-
1
-
-
0036852241
-
Cancer immunoediting: from immunosurveillance to tumor escape
-
COI: 1:CAS:528:DC%2BD38Xot1Chs70%3D, PID: 12407406
-
Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3(11):991–8. doi:10.1038/ni1102-991.
-
(2002)
Nat Immunol
, vol.3
, Issue.11
, pp. 991-998
-
-
Dunn, G.P.1
Bruce, A.T.2
Ikeda, H.3
Old, L.J.4
Schreiber, R.D.5
-
2
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
COI: 1:CAS:528:DC%2BD2sXotFOjtQ%3D%3D, PID: 17251916
-
Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer. 2007;7(2):95–106. doi:10.1038/nrc2051.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.2
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
3
-
-
84887862839
-
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
-
COI: 1:CAS:528:DC%2BC3sXhslygt7bF, PID: 24240160
-
Okazaki T, Chikuma S, Iwai Y, Fagarasan S, Honjo T. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. Nat Immunol. 2013;14(12):1212–8. doi:10.1038/ni.2762.
-
(2013)
Nat Immunol
, vol.14
, Issue.12
, pp. 1212-1218
-
-
Okazaki, T.1
Chikuma, S.2
Iwai, Y.3
Fagarasan, S.4
Honjo, T.5
-
4
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
COI: 1:CAS:528:DC%2BC3cXhtVCrtrbN, PID: 20525992
-
Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711–23. doi:10.1056/NEJMoa1003466.
-
(2010)
N Engl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O’Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
-
5
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
COI: 1:CAS:528:DC%2BC3MXosVegtro%3D, PID: 21639810
-
Robert C, Thomas L, Bondarenko I, O’Day S, Weber J, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364(26):2517–26. doi:10.1056/NEJMoa1104621.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
O’Day, S.4
Weber, J.5
Garbe, C.6
-
6
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
COI: 1:CAS:528:DC%2BC38XhtV2rs7fN, PID: 22658127
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443–54. doi:10.1056/NEJMoa1200690.
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
-
7
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
COI: 1:CAS:528:DC%2BC3sXht1emsbjP, PID: 23724846
-
Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med. 2013;369(2):134–44. doi:10.1056/NEJMoa1305133.
-
(2013)
N Engl J Med
, vol.369
, Issue.2
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.J.5
Kefford, R.6
-
8
-
-
84936749833
-
Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC2MXhsFKmt7rJ, PID: 25897158
-
Gettinger SN, Horn L, Gandhi L, Spigel DR, Antonia SJ, Rizvi NA, et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol. 2015;33(18):2004–12. doi:10.1200/JCO.2014.58.3708.
-
(2015)
J Clin Oncol
, vol.33
, Issue.18
, pp. 2004-2012
-
-
Gettinger, S.N.1
Horn, L.2
Gandhi, L.3
Spigel, D.R.4
Antonia, S.J.5
Rizvi, N.A.6
-
9
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
COI: 1:CAS:528:DC%2BC2MXhtFyrsbrF, PID: 25891173
-
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med. 2015;372(26):2521–32. doi:10.1056/NEJMoa1503093.
-
(2015)
N Engl J Med
, vol.372
, Issue.26
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
Arance, A.4
Grob, J.J.5
Mortier, L.6
-
10
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
PID: 25891304
-
Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med. 2015;372(21):2006–17. doi:10.1056/NEJMoa1414428.
-
(2015)
N Engl J Med
, vol.372
, Issue.21
, pp. 2006-2017
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
Robert, C.4
Grossmann, K.5
McDermott, D.6
-
11
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
COI: 1:CAS:528:DC%2BC38XhtV2rsbnJ, PID: 22658128
-
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455–65. doi:10.1056/NEJMoa1200694.
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
Hwu, W.J.4
Topalian, S.L.5
Hwu, P.6
-
12
-
-
0031405867
-
Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
-
COI: 1:CAS:528:DyaK1cXjsFaqsQ%3D%3D, PID: 9430233
-
Chambers CA, Sullivan TJ, Allison JP. Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity. 1997;7(6):885–95.
-
(1997)
Immunity
, vol.7
, Issue.6
, pp. 885-895
-
-
Chambers, C.A.1
Sullivan, T.J.2
Allison, J.P.3
-
13
-
-
77953747963
-
The PD-1 pathway in tolerance and autoimmunity
-
COI: 1:CAS:528:DC%2BC3cXovFaks7s%3D, PID: 20636820
-
Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010;236:219–42. doi:10.1111/j.1600-065X.2010.00923.x.
-
(2010)
Immunol Rev
, vol.236
, pp. 219-242
-
-
Francisco, L.M.1
Sage, P.T.2
Sharpe, A.H.3
-
14
-
-
84879579673
-
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy
-
COI: 1:CAS:528:DC%2BC3sXhtFajs7bN, PID: 23625198
-
Intlekofer AM, Thompson CB. At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy. J Leukoc Biol. 2013;94(1):25–39. doi:10.1189/jlb.1212621.
-
(2013)
J Leukoc Biol
, vol.94
, Issue.1
, pp. 25-39
-
-
Intlekofer, A.M.1
Thompson, C.B.2
-
15
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
COI: 1:CAS:528:DyaK2MXps1Oqtrw%3D, PID: 7584144
-
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995;3(5):541–7.
-
(1995)
Immunity
, vol.3
, Issue.5
, pp. 541-547
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, A.N.3
Lynch, W.P.4
Bluestone, J.A.5
Sharpe, A.H.6
-
16
-
-
23844529169
-
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
-
COI: 1:CAS:528:DC%2BD2MXpsFGgtb0%3D, PID: 16087865
-
Wang J, Yoshida T, Nakaki F, Hiai H, Okazaki T, Honjo T. Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Proc Natl Acad Sci. 2005;102(33):11823–8. doi:10.1073/pnas.0505497102.
-
(2005)
Proc Natl Acad Sci
, vol.102
, Issue.33
, pp. 11823-11828
-
-
Wang, J.1
Yoshida, T.2
Nakaki, F.3
Hiai, H.4
Okazaki, T.5
Honjo, T.6
-
17
-
-
28244492012
-
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade
-
COI: 1:CAS:528:DC%2BD2MXht1ent7vP, PID: 16301685
-
Maker AV, Attia P, Rosenberg SA. Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol. 2005;175(11):7746–54.
-
(2005)
J Immunol.
, vol.175
, Issue.11
, pp. 7746-7754
-
-
Maker, A.V.1
Attia, P.2
Rosenberg, S.A.3
-
18
-
-
84864052441
-
Management of immune-related adverse events and kinetics of response with ipilimumab
-
COI: 1:CAS:528:DC%2BC38Xht1ygsr%2FK, PID: 22614989
-
Weber JS, Kahler KC, Hauschild A. Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol. 2012;30(21):2691–7. doi:10.1200/JCO.2012.41.6750.
-
(2012)
J Clin Oncol
, vol.30
, Issue.21
, pp. 2691-2697
-
-
Weber, J.S.1
Kahler, K.C.2
Hauschild, A.3
-
19
-
-
33744792341
-
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
-
COI: 1:CAS:528:DC%2BD28XlvV2ksb4%3D, PID: 16710025
-
Beck KE, Blansfield JA, Tran KQ, Feldman AL, Hughes MS, Royal RE, et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol. 2006;24(15):2283–9. doi:10.1200/JCO.2005.04.5716.
