    • COI: 1:CAS:528:DC%2BC3sXhsFyns7bM, PID: 24089443
    • Ott PA, Hodi FS, Robert C. CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients. Clin Cancer Res. 2013;19(19):5300–9. doi:10.1158/1078-0432.CCR-13-0143.
    • (2013) Clin Cancer Res , vol.19 , Issue.19 , pp. 5300-5309
    • Ott, P.A.1    Hodi, F.S.2    Robert, C.3
  • 59
    • 84997714794 scopus 로고    scopus 로고
    • Weber JS, Antonia SJ, Topalian SL, Schadendorf D, Larkin JMG, Sznol M, et al. Safety profile of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL): a pooled analysis. J Clin Oncol. 2015;33 Suppl:abstr 9018.
    • Weber JS, Antonia SJ, Topalian SL, Schadendorf D, Larkin JMG, Sznol M, et al. Safety profile of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL): a pooled analysis. J Clin Oncol. 2015;33 Suppl:abstr 9018.
  • 60
    • 84997742159 scopus 로고    scopus 로고
    • Day D, Khoja L, Chen TW, Siu LL, Hansen AR. Tumor- and class-specific patterns of immune-related adverse events (irAEs) of immune checkpoint inhibitors (ICIs): a systematic review (SR). J Clin Oncol. 2016;34 Suppl:abstr 3065.
    • Day D, Khoja L, Chen TW, Siu LL, Hansen AR. Tumor- and class-specific patterns of immune-related adverse events (irAEs) of immune checkpoint inhibitors (ICIs): a systematic review (SR). J Clin Oncol. 2016;34 Suppl:abstr 3065.
  • 61
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
    • COI: 1:CAS:528:DC%2BC28XjslGmu7w%3D, PID: 26952546
    • Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387(10031):1909–20. doi:10.1016/S0140-6736(16)00561-4.
    • (2016) Lancet , vol.387 , Issue.10031 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3    van der Heijden, M.S.4    Balar, A.V.5    Necchi, A.6
  • 62
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • COI: 1:CAS:528:DC%2BC2cXitFamsrjE, PID: 25428503
    • Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature. 2014;515(7528):558–62. doi:10.1038/nature13904.
    • (2014) Nature , vol.515 , Issue.7528 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3    Braiteh, F.S.4    Loriot, Y.5    Cruz, C.6
  • 63
    • 84997816828 scopus 로고    scopus 로고
    • Kelly K, Patel MR, Infante JR, Iannotti N, Nikolinakos P, Leach J, et al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with metastatic or locally advanced solid tumors: assessment of safety and tolerability in a phase I, open-label expansion study. J Clin Oncol. 2015;33 Suppl:abstr 3044.
    • Kelly K, Patel MR, Infante JR, Iannotti N, Nikolinakos P, Leach J, et al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with metastatic or locally advanced solid tumors: assessment of safety and tolerability in a phase I, open-label expansion study. J Clin Oncol. 2015;33 Suppl:abstr 3044.
  • 64
    • 70349669259 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma
    • COI: 1:CAS:528:DC%2BD1MXhtF2lurvL, PID: 19755389
    • Brignone C, Escudier B, Grygar C, Marcu M, Triebel F. A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma. Clin Cancer Res. 2009;15(19):6225–31. doi:10.1158/1078-0432.CCR-09-0068.
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6225-6231
    • Brignone, C.1    Escudier, B.2    Grygar, C.3    Marcu, M.4    Triebel, F.5
  • 65
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • COI: 1:CAS:528:DC%2BC3cXjtlKms7c%3D, PID: 20160101
    • Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci. 2010;107(9):4275–80. doi:10.1073/pnas.0915174107.
    • (2010) Proc Natl Acad Sci , vol.107 , Issue.9 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 66
    • 84921456279 scopus 로고    scopus 로고
    • Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo
    • COI: 1:CAS:528:DC%2BC2MXhtVCgs7w%3D, PID: 25539810
    • Das R, Verma R, Sznol M, Boddupalli CS, Gettinger SN, Kluger H, et al. Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo. J Immunol. 2015;194(3):950–9. doi:10.4049/jimmunol.1401686.