-
(2006)
J Clin Oncol
, vol.24
, Issue.15
, pp. 2283-2289
-
-
Beck, K.E.1
Blansfield, J.A.2
Tran, K.Q.3
Feldman, A.L.4
Hughes, M.S.5
Royal, R.E.6
-
20
-
-
84876248304
-
Endocrine side effects induced by immune checkpoint inhibitors
-
COI: 1:CAS:528:DC%2BC3sXmtFehsb4%3D, PID: 23471977
-
Corsello SM, Barnabei A, Marchetti P, De Vecchis L, Salvatori R, Torino F. Endocrine side effects induced by immune checkpoint inhibitors. J Clin Endocrinol Metab. 2013;98(4):1361–75. doi:10.1210/jc.2012-4075.
-
(2013)
J Clin Endocrinol Metab
, vol.98
, Issue.4
, pp. 1361-1375
-
-
Corsello, S.M.1
Barnabei, A.2
Marchetti, P.3
De Vecchis, L.4
Salvatori, R.5
Torino, F.6
-
21
-
-
84899071058
-
-
Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P. Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci Transl Med. 2014;6(230):230ra45. doi:.
-
Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P. Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci Transl Med. 2014;6(230):230ra45. doi:10.1126/scitranslmed.3008002.
-
-
-
-
22
-
-
84872339660
-
The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network
-
COI: 1:CAS:528:DC%2BC3sXhsVGmurc%3D, PID: 23341990
-
Voskens CJ, Goldinger SM, Loquai C, Robert C, Kaehler KC, Berking C, et al. The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network. PLoS One. 2013;8(1):e53745. doi:10.1371/journal.pone.0053745.
-
(2013)
PLoS One
, vol.8
, Issue.1
-
-
Voskens, C.J.1
Goldinger, S.M.2
Loquai, C.3
Robert, C.4
Kaehler, K.C.5
Berking, C.6
-
23
-
-
84882879837
-
The risk of rash associated with ipilimumab in patients with cancer: a systematic review of the literature and meta-analysis
-
COI: 1:CAS:528:DC%2BC3sXhvFWhtbw%3D, PID: 23357570
-
Minkis K, Garden BC, Wu S, Pulitzer MP, Lacouture ME. The risk of rash associated with ipilimumab in patients with cancer: a systematic review of the literature and meta-analysis. J Am Acad Dermatol. 2013;69(3):e121–8. doi:10.1016/j.jaad.2012.12.963.
-
(2013)
J Am Acad Dermatol
, vol.69
, Issue.3
, pp. e121-e128
-
-
Minkis, K.1
Garden, B.C.2
Wu, S.3
Pulitzer, M.P.4
Lacouture, M.E.5
-
24
-
-
84896934432
-
Atypical neurological complications of ipilimumab therapy in patients with metastatic melanoma
-
COI: 1:CAS:528:DC%2BC2cXkslCruro%3D, PID: 24482447
-
Liao B, Shroff S, Kamiya-Matsuoka C, Tummala S. Atypical neurological complications of ipilimumab therapy in patients with metastatic melanoma. Neuro Oncol. 2014;16(4):589–93. doi:10.1093/neuonc/nou001.
-
(2014)
Neuro Oncol.
, vol.16
, Issue.4
, pp. 589-593
-
-
Liao, B.1
Shroff, S.2
Kamiya-Matsuoka, C.3
Tummala, S.4
-
25
-
-
84933678156
-
Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial
-
COI: 1:CAS:528:DC%2BC2MXlslCkuro%3D, PID: 25840693
-
Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial. Lancet Oncol. 2015;16(5):522–30. doi:10.1016/S1470-2045(15)70122-1.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.5
, pp. 522-530
-
-
Eggermont, A.M.1
Chiarion-Sileni, V.2
Grob, J.J.3
Dummer, R.4
Wolchok, J.D.5
Schmidt, H.6
-
26
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
PID: 26027431
-
Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015;373(1):23–34. doi:10.1056/NEJMoa1504030.
-
(2015)
N Engl J Med
, vol.373
, Issue.1
, pp. 23-34
-
-
Larkin, J.1
Chiarion-Sileni, V.2
Gonzalez, R.3
Grob, J.J.4
Cowey, C.L.5
Lao, C.D.6
-
27
-
-
77955256254
-
Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study
-
PID: 20147741
-
O’Day SJ, Maio M, Chiarion-Sileni V, Gajewski TF, Pehamberger H, Bondarenko IN, et al. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study. Ann Oncol. 2010;21(8):1712–7. doi:10.1093/annonc/mdq013.
-
(2010)
Ann Oncol
, vol.21
, Issue.8
, pp. 1712-1717
-
-
O’Day, S.J.1
Maio, M.2
Chiarion-Sileni, V.3
Gajewski, T.F.4
Pehamberger, H.5
Bondarenko, I.N.6
-
28
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study
-
COI: 1:CAS:528:DC%2BC3cXhtlGgtbY%3D, PID: 20004617
-
Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 2010;11(2):155–64. doi:10.1016/S1470-2045(09)70334-1.
-
(2010)
Lancet Oncol.
, vol.11
, Issue.2
, pp. 155-164
-
-
Wolchok, J.D.1
Neyns, B.2
Linette, G.3
Negrier, S.4
Lutzky, J.5
Thomas, L.6
-
29
-
-
58049202334
-
Phase I/II study of ipilimumab for patients with metastatic melanoma
-
COI: 1:CAS:528:DC%2BD1MXhs1Ggurc%3D, PID: 19018089
-
Weber JS, O’Day S, Urba W, Powderly J, Nichol G, Yellin M, et al. Phase I/II study of ipilimumab for patients with metastatic melanoma. J Clin Oncol. 2008;26(36):5950–6. doi:10.1200/JCO.2008.16.1927.
-
(2008)
J Clin Oncol
, vol.26
, Issue.36
, pp. 5950-5956
-
-
Weber, J.S.1
O’Day, S.2
Urba, W.3
Powderly, J.4
Nichol, G.5
Yellin, M.6
-
30
-
-
84940746759
-
Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis
-
PID: 26337719
-
Bertrand A, Kostine M, Barnetche T, Truchetet ME, Schaeverbeke T. Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis. BMC Med. 2015;13:211. doi:10.1186/s12916-015-0455-8.
-
(2015)
BMC Med
, vol.13
, pp. 211
-
-
Bertrand, A.1
Kostine, M.2
Barnetche, T.3
Truchetet, M.E.4
Schaeverbeke, T.5
-
31
-
-
84901246811
-
Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort
-
PID: 24885479
-
Ascierto PA, Simeone E, Sileni VC, Pigozzo J, Maio M, Altomonte M, et al. Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort. J Transl Med. 2014;12:116. doi:10.1186/1479-5876-12-116.
-
(2014)
J Transl Med.
, vol.12
, pp. 116
-
-
Ascierto, P.A.1
Simeone, E.2
Sileni, V.C.3
Pigozzo, J.4
Maio, M.5
Altomonte, M.6
-
32
-
-
84944261579
-
Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial sloan kettering cancer center
-
COI: 1:CAS:528:DC%2BC28Xmt1Cltbg%3D, PID: 26282644
-
Horvat TZ, Adel NG, Dang TO, Momtaz P, Postow MA, Callahan MK, et al. Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial sloan kettering cancer center. J Clin Oncol. 2015;33(28):3193–8. doi:10.1200/JCO.2015.60.8448.
-
(2015)
J Clin Oncol
, vol.33
, Issue.28
, pp. 3193-3198
-
-
Horvat, T.Z.1
Adel, N.G.2
Dang, T.O.3
Momtaz, P.4
Postow, M.A.5
Callahan, M.K.6
-
33
-
-
84863911486
-
Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study
-
COI: 1:CAS:528:DC%2BC38XhtVynsbvP, PID: 22547592
-
Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 2012;30(17):2046–54. doi:10.1200/JCO.2011.38.4032.
-
(2012)
J Clin Oncol
, vol.30
, Issue.17
, pp. 2046-2054
-
-
Lynch, T.J.1
Bondarenko, I.2
Luft, A.3
Serwatowski, P.4
Barlesi, F.5
Chacko, R.6
-
34
-
-
84901641673
-
Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial
-
COI: 1:CAS:528:DC%2BC2cXotFOrs74%3D, PID: 24831977
-
Kwon ED, Drake CG, Scher HI, Fizazi K, Bossi A, van den Eertwegh AJ, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2014;15(7):700–12. doi:10.1016/S1470-2045(14)70189-5.
-
(2014)
Lancet Oncol.
, vol.15
, Issue.7
, pp. 700-712
-
-
Kwon, E.D.1
Drake, C.G.2
Scher, H.I.3
Fizazi, K.4
Bossi, A.5
van den Eertwegh, A.J.6
-
35
-
-
37349072460
-
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
-
COI: 1:CAS:528:DC%2BD2sXhtlGqs7fO, PID: 18049334
-
Yang JC, Hughes M, Kammula U, Royal R, Sherry RM, Topalian SL, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother. 2007;30(8):825–30. doi:10.1097/CJI.0b013e318156e47e.
-
(2007)
J Immunother
, vol.30
, Issue.8
, pp. 825-830
-
-
Yang, J.C.1
Hughes, M.2
Kammula, U.3
Royal, R.4
Sherry, R.M.5
Topalian, S.L.6
-
36
-
-
84880508629
-
Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study
-
COI: 1:STN:280:DC%2BC3srgt1Cmtg%3D%3D, PID: 23535954
-
Slovin SF, Higano CS, Hamid O, Tejwani S, Harzstark A, Alumkal JJ, et al. Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. Ann Oncol. 2013;24(7):1813–21. doi:10.1093/annonc/mdt107.
-
(2013)
Ann Oncol
, vol.24
, Issue.7
, pp. 1813-1821
-
-
Slovin, S.F.1
Higano, C.S.2
Hamid, O.3
Tejwani, S.4
Harzstark, A.5
Alumkal, J.J.6
-
37
-
-
34250223096
-
A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
-
COI: 1:CAS:528:DC%2BD2sXivV2gtLs%3D, PID: 17363537
-
Small EJ, Tchekmedyian NS, Rini BI, Fong L, Lowy I, Allison JP. A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. Clin Cancer Res. 2007;13(6):1810–5. doi:10.1158/1078-0432.CCR-06-2318.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.6
, pp. 1810-1815
-
-
Small, E.J.1
Tchekmedyian, N.S.2
Rini, B.I.3
Fong, L.4
Lowy, I.5
Allison, J.P.6
-
38
-
-
77958050577
-
Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
-
COI: 1:CAS:528:DC%2BC3cXht1Wju77O, PID: 20842054
-
Royal RE, Levy C, Turner K, Mathur A, Hughes M, Kammula US, et al. Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother. 2010;33(8):828–33. doi:10.1097/CJI.0b013e3181eec14c.
-
(2010)
J Immunother
, vol.33
, Issue.8
, pp. 828-833
-
-
Royal, R.E.1
Levy, C.2
Turner, K.3
Mathur, A.4
Hughes, M.5
Kammula, U.S.6
-
39
-
-
84925379870
-
Identification and management of toxicities from immune checkpoint-blocking drugs
-
PID: 25384885
-
Teply BA, Lipson EJ. Identification and management of toxicities from immune checkpoint-blocking drugs. Oncology (Williston). 2014;28(Suppl 3):30–8.
-
(2014)
Oncology (Williston).
, vol.28
, pp. 30-38
-
-
Teply, B.A.1
Lipson, E.J.2
-
40
-
-
84949988089
-
Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
-
COI: 1:STN:280:DC%2BC283it1Khtw%3D%3D, PID: 26371282
-
Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol. 2015;26(12):2375–91. doi:10.1093/annonc/mdv383.
-
(2015)
Ann Oncol
, vol.26
, Issue.12
, pp. 2375-2391
-
-
Naidoo, J.1
Page, D.B.2
Li, B.T.3
Connell, L.C.4
Schindler, K.5
Lacouture, M.E.6
-
41
-
-
84997782537
-
-
Yervoy Safety Information. Accessed 14 July 2016.
-
Yervoy Safety Information. http://www.hcp.yervoy.com. Accessed 14 July 2016.
-
-
-
-
42
-
-
84997682107
-
-
Lin R, Yellin MJ, Lowy I, Safferman A, Chin K, Ibrahim R. An analysis of the effectiveness of specific guidelines for the management of ipilimumab-mediated diarrhea/colitis: prevention of gastrointestinal perforation and/or colectomy. J Clin Oncol (Meeting Abstracts). 2008;26(15):Suppl 9063.
-
Lin R, Yellin MJ, Lowy I, Safferman A, Chin K, Ibrahim R. An analysis of the effectiveness of specific guidelines for the management of ipilimumab-mediated diarrhea/colitis: prevention of gastrointestinal perforation and/or colectomy. J Clin Oncol (Meeting Abstracts). 2008;26(15):Suppl 9063.
-
-
-
-
43
-
-
84876678621
-
Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: detailed safety analysis from a phase 3 trial in patients with advanced melanoma
-
COI: 1:CAS:528:DC%2BC3sXmsFWmsr4%3D, PID: 23400564
-
Weber JS, Dummer R, de Pril V, Lebbe C, Hodi FS, Investigators MDX. Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: detailed safety analysis from a phase 3 trial in patients with advanced melanoma. Cancer. 2013;119(9):1675–82. doi:10.1002/cncr.27969.
-
(2013)
Cancer
, vol.119
, Issue.9
, pp. 1675-1682
-
-
Weber, J.S.1
Dummer, R.2
de Pril, V.3
Lebbe, C.4
Hodi, F.S.5
Investigators, M.D.X.6
-
44
-
-
84922584243
-
Long-term follow-up of ipilimumab-induced hypophysitis, a common adverse event of the anti-CTLA-4 antibody in melanoma
-
COI: 1:CAS:528:DC%2BC2MXksFehtrk%3D, PID: 25416723
-
Albarel F, Gaudy C, Castinetti F, Carre T, Morange I, Conte-Devolx B, et al. Long-term follow-up of ipilimumab-induced hypophysitis, a common adverse event of the anti-CTLA-4 antibody in melanoma. Eur J Endocrinol. 2015;172(2):195–204. doi:10.1530/EJE-14-0845.