    • (2015) J Immunol. , vol.194 , Issue.3 , pp. 950-959
    • Das, R.1    Verma, R.2    Sznol, M.3    Boddupalli, C.S.4    Gettinger, S.N.5    Kluger, H.6
  • 67
    • 84997726693 scopus 로고    scopus 로고
    • Patnaik A, Socinski MA, Gubens MA, Gandhi L, Stevenson J, Bachman RD, et al. Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. J Clin Oncol. 2015;33 Suppl:abstr 8011.
    • Patnaik A, Socinski MA, Gubens MA, Gandhi L, Stevenson J, Bachman RD, et al. Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. J Clin Oncol. 2015;33 Suppl:abstr 8011.
  • 68
    • 84997637886 scopus 로고    scopus 로고
    • Antonia SJ, Goldberg SB, Balmanoukian AS, Sanborn RE, Steele K, Narwal R, et al. Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC. J Clin Oncol. 2015;33 Suppl:abstr 3014.
    • Antonia SJ, Goldberg SB, Balmanoukian AS, Sanborn RE, Steele K, Narwal R, et al. Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC. J Clin Oncol. 2015;33 Suppl:abstr 3014.
  • 69
    • 44949096473 scopus 로고    scopus 로고
    • Chemotherapeutic drugs may be used to enhance the killing efficacy of human tumor antigen peptide-specific CTLs
    • COI: 1:CAS:528:DC%2BD1cXjt1Cju7g%3D, PID: 18481383
    • Correale P, Del Vecchio MT, La Placa M, Montagnani F, Di Genova G, Savellini GG, et al. Chemotherapeutic drugs may be used to enhance the killing efficacy of human tumor antigen peptide-specific CTLs. J Immunother. 2008;31(2):132–47. doi:10.1097/CJI.0b013e31815b69c8.
    • (2008) J Immunother , vol.31 , Issue.2 , pp. 132-147
    • Correale, P.1    Del Vecchio, M.T.2    La Placa, M.3    Montagnani, F.4    Di Genova, G.5    Savellini, G.G.6
  • 70
    • 77951178310 scopus 로고    scopus 로고
    • Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
    • COI: 1:CAS:528:DC%2BC3cXksVChsLo%3D, PID: 20234093
    • Ramakrishnan R, Assudani D, Nagaraj S, Hunter T, Cho HI, Antonia S, et al. Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice. J Clin Invest. 2010;120(4):1111–24. doi:10.1172/JCI40269.
    • (2010) J Clin Invest. , vol.120 , Issue.4 , pp. 1111-1124
    • Ramakrishnan, R.1    Assudani, D.2    Nagaraj, S.3    Hunter, T.4    Cho, H.I.5    Antonia, S.6
  • 71
    • 84997649846 scopus 로고    scopus 로고
    • Antonia SJ, Brahmer JR, Gettinger SN, Chow LQM, Juergens RA, Shepherd FA, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32 Suppl:abstr 8113.
    • Antonia SJ, Brahmer JR, Gettinger SN, Chow LQM, Juergens RA, Shepherd FA, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32 Suppl:abstr 8113.
  • 72
    • 84997805667 scopus 로고    scopus 로고
    • Bendell JC, Powderly JD, Lieu CH, Eckhardt SG, Hurwitz H, Hochster HS, et al. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with bevacizumab (bev) and/or FOLFOX in patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol. 2015;33 Suppl 3:abstr 704.
    • Bendell JC, Powderly JD, Lieu CH, Eckhardt SG, Hurwitz H, Hochster HS, et al. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with bevacizumab (bev) and/or FOLFOX in patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol. 2015;33 Suppl 3:abstr 704.
  • 73
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • COI: 1:CAS:528:DC%2BC3sXhsVKgu7vL, PID: 24048123
    • Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14(10):1014–22. doi:10.1038/ni.2703.