-
(2015)
Eur J Endocrinol
, vol.172
, Issue.2
, pp. 195-204
-
-
Albarel, F.1
Gaudy, C.2
Castinetti, F.3
Carre, T.4
Morange, I.5
Conte-Devolx, B.6
-
45
-
-
84884721380
-
Efficacy and safety of ipilimumab in metastatic melanoma patients surviving more than 2 years following treatment in a phase III trial (MDX010-20)
-
COI: 1:STN:280:DC%2BC3sfpsVanuw%3D%3D, PID: 23942774
-
McDermott D, Haanen J, Chen TT, Lorigan P, O’Day S, Investigators MDX. Efficacy and safety of ipilimumab in metastatic melanoma patients surviving more than 2 years following treatment in a phase III trial (MDX010-20). Ann Oncol. 2013;24(10):2694–8. doi:10.1093/annonc/mdt291.
-
(2013)
Ann Oncol
, vol.24
, Issue.10
, pp. 2694-2698
-
-
McDermott, D.1
Haanen, J.2
Chen, T.T.3
Lorigan, P.4
O’Day, S.5
Investigators, M.D.X.6
-
46
-
-
84874605864
-
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
-
COI: 1:CAS:528:DC%2BC3sXjvVart74%3D, PID: 23295794
-
Ribas A, Kefford R, Marshall MA, Punt CJ, Haanen JB, Marmol M, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol. 2013;31(5):616–22. doi:10.1200/JCO.2012.44.6112.
-
(2013)
J Clin Oncol
, vol.31
, Issue.5
, pp. 616-622
-
-
Ribas, A.1
Kefford, R.2
Marshall, M.A.3
Punt, C.J.4
Haanen, J.B.5
Marmol, M.6
-
47
-
-
76049092889
-
Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma
-
COI: 1:CAS:528:DC%2BC3cXhs1aru70%3D, PID: 20086001
-
Kirkwood JM, Lorigan P, Hersey P, Hauschild A, Robert C, McDermott D, et al. Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma. Clin Cancer Res. 2010;16(3):1042–8. doi:10.1158/1078-0432.CCR-09-2033.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.3
, pp. 1042-1048
-
-
Kirkwood, J.M.1
Lorigan, P.2
Hersey, P.3
Hauschild, A.4
Robert, C.5
McDermott, D.6
-
48
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
PID: 25891174
-
Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372(21):2018–28. doi:10.1056/NEJMoa1501824.
-
(2015)
N Engl J Med
, vol.372
, Issue.21
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
Leighl, N.4
Balmanoukian, A.S.5
Eder, J.P.6
-
49
-
-
84938205998
-
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
-
COI: 1:CAS:528:DC%2BC2MXhtFSjtr3L, PID: 26115796
-
Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol. 2015;16(8):908–18. doi:10.1016/S1470-2045(15)00083-2.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.8
, pp. 908-918
-
-
Ribas, A.1
Puzanov, I.2
Dummer, R.3
Schadendorf, D.4
Hamid, O.5
Robert, C.6
-
50
-
-
84908354848
-
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
-
COI: 1:CAS:528:DC%2BC2cXhtFGlsb%2FN, PID: 25034862
-
Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet. 2014;384(9948):1109–17. doi:10.1016/S0140-6736(14)60958-2.
-
(2014)
Lancet
, vol.384
, Issue.9948
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
Hodi, F.S.4
Hamid, O.5
Kefford, R.6
-
51
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC28XjsFyitL0%3D, PID: 26412456
-
Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373(17):1627–39. doi:10.1056/NEJMoa1507643.
-
(2015)
N Engl J Med
, vol.373
, Issue.17
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
Spigel, D.R.4
Steins, M.5
Ready, N.E.6
-
52
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC2MXht12qu7%2FJ, PID: 26028407
-
Brahmer J, Reckamp KL, Baas P, Crino L, Eberhardt WE, Poddubskaya E, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015;373(2):123–35. doi:10.1056/NEJMoa1504627.
-
(2015)
N Engl J Med
, vol.373
, Issue.2
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
Crino, L.4
Eberhardt, W.E.5
Poddubskaya, E.6
-
53
-
-
84946607195
-
Nivolumab versus everolimus in advanced renal-cell carcinoma
-
COI: 1:CAS:528:DC%2BC28XjsFyhsrg%3D, PID: 26406148
-
Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med. 2015;373(19):1803–13. doi:10.1056/NEJMoa1510665.
-
(2015)
N Engl J Med
, vol.373
, Issue.19
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
George, S.4
Hammers, H.J.5
Srinivas, S.6
-
54
-
-
84929572937
-
Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial
-
COI: 1:CAS:528:DC%2BC2MXpvFahsbY%3D, PID: 25452452
-
Motzer RJ, Rini BI, McDermott DF, Redman BG, Kuzel TM, Harrison MR, et al. Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial. J Clin Oncol. 2015;33(13):1430–7. doi:10.1200/JCO.2014.59.0703.
-
(2015)
J Clin Oncol
, vol.33
, Issue.13
, pp. 1430-1437
-
-
Motzer, R.J.1
Rini, B.I.2
McDermott, D.F.3
Redman, B.G.4
Kuzel, T.M.5
Harrison, M.R.6
-
55
-
-
84924901863
-
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
-
COI: 1:CAS:528:DC%2BC2MXjtFShs7s%3D, PID: 25704439
-
Rizvi NA, Mazieres J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 2015;16(3):257–65. doi:10.1016/S1470-2045(15)70054-9.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.3
, pp. 257-265
-
-
Rizvi, N.A.1
Mazieres, J.2
Planchard, D.3
Stinchcombe, T.E.4
Dy, G.K.5
Antonia, S.J.6
-
56
-
-
84931083080
-
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
-
COI: 1:CAS:528:DC%2BC2MXkvVWgsLk%3D, PID: 25795410
-
Weber JS, D’Angelo SP, Minor D, Hodi FS, Gutzmer R, Neyns B, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2015;16(4):375–84. doi:10.1016/S1470-2045(15)70076-8.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.4
, pp. 375-384
-
-
Weber, J.S.1
D’Angelo, S.P.2
Minor, D.3
Hodi, F.S.4
Gutzmer, R.5
Neyns, B.6
-
57
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
COI: 1:CAS:528:DC%2BC2MXisFGqsLg%3D, PID: 25399552
-
Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320–30. doi:10.1056/NEJMoa1412082.
-
(2015)
N Engl J Med
, vol.372
, Issue.4
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
Dutriaux, C.4
Maio, M.5
Mortier, L.6
-
58
-
-
84886443514
-
CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients
-
COI: 1:CAS:528:DC%2BC3sXhsFyns7bM, PID: 24089443
-
Ott PA, Hodi FS, Robert C. CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients. Clin Cancer Res. 2013;19(19):5300–9. doi:10.1158/1078-0432.CCR-13-0143.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.19
, pp. 5300-5309
-
-
Ott, P.A.1
Hodi, F.S.2
Robert, C.3
-
59
-
-
84997714794
-
-
Weber JS, Antonia SJ, Topalian SL, Schadendorf D, Larkin JMG, Sznol M, et al. Safety profile of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL): a pooled analysis. J Clin Oncol. 2015;33 Suppl:abstr 9018.
-
Weber JS, Antonia SJ, Topalian SL, Schadendorf D, Larkin JMG, Sznol M, et al. Safety profile of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL): a pooled analysis. J Clin Oncol. 2015;33 Suppl:abstr 9018.
-
-
-
-
60
-
-
84997742159
-
-
Day D, Khoja L, Chen TW, Siu LL, Hansen AR. Tumor- and class-specific patterns of immune-related adverse events (irAEs) of immune checkpoint inhibitors (ICIs): a systematic review (SR). J Clin Oncol. 2016;34 Suppl:abstr 3065.
-
Day D, Khoja L, Chen TW, Siu LL, Hansen AR. Tumor- and class-specific patterns of immune-related adverse events (irAEs) of immune checkpoint inhibitors (ICIs): a systematic review (SR). J Clin Oncol. 2016;34 Suppl:abstr 3065.
-
-
-
-
61
-
-
84959577118
-
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
-
COI: 1:CAS:528:DC%2BC28XjslGmu7w%3D, PID: 26952546
-
Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387(10031):1909–20. doi:10.1016/S0140-6736(16)00561-4.
-
(2016)
Lancet
, vol.387
, Issue.10031
, pp. 1909-1920
-
-
Rosenberg, J.E.1
Hoffman-Censits, J.2
Powles, T.3
van der Heijden, M.S.4
Balar, A.V.5
Necchi, A.6
-
62
-
-
84923078390
-
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
-
COI: 1:CAS:528:DC%2BC2cXitFamsrjE, PID: 25428503
-
Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature. 2014;515(7528):558–62. doi:10.1038/nature13904.
-
(2014)
Nature
, vol.515
, Issue.7528
, pp. 558-562
-
-
Powles, T.1
Eder, J.P.2
Fine, G.D.3
Braiteh, F.S.4
Loriot, Y.5
Cruz, C.6
-
63
-
-
84997816828
-
-
Kelly K, Patel MR, Infante JR, Iannotti N, Nikolinakos P, Leach J, et al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with metastatic or locally advanced solid tumors: assessment of safety and tolerability in a phase I, open-label expansion study. J Clin Oncol. 2015;33 Suppl:abstr 3044.
-
Kelly K, Patel MR, Infante JR, Iannotti N, Nikolinakos P, Leach J, et al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with metastatic or locally advanced solid tumors: assessment of safety and tolerability in a phase I, open-label expansion study. J Clin Oncol. 2015;33 Suppl:abstr 3044.
-
-
-
-
64
-
-
70349669259
-
A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma
-
COI: 1:CAS:528:DC%2BD1MXhtF2lurvL, PID: 19755389
-
Brignone C, Escudier B, Grygar C, Marcu M, Triebel F. A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma. Clin Cancer Res. 2009;15(19):6225–31. doi:10.1158/1078-0432.CCR-09-0068.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.19
, pp. 6225-6231
-
-
Brignone, C.1
Escudier, B.2
Grygar, C.3
Marcu, M.4
Triebel, F.5
-
65
-
-
77749279776
-
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
-
COI: 1:CAS:528:DC%2BC3cXjtlKms7c%3D, PID: 20160101
-
Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci. 2010;107(9):4275–80. doi:10.1073/pnas.0915174107.
-
(2010)
Proc Natl Acad Sci
, vol.107
, Issue.9
, pp. 4275-4280
-
-
Curran, M.A.1
Montalvo, W.2
Yagita, H.3
Allison, J.P.4
-
66
-
-
84921456279
-
Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo
-
COI: 1:CAS:528:DC%2BC2MXhtVCgs7w%3D, PID: 25539810
-
Das R, Verma R, Sznol M, Boddupalli CS, Gettinger SN, Kluger H, et al. Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo. J Immunol. 2015;194(3):950–9. doi:10.4049/jimmunol.1401686.
-
(2015)
J Immunol.
, vol.194
, Issue.3
, pp. 950-959
-
-
Das, R.1
Verma, R.2
Sznol, M.3
Boddupalli, C.S.4
Gettinger, S.N.5
Kluger, H.6
-
67
-
-
84997726693
-
-
Patnaik A, Socinski MA, Gubens MA, Gandhi L, Stevenson J, Bachman RD, et al. Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. J Clin Oncol. 2015;33 Suppl:abstr 8011.
-
Patnaik A, Socinski MA, Gubens MA, Gandhi L, Stevenson J, Bachman RD, et al. Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. J Clin Oncol. 2015;33 Suppl:abstr 8011.
-
-
-
-
68
-
-
84997637886
-
-
Antonia SJ, Goldberg SB, Balmanoukian AS, Sanborn RE, Steele K, Narwal R, et al. Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC. J Clin Oncol. 2015;33 Suppl:abstr 3014.
-
Antonia SJ, Goldberg SB, Balmanoukian AS, Sanborn RE, Steele K, Narwal R, et al. Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC. J Clin Oncol. 2015;33 Suppl:abstr 3014.
-
-
-
-
69
-
-
44949096473
-
Chemotherapeutic drugs may be used to enhance the killing efficacy of human tumor antigen peptide-specific CTLs
-
COI: 1:CAS:528:DC%2BD1cXjt1Cju7g%3D, PID: 18481383
-
Correale P, Del Vecchio MT, La Placa M, Montagnani F, Di Genova G, Savellini GG, et al. Chemotherapeutic drugs may be used to enhance the killing efficacy of human tumor antigen peptide-specific CTLs. J Immunother. 2008;31(2):132–47. doi:10.1097/CJI.0b013e31815b69c8.
-
(2008)
J Immunother
, vol.31
, Issue.2
, pp. 132-147
-
-
Correale, P.1
Del Vecchio, M.T.2
La Placa, M.3
Montagnani, F.4
Di Genova, G.5
Savellini, G.G.6
-
70
-
-
77951178310
-
Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
-
COI: 1:CAS:528:DC%2BC3cXksVChsLo%3D, PID: 20234093
-
Ramakrishnan R, Assudani D, Nagaraj S, Hunter T, Cho HI, Antonia S, et al. Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice. J Clin Invest. 2010;120(4):1111–24. doi:10.1172/JCI40269.
-
(2010)
J Clin Invest.
, vol.120
, Issue.4
, pp. 1111-1124
-
-
Ramakrishnan, R.1
Assudani, D.2
Nagaraj, S.3
Hunter, T.4
Cho, H.I.5
Antonia, S.6
-
71
-
-
84997649846
-
-
Antonia SJ, Brahmer JR, Gettinger SN, Chow LQM, Juergens RA, Shepherd FA, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32 Suppl:abstr 8113.
-
Antonia SJ, Brahmer JR, Gettinger SN, Chow LQM, Juergens RA, Shepherd FA, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32 Suppl:abstr 8113.