    • (2013) Nat Immunol , vol.14 , Issue.10 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 74
    • 78249257291 scopus 로고    scopus 로고
    • CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation
    • COI: 1:CAS:528:DC%2BC3cXhsValtLrI, PID: 21035406
    • Rakhra K, Bachireddy P, Zabuawala T, Zeiser R, Xu L, Kopelman A, et al. CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell. 2010;18(5):485–98. doi:10.1016/j.ccr.2010.10.002.
    • (2010) Cancer Cell , vol.18 , Issue.5 , pp. 485-498
    • Rakhra, K.1    Bachireddy, P.2    Zabuawala, T.3    Zeiser, R.4    Xu, L.5    Kopelman, A.6
  • 75
    • 84941419767 scopus 로고    scopus 로고
    • Cyclooxygenase-dependent tumor growth through evasion of immunity
    • COI: 1:CAS:528:DC%2BC2MXhsVKhu7bL, PID: 26343581
    • Zelenay S, van der Veen AG, Bottcher JP, Snelgrove KJ, Rogers N, Acton SE, et al. Cyclooxygenase-dependent tumor growth through evasion of immunity. Cell. 2015;162(6):1257–70. doi:10.1016/j.cell.2015.08.015.
    • (2015) Cell , vol.162 , Issue.6 , pp. 1257-1270
    • Zelenay, S.1    van der Veen, A.G.2    Bottcher, J.P.3    Snelgrove, K.J.4    Rogers, N.5    Acton, S.E.6
  • 76
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3sXjsFektL0%3D, PID: 23307859
    • Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res. 2013;19(5):1225–31. doi:10.1158/1078-0432.CCR-12-1630.
    • (2013) Clin Cancer Res , vol.19 , Issue.5 , pp. 1225-1231
    • Frederick, D.T.1    Piris, A.2    Cogdill, A.P.3    Cooper, Z.A.4    Lezcano, C.5    Ferrone, C.R.6
  • 77
    • 84925262623 scopus 로고    scopus 로고
    • Hu-Lieskovan S, Mok S, Homet Moreno B, Tsoi J, Robert L, Goedert L, et al. Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma. Sci Transl Med. 2015;7(279):279ra41. doi:.
    • Hu-Lieskovan S, Mok S, Homet Moreno B, Tsoi J, Robert L, Goedert L, et al. Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma. Sci Transl Med. 2015;7(279):279ra41. doi:10.1126/scitranslmed.aaa4691.
  • 78
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • COI: 1:CAS:528:DC%2BC3sXls1aktbg%3D, PID: 23550685
    • Ribas A, Hodi FS, Callahan M, Konto C, Wolchok J. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med. 2013;368(14):1365–6. doi:10.1056/NEJMc1302338.
    • (2013) N Engl J Med , vol.368 , Issue.14 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3    Konto, C.4    Wolchok, J.5
  • 79
    • 79551717184 scopus 로고    scopus 로고
    • Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma
    • COI: 1:CAS:528:DC%2BC3MXislensr4%3D, PID: 20922784
    • Rini BI, Stein M, Shannon P, Eddy S, Tyler A, Stephenson JJ Jr, et al. Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma. Cancer. 2011;117(4):758–67. doi:10.1002/cncr.25639.
    • (2011) Cancer , vol.117 , Issue.4 , pp. 758-767
    • Rini, B.I.1    Stein, M.2    Shannon, P.3    Eddy, S.4    Tyler, A.5    Stephenson, J.J.6
  • 80
    • 84997767616 scopus 로고    scopus 로고
    • Creelan BC, Chow LQ, Kim DW, Kim SW, Yeh T, Karakunnel JJ, et al. Safety and tolerability results from a phase I study of MEDI4736, a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib in patients (pts) with non-small-cell lung cancer (NSCLC). J Clin Oncol. 2015;33 Suppl:abstr 3047.
    • Creelan BC, Chow LQ, Kim DW, Kim SW, Yeh T, Karakunnel JJ, et al. Safety and tolerability results from a phase I study of MEDI4736, a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib in patients (pts) with non-small-cell lung cancer (NSCLC). J Clin Oncol. 2015;33 Suppl:abstr 3047.