-
-
-
-
72
-
-
84997805667
-
-
Bendell JC, Powderly JD, Lieu CH, Eckhardt SG, Hurwitz H, Hochster HS, et al. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with bevacizumab (bev) and/or FOLFOX in patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol. 2015;33 Suppl 3:abstr 704.
-
Bendell JC, Powderly JD, Lieu CH, Eckhardt SG, Hurwitz H, Hochster HS, et al. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with bevacizumab (bev) and/or FOLFOX in patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol. 2015;33 Suppl 3:abstr 704.
-
-
-
-
73
-
-
84886698315
-
Innate and adaptive immune cells in the tumor microenvironment
-
COI: 1:CAS:528:DC%2BC3sXhsVKgu7vL, PID: 24048123
-
Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14(10):1014–22. doi:10.1038/ni.2703.
-
(2013)
Nat Immunol
, vol.14
, Issue.10
, pp. 1014-1022
-
-
Gajewski, T.F.1
Schreiber, H.2
Fu, Y.X.3
-
74
-
-
78249257291
-
CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation
-
COI: 1:CAS:528:DC%2BC3cXhsValtLrI, PID: 21035406
-
Rakhra K, Bachireddy P, Zabuawala T, Zeiser R, Xu L, Kopelman A, et al. CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell. 2010;18(5):485–98. doi:10.1016/j.ccr.2010.10.002.
-
(2010)
Cancer Cell
, vol.18
, Issue.5
, pp. 485-498
-
-
Rakhra, K.1
Bachireddy, P.2
Zabuawala, T.3
Zeiser, R.4
Xu, L.5
Kopelman, A.6
-
75
-
-
84941419767
-
Cyclooxygenase-dependent tumor growth through evasion of immunity
-
COI: 1:CAS:528:DC%2BC2MXhsVKhu7bL, PID: 26343581
-
Zelenay S, van der Veen AG, Bottcher JP, Snelgrove KJ, Rogers N, Acton SE, et al. Cyclooxygenase-dependent tumor growth through evasion of immunity. Cell. 2015;162(6):1257–70. doi:10.1016/j.cell.2015.08.015.
-
(2015)
Cell
, vol.162
, Issue.6
, pp. 1257-1270
-
-
Zelenay, S.1
van der Veen, A.G.2
Bottcher, J.P.3
Snelgrove, K.J.4
Rogers, N.5
Acton, S.E.6
-
76
-
-
84874872137
-
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
-
COI: 1:CAS:528:DC%2BC3sXjsFektL0%3D, PID: 23307859
-
Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res. 2013;19(5):1225–31. doi:10.1158/1078-0432.CCR-12-1630.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.5
, pp. 1225-1231
-
-
Frederick, D.T.1
Piris, A.2
Cogdill, A.P.3
Cooper, Z.A.4
Lezcano, C.5
Ferrone, C.R.6
-
77
-
-
84925262623
-
-
Hu-Lieskovan S, Mok S, Homet Moreno B, Tsoi J, Robert L, Goedert L, et al. Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma. Sci Transl Med. 2015;7(279):279ra41. doi:.
-
Hu-Lieskovan S, Mok S, Homet Moreno B, Tsoi J, Robert L, Goedert L, et al. Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma. Sci Transl Med. 2015;7(279):279ra41. doi:10.1126/scitranslmed.aaa4691.
-
-
-
-
78
-
-
84875785905
-
Hepatotoxicity with combination of vemurafenib and ipilimumab
-
COI: 1:CAS:528:DC%2BC3sXls1aktbg%3D, PID: 23550685
-
Ribas A, Hodi FS, Callahan M, Konto C, Wolchok J. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med. 2013;368(14):1365–6. doi:10.1056/NEJMc1302338.
-
(2013)
N Engl J Med
, vol.368
, Issue.14
, pp. 1365-1366
-
-
Ribas, A.1
Hodi, F.S.2
Callahan, M.3
Konto, C.4
Wolchok, J.5
-
79
-
-
79551717184
-
Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma
-
COI: 1:CAS:528:DC%2BC3MXislensr4%3D, PID: 20922784
-
Rini BI, Stein M, Shannon P, Eddy S, Tyler A, Stephenson JJ Jr, et al. Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma. Cancer. 2011;117(4):758–67. doi:10.1002/cncr.25639.
-
(2011)
Cancer
, vol.117
, Issue.4
, pp. 758-767
-
-
Rini, B.I.1
Stein, M.2
Shannon, P.3
Eddy, S.4
Tyler, A.5
Stephenson, J.J.6
-
80
-
-
84997767616
-
-
Creelan BC, Chow LQ, Kim DW, Kim SW, Yeh T, Karakunnel JJ, et al. Safety and tolerability results from a phase I study of MEDI4736, a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib in patients (pts) with non-small-cell lung cancer (NSCLC). J Clin Oncol. 2015;33 Suppl:abstr 3047.
-
Creelan BC, Chow LQ, Kim DW, Kim SW, Yeh T, Karakunnel JJ, et al. Safety and tolerability results from a phase I study of MEDI4736, a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib in patients (pts) with non-small-cell lung cancer (NSCLC). J Clin Oncol. 2015;33 Suppl:abstr 3047.
-
-
-
-
81
-
-
84997627659
-
-
Ribas A, Butler M, Lutzky J, Lawrence DP, Robert C, Miller W, et al. Phase I study combining anti-PD-L1 (MEDI4736) with BRAF (dabrafenib) and/or MEK (trametinib) inhibitors in advanced melanoma. J Clin Oncol. 2015;33 Suppl:abstr 3003.
-
Ribas A, Butler M, Lutzky J, Lawrence DP, Robert C, Miller W, et al. Phase I study combining anti-PD-L1 (MEDI4736) with BRAF (dabrafenib) and/or MEK (trametinib) inhibitors in advanced melanoma. J Clin Oncol. 2015;33 Suppl:abstr 3003.
-
-
-
-
82
-
-
84997626963
-
-
Amin A, Plimack ER, Infante JR, Ernstoff MS, Rini BI, McDermott DF, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol. 2014;32(5 Suppl):abstr 5010.
-
Amin A, Plimack ER, Infante JR, Ernstoff MS, Rini BI, McDermott DF, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol. 2014;32(5 Suppl):abstr 5010.
-
-
-
-
83
-
-
84893876109
-
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
-
COI: 1:CAS:528:DC%2BC2cXis1ertbc%3D, PID: 24382348
-
Deng L, Liang H, Burnette B, Beckett M, Darga T, Weichselbaum RR, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 2014;124(2):687–95. doi:10.1172/JCI67313.
-
(2014)
J Clin Invest.
, vol.124
, Issue.2
, pp. 687-695
-
-
Deng, L.1
Liang, H.2
Burnette, B.3
Beckett, M.4
Darga, T.5
Weichselbaum, R.R.6
-
84
-
-
33846429184
-
Induced sensitization of tumor stroma leads to eradication of established cancer by T cells
-
COI: 1:CAS:528:DC%2BD2sXhtFGjsbY%3D, PID: 17210731
-
Zhang B, Bowerman NA, Salama JK, Schmidt H, Spiotto MT, Schietinger A, et al. Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. J Exp Med. 2007;204(1):49–55. doi:10.1084/jem.20062056.