  • 81
    • 84997627659 scopus 로고    scopus 로고
    • Ribas A, Butler M, Lutzky J, Lawrence DP, Robert C, Miller W, et al. Phase I study combining anti-PD-L1 (MEDI4736) with BRAF (dabrafenib) and/or MEK (trametinib) inhibitors in advanced melanoma. J Clin Oncol. 2015;33 Suppl:abstr 3003.
    • Ribas A, Butler M, Lutzky J, Lawrence DP, Robert C, Miller W, et al. Phase I study combining anti-PD-L1 (MEDI4736) with BRAF (dabrafenib) and/or MEK (trametinib) inhibitors in advanced melanoma. J Clin Oncol. 2015;33 Suppl:abstr 3003.
  • 82
    • 84997626963 scopus 로고    scopus 로고
    • Amin A, Plimack ER, Infante JR, Ernstoff MS, Rini BI, McDermott DF, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol. 2014;32(5 Suppl):abstr 5010.
    • Amin A, Plimack ER, Infante JR, Ernstoff MS, Rini BI, McDermott DF, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol. 2014;32(5 Suppl):abstr 5010.
  • 83
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • COI: 1:CAS:528:DC%2BC2cXis1ertbc%3D, PID: 24382348
    • Deng L, Liang H, Burnette B, Beckett M, Darga T, Weichselbaum RR, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 2014;124(2):687–95. doi:10.1172/JCI67313.
    • (2014) J Clin Invest. , vol.124 , Issue.2 , pp. 687-695
    • Deng, L.1    Liang, H.2    Burnette, B.3    Beckett, M.4    Darga, T.5    Weichselbaum, R.R.6
  • 84
    • 33846429184 scopus 로고    scopus 로고
    • Induced sensitization of tumor stroma leads to eradication of established cancer by T cells
    • COI: 1:CAS:528:DC%2BD2sXhtFGjsbY%3D, PID: 17210731
    • Zhang B, Bowerman NA, Salama JK, Schmidt H, Spiotto MT, Schietinger A, et al. Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. J Exp Med. 2007;204(1):49–55. doi:10.1084/jem.20062056.
    • (2007) J Exp Med , vol.204 , Issue.1 , pp. 49-55
    • Zhang, B.1    Bowerman, N.A.2    Salama, J.K.3    Schmidt, H.4    Spiotto, M.T.5    Schietinger, A.6
  • 85
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • COI: 1:CAS:528:DC%2BC38XktFOgurw%3D, PID: 22397654
    • Postow MA, Callahan MK, Barker CA, Yamada Y, Yuan J, Kitano S, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366(10):925–31. doi:10.1056/NEJMoa1112824.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3    Yamada, Y.4    Yuan, J.5    Kitano, S.6
  • 86
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BD3sXlsFGnt7c%3D, PID: 12826605
    • Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci. 2003;100(14):8372–7. doi:10.1073/pnas.1533209100.
    • (2003) Proc Natl Acad Sci , vol.100 , Issue.14 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3    Hwu, P.4    Topalian, S.L.5    Schwartzentruber, D.J.6
  • 87
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    • COI: 1:CAS:528:DC%2BD2MXhtVKgtb3L, PID: 16087944
    • Attia P, Phan GQ, Maker AV, Robinson MR, Quezado MM, Yang JC, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol. 2005;23(25):6043–53. doi:10.1200/JCO.2005.06.205.
    • (2005) J Clin Oncol , vol.23 , Issue.25 , pp. 6043-6053
    • Attia, P.1    Phan, G.Q.2    Maker, A.V.3    Robinson, M.R.4    Quezado, M.M.5    Yang, J.C.6
  • 88
    • 32644467549 scopus 로고    scopus 로고
    • Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206
    • COI: 1:CAS:528:DC%2BD28XktVCnsg%3D%3D, PID: 16204013
    • Ribas A, Camacho LH, Lopez-Berestein G, Pavlov D, Bulanhagui CA, Millham R, et al. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol. 2005;23(35):8968–77. doi:10.1200/JCO.2005.01.109.
    • (2005) J Clin Oncol , vol.23 , Issue.35 , pp. 8968-8977
    • Ribas, A.1    Camacho, L.H.2    Lopez-Berestein, G.3    Pavlov, D.4    Bulanhagui, C.A.5    Millham, R.6
  • 89
    • 69949095926 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
    • COI: 1:CAS:528:DC%2BD1MXhtVOntrbE, PID: 19671877
    • Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, et al. A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res. 2009;15(17):5591–8. doi:10.1158/1078-0432.CCR-09-1024.
    • (2009) Clin Cancer Res , vol.15 , Issue.17 , pp. 5591-5598
    • Weber, J.1    Thompson, J.A.2    Hamid, O.3    Minor, D.4    Amin, A.5    Ron, I.6
  • 90
    • 36748999428 scopus 로고    scopus 로고
    • Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
    • COI: 1:CAS:528:DC%2BD2sXhtlSmu7bN, PID: 17982122
    • Downey SG, Klapper JA, Smith FO, Yang JC, Sherry RM, Royal RE, et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res. 2007;13(22 Pt 1):6681–8. doi:10.1158/1078-0432.CCR-07-0187.
    • (2007) Clin Cancer Res , vol.13 , Issue.22 , pp. 6681-6688
    • Downey, S.G.1    Klapper, J.A.2    Smith, F.O.3    Yang, J.C.4    Sherry, R.M.5    Royal, R.E.6
  • 91
    • 32644454916 scopus 로고    scopus 로고
    • Prognostic significance of autoimmunity during treatment of melanoma with interferon
    • COI: 1:CAS:528:DC%2BD28XhsVWrsrw%3D, PID: 16481638
    • Gogas H, Ioannovich J, Dafni U, Stavropoulou-Giokas C, Frangia K, Tsoutsos D, et al. Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med. 2006;354(7):709–18. doi:10.1056/NEJMoa053007.
    • (2006) N Engl J Med , vol.354 , Issue.7 , pp. 709-718
    • Gogas, H.1    Ioannovich, J.2    Dafni, U.3    Stavropoulou-Giokas, C.4    Frangia, K.5    Tsoutsos, D.6
  • 92
    • 35649026211 scopus 로고    scopus 로고
    • Autoimmunity as a prognostic factor in melanoma patients treated with adjuvant low-dose interferon alpha
    • COI: 1:CAS:528:DC%2BD2sXhtlShtb3I, PID: 17680564
    • Satzger I, Meier A, Schenck F, Kapp A, Hauschild A, Gutzmer R. Autoimmunity as a prognostic factor in melanoma patients treated with adjuvant low-dose interferon alpha. Int J Cancer. 2007;121(11):2562–6. doi:10.1002/ijc.22951.
    • (2007) Int J Cancer , vol.121 , Issue.11 , pp. 2562-2566
    • Satzger, I.1    Meier, A.2    Schenck, F.3    Kapp, A.4    Hauschild, A.5    Gutzmer, R.6
  • 93
    • 84655165056 scopus 로고    scopus 로고
    • Continuous systemic corticosteroids do not affect the ongoing regression of metastatic melanoma for more than two years following ipilimumab therapy
    • COI: 1:CAS:528:DC%2BC3MXhsFWjtr3I, PID: 20593249
    • Harmankaya K, Erasim C, Koelblinger C, Ibrahim R, Hoos A, Pehamberger H, et al. Continuous systemic corticosteroids do not affect the ongoing regression of metastatic melanoma for more than two years following ipilimumab therapy. Med Oncol. 2011;28(4):1140–4. doi:10.1007/s12032-010-9606-0.
    • (2011) Med Oncol , vol.28 , Issue.4 , pp. 1140-1144
    • Harmankaya, K.1    Erasim, C.2    Koelblinger, C.3    Ibrahim, R.4    Hoos, A.5    Pehamberger, H.6
  • 94
    • 27444444916 scopus 로고    scopus 로고
    • Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells
    • COI: 1:CAS:528:DC%2BD2MXhtFSis73M, PID: 16224268
    • Hinrichs CS, Palmer DC, Rosenberg SA, Restifo NP. Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells. J Immunother. 2005;28(6):517–24.