-
(2007)
J Exp Med
, vol.204
, Issue.1
, pp. 49-55
-
-
Zhang, B.1
Bowerman, N.A.2
Salama, J.K.3
Schmidt, H.4
Spiotto, M.T.5
Schietinger, A.6
-
85
-
-
84857815877
-
Immunologic correlates of the abscopal effect in a patient with melanoma
-
COI: 1:CAS:528:DC%2BC38XktFOgurw%3D, PID: 22397654
-
Postow MA, Callahan MK, Barker CA, Yamada Y, Yuan J, Kitano S, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366(10):925–31. doi:10.1056/NEJMoa1112824.
-
(2012)
N Engl J Med
, vol.366
, Issue.10
, pp. 925-931
-
-
Postow, M.A.1
Callahan, M.K.2
Barker, C.A.3
Yamada, Y.4
Yuan, J.5
Kitano, S.6
-
86
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
COI: 1:CAS:528:DC%2BD3sXlsFGnt7c%3D, PID: 12826605
-
Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci. 2003;100(14):8372–7. doi:10.1073/pnas.1533209100.
-
(2003)
Proc Natl Acad Sci
, vol.100
, Issue.14
, pp. 8372-8377
-
-
Phan, G.Q.1
Yang, J.C.2
Sherry, R.M.3
Hwu, P.4
Topalian, S.L.5
Schwartzentruber, D.J.6
-
87
-
-
24944459890
-
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
-
COI: 1:CAS:528:DC%2BD2MXhtVKgtb3L, PID: 16087944
-
Attia P, Phan GQ, Maker AV, Robinson MR, Quezado MM, Yang JC, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol. 2005;23(25):6043–53. doi:10.1200/JCO.2005.06.205.
-
(2005)
J Clin Oncol
, vol.23
, Issue.25
, pp. 6043-6053
-
-
Attia, P.1
Phan, G.Q.2
Maker, A.V.3
Robinson, M.R.4
Quezado, M.M.5
Yang, J.C.6
-
88
-
-
32644467549
-
Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206
-
COI: 1:CAS:528:DC%2BD28XktVCnsg%3D%3D, PID: 16204013
-
Ribas A, Camacho LH, Lopez-Berestein G, Pavlov D, Bulanhagui CA, Millham R, et al. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol. 2005;23(35):8968–77. doi:10.1200/JCO.2005.01.109.
-
(2005)
J Clin Oncol
, vol.23
, Issue.35
, pp. 8968-8977
-
-
Ribas, A.1
Camacho, L.H.2
Lopez-Berestein, G.3
Pavlov, D.4
Bulanhagui, C.A.5
Millham, R.6
-
89
-
-
69949095926
-
A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
-
COI: 1:CAS:528:DC%2BD1MXhtVOntrbE, PID: 19671877
-
Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, et al. A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res. 2009;15(17):5591–8. doi:10.1158/1078-0432.CCR-09-1024.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.17
, pp. 5591-5598
-
-
Weber, J.1
Thompson, J.A.2
Hamid, O.3
Minor, D.4
Amin, A.5
Ron, I.6
-
90
-
-
36748999428
-
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
-
COI: 1:CAS:528:DC%2BD2sXhtlSmu7bN, PID: 17982122
-
Downey SG, Klapper JA, Smith FO, Yang JC, Sherry RM, Royal RE, et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res. 2007;13(22 Pt 1):6681–8. doi:10.1158/1078-0432.CCR-07-0187.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.22
, pp. 6681-6688
-
-
Downey, S.G.1
Klapper, J.A.2
Smith, F.O.3
Yang, J.C.4
Sherry, R.M.5
Royal, R.E.6
-
91
-
-
32644454916
-
Prognostic significance of autoimmunity during treatment of melanoma with interferon
-
COI: 1:CAS:528:DC%2BD28XhsVWrsrw%3D, PID: 16481638
-
Gogas H, Ioannovich J, Dafni U, Stavropoulou-Giokas C, Frangia K, Tsoutsos D, et al. Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med. 2006;354(7):709–18. doi:10.1056/NEJMoa053007.
-
(2006)
N Engl J Med
, vol.354
, Issue.7
, pp. 709-718
-
-
Gogas, H.1
Ioannovich, J.2
Dafni, U.3
Stavropoulou-Giokas, C.4
Frangia, K.5
Tsoutsos, D.6
-
92
-
-
35649026211
-
Autoimmunity as a prognostic factor in melanoma patients treated with adjuvant low-dose interferon alpha
-
COI: 1:CAS:528:DC%2BD2sXhtlShtb3I, PID: 17680564
-
Satzger I, Meier A, Schenck F, Kapp A, Hauschild A, Gutzmer R. Autoimmunity as a prognostic factor in melanoma patients treated with adjuvant low-dose interferon alpha. Int J Cancer. 2007;121(11):2562–6. doi:10.1002/ijc.22951.
-
(2007)
Int J Cancer
, vol.121
, Issue.11
, pp. 2562-2566
-
-
Satzger, I.1
Meier, A.2
Schenck, F.3
Kapp, A.4
Hauschild, A.5
Gutzmer, R.6
-
93
-
-
84655165056
-
Continuous systemic corticosteroids do not affect the ongoing regression of metastatic melanoma for more than two years following ipilimumab therapy
-
COI: 1:CAS:528:DC%2BC3MXhsFWjtr3I, PID: 20593249
-
Harmankaya K, Erasim C, Koelblinger C, Ibrahim R, Hoos A, Pehamberger H, et al. Continuous systemic corticosteroids do not affect the ongoing regression of metastatic melanoma for more than two years following ipilimumab therapy. Med Oncol. 2011;28(4):1140–4. doi:10.1007/s12032-010-9606-0.
-
(2011)
Med Oncol
, vol.28
, Issue.4
, pp. 1140-1144
-
-
Harmankaya, K.1
Erasim, C.2
Koelblinger, C.3
Ibrahim, R.4
Hoos, A.5
Pehamberger, H.6
-
94
-
-
27444444916
-
Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells
-
COI: 1:CAS:528:DC%2BD2MXhtFSis73M, PID: 16224268
-
Hinrichs CS, Palmer DC, Rosenberg SA, Restifo NP. Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells. J Immunother. 2005;28(6):517–24.
-
(2005)
J Immunother
, vol.28
, Issue.6
, pp. 517-524
-
-
Hinrichs, C.S.1
Palmer, D.C.2
Rosenberg, S.A.3
Restifo, N.P.4
-
95
-
-
84860446616
-
Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial
-
COI: 1:CAS:528:DC%2BC38Xmslyhsb4%3D, PID: 22456429
-
Margolin K, Ernstoff MS, Hamid O, Lawrence D, McDermott D, Puzanov I, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol. 2012;13(5):459–65. doi:10.1016/S1470-2045(12)70090-6.
-
(2012)
Lancet Oncol.