    • (2005) J Immunother , vol.28 , Issue.6 , pp. 517-524
    • Hinrichs, C.S.1    Palmer, D.C.2    Rosenberg, S.A.3    Restifo, N.P.4
  • 95
    • 84860446616 scopus 로고    scopus 로고
    • Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial
    • COI: 1:CAS:528:DC%2BC38Xmslyhsb4%3D, PID: 22456429
    • Margolin K, Ernstoff MS, Hamid O, Lawrence D, McDermott D, Puzanov I, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol. 2012;13(5):459–65. doi:10.1016/S1470-2045(12)70090-6.
    • (2012) Lancet Oncol. , vol.13 , Issue.5 , pp. 459-465
    • Margolin, K.1    Ernstoff, M.S.2    Hamid, O.3    Lawrence, D.4    McDermott, D.5    Puzanov, I.6
  • 96
    • 84877093633 scopus 로고    scopus 로고
    • Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control
    • Robert C, Schadendorf D, Messina M, Hodi FS, O’Day S, investigators MDX. Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control. Clin Cancer Res. 2013;19(8):2232–9. doi:10.1158/1078-0432.CCR-12-3080.
    • (2013) Clin Cancer Res , vol.19 , Issue.8 , pp. 2232-2239
    • Robert, C.1    Schadendorf, D.2    Messina, M.3    Hodi, F.S.4    O’Day, S.5    investigators, M.D.X.6
  • 97
    • 85016509105 scopus 로고    scopus 로고
    • Phase I/II study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab
    • COI: 1:CAS:528:DC%2BC28Xls1GrtL4%3D, PID: 26873574
    • Weber J, Gibney G, Kudchadkar R, Yu B, Cheng P, Martinez AJ, et al. Phase I/II study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab. Cancer Immunol Res. 2016;4(4):345–53. doi:10.1158/2326-6066.CIR-15-0193.
    • (2016) Cancer Immunol Res. , vol.4 , Issue.4 , pp. 345-353
    • Weber, J.1    Gibney, G.2    Kudchadkar, R.3    Yu, B.4    Cheng, P.5    Martinez, A.J.6
  • 98
    • 84967185844 scopus 로고    scopus 로고
    • Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy
    • COI: 1:CAS:528:DC%2BC28XnvV2qurc%3D, PID: 27124339
    • Bowyer S, Prithviraj P, Lorigan P, Larkin J, McArthur G, Atkinson V, et al. Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy. Br J Cancer. 2016;114(10):1084–9. doi:10.1038/bjc.2016.107.
    • (2016) Br J Cancer , vol.114 , Issue.10 , pp. 1084-1089
    • Bowyer, S.1    Prithviraj, P.2    Lorigan, P.3    Larkin, J.4    McArthur, G.5    Atkinson, V.6
  • 99
    • 84991110530 scopus 로고    scopus 로고
    • Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial
    • PID: 27269740
    • Weber JS, Gibney G, Sullivan RJ, Sosman JA, Slingluff CL Jr, Lawrence DP, et al. Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial. Lancet Oncol. 2016. doi:10.1016/S1470-2045(16)30126-7.
    • (2016) Lancet Oncol.
    • Weber, J.S.1    Gibney, G.2    Sullivan, R.J.3    Sosman, J.A.4    Slingluff, C.L.5    Lawrence, D.P.6
  • 100
    • 85003054266 scopus 로고    scopus 로고
    • Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders
    • PID: 26633184
    • Johnson DB, Sullivan RJ, Ott PA, Carlino MS, Khushalani NI, Ye F, et al. Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders. JAMA Oncol. 2016;2(2):234–40. doi:10.1001/jamaoncol.2015.4368.
    • (2016) JAMA Oncol. , vol.2 , Issue.2 , pp. 234-240
    • Johnson, D.B.1    Sullivan, R.J.2    Ott, P.A.3    Carlino, M.S.4    Khushalani, N.I.5    Ye, F.6
  • 101
    • 84977136814 scopus 로고    scopus 로고
    • Ipilimumab in patients with melanoma and autoimmune disease
    • PID: 25349698
    • Kyi C, Carvajal RD, Wolchok JD, Postow MA. Ipilimumab in patients with melanoma and autoimmune disease. J Immunother Cancer. 2014;2(1):35. doi:10.1186/s40425-014-0035-z.
    • (2014) J Immunother Cancer. , vol.2 , Issue.1 , pp. 35
    • Kyi, C.1    Carvajal, R.D.2    Wolchok, J.D.3    Postow, M.A.4
  • 102
    • 84905820239 scopus 로고    scopus 로고
    • Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma
    • PID: 24493726
    • Lipson EJ, Bodell MA, Kraus ES, Sharfman WH. Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma. J Clin Oncol. 2014;32(19):e69–71. doi:10.1200/JCO.2013.49.2314.
    • (2014) J Clin Oncol , vol.32 , Issue.19 , pp. e69-e71
    • Lipson, E.J.1    Bodell, M.A.2    Kraus, E.S.3    Sharfman, W.H.4
  • 103
    • 84997782881 scopus 로고    scopus 로고
    • Safety and efficacy of ipilimumab to treat advanced melanoma in the setting of liver transplantation
    • PID: 26082835
    • Morales RE, Shoushtari AN, Walsh MM, Grewal P, Lipson EJ, Carvajal RD. Safety and efficacy of ipilimumab to treat advanced melanoma in the setting of liver transplantation. J Immunother Cancer. 2015;3:22. doi:10.1186/s40425-015-0066-0.
    • (2015) J Immunother Cancer. , vol.3 , pp. 22
    • Morales, R.E.1    Shoushtari, A.N.2    Walsh, M.M.3    Grewal, P.4    Lipson, E.J.5    Carvajal, R.D.6
  • 104
    • 84997768520 scopus 로고    scopus 로고
    • FDA prescribing information. Accessed 13 July 2016
    • FDA prescribing information. http://www.accessdata.fda.gov. Accessed 13 July 2016.
  • 105
    • 84941619877 scopus 로고    scopus 로고
    • A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors
    • COI: 1:STN:280:DC%2BC2MjltlamtQ%3D%3D, PID: 25888611
    • Chen TW, Razak AR, Bedard PL, Siu LL, Hansen AR. A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors. Ann Oncol. 2015;26(9):1824–9. doi:10.1093/annonc/mdv182.
    • (2015) Ann Oncol , vol.26 , Issue.9 , pp. 1824-1829
    • Chen, T.W.1    Razak, A.R.2    Bedard, P.L.3    Siu, L.L.4    Hansen, A.R.5
  • 106
    • 84875132942 scopus 로고    scopus 로고
    • Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events
    • COI: 1:CAS:528:DC%2BC3sXnvVyju7s%3D, PID: 23521917
    • Shahabi V, Berman D, Chasalow SD, Wang L, Tsuchihashi Z, Hu B, et al. Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events. J Transl Med. 2013;11:75. doi:10.1186/1479-5876-11-75.
    • (2013) J Transl Med. , vol.11 , pp. 75
    • Shahabi, V.1    Berman, D.2    Chasalow, S.D.3    Wang, L.4    Tsuchihashi, Z.5    Hu, B.6
  • 107
    • 84997771368 scopus 로고    scopus 로고
    • Baseline circulating IL-17 predicts toxicity while TGF-beta1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma
    • PID: 26380086
    • Tarhini AA, Zahoor H, Lin Y, Malhotra U, Sander C, Butterfield LH, et al. Baseline circulating IL-17 predicts toxicity while TGF-beta1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma. J Immunother Cancer. 2015;3:39. doi:10.1186/s40425-015-0081-1.
    • (2015) J Immunother Cancer. , vol.3 , pp. 39
    • Tarhini, A.A.1    Zahoor, H.2    Lin, Y.3    Malhotra, U.4    Sander, C.5    Butterfield, L.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.