, vol.13
, Issue.5
, pp. 459-465
-
-
Margolin, K.1
Ernstoff, M.S.2
Hamid, O.3
Lawrence, D.4
McDermott, D.5
Puzanov, I.6
-
96
-
-
84877093633
-
Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control
-
Robert C, Schadendorf D, Messina M, Hodi FS, O’Day S, investigators MDX. Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control. Clin Cancer Res. 2013;19(8):2232–9. doi:10.1158/1078-0432.CCR-12-3080.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.8
, pp. 2232-2239
-
-
Robert, C.1
Schadendorf, D.2
Messina, M.3
Hodi, F.S.4
O’Day, S.5
investigators, M.D.X.6
-
97
-
-
85016509105
-
Phase I/II study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab
-
COI: 1:CAS:528:DC%2BC28Xls1GrtL4%3D, PID: 26873574
-
Weber J, Gibney G, Kudchadkar R, Yu B, Cheng P, Martinez AJ, et al. Phase I/II study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab. Cancer Immunol Res. 2016;4(4):345–53. doi:10.1158/2326-6066.CIR-15-0193.
-
(2016)
Cancer Immunol Res.
, vol.4
, Issue.4
, pp. 345-353
-
-
Weber, J.1
Gibney, G.2
Kudchadkar, R.3
Yu, B.4
Cheng, P.5
Martinez, A.J.6
-
98
-
-
84967185844
-
Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy
-
COI: 1:CAS:528:DC%2BC28XnvV2qurc%3D, PID: 27124339
-
Bowyer S, Prithviraj P, Lorigan P, Larkin J, McArthur G, Atkinson V, et al. Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy. Br J Cancer. 2016;114(10):1084–9. doi:10.1038/bjc.2016.107.
-
(2016)
Br J Cancer
, vol.114
, Issue.10
, pp. 1084-1089
-
-
Bowyer, S.1
Prithviraj, P.2
Lorigan, P.3
Larkin, J.4
McArthur, G.5
Atkinson, V.6
-
99
-
-
84991110530
-
Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial
-
PID: 27269740
-
Weber JS, Gibney G, Sullivan RJ, Sosman JA, Slingluff CL Jr, Lawrence DP, et al. Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial. Lancet Oncol. 2016. doi:10.1016/S1470-2045(16)30126-7.
-
(2016)
Lancet Oncol.
-
-
Weber, J.S.1
Gibney, G.2
Sullivan, R.J.3
Sosman, J.A.4
Slingluff, C.L.5
Lawrence, D.P.6
-
100
-
-
85003054266
-
Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders
-
PID: 26633184
-
Johnson DB, Sullivan RJ, Ott PA, Carlino MS, Khushalani NI, Ye F, et al. Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders. JAMA Oncol. 2016;2(2):234–40. doi:10.1001/jamaoncol.2015.4368.
-
(2016)
JAMA Oncol.
, vol.2
, Issue.2
, pp. 234-240
-
-
Johnson, D.B.1
Sullivan, R.J.2
Ott, P.A.3
Carlino, M.S.4
Khushalani, N.I.5
Ye, F.6
-
101
-
-
84977136814
-
Ipilimumab in patients with melanoma and autoimmune disease
-
PID: 25349698
-
Kyi C, Carvajal RD, Wolchok JD, Postow MA. Ipilimumab in patients with melanoma and autoimmune disease. J Immunother Cancer. 2014;2(1):35. doi:10.1186/s40425-014-0035-z.
-
(2014)
J Immunother Cancer.
, vol.2
, Issue.1
, pp. 35
-
-
Kyi, C.1
Carvajal, R.D.2
Wolchok, J.D.3
Postow, M.A.4
-
102
-
-
84905820239
-
Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma
-
PID: 24493726
-
Lipson EJ, Bodell MA, Kraus ES, Sharfman WH. Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma. J Clin Oncol. 2014;32(19):e69–71. doi:10.1200/JCO.2013.49.2314.
-
(2014)
J Clin Oncol
, vol.32
, Issue.19
, pp. e69-e71
-
-
Lipson, E.J.1
Bodell, M.A.2
Kraus, E.S.3
Sharfman, W.H.4
-
103
-
-
84997782881
-
Safety and efficacy of ipilimumab to treat advanced melanoma in the setting of liver transplantation
-
PID: 26082835
-
Morales RE, Shoushtari AN, Walsh MM, Grewal P, Lipson EJ, Carvajal RD. Safety and efficacy of ipilimumab to treat advanced melanoma in the setting of liver transplantation. J Immunother Cancer. 2015;3:22. doi:10.1186/s40425-015-0066-0.
-
(2015)
J Immunother Cancer.
, vol.3
, pp. 22
-
-
Morales, R.E.1
Shoushtari, A.N.2
Walsh, M.M.3
Grewal, P.4
Lipson, E.J.5
Carvajal, R.D.6
-
104
-
-
84997768520
-
-
FDA prescribing information. Accessed 13 July 2016
-
FDA prescribing information. http://www.accessdata.fda.gov. Accessed 13 July 2016.
-
-
-
-
105
-
-
84941619877
-
A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors
-
COI: 1:STN:280:DC%2BC2MjltlamtQ%3D%3D, PID: 25888611
-
Chen TW, Razak AR, Bedard PL, Siu LL, Hansen AR. A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors. Ann Oncol. 2015;26(9):1824–9. doi:10.1093/annonc/mdv182.
-
(2015)
Ann Oncol
, vol.26
, Issue.9
, pp. 1824-1829
-
-
Chen, T.W.1
Razak, A.R.2
Bedard, P.L.3
Siu, L.L.4
Hansen, A.R.5
-
106
-
-
84875132942
-
Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events
-
COI: 1:CAS:528:DC%2BC3sXnvVyju7s%3D, PID: 23521917
-
Shahabi V, Berman D, Chasalow SD, Wang L, Tsuchihashi Z, Hu B, et al. Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events. J Transl Med. 2013;11:75. doi:10.1186/1479-5876-11-75.
-
(2013)
J Transl Med.
, vol.11
, pp. 75
-
-
Shahabi, V.1
Berman, D.2
Chasalow, S.D.3
Wang, L.4
Tsuchihashi, Z.5
Hu, B.6
-
107
-
-
84997771368
-
Baseline circulating IL-17 predicts toxicity while TGF-beta1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma
-
PID: 26380086
-
Tarhini AA, Zahoor H, Lin Y, Malhotra U, Sander C, Butterfield LH, et al. Baseline circulating IL-17 predicts toxicity while TGF-beta1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma. J Immunother Cancer. 2015;3:39. doi:10.1186/s40425-015-0081-1.
-
(2015)
J Immunother Cancer.
, vol.3
, pp. 39
-
-
Tarhini, A.A.1
Zahoor, H.2
Lin, Y.3
Malhotra, U.4
Sander, C.5
Butterfield, L.H.6
-
108
-
-
84997781156
-
Evaluation of serum IL-17 levels during ipilimumab therapy: Correlation with colitis. J Clin Oncol
-
Callahan MK, Yang A, Tandon S, Xu Y, Subudhi SK, Roman RA, et al. Evaluation of serum IL-17 levels during ipilimumab therapy: Correlation with colitis. J Clin Oncol. 2011;29 Suppl:abstr 2505.
-
2011;29 Suppl:abstr
-
-
Callahan, M.K.1
Yang, A.2
Tandon, S.3
Xu, Y.4
Subudhi, S.K.5
Roman, R.A.6
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